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Entry version 143 (16 Oct 2019)
Sequence version 1 (01 Jun 2001)
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Protein

Haloacid dehalogenase-like hydrolase domain-containing protein 3

Gene

HDHD3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Haloacid dehalogenase-like hydrolase domain-containing protein 3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:HDHD3
Synonyms:C9orf158
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:28171 HDHD3

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9BSH5

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000119431

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134868152

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9BSH5

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
HDHD3

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74752302

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002873131 – 251Haloacid dehalogenase-like hydrolase domain-containing protein 3Add BLAST251

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei15N6-acetyllysine; alternateCombined sources1
Modified residuei15N6-succinyllysine; alternateBy similarity1

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMi

Acetylation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9BSH5

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9BSH5

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9BSH5

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9BSH5

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9BSH5

PeptideAtlas

More...
PeptideAtlasi
Q9BSH5

PRoteomics IDEntifications database

More...
PRIDEi
Q9BSH5

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
78894

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9BSH5

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9BSH5

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q9BSH5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000119431 Expressed in 180 organ(s), highest expression level in right adrenal gland

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9BSH5 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA020427
HPA024158
HPA024585

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
TRIP13Q156455EBI-745201,EBI-358993

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
123632, 6 interactors

Protein interaction database and analysis system

More...
IntActi
Q9BSH5, 15 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000238379

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1251
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9BSH5

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q9BSH5

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the HAD-like hydrolase superfamily.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3085 Eukaryota
COG1011 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000015582

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000075006

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9BSH5

Identification of Orthologs from Complete Genome Data

More...
OMAi
WQPCNGS

Database of Orthologous Groups

More...
OrthoDBi
1119971at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9BSH5

TreeFam database of animal gene trees

More...
TreeFami
TF315144

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.50.1000, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR036412 HAD-like_sf
IPR006439 HAD-SF_hydro_IA
IPR011949 HAD-SF_hydro_IA_REG-2-like
IPR041492 HAD_2
IPR023214 HAD_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13419 HAD_2, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00413 HADHALOGNASE

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF56784 SSF56784, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR02252 DREG-2, 1 hit
TIGR01549 HAD-SF-IA-v1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9BSH5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAHRLQIRLL TWDVKDTLLR LRHPLGEAYA TKARAHGLEV EPSALEQGFR
60 70 80 90 100
QAYRAQSHSF PNYGLSHGLT SRQWWLDVVL QTFHLAGVQD AQAVAPIAEQ
110 120 130 140 150
LYKDFSHPCT WQVLDGAEDT LRECRTRGLR LAVISNFDRR LEGILGGLGL
160 170 180 190 200
REHFDFVLTS EAAGWPKPDP RIFQEALRLA HMEPVVAAHV GDNYLCDYQG
210 220 230 240 250
PRAVGMHSFL VVGPQALDPV VRDSVPKEHI LPSLAHLLPA LDCLEGSTPG

L
Length:251
Mass (Da):28,000
Last modified:June 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iAFB5AF5C286A55DE
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_032298146G → E. Corresponds to variant dbSNP:rs1043836Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK315401 mRNA Translation: BAG37794.1
AL137066 Genomic DNA No translation available.
BC005048 mRNA Translation: AAH05048.1
BC031878 mRNA Translation: AAH31878.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS6793.1

NCBI Reference Sequences

More...
RefSeqi
NP_001291438.1, NM_001304509.1
NP_001291439.1, NM_001304510.1
NP_001291440.1, NM_001304511.1
NP_112496.1, NM_031219.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000238379; ENSP00000238379; ENSG00000119431
ENST00000374180; ENSP00000363295; ENSG00000119431

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
81932

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:81932

UCSC genome browser

More...
UCSCi
uc004bhi.2 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK315401 mRNA Translation: BAG37794.1
AL137066 Genomic DNA No translation available.
BC005048 mRNA Translation: AAH05048.1
BC031878 mRNA Translation: AAH31878.1
CCDSiCCDS6793.1
RefSeqiNP_001291438.1, NM_001304509.1
NP_001291439.1, NM_001304510.1
NP_001291440.1, NM_001304511.1
NP_112496.1, NM_031219.3

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3K1ZX-ray1.55A8-247[»]
SMRiQ9BSH5
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi123632, 6 interactors
IntActiQ9BSH5, 15 interactors
STRINGi9606.ENSP00000238379

PTM databases

iPTMnetiQ9BSH5
PhosphoSitePlusiQ9BSH5
SwissPalmiQ9BSH5

Polymorphism and mutation databases

BioMutaiHDHD3
DMDMi74752302

Proteomic databases

EPDiQ9BSH5
jPOSTiQ9BSH5
MassIVEiQ9BSH5
MaxQBiQ9BSH5
PaxDbiQ9BSH5
PeptideAtlasiQ9BSH5
PRIDEiQ9BSH5
ProteomicsDBi78894

Genome annotation databases

EnsembliENST00000238379; ENSP00000238379; ENSG00000119431
ENST00000374180; ENSP00000363295; ENSG00000119431
GeneIDi81932
KEGGihsa:81932
UCSCiuc004bhi.2 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
81932

GeneCards: human genes, protein and diseases

More...
GeneCardsi
HDHD3
HGNCiHGNC:28171 HDHD3
HPAiHPA020427
HPA024158
HPA024585
neXtProtiNX_Q9BSH5
OpenTargetsiENSG00000119431
PharmGKBiPA134868152

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3085 Eukaryota
COG1011 LUCA
GeneTreeiENSGT00390000015582
HOGENOMiHOG000075006
InParanoidiQ9BSH5
OMAiWQPCNGS
OrthoDBi1119971at2759
PhylomeDBiQ9BSH5
TreeFamiTF315144

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
HDHD3 human
EvolutionaryTraceiQ9BSH5

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
81932
PharosiQ9BSH5

Protein Ontology

More...
PROi
PR:Q9BSH5

Gene expression databases

BgeeiENSG00000119431 Expressed in 180 organ(s), highest expression level in right adrenal gland
GenevisibleiQ9BSH5 HS

Family and domain databases

Gene3Di3.40.50.1000, 1 hit
InterProiView protein in InterPro
IPR036412 HAD-like_sf
IPR006439 HAD-SF_hydro_IA
IPR011949 HAD-SF_hydro_IA_REG-2-like
IPR041492 HAD_2
IPR023214 HAD_sf
PfamiView protein in Pfam
PF13419 HAD_2, 1 hit
PRINTSiPR00413 HADHALOGNASE
SUPFAMiSSF56784 SSF56784, 1 hit
TIGRFAMsiTIGR02252 DREG-2, 1 hit
TIGR01549 HAD-SF-IA-v1, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiHDHD3_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9BSH5
Secondary accession number(s): B2RD47
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: June 1, 2001
Last modified: October 16, 2019
This is version 143 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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