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UniProtKB - Q9BSU3 (NAA11_HUMAN)
Protein
N-alpha-acetyltransferase 11
Gene
NAA11
Organism
Homo sapiens (Human)
Status
Functioni
Displays alpha (N-terminal) acetyltransferase activity. Proposed alternative catalytic subunit of the N-terminal acetyltransferase A (NatA) complex.
1 PublicationCatalytic activityi
- acetyl-CoA + N-terminal glycyl-[protein] = CoA + H+ + N-terminal Nα-acetylglycyl-[protein]By similarityEC:2.3.1.255By similarity
- acetyl-CoA + N-terminal L-alanyl-[protein] = CoA + H+ + N-terminal Nα-acetyl-L-alanyl-[protein]By similarityEC:2.3.1.255By similarity
- acetyl-CoA + N-terminal L-seryl-[protein] = CoA + H+ + N-terminal Nα-acetyl-L-seryl-[protein]By similarityEC:2.3.1.255By similarity
- acetyl-CoA + N-terminal L-valyl-[protein] = CoA + H+ + N-terminal Nα-acetyl-L-valyl-[protein]By similarityEC:2.3.1.255By similarity
- acetyl-CoA + N-terminal L-cysteinyl-[protein] = CoA + H+ + N-terminal Nα-acetyl-L-cysteinyl-[protein]By similarityEC:2.3.1.255By similarity
- acetyl-CoA + N-terminal L-threonyl-[protein] = CoA + H+ + N-terminal Nα-acetyl-L-threonyl-[protein]By similarityEC:2.3.1.255By similarity
GO - Molecular functioni
- peptide alpha-N-acetyltransferase activity Source: UniProtKB
- peptide-glutamate-N-acetyltransferase activity Source: GO_Central
- peptide-serine-N-acetyltransferase activity Source: GO_Central
GO - Biological processi
- N-terminal peptidyl-glutamic acid acetylation Source: GO_Central
- N-terminal peptidyl-serine acetylation Source: GO_Central
- N-terminal protein amino acid acetylation Source: UniProtKB
Keywordsi
Molecular function | Acyltransferase, Transferase |
Enzyme and pathway databases
PathwayCommonsi | Q9BSU3 |
SignaLinki | Q9BSU3 |
Names & Taxonomyi
Protein namesi | Recommended name: N-alpha-acetyltransferase 11 (EC:2.3.1.255By similarity)Alternative name(s): N-terminal acetyltransferase complex ARD1 subunit homolog B Short name: hARD2 NatA catalytic subunit Naa11 |
Gene namesi | Name:NAA11 Synonyms:ARD1B, ARD2 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:28125, NAA11 |
MIMi | 619432, gene |
neXtProti | NX_Q9BSU3 |
VEuPathDBi | HostDB:ENSG00000156269 |
Subcellular locationi
Cytoskeleton
- centrosome Source: HPA
Cytosol
- cytosol Source: HPA
Golgi apparatus
- Golgi apparatus Source: HPA
Nucleus
- nucleoplasm Source: HPA
Other locations
- NatA complex Source: UniProtKB
Keywords - Cellular componenti
Cytoplasm, NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 84779 |
OpenTargetsi | ENSG00000156269 |
PharmGKBi | PA165664264 |
Miscellaneous databases
Pharosi | Q9BSU3, Tbio |
Genetic variation databases
BioMutai | NAA11 |
DMDMi | 158706520 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000305009 | 1 – 229 | N-alpha-acetyltransferase 11Add BLAST | 229 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 186 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q9BSU3 |
jPOSTi | Q9BSU3 |
MassIVEi | Q9BSU3 |
MaxQBi | Q9BSU3 |
PaxDbi | Q9BSU3 |
PeptideAtlasi | Q9BSU3 |
PRIDEi | Q9BSU3 |
ProteomicsDBi | 78928 |
PTM databases
iPTMneti | Q9BSU3 |
PhosphoSitePlusi | Q9BSU3 |
Expressioni
Tissue specificityi
Present in several cell lines, with highest levels in MCF-7 cells (at protein level).1 Publication
Gene expression databases
Bgeei | ENSG00000156269, Expressed in secondary oocyte and 84 other tissues |
ExpressionAtlasi | Q9BSU3, baseline and differential |
Genevisiblei | Q9BSU3, HS |
Organism-specific databases
HPAi | ENSG00000156269, Group enriched (brain, placenta, testis) |
Interactioni
Subunit structurei
Component of the N-terminal acetyltransferase A (NatA) complex composed of NAA11 and NAA15 (Probable).
Interacts with HIF1A.
Curated1 PublicationBinary interactionsi
Q9BSU3
Protein-protein interaction databases
BioGRIDi | 124254, 58 interactors |
IntActi | Q9BSU3, 15 interactors |
STRINGi | 9606.ENSP00000286794 |
Miscellaneous databases
RNActi | Q9BSU3, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1 – 152 | N-acetyltransferasePROSITE-ProRule annotationAdd BLAST | 152 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 58 | Interaction with NAA15By similarityAdd BLAST | 58 | |
Regioni | 175 – 229 | DisorderedSequence analysisAdd BLAST | 55 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 175 – 200 | Polar residuesSequence analysisAdd BLAST | 26 | |
Compositional biasi | 215 – 229 | Polar residuesSequence analysisAdd BLAST | 15 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG3235, Eukaryota |
GeneTreei | ENSGT00940000163834 |
HOGENOMi | CLU_013985_7_0_1 |
InParanoidi | Q9BSU3 |
OMAi | KTESKYY |
OrthoDBi | 1489230at2759 |
PhylomeDBi | Q9BSU3 |
TreeFami | TF300078 |
Family and domain databases
InterProi | View protein in InterPro IPR016181, Acyl_CoA_acyltransferase IPR045047, Ard1-like IPR000182, GNAT_dom |
PANTHERi | PTHR23091, PTHR23091, 1 hit |
Pfami | View protein in Pfam PF00583, Acetyltransf_1, 1 hit |
SUPFAMi | SSF55729, SSF55729, 1 hit |
PROSITEi | View protein in PROSITE PS51186, GNAT, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q9BSU3-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MNIRNAQPDD LMNMQHCNLL CLPENYQMKY YLYHGLSWPQ LSYIAEDEDG
60 70 80 90 100
KIVGYVLAKM EEEPDDVPHG HITSLAVKRS HRRLGLAQKL MDQASRAMIE
110 120 130 140 150
NFNAKYVSLH VRKSNRPALH LYSNTLNFQI SEVEPKYYAD GEDAYAMKRD
160 170 180 190 200
LSQMADELRR QMDLKKGGYV VLGSRENQET QGSTLSDSEE ACQQKNPATE
210 220
ESGSDSKEPK ESVESTNVQD SSESSDSTS
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketH0Y8T0 | H0Y8T0_HUMAN | N-alpha-acetyltransferase 11 | NAA11 | 111 | Annotation score: |
Sequence cautioni
The sequence AAH04552 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAH63623 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAH80651 differs from that shown. Reason: Erroneous initiation.Curated
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_048164 | 6 | A → T. Corresponds to variant dbSNP:rs3811765Ensembl. | 1 | |
Natural variantiVAR_048165 | 19 | L → F. Corresponds to variant dbSNP:rs17003712Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC004552 mRNA Translation: AAH04552.2 Different initiation. BC063623 mRNA Translation: AAH63623.1 Different initiation. BC080651 mRNA Translation: AAH80651.1 Different initiation. |
CCDSi | CCDS47084.1 |
RefSeqi | NP_116082.1, NM_032693.2 XP_016864266.1, XM_017008777.1 XP_016864267.1, XM_017008778.1 XP_016864268.1, XM_017008779.1 |
Genome annotation databases
Ensembli | ENST00000286794; ENSP00000286794; ENSG00000156269 |
GeneIDi | 84779 |
KEGGi | hsa:84779 |
MANE-Selecti | ENST00000286794.5; ENSP00000286794.4; NM_032693.3; NP_116082.1 |
UCSCi | uc003hlt.5, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC004552 mRNA Translation: AAH04552.2 Different initiation. BC063623 mRNA Translation: AAH63623.1 Different initiation. BC080651 mRNA Translation: AAH80651.1 Different initiation. |
CCDSi | CCDS47084.1 |
RefSeqi | NP_116082.1, NM_032693.2 XP_016864266.1, XM_017008777.1 XP_016864267.1, XM_017008778.1 XP_016864268.1, XM_017008779.1 |
3D structure databases
SMRi | Q9BSU3 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 124254, 58 interactors |
IntActi | Q9BSU3, 15 interactors |
STRINGi | 9606.ENSP00000286794 |
PTM databases
iPTMneti | Q9BSU3 |
PhosphoSitePlusi | Q9BSU3 |
Genetic variation databases
BioMutai | NAA11 |
DMDMi | 158706520 |
Proteomic databases
EPDi | Q9BSU3 |
jPOSTi | Q9BSU3 |
MassIVEi | Q9BSU3 |
MaxQBi | Q9BSU3 |
PaxDbi | Q9BSU3 |
PeptideAtlasi | Q9BSU3 |
PRIDEi | Q9BSU3 |
ProteomicsDBi | 78928 |
Protocols and materials databases
Antibodypediai | 44611, 43 antibodies from 16 providers |
DNASUi | 84779 |
Genome annotation databases
Ensembli | ENST00000286794; ENSP00000286794; ENSG00000156269 |
GeneIDi | 84779 |
KEGGi | hsa:84779 |
MANE-Selecti | ENST00000286794.5; ENSP00000286794.4; NM_032693.3; NP_116082.1 |
UCSCi | uc003hlt.5, human |
Organism-specific databases
CTDi | 84779 |
DisGeNETi | 84779 |
GeneCardsi | NAA11 |
HGNCi | HGNC:28125, NAA11 |
HPAi | ENSG00000156269, Group enriched (brain, placenta, testis) |
MIMi | 619432, gene |
neXtProti | NX_Q9BSU3 |
OpenTargetsi | ENSG00000156269 |
PharmGKBi | PA165664264 |
VEuPathDBi | HostDB:ENSG00000156269 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3235, Eukaryota |
GeneTreei | ENSGT00940000163834 |
HOGENOMi | CLU_013985_7_0_1 |
InParanoidi | Q9BSU3 |
OMAi | KTESKYY |
OrthoDBi | 1489230at2759 |
PhylomeDBi | Q9BSU3 |
TreeFami | TF300078 |
Enzyme and pathway databases
PathwayCommonsi | Q9BSU3 |
SignaLinki | Q9BSU3 |
Miscellaneous databases
BioGRID-ORCSi | 84779, 5 hits in 1047 CRISPR screens |
GenomeRNAii | 84779 |
Pharosi | Q9BSU3, Tbio |
PROi | PR:Q9BSU3 |
RNActi | Q9BSU3, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000156269, Expressed in secondary oocyte and 84 other tissues |
ExpressionAtlasi | Q9BSU3, baseline and differential |
Genevisiblei | Q9BSU3, HS |
Family and domain databases
InterProi | View protein in InterPro IPR016181, Acyl_CoA_acyltransferase IPR045047, Ard1-like IPR000182, GNAT_dom |
PANTHERi | PTHR23091, PTHR23091, 1 hit |
Pfami | View protein in Pfam PF00583, Acetyltransf_1, 1 hit |
SUPFAMi | SSF55729, SSF55729, 1 hit |
PROSITEi | View protein in PROSITE PS51186, GNAT, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | NAA11_HUMAN | |
Accessioni | Q9BSU3Primary (citable) accession number: Q9BSU3 Secondary accession number(s): Q66K19, Q6P479 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 2, 2007 |
Last sequence update: | October 2, 2007 | |
Last modified: | February 23, 2022 | |
This is version 145 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 4
Human chromosome 4: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families