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Protein

MARVEL domain-containing protein 1

Gene

MARVELD1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Microtubule-associated protein that exhibits cell cycle-dependent localization and can inhibit cell proliferation and migration.By similarity

Miscellaneous

Down-regulated in primary multiple tumors derived from ovary, vulva, uterus, cervix, breast, testis, kidney bladder and liver. The reduced expression is owing to DNA methylation and could be reversed by pharmacologic demethylation (PubMed:19364627).1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processCell cycle

Names & Taxonomyi

Protein namesi
Recommended name:
MARVEL domain-containing protein 1
Gene namesi
Name:MARVELD1
Synonyms:MRVLDC1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000155254.12
HGNCiHGNC:28674 MARVELD1
neXtProtiNX_Q9BSK0

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 29CytoplasmicSequence analysisAdd BLAST29
Transmembranei30 – 50HelicalSequence analysisAdd BLAST21
Topological domaini51 – 59ExtracellularSequence analysis9
Transmembranei60 – 80HelicalSequence analysisAdd BLAST21
Topological domaini81 – 94CytoplasmicSequence analysisAdd BLAST14
Transmembranei95 – 115HelicalSequence analysisAdd BLAST21
Topological domaini116 – 138ExtracellularSequence analysisAdd BLAST23
Transmembranei139 – 159HelicalSequence analysisAdd BLAST21
Topological domaini160 – 173CytoplasmicSequence analysisAdd BLAST14

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Cytoskeleton, Membrane, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi83742
OpenTargetsiENSG00000155254
PharmGKBiPA134937190

Polymorphism and mutation databases

BioMutaiMARVELD1
DMDMi74752303

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002715221 – 173MARVEL domain-containing protein 1Add BLAST173

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ9BSK0
PeptideAtlasiQ9BSK0
PRIDEiQ9BSK0
ProteomicsDBi78908

PTM databases

iPTMnetiQ9BSK0
PhosphoSitePlusiQ9BSK0
SwissPalmiQ9BSK0

Expressioni

Tissue specificityi

Widely expressed in normal tissues. Down-regulated in multiple primary tumors.1 Publication

Gene expression databases

BgeeiENSG00000155254 Expressed in 206 organ(s), highest expression level in metanephros
CleanExiHS_MARVELD1
GenevisibleiQ9BSK0 HS

Interactioni

Protein-protein interaction databases

BioGridi123750, 1 interactor
STRINGi9606.ENSP00000441365

Structurei

3D structure databases

ProteinModelPortaliQ9BSK0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini26 – 166MARVELPROSITE-ProRule annotationAdd BLAST141

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi3 – 6Poly-Pro4

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4788 Eukaryota
ENOG4111IAF LUCA
GeneTreeiENSGT00510000049375
HOVERGENiHBG081949
InParanoidiQ9BSK0
OMAiALYGCCR
OrthoDBiEOG091G11L9
PhylomeDBiQ9BSK0
TreeFamiTF316174

Family and domain databases

InterProiView protein in InterPro
IPR008253 Marvel
PfamiView protein in Pfam
PF01284 MARVEL, 1 hit
PROSITEiView protein in PROSITE
PS51225 MARVEL, 1 hit

Sequencei

Sequence statusi: Complete.

Q9BSK0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLPPPPRQPP PQARAARGAV RLQRPFLRSP LGVLRLLQLL AGAAFWITIA
60 70 80 90 100
TSKYQGPVHF ALFVSVLFWL LTLGLYFLTL LGKHELVPVL GSRWLMVNVA
110 120 130 140 150
HDVLAAALYG AATGIMSDQM QRHSYCNLKD YPLPCAYHAF LAAAVCGGVC
160 170
HGLYLLSALY GCGRRCQGKQ EVA
Length:173
Mass (Da):18,914
Last modified:June 1, 2001 - v1
Checksum:iD39B3DBF06EB32EA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL355315 Genomic DNA No translation available.
BC004995 mRNA No translation available.
BC062544 mRNA No translation available.
RefSeqiNP_113672.1, NM_031484.3
UniGeneiHs.744073

Genome annotation databases

EnsembliENST00000285605; ENSP00000441365; ENSG00000155254
GeneIDi83742
KEGGihsa:83742
UCSCiuc001koj.5 human

Similar proteinsi

Entry informationi

Entry nameiMALD1_HUMAN
AccessioniPrimary (citable) accession number: Q9BSK0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: June 1, 2001
Last modified: September 12, 2018
This is version 116 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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