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Protein

Protein YIPF4

Gene

YIPF4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in the maintenance of the Golgi structure.1 Publication

Names & Taxonomyi

Protein namesi
Recommended name:
Protein YIPF4
Alternative name(s):
YIP1 family member 4
Gene namesi
Name:YIPF4
ORF Names:Nbla11189
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000119820.10
HGNCiHGNC:28145 YIPF4
MIMi617534 gene
neXtProtiNX_Q9BSR8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 113Cytoplasmic1 PublicationAdd BLAST113
Transmembranei114 – 134HelicalSequence analysisAdd BLAST21
Topological domaini135 – 138ExtracellularCurated4
Transmembranei139 – 159HelicalSequence analysisAdd BLAST21
Topological domaini160 – 166CytoplasmicCurated7
Transmembranei167 – 187HelicalSequence analysisAdd BLAST21
Topological domaini188 – 195ExtracellularCurated8
Transmembranei196 – 216HelicalSequence analysisAdd BLAST21
Topological domaini217 – 223CytoplasmicCurated7
Transmembranei224 – 244HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000119820
PharmGKBiPA142670547

Polymorphism and mutation databases

BioMutaiYIPF4
DMDMi74733045

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002426321 – 244Protein YIPF4Add BLAST244

Proteomic databases

EPDiQ9BSR8
MaxQBiQ9BSR8
PaxDbiQ9BSR8
PeptideAtlasiQ9BSR8
PRIDEiQ9BSR8
ProteomicsDBi78921

PTM databases

iPTMnetiQ9BSR8
PhosphoSitePlusiQ9BSR8

Expressioni

Tissue specificityi

Expressed in keratinocytes (at protein level).1 Publication

Developmental stagei

In primary foreskin keratinocytes, down-regulated during calcium-induced differentiation (at protein level). The physiological relevance of this observation is unclear as YIPF4 protein is expressed throughout the epithelial layers in organotypic raft cultures, a cell-culture model of stratified epithelium.1 Publication
(Microbial infection) Down-regulation upon calcium-induced keratinocyte differentiation is prevented in the presence of human papillomavirus (HPV), independently of HPV E5 protein (at protein level). The physiological relevance of this observation is unclear.1 Publication

Gene expression databases

BgeeiENSG00000119820 Expressed in 215 organ(s), highest expression level in corpus callosum
CleanExiHS_YIPF4
ExpressionAtlasiQ9BSR8 baseline and differential
GenevisibleiQ9BSR8 HS

Organism-specific databases

HPAiHPA017884

Interactioni

Subunit structurei

Interacts with YIPF3 and YIPF5.2 Publications
(Microbial infection) Interacts with human papillomavirus (HPV) E5 proteins.1 Publication

Binary interactionsi

Protein-protein interaction databases

BioGridi123999, 22 interactors
IntActiQ9BSR8, 35 interactors
MINTiQ9BSR8
STRINGi9606.ENSP00000238831

Structurei

3D structure databases

ProteinModelPortaliQ9BSR8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the YIP1 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IQ6V Eukaryota
ENOG4111EZE LUCA
GeneTreeiENSGT00730000111152
HOGENOMiHOG000285931
HOVERGENiHBG056534
InParanoidiQ9BSR8
OMAiQFSPTNG
OrthoDBiEOG091G0J2I
PhylomeDBiQ9BSR8
TreeFamiTF315055

Family and domain databases

InterProiView protein in InterPro
IPR006977 Yip1
PfamiView protein in Pfam
PF04893 Yip1, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q9BSR8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQPPGPPPAY APTNGDFTFV SSADAEDLSG SIASPDVKLN LGGDFIKEST
60 70 80 90 100
ATTFLRQRGY GWLLEVEDDD PEDNKPLLEE LDIDLKDIYY KIRCVLMPMP
110 120 130 140 150
SLGFNRQVVR DNPDFWGPLA VVLFFSMISL YGQFRVVSWI ITIWIFGSLT
160 170 180 190 200
IFLLARVLGG EVAYGQVLGV IGYSLLPLIV IAPVLLVVGS FEVVSTLIKL
210 220 230 240
FGVFWAAYSA ASLLVGEEFK TKKPLLIYPI FLLYIYFLSL YTGV
Length:244
Mass (Da):27,083
Last modified:June 1, 2001 - v1
Checksum:iBEC6F8EA9892F612
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H7C0D5H7C0D5_HUMAN
Protein YIPF4
YIPF4
58Annotation score:
H7C3X2H7C3X2_HUMAN
Protein YIPF4
YIPF4
33Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB072898 mRNA Translation: BAE45710.1
AK098486 mRNA Translation: BAC05315.1
BC004875 mRNA Translation: AAH04875.1
CCDSiCCDS1781.1
RefSeqiNP_115688.1, NM_032312.3
UniGeneiHs.468099

Genome annotation databases

EnsembliENST00000238831; ENSP00000238831; ENSG00000119820
GeneIDi84272
KEGGihsa:84272
UCSCiuc002rok.4 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB072898 mRNA Translation: BAE45710.1
AK098486 mRNA Translation: BAC05315.1
BC004875 mRNA Translation: AAH04875.1
CCDSiCCDS1781.1
RefSeqiNP_115688.1, NM_032312.3
UniGeneiHs.468099

3D structure databases

ProteinModelPortaliQ9BSR8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123999, 22 interactors
IntActiQ9BSR8, 35 interactors
MINTiQ9BSR8
STRINGi9606.ENSP00000238831

PTM databases

iPTMnetiQ9BSR8
PhosphoSitePlusiQ9BSR8

Polymorphism and mutation databases

BioMutaiYIPF4
DMDMi74733045

Proteomic databases

EPDiQ9BSR8
MaxQBiQ9BSR8
PaxDbiQ9BSR8
PeptideAtlasiQ9BSR8
PRIDEiQ9BSR8
ProteomicsDBi78921

Protocols and materials databases

DNASUi84272
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000238831; ENSP00000238831; ENSG00000119820
GeneIDi84272
KEGGihsa:84272
UCSCiuc002rok.4 human

Organism-specific databases

CTDi84272
EuPathDBiHostDB:ENSG00000119820.10
GeneCardsiYIPF4
HGNCiHGNC:28145 YIPF4
HPAiHPA017884
MIMi617534 gene
neXtProtiNX_Q9BSR8
OpenTargetsiENSG00000119820
PharmGKBiPA142670547
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IQ6V Eukaryota
ENOG4111EZE LUCA
GeneTreeiENSGT00730000111152
HOGENOMiHOG000285931
HOVERGENiHBG056534
InParanoidiQ9BSR8
OMAiQFSPTNG
OrthoDBiEOG091G0J2I
PhylomeDBiQ9BSR8
TreeFamiTF315055

Miscellaneous databases

ChiTaRSiYIPF4 human
GeneWikiiYIPF4
GenomeRNAii84272
PROiPR:Q9BSR8
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000119820 Expressed in 215 organ(s), highest expression level in corpus callosum
CleanExiHS_YIPF4
ExpressionAtlasiQ9BSR8 baseline and differential
GenevisibleiQ9BSR8 HS

Family and domain databases

InterProiView protein in InterPro
IPR006977 Yip1
PfamiView protein in Pfam
PF04893 Yip1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiYIPF4_HUMAN
AccessioniPrimary (citable) accession number: Q9BSR8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: June 1, 2001
Last modified: September 12, 2018
This is version 127 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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