UniProtKB - Q9BSM1 (PCGF1_HUMAN)
Polycomb group RING finger protein 1
PCGF1
Functioni
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 47 – 86 | RING-typePROSITE-ProRule annotationAdd BLAST | 40 |
GO - Molecular functioni
- metal ion binding Source: UniProtKB-KW
- promoter-specific chromatin binding Source: GO_Central
- protein C-terminus binding Source: UniProtKB
GO - Biological processi
- chromatin silencing Source: GO_Central
- histone H2A-K119 monoubiquitination Source: UniProtKB
- histone H2A monoubiquitination Source: UniProtKB
- negative regulation of transcription by RNA polymerase II Source: GO_Central
- regulation of transcription, DNA-templated Source: UniProtKB
Keywordsi
Molecular function | Repressor |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
SIGNORi | Q9BSM1 |
Names & Taxonomyi
Protein namesi | Recommended name: Polycomb group RING finger protein 1Alternative name(s): Nervous system Polycomb-1 Short name: NSPc1 RING finger protein 68 |
Gene namesi | Name:PCGF1 Synonyms:NSPC1, RNF68 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:17615 PCGF1 |
MIMi | 610231 gene |
neXtProti | NX_Q9BSM1 |
Subcellular locationi
Nucleus
- Nucleus 2 Publications
Nucleus
- nucleoplasm Source: HPA
- nucleus Source: UniProtKB
- PcG protein complex Source: UniProtKB
- PRC1 complex Source: GO_Central
Keywords - Cellular componenti
NucleusPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 109 | Y → F: Marked decrease of repressor activity. May be a kinase phosphorylation site. 1 Publication | 1 | |
Mutagenesisi | 191 | Y → A: Abolishes interaction with BCOR and BCORL1. 1 Publication | 1 | |
Mutagenesisi | 193 | R → A: Abolishes interaction with BCOR and BCORL1. 1 Publication | 1 | |
Mutagenesisi | 195 | S → F: Abolishes repressor activity. May be a PKC phosphorylation site. 1 Publication | 1 | |
Mutagenesisi | 206 | V → D: Abolishes interaction with BCOR and BCORL1. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 84759 |
OpenTargetsi | ENSG00000115289 |
PharmGKBi | PA134976631 |
Miscellaneous databases
Pharosi | Q9BSM1 |
Polymorphism and mutation databases
BioMutai | PCGF1 |
DMDMi | 223590124 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedCombined sources | |||
ChainiPRO_0000277855 | 2 – 259 | Polycomb group RING finger protein 1Add BLAST | 258 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylalanineCombined sources | 1 | |
Modified residuei | 3 | PhosphoserineCombined sources | 1 | |
Cross-linki | 24 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 88 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources |
Keywords - PTMi
Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | Q9BSM1 |
jPOSTi | Q9BSM1 |
MassIVEi | Q9BSM1 |
MaxQBi | Q9BSM1 |
PaxDbi | Q9BSM1 |
PeptideAtlasi | Q9BSM1 |
PRIDEi | Q9BSM1 |
ProteomicsDBi | 78914 [Q9BSM1-1] 78915 [Q9BSM1-3] |
PTM databases
iPTMneti | Q9BSM1 |
PhosphoSitePlusi | Q9BSM1 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000115289 Expressed in 215 organ(s), highest expression level in oocyte |
Genevisiblei | Q9BSM1 HS |
Organism-specific databases
HPAi | HPA011356 HPA069156 |
Interactioni
Subunit structurei
Interacts with BCORL1, forming heterodimers (PubMed:23523425, PubMed:27568929). The PCGF1-BCORL1 heterodimeric complex interacts with the KDM2B-SKP1 heterodimeric complex to form a homotetrameric polycomb repression complex 1 (PRC1.1) (PubMed:27568929).
Component of the repressive BCOR complex containing a Polycomb group subcomplex at least composed of RYBP, RING1 and RNF2/RING2 (PubMed:16943429). Specifically interacts with BCOR, RING1 and RNF2/RING2 (PubMed:16943429, PubMed:26687479, PubMed:23523425).
Component of a PRC1-like complex (PubMed:21282530, PubMed:26151332).
Interacts with CBX6, CBX7 and CBX8 (PubMed:21282530).
Interacts with DPPA4, NANOG, POU5F1 and RYBP (PubMed:26687479).
6 PublicationsBinary interactionsi
GO - Molecular functioni
- protein C-terminus binding Source: UniProtKB
Protein-protein interaction databases
BioGridi | 124243, 132 interactors |
CORUMi | Q9BSM1 |
DIPi | DIP-52708N |
IntActi | Q9BSM1, 44 interactors |
STRINGi | 9606.ENSP00000233630 |
Structurei
Secondary structure
3D structure databases
SMRi | Q9BSM1 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 86 – 247 | Required for repressor activityAdd BLAST | 162 | |
Regioni | 150 – 255 | Required for the interaction with the KDM2B-SKP1 heterodimeric complex1 PublicationAdd BLAST | 106 | |
Regioni | 167 – 255 | RING-finger and WD40-associated ubiquitin-like domain (RAWUL); sufficient for interaction with BCOR and BCORL12 PublicationsAdd BLAST | 89 |
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 47 – 86 | RING-typePROSITE-ProRule annotationAdd BLAST | 40 |
Keywords - Domaini
Zinc-fingerPhylogenomic databases
eggNOGi | KOG2660 Eukaryota ENOG410XPCN LUCA |
GeneTreei | ENSGT00940000159651 |
HOGENOMi | HOG000231946 |
InParanoidi | Q9BSM1 |
KOi | K11487 |
OMAi | QKYVRCS |
OrthoDBi | 1203951at2759 |
PhylomeDBi | Q9BSM1 |
TreeFami | TF324206 |
Family and domain databases
Gene3Di | 3.30.40.10, 1 hit |
InterProi | View protein in InterPro IPR032443 RAWUL IPR001841 Znf_RING IPR013083 Znf_RING/FYVE/PHD IPR017907 Znf_RING_CS |
Pfami | View protein in Pfam PF16207 RAWUL, 1 hit |
SMARTi | View protein in SMART SM00184 RING, 1 hit |
PROSITEi | View protein in PROSITE PS00518 ZF_RING_1, 1 hit PS50089 ZF_RING_2, 1 hit |
s (2)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MASPQGGQIA IAMRLRNQLQ SVYKMDPLRN EEEVRVKIKD LNEHIVCCLC
60 70 80 90 100
AGYFVDATTI TECLHTFCKS CIVKYLQTSK YCPMCNIKIH ETQPLLNLKL
110 120 130 140 150
DRVMQDIVYK LVPGLQDSEE KRIREFYQSR GLDRVTQPTG EEPALSNLGL
160 170 180 190 200
PFSSFDHSKA HYYRYDEQLN LCLERLSSGK DKNKSVLQNK YVRCSVRAEV
210 220 230 240 250
RHLRRVLCHR LMLNPQHVQL LFDNEVLPDH MTMKQIWLSR WFGKPSPLLL
QYSVKEKRR
Sequence cautioni
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_036393 | 1 – 83 | Missing in isoform 2. 1 PublicationAdd BLAST | 83 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF087884 mRNA Translation: AAP97183.1 Different initiation. AC005041 Genomic DNA No translation available. BC004952 mRNA Translation: AAH04952.1 Different initiation. |
CCDSi | CCDS1946.2 [Q9BSM1-1] |
RefSeqi | NP_116062.2, NM_032673.2 [Q9BSM1-1] |
Genome annotation databases
Ensembli | ENST00000233630; ENSP00000233630; ENSG00000115289 [Q9BSM1-1] |
GeneIDi | 84759 |
KEGGi | hsa:84759 |
UCSCi | uc002slz.4 human [Q9BSM1-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF087884 mRNA Translation: AAP97183.1 Different initiation. AC005041 Genomic DNA No translation available. BC004952 mRNA Translation: AAH04952.1 Different initiation. |
CCDSi | CCDS1946.2 [Q9BSM1-1] |
RefSeqi | NP_116062.2, NM_032673.2 [Q9BSM1-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
4HPL | X-ray | 2.00 | B | 167-255 | [»] | |
4HPM | X-ray | 1.85 | B/D | 167-255 | [»] | |
5JH5 | X-ray | 2.55 | C | 150-255 | [»] | |
SMRi | Q9BSM1 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGridi | 124243, 132 interactors |
CORUMi | Q9BSM1 |
DIPi | DIP-52708N |
IntActi | Q9BSM1, 44 interactors |
STRINGi | 9606.ENSP00000233630 |
PTM databases
iPTMneti | Q9BSM1 |
PhosphoSitePlusi | Q9BSM1 |
Polymorphism and mutation databases
BioMutai | PCGF1 |
DMDMi | 223590124 |
Proteomic databases
EPDi | Q9BSM1 |
jPOSTi | Q9BSM1 |
MassIVEi | Q9BSM1 |
MaxQBi | Q9BSM1 |
PaxDbi | Q9BSM1 |
PeptideAtlasi | Q9BSM1 |
PRIDEi | Q9BSM1 |
ProteomicsDBi | 78914 [Q9BSM1-1] 78915 [Q9BSM1-3] |
Protocols and materials databases
DNASUi | 84759 |
Genome annotation databases
Ensembli | ENST00000233630; ENSP00000233630; ENSG00000115289 [Q9BSM1-1] |
GeneIDi | 84759 |
KEGGi | hsa:84759 |
UCSCi | uc002slz.4 human [Q9BSM1-1] |
Organism-specific databases
CTDi | 84759 |
DisGeNETi | 84759 |
GeneCardsi | PCGF1 |
HGNCi | HGNC:17615 PCGF1 |
HPAi | HPA011356 HPA069156 |
MIMi | 610231 gene |
neXtProti | NX_Q9BSM1 |
OpenTargetsi | ENSG00000115289 |
PharmGKBi | PA134976631 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG2660 Eukaryota ENOG410XPCN LUCA |
GeneTreei | ENSGT00940000159651 |
HOGENOMi | HOG000231946 |
InParanoidi | Q9BSM1 |
KOi | K11487 |
OMAi | QKYVRCS |
OrthoDBi | 1203951at2759 |
PhylomeDBi | Q9BSM1 |
TreeFami | TF324206 |
Enzyme and pathway databases
SIGNORi | Q9BSM1 |
Miscellaneous databases
ChiTaRSi | PCGF1 human |
GeneWikii | PCGF1 |
GenomeRNAii | 84759 |
Pharosi | Q9BSM1 |
PROi | PR:Q9BSM1 |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000115289 Expressed in 215 organ(s), highest expression level in oocyte |
Genevisiblei | Q9BSM1 HS |
Family and domain databases
Gene3Di | 3.30.40.10, 1 hit |
InterProi | View protein in InterPro IPR032443 RAWUL IPR001841 Znf_RING IPR013083 Znf_RING/FYVE/PHD IPR017907 Znf_RING_CS |
Pfami | View protein in Pfam PF16207 RAWUL, 1 hit |
SMARTi | View protein in SMART SM00184 RING, 1 hit |
PROSITEi | View protein in PROSITE PS00518 ZF_RING_1, 1 hit PS50089 ZF_RING_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | PCGF1_HUMAN | |
Accessioni | Q9BSM1Primary (citable) accession number: Q9BSM1 Secondary accession number(s): Q7Z506 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 20, 2007 |
Last sequence update: | February 10, 2009 | |
Last modified: | October 16, 2019 | |
This is version 150 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Complete proteome, Reference proteomeDocuments
- Human chromosome 2
Human chromosome 2: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references