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Protein

tRNA-splicing endonuclease subunit Sen34

Gene

TSEN34

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Constitutes one of the two catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body. It probably carries the active site for 3'-splice site cleavage. The tRNA splicing endonuclease is also involved in mRNA processing via its association with pre-mRNA 3'-end processing factors, establishing a link between pre-tRNA splicing and pre-mRNA 3'-end formation, suggesting that the endonuclease subunits function in multiple RNA-processing events.1 Publication

Miscellaneous

Belongs to the leukocyte receptor cluster (LRC) present on 19q13.4.

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • PretRNA = a 3'-half-tRNA molecule with a 5'-OH end + a 5'-half-tRNA molecule with a 2',3'-cyclic phosphate end + an intron with a 2',3'-cyclic phosphate and a 5'-hydroxyl terminus. EC:4.6.1.16

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei247By similarity1
Active sitei255By similarity1
Active sitei286By similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • lyase activity Source: UniProtKB-KW
  • nucleic acid binding Source: InterPro
  • tRNA-intron endonuclease activity Source: GO_Central

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionLyase
Biological processmRNA processing, tRNA processing

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
MetaCyc:HS10201-MONOMER

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-6784531 tRNA processing in the nucleus

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
tRNA-splicing endonuclease subunit Sen34 (EC:4.6.1.16)
Alternative name(s):
Leukocyte receptor cluster member 5
tRNA-intron endonuclease Sen34
Short name:
HsSen34
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TSEN34
Synonyms:LENG5, SEN34
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000170892.10

Human Gene Nomenclature Database

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HGNCi
HGNC:15506 TSEN34

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
608754 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9BSV6

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Pontocerebellar hypoplasia 2C (PCH2C)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA disorder characterized by an abnormally small cerebellum and brainstem, and progressive microcephaly from birth combined with extrapyramidal dyskinesia. Severe chorea occurs and epilepsy is frequent. There are no signs of spinal cord anterior horn cells degeneration.
See also OMIM:612390
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_05481158R → W in PCH2C. 1 PublicationCorresponds to variant dbSNP:rs113994150EnsemblClinVar.1

Keywords - Diseasei

Disease mutation, Neurodegeneration, Pontocerebellar hypoplasia

Organism-specific databases

DisGeNET

More...
DisGeNETi
79042

MalaCards human disease database

More...
MalaCardsi
TSEN34
MIMi612390 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000170892

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
2524 Pontocerebellar hypoplasia type 2

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134871088

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
TSEN34

Domain mapping of disease mutations (DMDM)

More...
DMDMi
50401668

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001094631 – 310tRNA-splicing endonuclease subunit Sen34Add BLAST310

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q9BSV6

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9BSV6

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9BSV6

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9BSV6

PeptideAtlas

More...
PeptideAtlasi
Q9BSV6

PRoteomics IDEntifications database

More...
PRIDEi
Q9BSV6

ProteomicsDB human proteome resource

More...
ProteomicsDBi
78929

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9BSV6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9BSV6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000170892 Expressed in 224 organ(s), highest expression level in blood

CleanEx database of gene expression profiles

More...
CleanExi
HS_TSEN34

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9BSV6 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9BSV6 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA041111
HPA048208

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

tRNA splicing endonuclease is a heterotetramer composed of TSEN2, TSEN15, TSEN34/LENG5 and TSEN54. tRNA splicing endonuclease complex also contains proteins of the pre-mRNA 3'-end processing machinery such as CLP1, CPSF1, CPSF4 and CSTF2.1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
122505, 17 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
Q9BSV6

Protein interaction database and analysis system

More...
IntActi
Q9BSV6, 3 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000305524

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q9BSV6

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the tRNA-intron endonuclease family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG4133 Eukaryota
COG1676 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00390000003912

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000232197

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG054846

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9BSV6

KEGG Orthology (KO)

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KOi
K15323

Database of Orthologous Groups

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OrthoDBi
1621103at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q9BSV6

TreeFam database of animal gene trees

More...
TreeFami
TF314631

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
3.40.1350.10, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR011856 tRNA_endonuc-like_dom_sf
IPR036167 tRNA_intron_Endo_cat-like_sf
IPR006677 tRNA_intron_Endonuc_cat-like
IPR006676 tRNA_splic
IPR016690 tRNA_splic_SEN34

The PANTHER Classification System

More...
PANTHERi
PTHR13070 PTHR13070, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF01974 tRNA_int_endo, 1 hit

PIRSF; a whole-protein classification database

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PIRSFi
PIRSF017250 tRNA_splic_SEN34, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF53032 SSF53032, 1 hit

TIGRFAMs; a protein family database

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TIGRFAMsi
TIGR00324 endA, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

Q9BSV6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLVVEVANGR SLVWGAEAVQ ALRERLGVGG RTVGALPRGP RQNSRLGLPL
60 70 80 90 100
LLMPEEARLL AEIGAVTLVS APRPDSRHHS LALTSFKRQQ EESFQEQSAL
110 120 130 140 150
AAEARETRRQ ELLEKITEGQ AAKKQKLEQA SGASSSQEAG SSQAAKEDET
160 170 180 190 200
SDGQASGEQE EAGPSSSQAG PSNGVAPLPR SALLVQLATA RPRPVKARPL
210 220 230 240 250
DWRVQSKDWP HAGRPAHELR YSIYRDLWER GFFLSAAGKF GGDFLVYPGD
260 270 280 290 300
PLRFHAHYIA QCWAPEDTIP LQDLVAAGRL GTSVRKTLLL CSPQPDGKVV
310
YTSLQWASLQ
Length:310
Mass (Da):33,652
Last modified:June 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1C1522D030148EC3
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E7EQB3E7EQB3_HUMAN
tRNA-splicing endonuclease subunit ...
TSEN34
315Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A9C4B9A9C4B9_HUMAN
tRNA-splicing endonuclease subunit ...
TSEN34
251Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B0V3J0B0V3J0_HUMAN
tRNA-splicing endonuclease subunit ...
TSEN34
242Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JNK5A0A0G2JNK5_HUMAN
tRNA-splicing endonuclease subunit ...
TSEN34
252Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAB15284 differs from that shown. Reason: Erroneous termination at position 311. Translated as stop.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05481158R → W in PCH2C. 1 PublicationCorresponds to variant dbSNP:rs113994150EnsemblClinVar.1
Natural variantiVAR_061149112L → V1 PublicationCorresponds to variant dbSNP:rs17849378EnsemblClinVar.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK025929 mRNA Translation: BAB15284.1 Sequence problems.
CU457734 Genomic DNA No translation available.
CU151838 Genomic DNA No translation available.
CH471135 Genomic DNA Translation: EAW72203.1
BC004530 mRNA Translation: AAH04530.1
BC020805 mRNA Translation: AAH20805.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS42609.1

NCBI Reference Sequences

More...
RefSeqi
NP_001070914.1, NM_001077446.3
NP_001269261.1, NM_001282332.1
NP_076980.2, NM_024075.4
XP_011525596.1, XM_011527294.2
XP_011525597.1, XM_011527295.1

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.15580

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000302937; ENSP00000305524; ENSG00000170892
ENST00000396383; ENSP00000379667; ENSG00000170892
ENST00000396388; ENSP00000379671; ENSG00000170892
ENST00000611560; ENSP00000480422; ENSG00000274796
ENST00000611798; ENSP00000480899; ENSG00000278605
ENST00000612236; ENSP00000480503; ENSG00000274129
ENST00000612393; ENSP00000478622; ENSG00000278622
ENST00000613310; ENSP00000477766; ENSG00000274078
ENST00000613712; ENSP00000484865; ENSG00000273896
ENST00000613888; ENSP00000481068; ENSG00000278712
ENST00000614948; ENSP00000478156; ENSG00000278622
ENST00000614984; ENSP00000483266; ENSG00000278712
ENST00000615000; ENSP00000479654; ENSG00000278605
ENST00000615079; ENSP00000484694; ENSG00000278605
ENST00000615900; ENSP00000484964; ENSG00000274078
ENST00000615975; ENSP00000484225; ENSG00000278622
ENST00000616063; ENSP00000480964; ENSG00000274129
ENST00000616209; ENSP00000481374; ENSG00000274672
ENST00000617149; ENSP00000481639; ENSG00000273896
ENST00000617902; ENSP00000484465; ENSG00000275165
ENST00000618135; ENSP00000479576; ENSG00000274129
ENST00000619994; ENSP00000482084; ENSG00000275165
ENST00000622524; ENSP00000483436; ENSG00000274672
ENST00000622538; ENSP00000482527; ENSG00000274796

Database of genes from NCBI RefSeq genomes

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GeneIDi
79042

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:79042

UCSC genome browser

More...
UCSCi
uc032icq.1 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK025929 mRNA Translation: BAB15284.1 Sequence problems.
CU457734 Genomic DNA No translation available.
CU151838 Genomic DNA No translation available.
CH471135 Genomic DNA Translation: EAW72203.1
BC004530 mRNA Translation: AAH04530.1
BC020805 mRNA Translation: AAH20805.1
CCDSiCCDS42609.1
RefSeqiNP_001070914.1, NM_001077446.3
NP_001269261.1, NM_001282332.1
NP_076980.2, NM_024075.4
XP_011525596.1, XM_011527294.2
XP_011525597.1, XM_011527295.1
UniGeneiHs.15580

3D structure databases

ProteinModelPortaliQ9BSV6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122505, 17 interactors
CORUMiQ9BSV6
IntActiQ9BSV6, 3 interactors
STRINGi9606.ENSP00000305524

PTM databases

iPTMnetiQ9BSV6
PhosphoSitePlusiQ9BSV6

Polymorphism and mutation databases

BioMutaiTSEN34
DMDMi50401668

Proteomic databases

EPDiQ9BSV6
jPOSTiQ9BSV6
MaxQBiQ9BSV6
PaxDbiQ9BSV6
PeptideAtlasiQ9BSV6
PRIDEiQ9BSV6
ProteomicsDBi78929

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
79042
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000302937; ENSP00000305524; ENSG00000170892
ENST00000396383; ENSP00000379667; ENSG00000170892
ENST00000396388; ENSP00000379671; ENSG00000170892
ENST00000611560; ENSP00000480422; ENSG00000274796
ENST00000611798; ENSP00000480899; ENSG00000278605
ENST00000612236; ENSP00000480503; ENSG00000274129
ENST00000612393; ENSP00000478622; ENSG00000278622
ENST00000613310; ENSP00000477766; ENSG00000274078
ENST00000613712; ENSP00000484865; ENSG00000273896
ENST00000613888; ENSP00000481068; ENSG00000278712
ENST00000614948; ENSP00000478156; ENSG00000278622
ENST00000614984; ENSP00000483266; ENSG00000278712
ENST00000615000; ENSP00000479654; ENSG00000278605
ENST00000615079; ENSP00000484694; ENSG00000278605
ENST00000615900; ENSP00000484964; ENSG00000274078
ENST00000615975; ENSP00000484225; ENSG00000278622
ENST00000616063; ENSP00000480964; ENSG00000274129
ENST00000616209; ENSP00000481374; ENSG00000274672
ENST00000617149; ENSP00000481639; ENSG00000273896
ENST00000617902; ENSP00000484465; ENSG00000275165
ENST00000618135; ENSP00000479576; ENSG00000274129
ENST00000619994; ENSP00000482084; ENSG00000275165
ENST00000622524; ENSP00000483436; ENSG00000274672
ENST00000622538; ENSP00000482527; ENSG00000274796
GeneIDi79042
KEGGihsa:79042
UCSCiuc032icq.1 human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
79042
DisGeNETi79042
EuPathDBiHostDB:ENSG00000170892.10

GeneCards: human genes, protein and diseases

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GeneCardsi
TSEN34
HGNCiHGNC:15506 TSEN34
HPAiHPA041111
HPA048208
MalaCardsiTSEN34
MIMi608754 gene
612390 phenotype
neXtProtiNX_Q9BSV6
OpenTargetsiENSG00000170892
Orphaneti2524 Pontocerebellar hypoplasia type 2
PharmGKBiPA134871088

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG4133 Eukaryota
COG1676 LUCA
GeneTreeiENSGT00390000003912
HOGENOMiHOG000232197
HOVERGENiHBG054846
InParanoidiQ9BSV6
KOiK15323
OrthoDBi1621103at2759
PhylomeDBiQ9BSV6
TreeFamiTF314631

Enzyme and pathway databases

BioCyciMetaCyc:HS10201-MONOMER
ReactomeiR-HSA-6784531 tRNA processing in the nucleus

Miscellaneous databases

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
TSEN34

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
79042

Protein Ontology

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PROi
PR:Q9BSV6

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000170892 Expressed in 224 organ(s), highest expression level in blood
CleanExiHS_TSEN34
ExpressionAtlasiQ9BSV6 baseline and differential
GenevisibleiQ9BSV6 HS

Family and domain databases

Gene3Di3.40.1350.10, 1 hit
InterProiView protein in InterPro
IPR011856 tRNA_endonuc-like_dom_sf
IPR036167 tRNA_intron_Endo_cat-like_sf
IPR006677 tRNA_intron_Endonuc_cat-like
IPR006676 tRNA_splic
IPR016690 tRNA_splic_SEN34
PANTHERiPTHR13070 PTHR13070, 1 hit
PfamiView protein in Pfam
PF01974 tRNA_int_endo, 1 hit
PIRSFiPIRSF017250 tRNA_splic_SEN34, 1 hit
SUPFAMiSSF53032 SSF53032, 1 hit
TIGRFAMsiTIGR00324 endA, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSEN34_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9BSV6
Secondary accession number(s): A6NNB1
, B0V3J1, Q9BVT1, Q9H6H5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: June 1, 2001
Last modified: January 16, 2019
This is version 144 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
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