UniProtKB - Q9BSR8 (YIPF4_HUMAN)
Protein
Protein YIPF4
Gene
YIPF4
Organism
Homo sapiens (Human)
Status
Functioni
Involved in the maintenance of the Golgi structure.1 Publication
GO - Biological processi
- viral process Source: UniProtKB-KW
Keywordsi
Biological process | Host-virus interaction |
Enzyme and pathway databases
PathwayCommonsi | Q9BSR8 |
Names & Taxonomyi
Protein namesi | Recommended name: Protein YIPF4Alternative name(s): YIP1 family member 4 |
Gene namesi | Name:YIPF4 ORF Names:Nbla11189 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000119820.10 |
HGNCi | HGNC:28145, YIPF4 |
MIMi | 617534, gene |
neXtProti | NX_Q9BSR8 |
Subcellular locationi
Golgi apparatus
- cis-Golgi network membrane 3 Publications; Multi-pass membrane protein 1 Publication
Endoplasmic reticulum
- endoplasmic reticulum Source: LIFEdb
Golgi apparatus
- Golgi apparatus Source: HPA
Plasma Membrane
- plasma membrane Source: HPA
Other locations
- integral component of membrane Source: UniProtKB-KW
- intracellular membrane-bounded organelle Source: HPA
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 113 | Cytoplasmic1 PublicationAdd BLAST | 113 | |
Transmembranei | 114 – 134 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 135 – 138 | ExtracellularCurated | 4 | |
Transmembranei | 139 – 159 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 160 – 166 | CytoplasmicCurated | 7 | |
Transmembranei | 167 – 187 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 188 – 195 | ExtracellularCurated | 8 | |
Transmembranei | 196 – 216 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 217 – 223 | CytoplasmicCurated | 7 | |
Transmembranei | 224 – 244 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
Golgi apparatus, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 84272 |
OpenTargetsi | ENSG00000119820 |
PharmGKBi | PA142670547 |
Miscellaneous databases
Pharosi | Q9BSR8, Tbio |
Polymorphism and mutation databases
BioMutai | YIPF4 |
DMDMi | 74733045 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000242632 | 1 – 244 | Protein YIPF4Add BLAST | 244 |
Proteomic databases
EPDi | Q9BSR8 |
jPOSTi | Q9BSR8 |
MassIVEi | Q9BSR8 |
MaxQBi | Q9BSR8 |
PaxDbi | Q9BSR8 |
PeptideAtlasi | Q9BSR8 |
PRIDEi | Q9BSR8 |
ProteomicsDBi | 78921 |
PTM databases
iPTMneti | Q9BSR8 |
PhosphoSitePlusi | Q9BSR8 |
SwissPalmi | Q9BSR8 |
Expressioni
Tissue specificityi
Expressed in keratinocytes (at protein level).1 Publication
Developmental stagei
In primary foreskin keratinocytes, down-regulated during calcium-induced differentiation (at protein level). The physiological relevance of this observation is unclear as YIPF4 protein is expressed throughout the epithelial layers in organotypic raft cultures, a cell-culture model of stratified epithelium.1 Publication
(Microbial infection) Down-regulation upon calcium-induced keratinocyte differentiation is prevented in the presence of human papillomavirus (HPV), independently of HPV E5 protein (at protein level). The physiological relevance of this observation is unclear.1 Publication
Gene expression databases
Bgeei | ENSG00000119820, Expressed in corpus callosum and 230 other tissues |
ExpressionAtlasi | Q9BSR8, baseline and differential |
Genevisiblei | Q9BSR8, HS |
Organism-specific databases
HPAi | ENSG00000119820, Low tissue specificity |
Interactioni
Subunit structurei
Interacts with YIPF3 and YIPF5.
2 Publications(Microbial infection) Interacts with human papillomavirus (HPV) E5 proteins.
1 PublicationBinary interactionsi
Hide detailsQ9BSR8
Protein-protein interaction databases
BioGRIDi | 123999, 51 interactors |
IntActi | Q9BSR8, 51 interactors |
MINTi | Q9BSR8 |
STRINGi | 9606.ENSP00000238831 |
Miscellaneous databases
RNActi | Q9BSR8, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the YIP1 family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3103, Eukaryota |
GeneTreei | ENSGT00940000153168 |
HOGENOMi | CLU_072083_0_0_1 |
InParanoidi | Q9BSR8 |
OMAi | PDVKLNM |
OrthoDBi | 1242956at2759 |
PhylomeDBi | Q9BSR8 |
TreeFami | TF315055 |
Family and domain databases
InterProi | View protein in InterPro IPR006977, Yip1 |
Pfami | View protein in Pfam PF04893, Yip1, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
Q9BSR8-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MQPPGPPPAY APTNGDFTFV SSADAEDLSG SIASPDVKLN LGGDFIKEST
60 70 80 90 100
ATTFLRQRGY GWLLEVEDDD PEDNKPLLEE LDIDLKDIYY KIRCVLMPMP
110 120 130 140 150
SLGFNRQVVR DNPDFWGPLA VVLFFSMISL YGQFRVVSWI ITIWIFGSLT
160 170 180 190 200
IFLLARVLGG EVAYGQVLGV IGYSLLPLIV IAPVLLVVGS FEVVSTLIKL
210 220 230 240
FGVFWAAYSA ASLLVGEEFK TKKPLLIYPI FLLYIYFLSL YTGV
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketH7C0D5 | H7C0D5_HUMAN | Protein YIPF4 | YIPF4 | 58 | Annotation score: | ||
H7C3X2 | H7C3X2_HUMAN | Protein YIPF4 | YIPF4 | 33 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB072898 mRNA Translation: BAE45710.1 AK098486 mRNA Translation: BAC05315.1 BC004875 mRNA Translation: AAH04875.1 |
CCDSi | CCDS1781.1 |
RefSeqi | NP_115688.1, NM_032312.3 |
Genome annotation databases
Ensembli | ENST00000238831; ENSP00000238831; ENSG00000119820 |
GeneIDi | 84272 |
KEGGi | hsa:84272 |
UCSCi | uc002rok.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB072898 mRNA Translation: BAE45710.1 AK098486 mRNA Translation: BAC05315.1 BC004875 mRNA Translation: AAH04875.1 |
CCDSi | CCDS1781.1 |
RefSeqi | NP_115688.1, NM_032312.3 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 123999, 51 interactors |
IntActi | Q9BSR8, 51 interactors |
MINTi | Q9BSR8 |
STRINGi | 9606.ENSP00000238831 |
PTM databases
iPTMneti | Q9BSR8 |
PhosphoSitePlusi | Q9BSR8 |
SwissPalmi | Q9BSR8 |
Polymorphism and mutation databases
BioMutai | YIPF4 |
DMDMi | 74733045 |
Proteomic databases
EPDi | Q9BSR8 |
jPOSTi | Q9BSR8 |
MassIVEi | Q9BSR8 |
MaxQBi | Q9BSR8 |
PaxDbi | Q9BSR8 |
PeptideAtlasi | Q9BSR8 |
PRIDEi | Q9BSR8 |
ProteomicsDBi | 78921 |
Protocols and materials databases
Antibodypediai | 14283, 87 antibodies |
DNASUi | 84272 |
Genome annotation databases
Ensembli | ENST00000238831; ENSP00000238831; ENSG00000119820 |
GeneIDi | 84272 |
KEGGi | hsa:84272 |
UCSCi | uc002rok.4, human |
Organism-specific databases
CTDi | 84272 |
DisGeNETi | 84272 |
EuPathDBi | HostDB:ENSG00000119820.10 |
GeneCardsi | YIPF4 |
HGNCi | HGNC:28145, YIPF4 |
HPAi | ENSG00000119820, Low tissue specificity |
MIMi | 617534, gene |
neXtProti | NX_Q9BSR8 |
OpenTargetsi | ENSG00000119820 |
PharmGKBi | PA142670547 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3103, Eukaryota |
GeneTreei | ENSGT00940000153168 |
HOGENOMi | CLU_072083_0_0_1 |
InParanoidi | Q9BSR8 |
OMAi | PDVKLNM |
OrthoDBi | 1242956at2759 |
PhylomeDBi | Q9BSR8 |
TreeFami | TF315055 |
Enzyme and pathway databases
PathwayCommonsi | Q9BSR8 |
Miscellaneous databases
BioGRID-ORCSi | 84272, 6 hits in 821 CRISPR screens |
ChiTaRSi | YIPF4, human |
GeneWikii | YIPF4 |
GenomeRNAii | 84272 |
Pharosi | Q9BSR8, Tbio |
PROi | PR:Q9BSR8 |
RNActi | Q9BSR8, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000119820, Expressed in corpus callosum and 230 other tissues |
ExpressionAtlasi | Q9BSR8, baseline and differential |
Genevisiblei | Q9BSR8, HS |
Family and domain databases
InterProi | View protein in InterPro IPR006977, Yip1 |
Pfami | View protein in Pfam PF04893, Yip1, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | YIPF4_HUMAN | |
Accessioni | Q9BSR8Primary (citable) accession number: Q9BSR8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 27, 2006 |
Last sequence update: | June 1, 2001 | |
Last modified: | December 2, 2020 | |
This is version 139 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human chromosome 2
Human chromosome 2: entries, gene names and cross-references to MIM