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Protein

Ubiquitin-associated domain-containing protein 1

Gene

UBAC1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Non-catalytic subunit of the KPC complex that acts as E3 ubiquitin-protein ligase. Required for poly-ubiquitination and proteasome-mediated degradation of CDKN1B during G1 phase of the cell cycle.2 Publications

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Biological processi

Keywordsi

Biological processUbl conjugation pathway

Enzyme and pathway databases

ReactomeiR-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation
UniPathwayi
UPA00143

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin-associated domain-containing protein 1
Short name:
UBA domain-containing protein 1
Alternative name(s):
E3 ubiquitin-protein ligase subunit KPC2
Glialblastoma cell differentiation-related protein 1
Kip1 ubiquitination-promoting complex protein 2
Gene namesi
Name:UBAC1
Synonyms:GBDR1, KPC2, UBADC1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000130560.8
HGNCiHGNC:30221 UBAC1
MIMi608129 gene
neXtProtiNX_Q9BSL1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi10422
OpenTargetsiENSG00000130560
PharmGKBiPA162407814

Polymorphism and mutation databases

BioMutaiUBAC1
DMDMi74752306

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002504491 – 405Ubiquitin-associated domain-containing protein 1Add BLAST405

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ9BSL1
MaxQBiQ9BSL1
PaxDbiQ9BSL1
PeptideAtlasiQ9BSL1
PRIDEiQ9BSL1
ProteomicsDBi78913

PTM databases

iPTMnetiQ9BSL1
PhosphoSitePlusiQ9BSL1

Expressioni

Tissue specificityi

Ubiquitous.1 Publication

Gene expression databases

BgeeiENSG00000130560 Expressed in 218 organ(s), highest expression level in gastrocnemius
CleanExiHS_UBAC1
ExpressionAtlasiQ9BSL1 baseline and differential
GenevisibleiQ9BSL1 HS

Organism-specific databases

HPAiHPA005651

Interactioni

Subunit structurei

Component of the KPC complex composed of RNF123/KPC1 and UBAC1/KPC2. Interacts with RNF123 via its N-terminal domain. Interacts with the proteasome via its N-terminal domain.2 Publications

Binary interactionsi

Protein-protein interaction databases

BioGridi115691, 70 interactors
CORUMiQ9BSL1
DIPiDIP-47279N
IntActiQ9BSL1, 22 interactors
MINTiQ9BSL1
STRINGi9606.ENSP00000360821

Structurei

Secondary structure

1405
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ9BSL1
SMRiQ9BSL1
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9BSL1

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini14 – 98Ubiquitin-likeAdd BLAST85
Domaini187 – 231UBA 1PROSITE-ProRule annotationAdd BLAST45
Domaini288 – 328UBA 2PROSITE-ProRule annotationAdd BLAST41
Domaini353 – 392STI1Add BLAST40

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IHU5 Eukaryota
ENOG410Y2UN LUCA
GeneTreeiENSGT00390000014658
HOGENOMiHOG000231457
HOVERGENiHBG053148
InParanoidiQ9BSL1
KOiK12174
OMAiVTHHKLI
OrthoDBiEOG091G05QY
PhylomeDBiQ9BSL1
TreeFamiTF324579

Family and domain databases

InterProiView protein in InterPro
IPR006636 STI1_HS-bd
IPR015940 UBA
IPR009060 UBA-like_sf
IPR029071 Ubiquitin-like_domsf
PfamiView protein in Pfam
PF00627 UBA, 2 hits
SMARTiView protein in SMART
SM00727 STI1, 1 hit
SM00165 UBA, 2 hits
SUPFAMiSSF46934 SSF46934, 2 hits
SSF54236 SSF54236, 1 hit
PROSITEiView protein in PROSITE
PS50030 UBA, 2 hits

Sequencei

Sequence statusi: Complete.

Q9BSL1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MFVQEEKIFA GKVLRLHICA SDGAEWLEEA TEDTSVEKLK ERCLKHCAHG
60 70 80 90 100
SLEDPKSITH HKLIHAASER VLSDARTILE ENIQDQDVLL LIKKRAPSPL
110 120 130 140 150
PKMADVSAEE KKKQDQKAPD KEAILRATAN LPSYNMDRAA VQTNMRDFQT
160 170 180 190 200
ELRKILVSLI EVAQKLLALN PDAVELFKKA NAMLDEDEDE RVDEAALRQL
210 220 230 240 250
TEMGFPENRA TKALQLNHMS VPQAMEWLIE HAEDPTIDTP LPGQAPPEAE
260 270 280 290 300
GATAAASEAA AGASATDEEA RDELTEIFKK IRRKREFRAD ARAVISLMEM
310 320 330 340 350
GFDEKEVIDA LRVNNNQQNA ACEWLLGDRK PSPEELDKGI DPDSPLFQAI
360 370 380 390 400
LDNPVVQLGL TNPKTLLAFE DMLENPLNST QWMNDPETGP VMLQISRIFQ

TLNRT
Length:405
Mass (Da):45,338
Last modified:June 1, 2001 - v1
Checksum:i5FC8EC84A8602CBE
GO

Sequence cautioni

The sequence AAC21559 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti244Q → R in AAC21559 (Ref. 4) Curated1
Sequence conflicti269Missing in AAD51084 (PubMed:10857748).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_027562374E → D. Corresponds to variant dbSNP:rs11103231Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF176796 mRNA Translation: AAD51084.1
AL355574 Genomic DNA No translation available.
BC004967 mRNA Translation: AAH04967.1
BC011822 mRNA Translation: AAH11822.1
AF068195 mRNA Translation: AAC21559.1 Different initiation.
CCDSiCCDS35177.1
RefSeqiNP_057256.2, NM_016172.2
UniGeneiHs.9194

Genome annotation databases

EnsembliENST00000371756; ENSP00000360821; ENSG00000130560
GeneIDi10422
KEGGihsa:10422
UCSCiuc004cgt.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF176796 mRNA Translation: AAD51084.1
AL355574 Genomic DNA No translation available.
BC004967 mRNA Translation: AAH04967.1
BC011822 mRNA Translation: AAH11822.1
AF068195 mRNA Translation: AAC21559.1 Different initiation.
CCDSiCCDS35177.1
RefSeqiNP_057256.2, NM_016172.2
UniGeneiHs.9194

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2DAINMR-A172-241[»]
ProteinModelPortaliQ9BSL1
SMRiQ9BSL1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115691, 70 interactors
CORUMiQ9BSL1
DIPiDIP-47279N
IntActiQ9BSL1, 22 interactors
MINTiQ9BSL1
STRINGi9606.ENSP00000360821

PTM databases

iPTMnetiQ9BSL1
PhosphoSitePlusiQ9BSL1

Polymorphism and mutation databases

BioMutaiUBAC1
DMDMi74752306

Proteomic databases

EPDiQ9BSL1
MaxQBiQ9BSL1
PaxDbiQ9BSL1
PeptideAtlasiQ9BSL1
PRIDEiQ9BSL1
ProteomicsDBi78913

Protocols and materials databases

DNASUi10422
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000371756; ENSP00000360821; ENSG00000130560
GeneIDi10422
KEGGihsa:10422
UCSCiuc004cgt.3 human

Organism-specific databases

CTDi10422
DisGeNETi10422
EuPathDBiHostDB:ENSG00000130560.8
GeneCardsiUBAC1
HGNCiHGNC:30221 UBAC1
HPAiHPA005651
MIMi608129 gene
neXtProtiNX_Q9BSL1
OpenTargetsiENSG00000130560
PharmGKBiPA162407814
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IHU5 Eukaryota
ENOG410Y2UN LUCA
GeneTreeiENSGT00390000014658
HOGENOMiHOG000231457
HOVERGENiHBG053148
InParanoidiQ9BSL1
KOiK12174
OMAiVTHHKLI
OrthoDBiEOG091G05QY
PhylomeDBiQ9BSL1
TreeFamiTF324579

Enzyme and pathway databases

UniPathwayi
UPA00143

ReactomeiR-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation

Miscellaneous databases

ChiTaRSiUBAC1 human
EvolutionaryTraceiQ9BSL1
GeneWikiiUBAC1
GenomeRNAii10422
PROiPR:Q9BSL1
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000130560 Expressed in 218 organ(s), highest expression level in gastrocnemius
CleanExiHS_UBAC1
ExpressionAtlasiQ9BSL1 baseline and differential
GenevisibleiQ9BSL1 HS

Family and domain databases

InterProiView protein in InterPro
IPR006636 STI1_HS-bd
IPR015940 UBA
IPR009060 UBA-like_sf
IPR029071 Ubiquitin-like_domsf
PfamiView protein in Pfam
PF00627 UBA, 2 hits
SMARTiView protein in SMART
SM00727 STI1, 1 hit
SM00165 UBA, 2 hits
SUPFAMiSSF46934 SSF46934, 2 hits
SSF54236 SSF54236, 1 hit
PROSITEiView protein in PROSITE
PS50030 UBA, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiUBAC1_HUMAN
AccessioniPrimary (citable) accession number: Q9BSL1
Secondary accession number(s): O75500, Q9UMW7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: June 1, 2001
Last modified: November 7, 2018
This is version 154 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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