NAA11

Functionⁱ

Displays alpha (N-terminal) acetyltransferase activity. Proposed alternative catalytic subunit of the N-terminal acetyltransferase A (NatA) complex.1 Publication

Catalytic activityⁱ

Acetyl-CoA + an N-terminal-glycyl-[protein] = an N-terminal-N(alpha)-acetyl-glycyl-[protein] + CoA.By similarity

Acetyl-CoA + an N-terminal-L-alanyl-[protein] = an N-terminal-N(alpha)-acetyl-L-alanyl-[protein] + CoA.By similarity

Acetyl-CoA + an N-terminal-L-seryl-[protein] = an N-terminal-N(alpha)-acetyl-L-seryl-[protein] + CoA.By similarity

Acetyl-CoA + an N-terminal-L-valyl-[protein] = an N-terminal-N(alpha)-acetyl-L-valyl-[protein] + CoA.By similarity

Acetyl-CoA + an N-terminal-L-cysteinyl-[protein] = an N-terminal-N(alpha)-acetyl-L-cysteinyl-[protein] + CoA.By similarity

Acetyl-CoA + an N-terminal-L-threonyl-[protein] = an N-terminal-N(alpha)-acetyl-L-threonyl-[protein] + CoA.By similarity

GO - Molecular functionⁱ

peptide alpha-N-acetyltransferase activity
Source: UniProtKB
Inferred from direct assayⁱ
- 16638120
peptide-glutamate-N-acetyltransferase activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
peptide-serine-N-acetyltransferase activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

N-terminal peptidyl-glutamic acid acetylation
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
N-terminal peptidyl-serine acetylation
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
N-terminal protein amino acid acetylation
Source: UniProtKB
Inferred from direct assayⁱ
- 16638120

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Acyltransferase, Transferase

Molecular function

Acyltransferase, Transferase

Enzyme and pathway databases

BRENDAⁱ	2.3.1.88 2681

BRENDAⁱ

2.3.1.88 2681

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: N-alpha-acetyltransferase 11 (EC:2.3.1.255By similarity) Alternative name(s): N-terminal acetyltransferase complex ARD1 subunit homolog B Short name: hARD2 NatA catalytic subunit Naa11
Gene namesⁱ	Name:NAA11 Synonyms:ARD1B, ARD2
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 4

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000156269.4
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:28125 NAA11
neXtProtⁱ	NX_Q9BSU3

Keywords - Cellular componentⁱ

Cytoplasm, Nucleus

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	84779
Open Targets More...OpenTargetsⁱ	ENSG00000156269
PharmGKBⁱ	PA165664264

Polymorphism and mutation databases

BioMutaⁱ	NAA11
DMDMⁱ	158706520

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000305009	1 – 229	N-alpha-acetyltransferase 11Add BLAST		229

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	186	PhosphoserineCombined sources		1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

EPDⁱ	Q9BSU3
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q9BSU3
PaxDbⁱ	Q9BSU3
PeptideAtlas More...PeptideAtlasⁱ	Q9BSU3
PRIDEⁱ	Q9BSU3
ProteomicsDBⁱ	78928

PTM databases

iPTMnetⁱ	Q9BSU3
PhosphoSitePlusⁱ	Q9BSU3

Expressionⁱ

Tissue specificityⁱ

Present in several cell lines, with highest levels in MCF-7 cells (at protein level).1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000156269 Expressed in 69 organ(s), highest expression level in secondary oocyte
CleanExⁱ	HS_ARD1B
ExpressionAtlasⁱ	Q9BSU3 baseline and differential
Genevisibleⁱ	Q9BSU3 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA035922

HPAⁱ

HPA035922

Interactionⁱ

Subunit structureⁱ

Component of the N-terminal acetyltransferase A (NatA) complex composed of NAA11 and NAA15 (Probable). Interacts with HIF1A.Curated1 Publication

Protein-protein interaction databases

BioGridⁱ	124254, 1 interactor
IntActⁱ	Q9BSU3, 12 interactors
STRINGⁱ	9606.ENSP00000286794

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9BSU3
SMRⁱ	Q9BSU3
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	1 – 152	N-acetyltransferasePROSITE-ProRule annotationAdd BLAST		152

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	1 – 58	Interaction with NAA15By similarityAdd BLAST		58

Sequence similaritiesⁱ

Belongs to the acetyltransferase family. ARD1 subfamily.Curated

Phylogenomic databases

eggNOGⁱ	KOG3235 Eukaryota COG0456 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00550000074803
HOGENOMⁱ	HOG000078523
HOVERGENⁱ	HBG050561
InParanoidⁱ	Q9BSU3
KEGG Orthology (KO) More...KOⁱ	K20791
OMAⁱ	EPDDVPH
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0JI1
PhylomeDBⁱ	Q9BSU3
TreeFamⁱ	TF300078

Family and domain databases

InterProⁱ	View protein in InterPro IPR016181 Acyl_CoA_acyltransferase IPR000182 GNAT_dom
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00583 Acetyltransf_1, 1 hit
SUPFAMⁱ	SSF55729 SSF55729, 1 hit
PROSITEⁱ	View protein in PROSITE PS51186 GNAT, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show all Align All

Q9BSU3-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MNIRNAQPDD LMNMQHCNLL CLPENYQMKY YLYHGLSWPQ LSYIAEDEDG 
        60         70         80         90        100
KIVGYVLAKM EEEPDDVPHG HITSLAVKRS HRRLGLAQKL MDQASRAMIE 
       110        120        130        140        150
NFNAKYVSLH VRKSNRPALH LYSNTLNFQI SEVEPKYYAD GEDAYAMKRD 
       160        170        180        190        200
LSQMADELRR QMDLKKGGYV VLGSRENQET QGSTLSDSEE ACQQKNPATE 
       210        220 
ESGSDSKEPK ESVESTNVQD SSESSDSTS

Length:229

Mass (Da):25,979

Last modified:October 2, 2007 - v3

Checksum:ⁱF547D816A1E07ACE

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	H0Y8T0	H0Y8T0_HUMAN		N-alpha-acetyltransferase 11 N-alpha-acetyltransferase 11	NAA11	111	Annotation score:

Sequence cautionⁱ

The sequence AAH04552 differs from that shown. Reason: Erroneous initiation.Curated

The sequence AAH63623 differs from that shown. Reason: Erroneous initiation.Curated

The sequence AAH80651 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_048164	6	A → T. Corresponds to variant dbSNP:rs3811765Ensembl.		1
Natural variantⁱVAR_048165	19	L → F. Corresponds to variant dbSNP:rs17003712Ensembl.		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	BC004552 mRNA Translation: AAH04552.2 Different initiation. BC063623 mRNA Translation: AAH63623.1 Different initiation. BC080651 mRNA Translation: AAH80651.1 Different initiation.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS47084.1
NCBI Reference Sequences More...RefSeqⁱ	NP_116082.1, NM_032693.2 XP_016864266.1, XM_017008777.1 XP_016864267.1, XM_017008778.1 XP_016864268.1, XM_017008779.1
UniGeneⁱ	Hs.676048

Genome annotation databases

Ensemblⁱ	ENST00000286794; ENSP00000286794; ENSG00000156269
GeneIDⁱ	84779
KEGGⁱ	hsa:84779
UCSC genome browser More...UCSCⁱ	uc003hlt.5 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9BSU3	N-alpha-acetyltransferase 11 (Fragment)		HUMAN		111	UniRef100_Q9BSU3

Protein	Similar proteins		Species	Score	Length	Source
Q9BSU3	N-alpha-acetyltransferase 11 (Fragment)		HUMAN		111	UniRef90_Q9BSU3
N(alpha)-acetyltransferase 11, NatA catalytic subunit		MACMU		229
Uncharacterized protein		RHIRO		229
N-alpha-acetyltransferase 11, NatA catalytic subunit		MACFA		229
Uncharacterized protein		RHIBE		229
+17

Protein	Similar proteins		Species	Score	Length	Source
Q9BSU3	N-alpha-acetyltransferase 11		MOUSE		218	UniRef50_Q9BSU3
N-alpha-acetyltransferase 11 (Fragment)		HUMAN		111
NAA11 isoform 3		PANTR		229
N(alpha)-acetyltransferase 11, NatA catalytic subunit		MACMU		229
Uncharacterized protein		RHIRO		229
+374

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	BC004552 mRNA Translation: AAH04552.2 Different initiation. BC063623 mRNA Translation: AAH63623.1 Different initiation. BC080651 mRNA Translation: AAH80651.1 Different initiation.
CCDSⁱ	CCDS47084.1
RefSeqⁱ	NP_116082.1, NM_032693.2 XP_016864266.1, XM_017008777.1 XP_016864267.1, XM_017008778.1 XP_016864268.1, XM_017008779.1
UniGeneⁱ	Hs.676048

3D structure databases

ProteinModelPortalⁱ	Q9BSU3
SMRⁱ	Q9BSU3
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	124254, 1 interactor
IntActⁱ	Q9BSU3, 12 interactors
STRINGⁱ	9606.ENSP00000286794

PTM databases

iPTMnetⁱ	Q9BSU3
PhosphoSitePlusⁱ	Q9BSU3

Polymorphism and mutation databases

BioMutaⁱ	NAA11
DMDMⁱ	158706520

Proteomic databases

EPDⁱ	Q9BSU3
MaxQBⁱ	Q9BSU3
PaxDbⁱ	Q9BSU3
PeptideAtlasⁱ	Q9BSU3
PRIDEⁱ	Q9BSU3
ProteomicsDBⁱ	78928

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	84779
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000286794; ENSP00000286794; ENSG00000156269
GeneIDⁱ	84779
KEGGⁱ	hsa:84779
UCSCⁱ	uc003hlt.5 human

Organism-specific databases

CTDⁱ	84779
DisGeNETⁱ	84779
EuPathDBⁱ	HostDB:ENSG00000156269.4
GeneCardsⁱ	NAA11
HGNCⁱ	HGNC:28125 NAA11
HPAⁱ	HPA035922
neXtProtⁱ	NX_Q9BSU3
OpenTargetsⁱ	ENSG00000156269
PharmGKBⁱ	PA165664264
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG3235 Eukaryota COG0456 LUCA
GeneTreeⁱ	ENSGT00550000074803
HOGENOMⁱ	HOG000078523
HOVERGENⁱ	HBG050561
InParanoidⁱ	Q9BSU3
KOⁱ	K20791
OMAⁱ	EPDDVPH
OrthoDBⁱ	EOG091G0JI1
PhylomeDBⁱ	Q9BSU3
TreeFamⁱ	TF300078

Enzyme and pathway databases

BRENDAⁱ	2.3.1.88 2681

BRENDAⁱ

2.3.1.88 2681

Miscellaneous databases

GenomeRNAiⁱ	84779
Protein Ontology More...PROⁱ	PR:Q9BSU3

Gene expression databases

Bgeeⁱ	ENSG00000156269 Expressed in 69 organ(s), highest expression level in secondary oocyte
CleanExⁱ	HS_ARD1B
ExpressionAtlasⁱ	Q9BSU3 baseline and differential
Genevisibleⁱ	Q9BSU3 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR016181 Acyl_CoA_acyltransferase IPR000182 GNAT_dom
Pfamⁱ	View protein in Pfam PF00583 Acetyltransf_1, 1 hit
SUPFAMⁱ	SSF55729 SSF55729, 1 hit
PROSITEⁱ	View protein in PROSITE PS51186 GNAT, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	NAA11_HUMAN
Accessionⁱ	Q9BSU3Primary (citable) accession number: Q9BSU3 Secondary accession number(s): Q66K19, Q6P479
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 2, 2007
	Last sequence update:	October 2, 2007
	Last modified:	November 7, 2018
	This is version 126 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human chromosome 4
Human chromosome 4: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations

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UniProtKB - Q9BSU3 (NAA11_HUMAN)

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N-alpha-acetyltransferase 11

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Other locations

Cytosol

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ