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Protein

Gamma-tubulin complex component 2

Gene

TUBGCP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome.

GO - Molecular functioni

  • gamma-tubulin binding Source: GO_Central
  • structural constituent of cytoskeleton Source: GO_Central

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-HSA-380270 Recruitment of mitotic centrosome proteins and complexes
R-HSA-380320 Recruitment of NuMA to mitotic centrosomes

Names & Taxonomyi

Protein namesi
Recommended name:
Gamma-tubulin complex component 2
Short name:
GCP-2
Short name:
hGCP2
Alternative name(s):
Gamma-ring complex protein 103 kDa
Short name:
h103p
Short name:
hGrip103
Spindle pole body protein Spc97 homolog
Short name:
hSpc97
Gene namesi
Name:TUBGCP2
Synonyms:GCP2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000130640.13
HGNCiHGNC:18599 TUBGCP2
MIMi617817 gene
neXtProtiNX_Q9BSJ2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

Pathology & Biotechi

Organism-specific databases

DisGeNETi10844
OpenTargetsiENSG00000130640
PharmGKBiPA38598

Polymorphism and mutation databases

BioMutaiTUBGCP2
DMDMi21450889

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000781131 – 902Gamma-tubulin complex component 2Add BLAST902

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei83PhosphotyrosineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9BSJ2
MaxQBiQ9BSJ2
PaxDbiQ9BSJ2
PeptideAtlasiQ9BSJ2
PRIDEiQ9BSJ2
ProteomicsDBi78900

PTM databases

iPTMnetiQ9BSJ2
PhosphoSitePlusiQ9BSJ2

Expressioni

Tissue specificityi

Ubiquitously expressed.

Gene expression databases

BgeeiENSG00000130640 Expressed in 221 organ(s), highest expression level in right uterine tube
CleanExiHS_TUBGCP2
ExpressionAtlasiQ9BSJ2 baseline and differential
GenevisibleiQ9BSJ2 HS

Organism-specific databases

HPAiHPA037885

Interactioni

Subunit structurei

Gamma-tubulin complex is composed of gamma-tubulin, TUBGCP2, TUBGCP3, TUBGCP4, TUBGCP5 and TUBGCP6. Interacts with ATF5; the ATF5:PCNT:polyglutamylated tubulin (PGT) tripartite unites the mother centriole and the pericentriolar material (PCM) in the centrosome (PubMed:26213385).2 Publications

GO - Molecular functioni

Protein-protein interaction databases

BioGridi116055, 107 interactors
CORUMiQ9BSJ2
IntActiQ9BSJ2, 46 interactors
MINTiQ9BSJ2
STRINGi9606.ENSP00000252936

Structurei

3D structure databases

ProteinModelPortaliQ9BSJ2
SMRiQ9BSJ2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi109 – 112Poly-Ala4

Sequence similaritiesi

Belongs to the TUBGCP family.Curated

Phylogenomic databases

eggNOGiKOG2001 Eukaryota
ENOG410XNRE LUCA
GeneTreeiENSGT00850000132278
HOGENOMiHOG000273895
HOVERGENiHBG026103
InParanoidiQ9BSJ2
KOiK16569
OMAiVDKGECM
OrthoDBiEOG091G01V2
PhylomeDBiQ9BSJ2
TreeFamiTF324047

Family and domain databases

InterProiView protein in InterPro
IPR007259 GCP
PANTHERiPTHR19302 PTHR19302, 1 hit
PfamiView protein in Pfam
PF04130 Spc97_Spc98, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket
Note: Additional isoforms may exist. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

This entry has 3 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9BSJ2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSEFRIHHDV NELLSLLRVH GGDGAEVYID LLQKNRTPYV TTTVSAHSAK
60 70 80 90 100
VKIAEFSRTP EDFLKKYDEL KSKNTRNLDP LVYLLSKLTE DKETLQYLQQ
110 120 130 140 150
NAKERAELAA AAVGSSTTSI NVPAAASKIS MQELEELRKQ LGSVATGSTL
160 170 180 190 200
QQSLELKRKM LRDKQNKKNS GQHLPIFPAW VYERPALIGD FLIGAGISTD
210 220 230 240 250
TALPIGTLPL ASQESAVVED LLYVLVGVDG RYVSAQPLAG RQSRTFLVDP
260 270 280 290 300
NLDLSIRELV HRILPVAASY SAVTRFIEEK SSFEYGQVNH ALAAAMRTLV
310 320 330 340 350
KEHLILVSQL EQLHRQGLLS LQKLWFYIQP AMRTMDILAS LATSVDKGEC
360 370 380 390 400
LGGSTLSLLH DRSFSYTGDS QAQELCLYLT KAASAPYFEV LEKWIYRGII
410 420 430 440 450
HDPYSEFMVE EHELRKERIQ EDYNDKYWDQ RYTIVQQQIP SFLQKMADKI
460 470 480 490 500
LSTGKYLNVV RECGHDVTCP VAKEIIYTLK ERAYVEQIEK AFNYASKVLL
510 520 530 540 550
DFLMEEKELV AHLRSIKRYF LMDQGDFFVH FMDLAEEELR KPVEDITPPR
560 570 580 590 600
LEALLELALR MSTANTDPFK DDLKIDLMPH DLITQLLRVL AIETKQEKAM
610 620 630 640 650
AHADPTELAL SGLEAFSFDY IVKWPLSLII NRKALTRYQM LFRHMFYCKH
660 670 680 690 700
VERQLCSVWI SNKTAKQHSL HSAQWFAGAF TLRQRMLNFV QNIQYYMMFE
710 720 730 740 750
VMEPTWHILE KNLKSASNID DVLGHHTGFL DTCLKDCMLT NPELLKVFSK
760 770 780 790 800
LMSVCVMFTN CMQKFTQSMK LDGELGGQTL EHSTVLGLPA GAEERARKEL
810 820 830 840 850
ARKHLAEHAD TVQLVSGFEA TINKFDKNFS AHLLDLLARL SIYSTSDCEH
860 870 880 890 900
GMASVISRLD FNGFYTERLE RLSAERSQKA TPQVPVLRGP PAPAPRVAVT

AQ
Length:902
Mass (Da):102,534
Last modified:June 6, 2002 - v2
Checksum:i4FAAF864A3758E6A
GO
Isoform 2 (identifier: Q9BSJ2-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-130: Missing.

Note: No experimental confirmation available.
Show »
Length:772
Mass (Da):88,091
Checksum:i648F3F29C7510172
GO
Isoform 3 (identifier: Q9BSJ2-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     205-205: I → IVLLRWNLALSPRLKCSGVISAHCNLHLP

Note: No experimental confirmation available.Curated
Show »
Length:930
Mass (Da):105,628
Checksum:iE90F119D86C00010
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B3KTU7B3KTU7_HUMAN
Gamma-tubulin complex component
TUBGCP2
495Annotation score:
F2Z2B9F2Z2B9_HUMAN
Gamma-tubulin complex component
TUBGCP2
721Annotation score:
R4GMM4R4GMM4_HUMAN
Gamma-tubulin complex component 2
TUBGCP2
78Annotation score:

Sequence cautioni

The sequence BC005011 differs from that shown. Reason: Frameshift at position 513.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti279E → G in BAG59730 (PubMed:14702039).Curated1
Sequence conflicti641L → F in BC005011 (PubMed:15489334).Curated1
Isoform 3 (identifier: Q9BSJ2-4)
Sequence conflicti209R → G in AAI43248 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_022126111A → T. Corresponds to variant dbSNP:rs2298121Ensembl.1
Natural variantiVAR_049249193I → T. Corresponds to variant dbSNP:rs11101682Ensembl.1
Natural variantiVAR_049250809A → T. Corresponds to variant dbSNP:rs11101677Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0446981 – 130Missing in isoform 2. 1 PublicationAdd BLAST130
Alternative sequenceiVSP_045982205I → IVLLRWNLALSPRLKCSGVI SAHCNLHLP in isoform 3. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF042379 mRNA Translation: AAC39728.1
AK297251 mRNA Translation: BAG59730.1
AL360181 Genomic DNA No translation available.
AL592071 Genomic DNA No translation available.
BC005011 mRNA No translation available.
BC093770 mRNA Translation: AAH93770.1
BC111957 mRNA Translation: AAI11958.1
BC143247 mRNA Translation: AAI43248.1
CCDSiCCDS58104.1 [Q9BSJ2-3]
CCDS58105.1 [Q9BSJ2-4]
CCDS7676.1 [Q9BSJ2-1]
RefSeqiNP_001243546.1, NM_001256617.1 [Q9BSJ2-4]
NP_001243547.1, NM_001256618.1 [Q9BSJ2-3]
NP_006650.1, NM_006659.3 [Q9BSJ2-1]
UniGeneiHs.523370

Genome annotation databases

EnsembliENST00000252936; ENSP00000252936; ENSG00000130640 [Q9BSJ2-1]
ENST00000368563; ENSP00000357551; ENSG00000130640 [Q9BSJ2-1]
ENST00000417178; ENSP00000395666; ENSG00000130640 [Q9BSJ2-3]
ENST00000543663; ENSP00000446093; ENSG00000130640 [Q9BSJ2-4]
GeneIDi10844
KEGGihsa:10844
UCSCiuc001lmg.2 human [Q9BSJ2-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF042379 mRNA Translation: AAC39728.1
AK297251 mRNA Translation: BAG59730.1
AL360181 Genomic DNA No translation available.
AL592071 Genomic DNA No translation available.
BC005011 mRNA No translation available.
BC093770 mRNA Translation: AAH93770.1
BC111957 mRNA Translation: AAI11958.1
BC143247 mRNA Translation: AAI43248.1
CCDSiCCDS58104.1 [Q9BSJ2-3]
CCDS58105.1 [Q9BSJ2-4]
CCDS7676.1 [Q9BSJ2-1]
RefSeqiNP_001243546.1, NM_001256617.1 [Q9BSJ2-4]
NP_001243547.1, NM_001256618.1 [Q9BSJ2-3]
NP_006650.1, NM_006659.3 [Q9BSJ2-1]
UniGeneiHs.523370

3D structure databases

ProteinModelPortaliQ9BSJ2
SMRiQ9BSJ2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116055, 107 interactors
CORUMiQ9BSJ2
IntActiQ9BSJ2, 46 interactors
MINTiQ9BSJ2
STRINGi9606.ENSP00000252936

PTM databases

iPTMnetiQ9BSJ2
PhosphoSitePlusiQ9BSJ2

Polymorphism and mutation databases

BioMutaiTUBGCP2
DMDMi21450889

Proteomic databases

EPDiQ9BSJ2
MaxQBiQ9BSJ2
PaxDbiQ9BSJ2
PeptideAtlasiQ9BSJ2
PRIDEiQ9BSJ2
ProteomicsDBi78900

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000252936; ENSP00000252936; ENSG00000130640 [Q9BSJ2-1]
ENST00000368563; ENSP00000357551; ENSG00000130640 [Q9BSJ2-1]
ENST00000417178; ENSP00000395666; ENSG00000130640 [Q9BSJ2-3]
ENST00000543663; ENSP00000446093; ENSG00000130640 [Q9BSJ2-4]
GeneIDi10844
KEGGihsa:10844
UCSCiuc001lmg.2 human [Q9BSJ2-1]

Organism-specific databases

CTDi10844
DisGeNETi10844
EuPathDBiHostDB:ENSG00000130640.13
GeneCardsiTUBGCP2
HGNCiHGNC:18599 TUBGCP2
HPAiHPA037885
MIMi617817 gene
neXtProtiNX_Q9BSJ2
OpenTargetsiENSG00000130640
PharmGKBiPA38598
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2001 Eukaryota
ENOG410XNRE LUCA
GeneTreeiENSGT00850000132278
HOGENOMiHOG000273895
HOVERGENiHBG026103
InParanoidiQ9BSJ2
KOiK16569
OMAiVDKGECM
OrthoDBiEOG091G01V2
PhylomeDBiQ9BSJ2
TreeFamiTF324047

Enzyme and pathway databases

ReactomeiR-HSA-380270 Recruitment of mitotic centrosome proteins and complexes
R-HSA-380320 Recruitment of NuMA to mitotic centrosomes

Miscellaneous databases

ChiTaRSiTUBGCP2 human
GeneWikiiTUBGCP2
GenomeRNAii10844
PROiPR:Q9BSJ2
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000130640 Expressed in 221 organ(s), highest expression level in right uterine tube
CleanExiHS_TUBGCP2
ExpressionAtlasiQ9BSJ2 baseline and differential
GenevisibleiQ9BSJ2 HS

Family and domain databases

InterProiView protein in InterPro
IPR007259 GCP
PANTHERiPTHR19302 PTHR19302, 1 hit
PfamiView protein in Pfam
PF04130 Spc97_Spc98, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiGCP2_HUMAN
AccessioniPrimary (citable) accession number: Q9BSJ2
Secondary accession number(s): B4DM18
, B7ZKL8, F5H4E0, F5H4L0, O43632, Q5VWX7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 6, 2002
Last sequence update: June 6, 2002
Last modified: November 7, 2018
This is version 164 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
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