TINF2

Functionⁱ

Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Plays a role in shelterin complex assembly. Isoform 1 may have additional role in tethering telomeres to the nuclear matrix.2 Publications

GO - Molecular functionⁱ

telomeric DNA binding
Source: UniProtKB
Inferred from direct assayⁱ
- 12768206

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

negative regulation of epithelial cell proliferation
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 15741234
negative regulation of protein ADP-ribosylation
Source: BHF-UCL
Inferred from direct assayⁱ
- 15133513
negative regulation of telomere maintenance via telomerase
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 15133513
protein localization to chromosome, telomeric region
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 15133513
- 18443218
regulation of telomere maintenance via telomere lengthening
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 18669893
telomere assembly
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 16880378
telomere capping
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 18443218

View the complete GO annotation on QuickGO ...

Enzyme and pathway databases

Reactomeⁱ	R-HSA-1221632 Meiotic synapsis R-HSA-171306 Packaging Of Telomere Ends R-HSA-2559586 DNA Damage/Telomere Stress Induced Senescence
SIGNORⁱ	Q9BSI4

Protein family/group databases

MoonDBⁱ	Q9BSI4 Predicted

MoonDBⁱ

Q9BSI4 Predicted

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: TERF1-interacting nuclear factor 2 Alternative name(s): TRF1-interacting nuclear protein 2
Gene namesⁱ	Name:TINF2 Synonyms:TIN2
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 14

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000092330.15
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:11824 TINF2
MIMⁱ	604319 gene
neXtProtⁱ	NX_Q9BSI4

Keywords - Cellular componentⁱ

Chromosome, Nucleus, Telomere

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Dyskeratosis congenita, autosomal dominant, 3 (DKCA3)1 Publication

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA rare multisystem disorder caused by defective telomere maintenance. It is characterized by progressive bone marrow failure, and the clinical triad of reticulated skin hyperpigmentation, nail dystrophy, and mucosal leukoplakia. Common but variable features include premature graying, aplastic anemia, low platelets, osteoporosis, pulmonary fibrosis, and liver fibrosis among others. Early mortality is often associated with bone marrow failure, infections, fatal pulmonary complications, or malignancy.

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_043914	280	K → E in DKCA3. 1 PublicationCorresponds to variant dbSNP:rs121918543EnsemblClinVar.		1
Natural variantⁱVAR_043916	282	R → S in DKCA3. 1 PublicationCorresponds to variant dbSNP:rs121918545EnsemblClinVar.		1

Dyskeratosis congenita, autosomal dominant, 5 (DKCA5)1 Publication

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA disease characterized by bone marrow hypoplasia, nail dystrophy, fine sparse hair, fine reticulate skin pigmentation, oral leukoplakia, bilateral exudative retinopathy, cerebellar hypoplasia, and growth retardation.

Mutagenesis

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Mutagenesisⁱ	258	F → A: Abolishes interaction with TERF1. 1 Publication		1
Mutagenesisⁱ	262	P → A: Does not effect interaction with TERF1. 1 Publication		1

Keywords - Diseaseⁱ

Disease mutation, Dyskeratosis congenita

Organism-specific databases

DisGeNET More...DisGeNETⁱ	26277
GeneReviewsⁱ	TINF2
MalaCards human disease database More...MalaCardsⁱ	TINF2
MIMⁱ	268130 phenotype 613990 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000092330
Orphanetⁱ	1775 Dyskeratosis congenita 3322 Hoyeraal-Hreidarsson syndrome 3088 Revesz syndrome
PharmGKBⁱ	PA36530

Polymorphism and mutation databases

BioMutaⁱ	TINF2
DMDMⁱ	21542262

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Initiator methionineⁱ		RemovedCombined sources
ChainⁱPRO_0000072541	2 – 451	TERF1-interacting nuclear factor 2Add BLAST		450

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	2	N-acetylalanineCombined sources	1
Modified residueⁱ	295	PhosphoserineCombined sources	1
Cross-linkⁱ	302	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linkⁱ	306	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linkⁱ	341	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linkⁱ	353	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMⁱ

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDⁱ	Q9BSI4
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q9BSI4
PaxDbⁱ	Q9BSI4
PeptideAtlas More...PeptideAtlasⁱ	Q9BSI4
PRIDEⁱ	Q9BSI4
ProteomicsDBⁱ	78895 78896 [Q9BSI4-2] 78897 [Q9BSI4-3]

PTM databases

iPTMnetⁱ	Q9BSI4
PhosphoSitePlusⁱ	Q9BSI4

Expressionⁱ

Tissue specificityⁱ

Detected in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.

Gene expression databases

Bgeeⁱ	ENSG00000092330 Expressed in 226 organ(s), highest expression level in left adrenal gland
CleanExⁱ	HS_TINF2
ExpressionAtlasⁱ	Q9BSI4 baseline and differential
Genevisibleⁱ	Q9BSI4 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA059061 HPA069807

HPAⁱ

HPA059061
HPA069807

Interactionⁱ

Subunit structureⁱ

Monomer. Found in a complex with POT1; TERF1 and TNKS1. Component of the shelterin complex (telosome) composed of TERF1, TERF2, TINF2, TERF2IP ACD and POT1. Interacts with TERF1, TERF2 and ACD.5 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
ACD	Q96AP0	16	EBI-717399,EBI-717666
ACTB	P60709	2	EBI-717399,EBI-353944
AIPL1	Q9NZN9	2	EBI-717399,EBI-6557414
ANKMY2	Q8IV38	2	EBI-717399,EBI-9393876
ANXA4	P09525	2	EBI-717399,EBI-2556852
ANXA5	P08758	2	EBI-717399,EBI-296601
ARHGDIA	P52565	2	EBI-717399,EBI-712693
ARID3B	Q8IVW6	2	EBI-717399,EBI-5458329
BAG3	O95817	2	EBI-717399,EBI-747185
CALD1	Q05682	2	EBI-717399,EBI-1642116
CCDC43	Q96MW1	2	EBI-717399,EBI-9247198
CCDC9	Q9Y3X0	2	EBI-717399,EBI-2557532
CLK3	P49761	2	EBI-717399,EBI-745579
CPNE3	O75131	2	EBI-717399,EBI-718988
DBN1	Q16643	2	EBI-717399,EBI-351394
DCX	O43602	2	EBI-717399,EBI-8646694
EIF4B	P23588	2	EBI-717399,EBI-970310
ENO2	P09104	2	EBI-717399,EBI-713154
FAM131B	Q86XD5	2	EBI-717399,EBI-11308812
GAPDH	P04406	2	EBI-717399,EBI-354056
KCTD17	Q8N5Z5	2	EBI-717399,EBI-743960
LGALSL	Q3ZCW2	2	EBI-717399,EBI-10241423
LTA4H	P09960	2	EBI-717399,EBI-721089
MAP2K3	P46734	2	EBI-717399,EBI-602462
NCDN	Q9UBB6	2	EBI-717399,EBI-1053490
NOL3	O60936	2	EBI-717399,EBI-740992
PAGE2	Q7Z2X7	2	EBI-717399,EBI-10256818
PEX5	P50542	2	EBI-717399,EBI-597835
PGM1	P36871	2	EBI-717399,EBI-2861475
PGM2	Q96G03	2	EBI-717399,EBI-4399372
PKM	P14618	2	EBI-717399,EBI-353408
POT1	Q9NUX5	3	EBI-717399,EBI-752420
PPP1R2	P41236	2	EBI-717399,EBI-1056517
PRKCB	P05771	2	EBI-717399,EBI-706216
RGS14	O43566	2	EBI-717399,EBI-750603
RPSA	P08865	2	EBI-717399,EBI-354112
SCRN2	Q96FV2	2	EBI-717399,EBI-11306862
SULT1C2	O00338	2	EBI-717399,EBI-3913419
TAGLN	Q01995	2	EBI-717399,EBI-1054248
TBL1X	O60907	2	EBI-717399,EBI-3505105
TERF1	P54274	11	EBI-717399,EBI-710997
TERF2	Q15554	11	EBI-717399,EBI-706637
TERF2IP	Q9NYB0	3	EBI-717418,EBI-750109
TOMM34	Q15785	2	EBI-717399,EBI-1054499
TRIM16	O95361	2	EBI-717399,EBI-727384
TRIP10	Q15642	2	EBI-717399,EBI-739936
TUBB	P07437	2	EBI-717399,EBI-350864
TXNDC17	Q9BRA2	2	EBI-717399,EBI-1055906
YWHAG	P61981	2	EBI-717399,EBI-359832

Protein-protein interaction databases

BioGridⁱ	117660, 117 interactors
ComplexPortalⁱ	CPX-152 Shelterin complex
CORUMⁱ	Q9BSI4
Database of interacting proteins More...DIPⁱ	DIP-29413N
ELMⁱ	Q9BSI4
IntActⁱ	Q9BSI4, 115 interactors
Molecular INTeraction database More...MINTⁱ	Q9BSI4
STRINGⁱ	9606.ENSP00000267415

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	8 – 24	Combined sources	17
Helixⁱ	28 – 30	Combined sources	3
Helixⁱ	31 – 44	Combined sources	14
Helixⁱ	51 – 71	Combined sources	21
Helixⁱ	76 – 86	Combined sources	11
Helixⁱ	101 – 122	Combined sources	22
Helixⁱ	128 – 138	Combined sources	11
Helixⁱ	141 – 160	Combined sources	20
Helixⁱ	169 – 177	Combined sources	9
Helixⁱ	187 – 195	Combined sources	9
Beta strandⁱ	263 – 265	Combined sources	3

Show more details

3D structure databases

ProteinModelPortalⁱ	Q9BSI4
SMRⁱ	Q9BSI4
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	Q9BSI4

EvolutionaryTraceⁱ

Q9BSI4

Family & Domainsⁱ

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	256 – 278	TBMAdd BLAST		23
Motifⁱ	262 – 268	Nuclear localization signalSequence analysis		7

Domainⁱ

The TBM domain mediates interaction with TERF1.1 Publication

Phylogenomic databases

eggNOGⁱ	ENOG410IHMP Eukaryota ENOG410Z499 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00400000022326
HOGENOMⁱ	HOG000247003
HOVERGENⁱ	HBG057120
InParanoidⁱ	Q9BSI4
KEGG Orthology (KO) More...KOⁱ	K11112
OMAⁱ	LIPTFCE
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0M9F
PhylomeDBⁱ	Q9BSI4
TreeFamⁱ	TF334731

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd11657 TIN2_N, 1 hit
InterProⁱ	View protein in InterPro IPR039098 TINF2 IPR029400 TINF2_N
PANTHERⁱ	PTHR15512 PTHR15512, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF14973 TINF2_N, 1 hit

Sequences (3+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsⁱ produced by alternative splicing. Align Add to basket

Note: Experimental confirmation may be lacking for some isoforms.

This entry has 3 described isoforms and 7 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q9BSI4-1) [UniParc]FASTA Add to basket

Also known as: TIN2L

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MATPLVAGPA ALRFAAAASW QVVRGRCVEH FPRVLEFLRS LRAVAPGLVR 
        60         70         80         90        100
YRHHERLCMG LKAKVVVELI LQGRPWAQVL KALNHHFPES GPIVRDPKAT 
       110        120        130        140        150
KQDLRKILEA QETFYQQVKQ LSEAPVDLAS KLQELEQEYG EPFLAAMEKL 
       160        170        180        190        200
LFEYLCQLEK ALPTPQAQQL QDVLSWMQPG VSITSSLAWR QYGVDMGWLL 
       210        220        230        240        250
PECSVTDSVN LAEPMEQNPP QQQRLALHNP LPKAKPGTHL PQGPSSRTHP 
       260        270        280        290        300
EPLAGRHFNL APLGRRRVQS QWASTRGGHK ERPTVMLFPF RNLGSPTQVI 
       310        320        330        340        350
SKPESKEEHA IYTADLAMGT RAASTGKSKS PCQTLGGRAL KENPVDLPAT 
       360        370        380        390        400
EQKENCLDCY MDPLRLSLLP PRARKPVCPP SLCSSVITIG DLVLDSDEEE 
       410        420        430        440        450
NGQGEGKESL ENYQKTKFDT LIPTLCEYLP PSGHGAIPVS SCDCRDSSRP 

L

Length:451

Mass (Da):50,023

Last modified:June 1, 2001 - v1

Checksum:ⁱE5A7FD11CE523979

GO

Isoform 2 (identifier: Q9BSI4-2) [UniParc]FASTA Add to basket

Also known as: TIN2S

The sequence of this isoform differs from the canonical sequence as follows:
355-451: Missing.

« Hide

        10         20         30         40         50
MATPLVAGPA ALRFAAAASW QVVRGRCVEH FPRVLEFLRS LRAVAPGLVR 
        60         70         80         90        100
YRHHERLCMG LKAKVVVELI LQGRPWAQVL KALNHHFPES GPIVRDPKAT 
       110        120        130        140        150
KQDLRKILEA QETFYQQVKQ LSEAPVDLAS KLQELEQEYG EPFLAAMEKL 
       160        170        180        190        200
LFEYLCQLEK ALPTPQAQQL QDVLSWMQPG VSITSSLAWR QYGVDMGWLL 
       210        220        230        240        250
PECSVTDSVN LAEPMEQNPP QQQRLALHNP LPKAKPGTHL PQGPSSRTHP 
       260        270        280        290        300
EPLAGRHFNL APLGRRRVQS QWASTRGGHK ERPTVMLFPF RNLGSPTQVI 
       310        320        330        340        350
SKPESKEEHA IYTADLAMGT RAASTGKSKS PCQTLGGRAL KENPVDLPAT 

EQKE

Show »

Length:354

Mass (Da):39,444

Checksum:ⁱ903B69D7B6A15C01

GO

Isoform 3 (identifier: Q9BSI4-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
134-137: ELEQ → VRLV
138-451: Missing.

« Hide

        10         20         30         40         50
MATPLVAGPA ALRFAAAASW QVVRGRCVEH FPRVLEFLRS LRAVAPGLVR 
        60         70         80         90        100
YRHHERLCMG LKAKVVVELI LQGRPWAQVL KALNHHFPES GPIVRDPKAT 
       110        120        130 
KQDLRKILEA QETFYQQVKQ LSEAPVDLAS KLQVRLV

Show »

Length:137

Mass (Da):15,434

Checksum:ⁱ3BA7286B15EAC870

GO

Computationally mapped potential isoform sequencesⁱ

There are 7 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

H0YKG7	H0YKG7_HUMAN	TERF1-interacting nuclear factor 2 TERF1-interacting nuclear factor 2	TINF2	274	Annotation score:
H0YKA6	H0YKA6_HUMAN	TERF1-interacting nuclear factor 2 TERF1-interacting nuclear factor 2	TINF2	146	Annotation score:
B4DFJ1	B4DFJ1_HUMAN	cDNA FLJ53728, highly similar to TE... cDNA FLJ53728, highly similar to TERF1-interacting nuclear factor 2	TINF2	416	Annotation score:
H0YL20	H0YL20_HUMAN	TERF1 (TRF1)-interacting nuclear fa... TERF1 (TRF1)-interacting nuclear factor 2, isoform CRA_b (TERF1-interacting nuclear factor 2)	TINF2 hCG_38254	140	Annotation score:
H0YMN3	H0YMN3_HUMAN	TERF1-interacting nuclear factor 2 TERF1-interacting nuclear factor 2	TINF2	71	Annotation score:
H0YLC9	H0YLC9_HUMAN	TERF1-interacting nuclear factor 2 TERF1-interacting nuclear factor 2	TINF2	290	Annotation score:
H0YL96	H0YL96_HUMAN	TERF1-interacting nuclear factor 2 TERF1-interacting nuclear factor 2	TINF2	85	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	44	V → I in BAB14440 (PubMed:14702039).Curated	1
Sequence conflictⁱ	67	Missing in BAB14440 (PubMed:14702039).Curated	1
Sequence conflictⁱ	302	K → N in AAF18439 (PubMed:10581025).Curated	1
Sequence conflictⁱ	323 – 332	ASTGKSKSPC → PSNGKYKGPY in AAF18439 (PubMed:10581025).Curated	10

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_051423	43	A → T. Corresponds to variant dbSNP:rs35653076Ensembl.	1
Natural variantⁱVAR_051424	237	G → D. Corresponds to variant dbSNP:rs17102313EnsemblClinVar.	1
Natural variantⁱVAR_051425	241	P → S. Corresponds to variant dbSNP:rs17102311EnsemblClinVar.	1
Natural variantⁱVAR_043914	280	K → E in DKCA3. 1 PublicationCorresponds to variant dbSNP:rs121918543EnsemblClinVar.	1
Natural variantⁱVAR_043915	282	R → H in DKCA3 and DKCA5. 1 PublicationCorresponds to variant dbSNP:rs121918544EnsemblClinVar.	1
Natural variantⁱVAR_043916	282	R → S in DKCA3. 1 PublicationCorresponds to variant dbSNP:rs121918545EnsemblClinVar.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_003987	134 – 137	ELEQ → VRLV in isoform 3. 1 Publication	4
Alternative sequenceⁱVSP_003988	138 – 451	Missing in isoform 3. 1 PublicationAdd BLAST	314
Alternative sequenceⁱVSP_003989	355 – 451	Missing in isoform 2. 1 PublicationAdd BLAST	97

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF195512 mRNA Translation: AAF18439.1 AK023166 mRNA Translation: BAB14440.1 BC005030 mRNA Translation: AAH05030.1 BC019343 mRNA Translation: AAH19343.1 EU851975 mRNA Translation: ACF17559.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS41936.1 [Q9BSI4-1] CCDS41937.1 [Q9BSI4-2]
NCBI Reference Sequences More...RefSeqⁱ	NP_001092744.1, NM_001099274.1 [Q9BSI4-1] NP_036593.2, NM_012461.2 [Q9BSI4-2]
UniGeneⁱ	Hs.496191

Genome annotation databases

Ensemblⁱ	ENST00000267415; ENSP00000267415; ENSG00000092330 [Q9BSI4-1] ENST00000399423; ENSP00000382350; ENSG00000092330 [Q9BSI4-2] ENST00000559969; ENSP00000452800; ENSG00000092330 [Q9BSI4-1] ENST00000642408; ENSP00000495309; ENSG00000284915 [Q9BSI4-1] ENST00000642983; ENSP00000494089; ENSG00000284915 [Q9BSI4-2] ENST00000646576; ENSP00000495019; ENSG00000284915 [Q9BSI4-1]
GeneIDⁱ	26277
KEGGⁱ	hsa:26277
UCSC genome browser More...UCSCⁱ	uc001woa.5 human [Q9BSI4-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9BSI4	Full-length cDNA clone CS0DI083YG01 of Placenta of Homo sapiens (human)		HUMAN		140	UniRef100_Q9BSI4
Isoform 2 of TERF1-interacting nuclear factor 2		HUMAN		354
TERF1-interacting nuclear factor 2 (Fragment)		HUMAN		146
UPI0000E013AF		HUMAN		237

Protein	Similar proteins		Species	Score	Length	Source
Q9BSI4	Full-length cDNA clone CS0DI083YG01 of Placenta of Homo sapiens (human)		HUMAN		140	UniRef90_Q9BSI4
TERF1-interacting nuclear factor 2		PANTR		453
Uncharacterized protein		PANPA		453
Uncharacterized protein		MACMU		451
Uncharacterized protein		COLAP		451
+30
Q9BSI4-3	TERF1 interacting nuclear factor 2		PANTR		142	UniRef90_Q9BSI4-3
Uncharacterized protein		PANPA		142
TERF1 (TRF1)-interacting nuclear factor 2, isoform CRA_b		HUMAN		140
TINF2 isoform 2		PONAB		140
Uncharacterized protein		NOMLE		140
+14

Protein	Similar proteins		Species	Score	Length	Source
Q9BSI4	Full-length cDNA clone CS0DI083YG01 of Placenta of Homo sapiens (human)		HUMAN		140	UniRef50_Q9BSI4
TERF1-interacting nuclear factor 2		PANTR		453
Uncharacterized protein		PANPA		453
Uncharacterized protein		NOMLE		451
Uncharacterized protein		PONAB		451
+214
Q9BSI4-3	TERF1 interacting nuclear factor 2		PANTR		142	UniRef50_Q9BSI4-3
Uncharacterized protein		PANPA		142
Uncharacterized protein		COLAP		140
Uncharacterized protein		MACMU		140
Uncharacterized protein		PAPAN		140
+17

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF195512 mRNA Translation: AAF18439.1 AK023166 mRNA Translation: BAB14440.1 BC005030 mRNA Translation: AAH05030.1 BC019343 mRNA Translation: AAH19343.1 EU851975 mRNA Translation: ACF17559.1
CCDSⁱ	CCDS41936.1 [Q9BSI4-1] CCDS41937.1 [Q9BSI4-2]
RefSeqⁱ	NP_001092744.1, NM_001099274.1 [Q9BSI4-1] NP_036593.2, NM_012461.2 [Q9BSI4-2]
UniGeneⁱ	Hs.496191

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	3BQO	X-ray	2.00	B	257-276	[»]
	3BU8	X-ray	2.15	C/D	258-275	[»]
	5XYF	X-ray	2.20	A	2-202	[»]
ProteinModelPortalⁱ	Q9BSI4
SMRⁱ	Q9BSI4
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	117660, 117 interactors
ComplexPortalⁱ	CPX-152 Shelterin complex
CORUMⁱ	Q9BSI4
DIPⁱ	DIP-29413N
ELMⁱ	Q9BSI4
IntActⁱ	Q9BSI4, 115 interactors
MINTⁱ	Q9BSI4
STRINGⁱ	9606.ENSP00000267415

Protein family/group databases

MoonDBⁱ	Q9BSI4 Predicted

MoonDBⁱ

Q9BSI4 Predicted

PTM databases

iPTMnetⁱ	Q9BSI4
PhosphoSitePlusⁱ	Q9BSI4

Polymorphism and mutation databases

BioMutaⁱ	TINF2
DMDMⁱ	21542262

Proteomic databases

EPDⁱ	Q9BSI4
MaxQBⁱ	Q9BSI4
PaxDbⁱ	Q9BSI4
PeptideAtlasⁱ	Q9BSI4
PRIDEⁱ	Q9BSI4
ProteomicsDBⁱ	78895 78896 [Q9BSI4-2] 78897 [Q9BSI4-3]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	26277
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000267415; ENSP00000267415; ENSG00000092330 [Q9BSI4-1] ENST00000399423; ENSP00000382350; ENSG00000092330 [Q9BSI4-2] ENST00000559969; ENSP00000452800; ENSG00000092330 [Q9BSI4-1] ENST00000642408; ENSP00000495309; ENSG00000284915 [Q9BSI4-1] ENST00000642983; ENSP00000494089; ENSG00000284915 [Q9BSI4-2] ENST00000646576; ENSP00000495019; ENSG00000284915 [Q9BSI4-1]
GeneIDⁱ	26277
KEGGⁱ	hsa:26277
UCSCⁱ	uc001woa.5 human [Q9BSI4-1]

Organism-specific databases

CTDⁱ	26277
DisGeNETⁱ	26277
EuPathDBⁱ	HostDB:ENSG00000092330.15
GeneCardsⁱ	TINF2
GeneReviewsⁱ	TINF2
HGNCⁱ	HGNC:11824 TINF2
HPAⁱ	HPA059061 HPA069807
MalaCardsⁱ	TINF2
MIMⁱ	268130 phenotype 604319 gene 613990 phenotype
neXtProtⁱ	NX_Q9BSI4
OpenTargetsⁱ	ENSG00000092330
Orphanetⁱ	1775 Dyskeratosis congenita 3322 Hoyeraal-Hreidarsson syndrome 3088 Revesz syndrome
PharmGKBⁱ	PA36530
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IHMP Eukaryota ENOG410Z499 LUCA
GeneTreeⁱ	ENSGT00400000022326
HOGENOMⁱ	HOG000247003
HOVERGENⁱ	HBG057120
InParanoidⁱ	Q9BSI4
KOⁱ	K11112
OMAⁱ	LIPTFCE
OrthoDBⁱ	EOG091G0M9F
PhylomeDBⁱ	Q9BSI4
TreeFamⁱ	TF334731

Enzyme and pathway databases

Reactomeⁱ	R-HSA-1221632 Meiotic synapsis R-HSA-171306 Packaging Of Telomere Ends R-HSA-2559586 DNA Damage/Telomere Stress Induced Senescence
SIGNORⁱ	Q9BSI4

Miscellaneous databases

ChiTaRSⁱ	TINF2 human
EvolutionaryTraceⁱ	Q9BSI4
GeneWikiⁱ	TINF2
GenomeRNAiⁱ	26277
Protein Ontology More...PROⁱ	PR:Q9BSI4
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000092330 Expressed in 226 organ(s), highest expression level in left adrenal gland
CleanExⁱ	HS_TINF2
ExpressionAtlasⁱ	Q9BSI4 baseline and differential
Genevisibleⁱ	Q9BSI4 HS

Family and domain databases

CDDⁱ	cd11657 TIN2_N, 1 hit
InterProⁱ	View protein in InterPro IPR039098 TINF2 IPR029400 TINF2_N
PANTHERⁱ	PTHR15512 PTHR15512, 1 hit
Pfamⁱ	View protein in Pfam PF14973 TINF2_N, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	TINF2_HUMAN
Accessionⁱ	Q9BSI4Primary (citable) accession number: Q9BSI4 Secondary accession number(s): B3W5Q7, Q9H904, Q9UHC2
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	June 20, 2002
	Last sequence update:	June 1, 2001
	Last modified:	November 7, 2018
	This is version 159 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human chromosome 14
Human chromosome 14: entries, gene names and cross-references to MIM

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UniProtKB - Q9BSI4 (TINF2_HUMAN)

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TERF1-interacting nuclear factor 2

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ