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Protein

N-alpha-acetyltransferase 11

Gene

NAA11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Displays alpha (N-terminal) acetyltransferase activity. Proposed alternative catalytic subunit of the N-terminal acetyltransferase A (NatA) complex.1 Publication

Catalytic activityi

Acetyl-CoA + an N-terminal-glycyl-[protein] = an N-terminal-N(alpha)-acetyl-glycyl-[protein] + CoA.By similarity
Acetyl-CoA + an N-terminal-L-alanyl-[protein] = an N-terminal-N(alpha)-acetyl-L-alanyl-[protein] + CoA.By similarity
Acetyl-CoA + an N-terminal-L-seryl-[protein] = an N-terminal-N(alpha)-acetyl-L-seryl-[protein] + CoA.By similarity
Acetyl-CoA + an N-terminal-L-valyl-[protein] = an N-terminal-N(alpha)-acetyl-L-valyl-[protein] + CoA.By similarity
Acetyl-CoA + an N-terminal-L-cysteinyl-[protein] = an N-terminal-N(alpha)-acetyl-L-cysteinyl-[protein] + CoA.By similarity
Acetyl-CoA + an N-terminal-L-threonyl-[protein] = an N-terminal-N(alpha)-acetyl-L-threonyl-[protein] + CoA.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAcyltransferase, Transferase

Enzyme and pathway databases

BRENDAi2.3.1.88 2681

Names & Taxonomyi

Protein namesi
Recommended name:
N-alpha-acetyltransferase 11 (EC:2.3.1.255By similarity)
Alternative name(s):
N-terminal acetyltransferase complex ARD1 subunit homolog B
Short name:
hARD2
NatA catalytic subunit Naa11
Gene namesi
Name:NAA11
Synonyms:ARD1B, ARD2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiHostDB:ENSG00000156269.4
HGNCiHGNC:28125 NAA11
neXtProtiNX_Q9BSU3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi84779
OpenTargetsiENSG00000156269
PharmGKBiPA165664264

Polymorphism and mutation databases

BioMutaiNAA11
DMDMi158706520

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003050091 – 229N-alpha-acetyltransferase 11Add BLAST229

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei186PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9BSU3
MaxQBiQ9BSU3
PaxDbiQ9BSU3
PeptideAtlasiQ9BSU3
PRIDEiQ9BSU3
ProteomicsDBi78928

PTM databases

iPTMnetiQ9BSU3
PhosphoSitePlusiQ9BSU3

Expressioni

Tissue specificityi

Present in several cell lines, with highest levels in MCF-7 cells (at protein level).1 Publication

Gene expression databases

BgeeiENSG00000156269
CleanExiHS_ARD1B
ExpressionAtlasiQ9BSU3 baseline and differential
GenevisibleiQ9BSU3 HS

Organism-specific databases

HPAiHPA035922

Interactioni

Subunit structurei

Component of the N-terminal acetyltransferase A (NatA) complex composed of NAA11 and NAA15 (Probable). Interacts with HIF1A.Curated1 Publication

Protein-protein interaction databases

BioGridi124254, 1 interactor
IntActiQ9BSU3, 12 interactors
STRINGi9606.ENSP00000286794

Structurei

3D structure databases

ProteinModelPortaliQ9BSU3
SMRiQ9BSU3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 152N-acetyltransferasePROSITE-ProRule annotationAdd BLAST152

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 58Interaction with NAA15By similarityAdd BLAST58

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3235 Eukaryota
COG0456 LUCA
GeneTreeiENSGT00550000074803
HOGENOMiHOG000078523
HOVERGENiHBG050561
InParanoidiQ9BSU3
KOiK20791
OMAiMAKEICP
OrthoDBiEOG091G0JI1
PhylomeDBiQ9BSU3
TreeFamiTF300078

Family and domain databases

InterProiView protein in InterPro
IPR016181 Acyl_CoA_acyltransferase
IPR000182 GNAT_dom
PfamiView protein in Pfam
PF00583 Acetyltransf_1, 1 hit
SUPFAMiSSF55729 SSF55729, 1 hit
PROSITEiView protein in PROSITE
PS51186 GNAT, 1 hit

Sequencei

Sequence statusi: Complete.

Q9BSU3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNIRNAQPDD LMNMQHCNLL CLPENYQMKY YLYHGLSWPQ LSYIAEDEDG
60 70 80 90 100
KIVGYVLAKM EEEPDDVPHG HITSLAVKRS HRRLGLAQKL MDQASRAMIE
110 120 130 140 150
NFNAKYVSLH VRKSNRPALH LYSNTLNFQI SEVEPKYYAD GEDAYAMKRD
160 170 180 190 200
LSQMADELRR QMDLKKGGYV VLGSRENQET QGSTLSDSEE ACQQKNPATE
210 220
ESGSDSKEPK ESVESTNVQD SSESSDSTS
Length:229
Mass (Da):25,979
Last modified:October 2, 2007 - v3
Checksum:iF547D816A1E07ACE
GO

Sequence cautioni

The sequence AAH04552 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAH63623 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAH80651 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0481646A → T. Corresponds to variant dbSNP:rs3811765Ensembl.1
Natural variantiVAR_04816519L → F. Corresponds to variant dbSNP:rs17003712Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC004552 mRNA Translation: AAH04552.2 Different initiation.
BC063623 mRNA Translation: AAH63623.1 Different initiation.
BC080651 mRNA Translation: AAH80651.1 Different initiation.
CCDSiCCDS47084.1
RefSeqiNP_116082.1, NM_032693.2
XP_016864266.1, XM_017008777.1
XP_016864267.1, XM_017008778.1
XP_016864268.1, XM_017008779.1
UniGeneiHs.676048

Genome annotation databases

EnsembliENST00000286794; ENSP00000286794; ENSG00000156269
GeneIDi84779
KEGGihsa:84779
UCSCiuc003hlt.5 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiNAA11_HUMAN
AccessioniPrimary (citable) accession number: Q9BSU3
Secondary accession number(s): Q66K19, Q6P479
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: October 2, 2007
Last modified: July 18, 2018
This is version 124 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

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