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Protein

Extended synaptotagmin-1

Gene

ESYT1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Binds glycerophospholipids in a barrel-like domain and may play a role in cellular lipid transport (By similarity). Binds calcium (via the C2 domains) and translocates to sites of contact between the endoplasmic reticulum and the cell membrane in response to increased cytosolic calcium levels. Helps tether the endoplasmic reticulum to the cell membrane and promotes the formation of appositions between the endoplasmic reticulum and the cell membrane.By similarity2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi344Calcium 1; via carbonyl oxygenBy similarity1
Metal bindingi345Calcium 1By similarity1
Metal bindingi345Calcium 2By similarity1
Metal bindingi357Calcium 2By similarity1
Metal bindingi404Calcium 1By similarity1
Metal bindingi404Calcium 2By similarity1
Metal bindingi406Calcium 1By similarity1
Metal bindingi406Calcium 2By similarity1
Metal bindingi406Calcium 3; via carbonyl oxygenBy similarity1
Metal bindingi408Calcium 3; via carbonyl oxygenBy similarity1
Metal bindingi410Calcium 3By similarity1
Metal bindingi411Calcium 1By similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • calcium-dependent phospholipid binding Source: GO_Central
  • calcium ion binding Source: GO_Central
  • identical protein binding Source: IntAct
  • phosphatidylcholine binding Source: GO_Central
  • phosphatidylethanolamine binding Source: GO_Central
  • phosphatidylinositol binding Source: GO_Central

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processLipid transport, Transport
LigandCalcium, Lipid-binding, Metal-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-1660662 Glycosphingolipid metabolism

Protein family/group databases

Transport Classification Database

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TCDBi
9.A.57.1.1 the extended-synaptotagmin (e-syt) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Extended synaptotagmin-1Curated
Short name:
E-Syt11 Publication
Alternative name(s):
Membrane-bound C2 domain-containing protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ESYT1Imported
Synonyms:FAM62A, KIAA0747, MBC2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000139641.12

Human Gene Nomenclature Database

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HGNCi
HGNC:29534 ESYT1

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9BSJ8

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 38CytoplasmicSequence analysisAdd BLAST38
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei39 – 59HelicalSequence analysisAdd BLAST21
Topological domaini60 – 62LumenalSequence analysis3
Transmembranei63 – 83HelicalSequence analysisAdd BLAST21
Topological domaini84 – 1104CytoplasmicSequence analysisAdd BLAST1021

Keywords - Cellular componenti

Cell membrane, Endoplasmic reticulum, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi406D → A: No effect on translocation to sites of contact between the endoplasmic reticulum and the cell membrane. 1 Publication1
Mutagenesisi663D → A: Abolishes location at the cell membrane; when associated with A-675 and 722-A--A-729. 1 Publication1
Mutagenesisi675D → A: Abolishes location at the cell membrane; when associated with A-675 and 722-A--A-729. 1 Publication1
Mutagenesisi722 – 729DKDLDKDD → AKALAKAA: Abolishes location at the cell membrane; when associated with A-663 and A-675. 1 Publication8
Mutagenesisi724D → A: Loss of translocation to sites of contact between the endoplasmic reticulum and the cell membrane. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
23344

Open Targets

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OpenTargetsi
ENSG00000139641

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA165512688

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

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ChEMBLi
CHEMBL3621033

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ESYT1

Domain mapping of disease mutations (DMDM)

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DMDMi
74733019

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002343441 – 1104Extended synaptotagmin-1Add BLAST1104

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionineCombined sources1
Modified residuei324Phosphoserine; by CDK5By similarity1
Modified residuei817N6-acetyllysineCombined sources1
Modified residuei820PhosphoserineCombined sources1
Modified residuei941PhosphoserineCombined sources1
Modified residuei948PhosphothreonineCombined sources1
Modified residuei949PhosphoserineCombined sources1
Modified residuei963PhosphoserineCombined sources1
Modified residuei1009PhosphotyrosineBy similarity1
Modified residuei1034PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated on Ser residues in insulin-treated adipocytes (in vitro); this promotes interaction with SLC2A4.By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q9BSJ8

MaxQB - The MaxQuant DataBase

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MaxQBi
Q9BSJ8

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q9BSJ8

PeptideAtlas

More...
PeptideAtlasi
Q9BSJ8

PRoteomics IDEntifications database

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PRIDEi
Q9BSJ8

ProteomicsDB human proteome resource

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ProteomicsDBi
78906
78907 [Q9BSJ8-2]

2D gel databases

USC-OGP 2-DE database

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OGPi
Q9Y416

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q9BSJ8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q9BSJ8

SwissPalm database of S-palmitoylation events

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SwissPalmi
Q9BSJ8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000139641 Expressed in 237 organ(s), highest expression level in vagina

CleanEx database of gene expression profiles

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CleanExi
HS_FAM62A

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q9BSJ8 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q9BSJ8 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA016858
HPA076926

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts (phosphorylated form) with SLC2A4 (By similarity). Interacts with ESYT2 and ESYT3.By similarity1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
116927, 50 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
Q9BSJ8

Database of interacting proteins

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DIPi
DIP-57197N

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

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ELMi
Q9BSJ8

Protein interaction database and analysis system

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IntActi
Q9BSJ8, 28 interactors

Molecular INTeraction database

More...
MINTi
Q9BSJ8

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000267113

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q9BSJ8

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q9BSJ8

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini135 – 313SMP-LTDPROSITE-ProRule annotationAdd BLAST179
Domaini316 – 417C2 1PROSITE-ProRule annotationAdd BLAST102
Domaini465 – 558C2 2PROSITE-ProRule annotationAdd BLAST94
Domaini634 – 735C2 3PROSITE-ProRule annotationAdd BLAST102
Domaini785 – 877C2 4PROSITE-ProRule annotationAdd BLAST93
Domaini972 – 1077C2 5PROSITE-ProRule annotationAdd BLAST106

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1018 – 1025Required for phosphatidylinositol 4,5-bisphosphate-dependent location at the cell membraneBy similarity8

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili91 – 116Sequence analysisAdd BLAST26

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi924 – 935Poly-SerAdd BLAST12
Compositional biasi1012 – 1015Poly-Leu4

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Anchored to the endoplasmic reticulum membrane by a transmembrane hairpin structure; both N-terminus and C-terminus are cytoplasmic.1 Publication
The C2 domains mediate lipid and calcium binding. The N-terminal C2 domain binds calcium ions and is important for calcium-dependent lipid binding and interaction with membranes. Two calcium ions are bound at a high-affinity site and a third calcium ion is bound with lower affinity. May bind up to four calcium ions. In contrast, the second C2 domain apparently does not bind calcium (By similarity). The third C2 domain mediates interaction with membranes enriched in phosphatidylinositol 4,5-bisphosphate and is required for translocation to the cell membrane in response to increased cytosolic calcium levels (PubMed:24183667 and PubMed:23791178).By similarity
The SMP-LTD domain is a barrel-like domain that can bind various types of glycerophospholipids in its interior (By similarity).By similarity

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the extended synaptotagmin family.Curated

Keywords - Domaini

Coiled coil, Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410ISCC Eukaryota
ENOG410XPR4 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000156561

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG055795

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q9BSJ8

Identification of Orthologs from Complete Genome Data

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OMAi
TVWYYSE

Database for complete collections of gene phylogenies

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PhylomeDBi
Q9BSJ8

TreeFam database of animal gene trees

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TreeFami
TF324255

Family and domain databases

Conserved Domains Database

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CDDi
cd08391 C2A_C2C_Synaptotagmin_like, 2 hits
cd04050 C2B_Synaptotagmin-like, 2 hits
cd04030 C2C_KIAA1228, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
2.60.40.150, 5 hits

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR000008 C2_dom
IPR035892 C2_domain_sf
IPR037752 C2C_KIAA1228
IPR037733 Ext_Synaptotagmin_C2A
IPR037749 Ext_Synaptotagmin_C2B
IPR031468 SMP_LBD
IPR039010 Synaptotagmin_SMP

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00168 C2, 5 hits
PF17047 SMP_LBD, 1 hit

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR00360 C2DOMAIN

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00239 C2, 5 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50004 C2, 5 hits
PS51847 SMP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9BSJ8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MERSPGEGPS PSPMDQPSAP SDPTDQPPAA HAKPDPGSGG QPAGPGAAGE
60 70 80 90 100
ALAVLTSFGR RLLVLIPVYL AGAVGLSVGF VLFGLALYLG WRRVRDEKER
110 120 130 140 150
SLRAARQLLD DEEQLTAKTL YMSHRELPAW VSFPDVEKAE WLNKIVAQVW
160 170 180 190 200
PFLGQYMEKL LAETVAPAVR GSNPHLQTFT FTRVELGEKP LRIIGVKVHP
210 220 230 240 250
GQRKEQILLD LNISYVGDVQ IDVEVKKYFC KAGVKGMQLH GVLRVILEPL
260 270 280 290 300
IGDLPFVGAV SMFFIRRPTL DINWTGMTNL LDIPGLSSLS DTMIMDSIAA
310 320 330 340 350
FLVLPNRLLV PLVPDLQDVA QLRSPLPRGI IRIHLLAARG LSSKDKYVKG
360 370 380 390 400
LIEGKSDPYA LVRLGTQTFC SRVIDEELNP QWGETYEVMV HEVPGQEIEV
410 420 430 440 450
EVFDKDPDKD DFLGRMKLDV GKVLQASVLD DWFPLQGGQG QVHLRLEWLS
460 470 480 490 500
LLSDAEKLEQ VLQWNWGVSS RPDPPSAAIL VVYLDRAQDL PLKKGNKEPN
510 520 530 540 550
PMVQLSIQDV TQESKAVYST NCPVWEEAFR FFLQDPQSQE LDVQVKDDSR
560 570 580 590 600
ALTLGALTLP LARLLTAPEL ILDQWFQLSS SGPNSRLYMK LVMRILYLDS
610 620 630 640 650
SEICFPTVPG CPGAWDVDSE NPQRGSSVDA PPRPCHTTPD SQFGTEHVLR
660 670 680 690 700
IHVLEAQDLI AKDRFLGGLV KGKSDPYVKL KLAGRSFRSH VVREDLNPRW
710 720 730 740 750
NEVFEVIVTS VPGQELEVEV FDKDLDKDDF LGRCKVRLTT VLNSGFLDEW
760 770 780 790 800
LTLEDVPSGR LHLRLERLTP RPTAAELEEV LQVNSLIQTQ KSAELAAALL
810 820 830 840 850
SIYMERAEDL PLRKGTKHLS PYATLTVGDS SHKTKTISQT SAPVWDESAS
860 870 880 890 900
FLIRKPHTES LELQVRGEGT GVLGSLSLPL SELLVADQLC LDRWFTLSSG
910 920 930 940 950
QGQVLLRAQL GILVSQHSGV EAHSHSYSHS SSSLSEEPEL SGGPPHITSS
960 970 980 990 1000
APELRQRLTH VDSPLEAPAG PLGQVKLTLW YYSEERKLVS IVHGCRSLRQ
1010 1020 1030 1040 1050
NGRDPPDPYV SLLLLPDKNR GTKRRTSQKK RTLSPEFNER FEWELPLDEA
1060 1070 1080 1090 1100
QRRKLDVSVK SNSSFMSRER ELLGKVQLDL AETDLSQGVA RWYDLMDNKD

KGSS
Length:1,104
Mass (Da):122,856
Last modified:June 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE72B20C458B96F19
GO
Isoform 2 (identifier: Q9BSJ8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     491-491: P → PMVTSELYPPQ

Note: No experimental confirmation available.
Show »
Length:1,114
Mass (Da):124,003
Checksum:i3ECE7EC47B8A90A8
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8VZB1F8VZB1_HUMAN
Extended synaptotagmin-1
ESYT1
88Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAB15139 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAB15268 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti133F → L in BAF83026 (PubMed:14702039).Curated1
Sequence conflicti489D → N in BAB15139 (PubMed:14702039).Curated1
Sequence conflicti738L → F in BAB15139 (PubMed:14702039).Curated1
Sequence conflicti785S → R in BAF83026 (PubMed:14702039).Curated1
Sequence conflicti998L → P in BAB15139 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_038190764R → C. Corresponds to variant dbSNP:rs35075600Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_018277491P → PMVTSELYPPQ in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
DQ993200 mRNA Translation: ABJ97705.1
AK025463 mRNA Translation: BAB15139.1 Different initiation.
AK025878 mRNA Translation: BAB15268.1 Different initiation.
AK290337 mRNA Translation: BAF83026.1
CH471054 Genomic DNA Translation: EAW96891.1
BC004998 mRNA Translation: AAH04998.1
AB018290 mRNA Translation: BAA34467.1
AL050134 mRNA Translation: CAB43284.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS53801.1 [Q9BSJ8-2]
CCDS8904.1 [Q9BSJ8-1]

Protein sequence database of the Protein Information Resource

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PIRi
T08769
T13156

NCBI Reference Sequences

More...
RefSeqi
NP_001171725.1, NM_001184796.1 [Q9BSJ8-2]
NP_056107.1, NM_015292.2 [Q9BSJ8-1]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.632729

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000267113; ENSP00000267113; ENSG00000139641 [Q9BSJ8-2]
ENST00000394048; ENSP00000377612; ENSG00000139641 [Q9BSJ8-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
23344

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:23344

UCSC genome browser

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UCSCi
uc001sjq.4 human [Q9BSJ8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ993200 mRNA Translation: ABJ97705.1
AK025463 mRNA Translation: BAB15139.1 Different initiation.
AK025878 mRNA Translation: BAB15268.1 Different initiation.
AK290337 mRNA Translation: BAF83026.1
CH471054 Genomic DNA Translation: EAW96891.1
BC004998 mRNA Translation: AAH04998.1
AB018290 mRNA Translation: BAA34467.1
AL050134 mRNA Translation: CAB43284.1
CCDSiCCDS53801.1 [Q9BSJ8-2]
CCDS8904.1 [Q9BSJ8-1]
PIRiT08769
T13156
RefSeqiNP_001171725.1, NM_001184796.1 [Q9BSJ8-2]
NP_056107.1, NM_015292.2 [Q9BSJ8-1]
UniGeneiHs.632729

3D structure databases

ProteinModelPortaliQ9BSJ8
SMRiQ9BSJ8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116927, 50 interactors
CORUMiQ9BSJ8
DIPiDIP-57197N
ELMiQ9BSJ8
IntActiQ9BSJ8, 28 interactors
MINTiQ9BSJ8
STRINGi9606.ENSP00000267113

Chemistry databases

ChEMBLiCHEMBL3621033

Protein family/group databases

TCDBi9.A.57.1.1 the extended-synaptotagmin (e-syt) family

PTM databases

iPTMnetiQ9BSJ8
PhosphoSitePlusiQ9BSJ8
SwissPalmiQ9BSJ8

Polymorphism and mutation databases

BioMutaiESYT1
DMDMi74733019

2D gel databases

OGPiQ9Y416

Proteomic databases

EPDiQ9BSJ8
MaxQBiQ9BSJ8
PaxDbiQ9BSJ8
PeptideAtlasiQ9BSJ8
PRIDEiQ9BSJ8
ProteomicsDBi78906
78907 [Q9BSJ8-2]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
23344
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000267113; ENSP00000267113; ENSG00000139641 [Q9BSJ8-2]
ENST00000394048; ENSP00000377612; ENSG00000139641 [Q9BSJ8-1]
GeneIDi23344
KEGGihsa:23344
UCSCiuc001sjq.4 human [Q9BSJ8-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
23344
DisGeNETi23344
EuPathDBiHostDB:ENSG00000139641.12

GeneCards: human genes, protein and diseases

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GeneCardsi
ESYT1
HGNCiHGNC:29534 ESYT1
HPAiHPA016858
HPA076926
neXtProtiNX_Q9BSJ8
OpenTargetsiENSG00000139641
PharmGKBiPA165512688

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410ISCC Eukaryota
ENOG410XPR4 LUCA
GeneTreeiENSGT00940000156561
HOVERGENiHBG055795
InParanoidiQ9BSJ8
OMAiTVWYYSE
PhylomeDBiQ9BSJ8
TreeFamiTF324255

Enzyme and pathway databases

ReactomeiR-HSA-1660662 Glycosphingolipid metabolism

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
ESYT1 human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
FAM62A

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
23344

Protein Ontology

More...
PROi
PR:Q9BSJ8

Gene expression databases

BgeeiENSG00000139641 Expressed in 237 organ(s), highest expression level in vagina
CleanExiHS_FAM62A
ExpressionAtlasiQ9BSJ8 baseline and differential
GenevisibleiQ9BSJ8 HS

Family and domain databases

CDDicd08391 C2A_C2C_Synaptotagmin_like, 2 hits
cd04050 C2B_Synaptotagmin-like, 2 hits
cd04030 C2C_KIAA1228, 1 hit
Gene3Di2.60.40.150, 5 hits
InterProiView protein in InterPro
IPR000008 C2_dom
IPR035892 C2_domain_sf
IPR037752 C2C_KIAA1228
IPR037733 Ext_Synaptotagmin_C2A
IPR037749 Ext_Synaptotagmin_C2B
IPR031468 SMP_LBD
IPR039010 Synaptotagmin_SMP
PfamiView protein in Pfam
PF00168 C2, 5 hits
PF17047 SMP_LBD, 1 hit
PRINTSiPR00360 C2DOMAIN
SMARTiView protein in SMART
SM00239 C2, 5 hits
PROSITEiView protein in PROSITE
PS50004 C2, 5 hits
PS51847 SMP, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiESYT1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9BSJ8
Secondary accession number(s): A0FGR7
, A8K2S2, O94848, Q6PJN4, Q9H6J1, Q9H6W2, Q9Y416
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: June 1, 2001
Last modified: December 5, 2018
This is version 155 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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