UniProtKB - Q9BSR8 (YIPF4_HUMAN)

BLAST

>sp|Q9BSR8|YIPF4_HUMAN Protein YIPF4 OS=Homo sapiens OX=9606 GN=YIPF4 PE=1 SV=1
MQPPGPPPAYAPTNGDFTFVSSADAEDLSGSIASPDVKLNLGGDFIKESTATTFLRQRGY
GWLLEVEDDDPEDNKPLLEELDIDLKDIYYKIRCVLMPMPSLGFNRQVVRDNPDFWGPLA
VVLFFSMISLYGQFRVVSWIITIWIFGSLTIFLLARVLGGEVAYGQVLGVIGYSLLPLIV
IAPVLLVVGSFEVVSTLIKLFGVFWAAYSAASLLVGEEFKTKKPLLIYPIFLLYIYFLSL
YTGV

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History
Entry version 127 (12 Sep 2018)
Sequence version 1 (01 Jun 2001)
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Protein

Protein YIPF4

Gene

YIPF4

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Protein YIPF4 Alternative name(s): YIP1 family member 4
Gene namesⁱ	Name:YIPF4 ORF Names:Nbla11189
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 2

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000119820.10
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:28145 YIPF4
MIMⁱ	617534 gene
neXtProtⁱ	NX_Q9BSR8

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 113	Cytoplasmic1 PublicationAdd BLAST	113
Transmembraneⁱ	114 – 134	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	135 – 138	ExtracellularCurated	4
Transmembraneⁱ	139 – 159	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	160 – 166	CytoplasmicCurated	7
Transmembraneⁱ	167 – 187	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	188 – 195	ExtracellularCurated	8
Transmembraneⁱ	196 – 216	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	217 – 223	CytoplasmicCurated	7
Transmembraneⁱ	224 – 244	HelicalSequence analysisAdd BLAST	21

Keywords - Cellular componentⁱ

Golgi apparatus, Membrane

Pathology & Biotechⁱ

Organism-specific databases

Open Targets More...OpenTargetsⁱ	ENSG00000119820
PharmGKBⁱ	PA142670547

Polymorphism and mutation databases

BioMutaⁱ	YIPF4
DMDMⁱ	74733045

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000242632	1 – 244	Protein YIPF4Add BLAST		244

Proteomic databases

EPDⁱ	Q9BSR8
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q9BSR8
PaxDbⁱ	Q9BSR8
PeptideAtlas More...PeptideAtlasⁱ	Q9BSR8
PRIDEⁱ	Q9BSR8
ProteomicsDBⁱ	78921

PTM databases

iPTMnetⁱ	Q9BSR8
PhosphoSitePlusⁱ	Q9BSR8

Expressionⁱ

Tissue specificityⁱ

Expressed in keratinocytes (at protein level).1 Publication

Developmental stageⁱ

In primary foreskin keratinocytes, down-regulated during calcium-induced differentiation (at protein level). The physiological relevance of this observation is unclear as YIPF4 protein is expressed throughout the epithelial layers in organotypic raft cultures, a cell-culture model of stratified epithelium.1 Publication

(Microbial infection) Down-regulation upon calcium-induced keratinocyte differentiation is prevented in the presence of human papillomavirus (HPV), independently of HPV E5 protein (at protein level). The physiological relevance of this observation is unclear.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000119820 Expressed in 215 organ(s), highest expression level in corpus callosum
CleanExⁱ	HS_YIPF4
ExpressionAtlasⁱ	Q9BSR8 baseline and differential
Genevisibleⁱ	Q9BSR8 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA017884

HPAⁱ

HPA017884

Interactionⁱ

Subunit structureⁱ

(Microbial infection) Interacts with human papillomavirus (HPV) E5 proteins.1 Publication

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
FATE1	Q969F0	5	EBI-751253,EBI-743099
RNF185	Q96GF1	3	EBI-751253,EBI-2340249
YIPF3	Q9GZM5	6	EBI-751253,EBI-743787

Protein-protein interaction databases

BioGridⁱ	123999, 22 interactors
IntActⁱ	Q9BSR8, 35 interactors
Molecular INTeraction database More...MINTⁱ	Q9BSR8
STRINGⁱ	9606.ENSP00000238831

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9BSR8
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the YIP1 family.Curated

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	ENOG410IQ6V Eukaryota ENOG4111EZE LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00730000111152
HOGENOMⁱ	HOG000285931
HOVERGENⁱ	HBG056534
InParanoidⁱ	Q9BSR8
OMAⁱ	QFSPTNG
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0J2I
PhylomeDBⁱ	Q9BSR8
TreeFamⁱ	TF315055

Family and domain databases

InterProⁱ	View protein in InterPro IPR006977 Yip1
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF04893 Yip1, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show all Align All

Q9BSR8-1 [UniParc]FASTA Add to basket

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        10         20         30         40         50
MQPPGPPPAY APTNGDFTFV SSADAEDLSG SIASPDVKLN LGGDFIKEST 
        60         70         80         90        100
ATTFLRQRGY GWLLEVEDDD PEDNKPLLEE LDIDLKDIYY KIRCVLMPMP 
       110        120        130        140        150
SLGFNRQVVR DNPDFWGPLA VVLFFSMISL YGQFRVVSWI ITIWIFGSLT 
       160        170        180        190        200
IFLLARVLGG EVAYGQVLGV IGYSLLPLIV IAPVLLVVGS FEVVSTLIKL 
       210        220        230        240 
FGVFWAAYSA ASLLVGEEFK TKKPLLIYPI FLLYIYFLSL YTGV

Length:244

Mass (Da):27,083

Last modified:June 1, 2001 - v1

Checksum:ⁱBEC6F8EA9892F612

Computationally mapped potential isoform sequencesⁱ

There are 2 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

H7C0D5	H7C0D5_HUMAN	Protein YIPF4 Protein YIPF4	YIPF4	58	Annotation score:
H7C3X2	H7C3X2_HUMAN	Protein YIPF4 Protein YIPF4	YIPF4	33	Annotation score:

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB072898 mRNA Translation: BAE45710.1 AK098486 mRNA Translation: BAC05315.1 BC004875 mRNA Translation: AAH04875.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS1781.1
NCBI Reference Sequences More...RefSeqⁱ	NP_115688.1, NM_032312.3
UniGeneⁱ	Hs.468099

Genome annotation databases

Ensemblⁱ	ENST00000238831; ENSP00000238831; ENSG00000119820
GeneIDⁱ	84272
KEGGⁱ	hsa:84272
UCSC genome browser More...UCSCⁱ	uc002rok.4 human

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9BSR8	Protein YIPF		PANTR		244	UniRef100_Q9BSR8
Protein YIPF		PANPA		244
Protein YIPF		GORGO		244
Protein YIPF		ICTTR		244

Protein	Similar proteins		Species	Score	Length	Source
Q9BSR8	Protein YIPF4		CHICK		249	UniRef90_Q9BSR8
Protein YIPF4		MOUSE		246
Protein YIPF4		RAT		246
Protein YIPF		PANTR		244
Protein YIPF		PANPA		244
+99

Protein	Similar proteins		Species	Score	Length	Source
Q9BSR8	Protein YIPF4		CHICK		249	UniRef50_Q9BSR8
Protein YIPF4		MOUSE		246
Protein YIPF4		RAT		246
Protein YIPF		PANTR		244
Protein YIPF		PANPA		244
+198

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB072898 mRNA Translation: BAE45710.1 AK098486 mRNA Translation: BAC05315.1 BC004875 mRNA Translation: AAH04875.1
CCDSⁱ	CCDS1781.1
RefSeqⁱ	NP_115688.1, NM_032312.3
UniGeneⁱ	Hs.468099

3D structure databases

ProteinModelPortalⁱ	Q9BSR8
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	123999, 22 interactors
IntActⁱ	Q9BSR8, 35 interactors
MINTⁱ	Q9BSR8
STRINGⁱ	9606.ENSP00000238831

PTM databases

iPTMnetⁱ	Q9BSR8
PhosphoSitePlusⁱ	Q9BSR8

Polymorphism and mutation databases

BioMutaⁱ	YIPF4
DMDMⁱ	74733045

Proteomic databases

EPDⁱ	Q9BSR8
MaxQBⁱ	Q9BSR8
PaxDbⁱ	Q9BSR8
PeptideAtlasⁱ	Q9BSR8
PRIDEⁱ	Q9BSR8
ProteomicsDBⁱ	78921

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	84272
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000238831; ENSP00000238831; ENSG00000119820
GeneIDⁱ	84272
KEGGⁱ	hsa:84272
UCSCⁱ	uc002rok.4 human

Organism-specific databases

CTDⁱ	84272
EuPathDBⁱ	HostDB:ENSG00000119820.10
GeneCardsⁱ	YIPF4
HGNCⁱ	HGNC:28145 YIPF4
HPAⁱ	HPA017884
MIMⁱ	617534 gene
neXtProtⁱ	NX_Q9BSR8
OpenTargetsⁱ	ENSG00000119820
PharmGKBⁱ	PA142670547
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IQ6V Eukaryota ENOG4111EZE LUCA
GeneTreeⁱ	ENSGT00730000111152
HOGENOMⁱ	HOG000285931
HOVERGENⁱ	HBG056534
InParanoidⁱ	Q9BSR8
OMAⁱ	QFSPTNG
OrthoDBⁱ	EOG091G0J2I
PhylomeDBⁱ	Q9BSR8
TreeFamⁱ	TF315055

Miscellaneous databases

ChiTaRSⁱ	YIPF4 human
GeneWikiⁱ	YIPF4
GenomeRNAiⁱ	84272
Protein Ontology More...PROⁱ	PR:Q9BSR8
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000119820 Expressed in 215 organ(s), highest expression level in corpus callosum
CleanExⁱ	HS_YIPF4
ExpressionAtlasⁱ	Q9BSR8 baseline and differential
Genevisibleⁱ	Q9BSR8 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR006977 Yip1
Pfamⁱ	View protein in Pfam PF04893 Yip1, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	YIPF4_HUMAN
Accessionⁱ	Q9BSR8Primary (citable) accession number: Q9BSR8
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	June 27, 2006
	Last sequence update:	June 1, 2001
	Last modified:	September 12, 2018
	This is version 127 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human chromosome 2
Human chromosome 2: entries, gene names and cross-references to MIM
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

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UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q9BSR8 (YIPF4_HUMAN)

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Protein YIPF4

YIPF4

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Golgi apparatus

Endoplasmic reticulum

Golgi apparatus

Plasma Membrane

Other locations

Topology

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ