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Entry version 156 (02 Dec 2020)
Sequence version 3 (20 Apr 2010)
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Protein

Zinc finger protein 577

Gene

ZNF577

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be involved in transcriptional regulation.

Caution

It is uncertain whether Met-1 or Met-8 is the initiator.Curated

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri158 – 180C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri186 – 208C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri214 – 236C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri242 – 264C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri270 – 292C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri298 – 320C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri326 – 348C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri354 – 376C2H2-type 8PROSITE-ProRule annotationAdd BLAST23

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q9BSK1

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-212436, Generic Transcription Pathway

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger protein 577
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZNF577
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Eukaryotic Pathogen and Host Database Resources

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EuPathDBi
HostDB:ENSG00000161551.12

Human Gene Nomenclature Database

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HGNCi
HGNC:28673, ZNF577

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9BSK1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
84765

Open Targets

More...
OpenTargetsi
ENSG00000161551

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134942499

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9BSK1, Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ZNF577

Domain mapping of disease mutations (DMDM)

More...
DMDMi
294862491

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002345901 – 485Zinc finger protein 577Add BLAST485

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9BSK1

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9BSK1

PeptideAtlas

More...
PeptideAtlasi
Q9BSK1

PRoteomics IDEntifications database

More...
PRIDEi
Q9BSK1

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
78909 [Q9BSK1-1]
78910 [Q9BSK1-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9BSK1

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9BSK1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000161551, Expressed in corpus callosum and 167 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9BSK1, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9BSK1, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000161551, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
124246, 5 interactors

Protein interaction database and analysis system

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IntActi
Q9BSK1, 1 interactor

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000301399

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9BSK1, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q9BSK1

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini23 – 94KRABPROSITE-ProRule annotationAdd BLAST72

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri158 – 180C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri186 – 208C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri214 – 236C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri242 – 264C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri270 – 292C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri298 – 320C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri326 – 348C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri354 – 376C2H2-type 8PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1721, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000163379

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_002678_0_2_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9BSK1

Identification of Orthologs from Complete Genome Data

More...
OMAi
CRLNRHQ

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9BSK1

TreeFam database of animal gene trees

More...
TreeFami
TF337922

Family and domain databases

Conserved Domains Database

More...
CDDi
cd07765, KRAB_A-box, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001909, KRAB
IPR036051, KRAB_dom_sf
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01352, KRAB, 1 hit
PF00096, zf-C2H2, 8 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00349, KRAB, 1 hit
SM00355, ZnF_C2H2, 8 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF109640, SSF109640, 1 hit
SSF57667, SSF57667, 5 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50805, KRAB, 1 hit
PS00028, ZINC_FINGER_C2H2_1, 7 hits
PS50157, ZINC_FINGER_C2H2_2, 8 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9BSK1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MKNATIVMSV RREQGSSSGE GSLSFEDVAV GFTREEWQFL DQSQKVLYKE
60 70 80 90 100
VMLENYINLV SIGYRGTKPD SLFKLEQGEP PGIAEGAAHS QICPGFVIQS
110 120 130 140 150
RRYAGKDSDA FGGYGRSCLH IKRDKTLTGV KYHRCVKPSS PKSQLNDLQK
160 170 180 190 200
ICAGGKPHEC SVCGRAFSRK AQLIQHQRTE RGEKPHGCGE CGKTFMRKIQ
210 220 230 240 250
LTEHQRTHTG EKPHECSECG KAFSRKSQLM VHQRTHTGEK PYRCSKCGKA
260 270 280 290 300
FSRKCRLNRH QRSHTGEKLY GCSVCGKAFS QKAYLTAHQR LHTGDKPYKC
310 320 330 340 350
SDCGRTFYFK SDLTRHQRIH TGEKPYECSE CEKAFRSKSK LIQHQRTHTG
360 370 380 390 400
ERPYSCRECG KAFAHMSVLI KHEKTHIRET AINSLTVEKP SSRSHTSLYM
410 420 430 440 450
SELIQEQKTV NTVPIEMPSS GTPPLLNKSE RLVGRNVVIV EQPFPRNQAF
460 470 480
VVNQEFEQRI SLTNEVNVAP SVINYILYLT DIVSE
Length:485
Mass (Da):54,939
Last modified:April 20, 2010 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF2DB53CD82CBF8D5
GO
Isoform 2 (identifier: Q9BSK1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     95-153: Missing.

Show »
Length:426
Mass (Da):48,370
Checksum:iBB27DA1025B4C8D7
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1W2PQ54A0A1W2PQ54_HUMAN
Zinc finger protein 577
ZNF577
480Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1W2PPU1A0A1W2PPU1_HUMAN
Zinc finger protein 577
ZNF577
44Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1W2PRB6A0A1W2PRB6_HUMAN
Zinc finger protein 577
ZNF577
58Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1W2PRW0A0A1W2PRW0_HUMAN
Zinc finger protein 577
ZNF577
59Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1W2PS72A0A1W2PS72_HUMAN
Zinc finger protein 577
ZNF577
62Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1W2PRX5A0A1W2PRX5_HUMAN
Zinc finger protein 577
ZNF577
100Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1W2PPW0A0A1W2PPW0_HUMAN
Zinc finger protein 577
ZNF577
14Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH04992 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence BAF82168 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence EAW72049 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti50E → G in BAF84501 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_05513984A → V1 PublicationCorresponds to variant dbSNP:rs17856123Ensembl.1
Natural variantiVAR_055140123R → C1 PublicationCorresponds to variant dbSNP:rs17849895Ensembl.1
Natural variantiVAR_055141234R → K. Corresponds to variant dbSNP:rs9807847Ensembl.1
Natural variantiVAR_055142246K → E1 PublicationCorresponds to variant dbSNP:rs2288868Ensembl.1
Natural variantiVAR_055143346R → C. Corresponds to variant dbSNP:rs9807842Ensembl.1
Natural variantiVAR_033577357R → S. Corresponds to variant dbSNP:rs9807853Ensembl.1
Natural variantiVAR_055144373E → K. Corresponds to variant dbSNP:rs10407547Ensembl.1
Natural variantiVAR_055145375T → I. Corresponds to variant dbSNP:rs10407911Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_04081095 – 153Missing in isoform 2. 1 PublicationAdd BLAST59

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK289479 mRNA Translation: BAF82168.1 Different initiation.
AK291812 mRNA Translation: BAF84501.1
AC006272 Genomic DNA No translation available.
AC011460 Genomic DNA No translation available.
AC074141 Genomic DNA No translation available.
CH471135 Genomic DNA Translation: EAW72049.1 Sequence problems.
BC004992 mRNA Translation: AAH04992.1 Different initiation.

The Consensus CDS (CCDS) project

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CCDSi
CCDS12842.2 [Q9BSK1-1]
CCDS46160.1 [Q9BSK1-2]

NCBI Reference Sequences

More...
RefSeqi
NP_001129062.1, NM_001135590.1 [Q9BSK1-2]
NP_116068.2, NM_032679.2 [Q9BSK1-1]
XP_006723495.1, XM_006723432.3
XP_006723496.1, XM_006723433.2
XP_011525710.1, XM_011527408.2
XP_016882876.1, XM_017027387.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000301399; ENSP00000301399; ENSG00000161551 [Q9BSK1-1]
ENST00000451628; ENSP00000389652; ENSG00000161551 [Q9BSK1-2]
ENST00000639636; ENSP00000491349; ENSG00000161551 [Q9BSK1-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
84765

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:84765

UCSC genome browser

More...
UCSCi
uc002pxx.6, human [Q9BSK1-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK289479 mRNA Translation: BAF82168.1 Different initiation.
AK291812 mRNA Translation: BAF84501.1
AC006272 Genomic DNA No translation available.
AC011460 Genomic DNA No translation available.
AC074141 Genomic DNA No translation available.
CH471135 Genomic DNA Translation: EAW72049.1 Sequence problems.
BC004992 mRNA Translation: AAH04992.1 Different initiation.
CCDSiCCDS12842.2 [Q9BSK1-1]
CCDS46160.1 [Q9BSK1-2]
RefSeqiNP_001129062.1, NM_001135590.1 [Q9BSK1-2]
NP_116068.2, NM_032679.2 [Q9BSK1-1]
XP_006723495.1, XM_006723432.3
XP_006723496.1, XM_006723433.2
XP_011525710.1, XM_011527408.2
XP_016882876.1, XM_017027387.1

3D structure databases

SMRiQ9BSK1
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi124246, 5 interactors
IntActiQ9BSK1, 1 interactor
STRINGi9606.ENSP00000301399

PTM databases

iPTMnetiQ9BSK1
PhosphoSitePlusiQ9BSK1

Polymorphism and mutation databases

BioMutaiZNF577
DMDMi294862491

Proteomic databases

MassIVEiQ9BSK1
PaxDbiQ9BSK1
PeptideAtlasiQ9BSK1
PRIDEiQ9BSK1
ProteomicsDBi78909 [Q9BSK1-1]
78910 [Q9BSK1-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
19054, 62 antibodies

The DNASU plasmid repository

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DNASUi
84765

Genome annotation databases

EnsembliENST00000301399; ENSP00000301399; ENSG00000161551 [Q9BSK1-1]
ENST00000451628; ENSP00000389652; ENSG00000161551 [Q9BSK1-2]
ENST00000639636; ENSP00000491349; ENSG00000161551 [Q9BSK1-2]
GeneIDi84765
KEGGihsa:84765
UCSCiuc002pxx.6, human [Q9BSK1-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
84765
DisGeNETi84765
EuPathDBiHostDB:ENSG00000161551.12

GeneCards: human genes, protein and diseases

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GeneCardsi
ZNF577
HGNCiHGNC:28673, ZNF577
HPAiENSG00000161551, Low tissue specificity
neXtProtiNX_Q9BSK1
OpenTargetsiENSG00000161551
PharmGKBiPA134942499

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1721, Eukaryota
GeneTreeiENSGT00940000163379
HOGENOMiCLU_002678_0_2_1
InParanoidiQ9BSK1
OMAiCRLNRHQ
PhylomeDBiQ9BSK1
TreeFamiTF337922

Enzyme and pathway databases

PathwayCommonsiQ9BSK1
ReactomeiR-HSA-212436, Generic Transcription Pathway

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
84765, 14 hits in 868 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
ZNF577, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
84765
PharosiQ9BSK1, Tdark

Protein Ontology

More...
PROi
PR:Q9BSK1
RNActiQ9BSK1, protein

Gene expression databases

BgeeiENSG00000161551, Expressed in corpus callosum and 167 other tissues
ExpressionAtlasiQ9BSK1, baseline and differential
GenevisibleiQ9BSK1, HS

Family and domain databases

CDDicd07765, KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909, KRAB
IPR036051, KRAB_dom_sf
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type
PfamiView protein in Pfam
PF01352, KRAB, 1 hit
PF00096, zf-C2H2, 8 hits
SMARTiView protein in SMART
SM00349, KRAB, 1 hit
SM00355, ZnF_C2H2, 8 hits
SUPFAMiSSF109640, SSF109640, 1 hit
SSF57667, SSF57667, 5 hits
PROSITEiView protein in PROSITE
PS50805, KRAB, 1 hit
PS00028, ZINC_FINGER_C2H2_1, 7 hits
PS50157, ZINC_FINGER_C2H2_2, 8 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZN577_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9BSK1
Secondary accession number(s): A8K0B4, A8K6Z7, C9JFB9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: April 20, 2010
Last modified: December 2, 2020
This is version 156 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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