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UniProtKB - Q9BSH4 (TACO1_HUMAN)

Entry version 149 (02 Dec 2020)
Sequence version 1 (01 Jun 2001)
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Protein

Translational activator of cytochrome c oxidase 1

Gene

TACO1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Acts as a translational activator of mitochondrially-encoded cytochrome c oxidase 1.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator
Biological processTranslation regulation

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q9BSH4

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-5628897, TP53 Regulates Metabolic Genes
R-HSA-611105, Respiratory electron transport

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Translational activator of cytochrome c oxidase 1
Alternative name(s):
Coiled-coil domain-containing protein 44
Translational activator of mitochondrially-encoded cytochrome c oxidase I
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TACO1
Synonyms:CCDC44
ORF Names:PRO0477
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Eukaryotic Pathogen and Host Database Resources

More...EuPathDBi		HostDB:ENSG00000136463.7

Human Gene Nomenclature Database

More...HGNCi		HGNC:24316, TACO1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		612958, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9BSH4

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Leigh syndrome (LS)
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn early-onset progressive neurodegenerative disorder characterized by the presence of focal, bilateral lesions in one or more areas of the central nervous system including the brainstem, thalamus, basal ganglia, cerebellum and spinal cord. Clinical features depend on which areas of the central nervous system are involved and include subacute onset of psychomotor retardation, hypotonia, ataxia, weakness, vision loss, eye movement abnormalities, seizures, and dysphagia.
Related information in OMIM

Keywords - Diseasei

Leigh syndrome, Primary mitochondrial disease

Organism-specific databases

DisGeNET

More...DisGeNETi		51204

MalaCards human disease database

More...MalaCardsi		TACO1
MIMi256000, phenotype

Open Targets

More...OpenTargetsi		ENSG00000136463

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		255241, Leigh syndrome with leukodystrophy

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA165433031

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9BSH4, Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		TACO1

Domain mapping of disease mutations (DMDM)

More...DMDMi		33516968

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001759421 – 297Translational activator of cytochrome c oxidase 1Add BLAST297

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q9BSH4

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q9BSH4

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9BSH4

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q9BSH4

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9BSH4

PeptideAtlas

More...PeptideAtlasi		Q9BSH4

PRoteomics IDEntifications database

More...PRIDEi		Q9BSH4

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		78893

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9BSH4

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9BSH4

SwissPalm database of S-palmitoylation events

More...SwissPalmi		Q9BSH4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000136463, Expressed in right lobe of liver and 217 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9BSH4, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000136463, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		119377, 33 interactors

Protein interaction database and analysis system

More...IntActi		Q9BSH4, 30 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000258975

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9BSH4, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9BSH4

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili191 – 227Sequence analysisAdd BLAST37

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TACO1 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG2972, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000012820

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_062974_3_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9BSH4

Identification of Orthologs from Complete Genome Data

More...OMAi		ETIMYEG

Database of Orthologous Groups

More...OrthoDBi		1199273at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9BSH4

TreeFam database of animal gene trees

More...TreeFami		TF300070

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.10.200, 1 hit
3.30.70.980, 2 hits

HAMAP database of protein families

More...HAMAPi		MF_00693, Transcrip_reg_TACO1, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR017856, Integrase-like_N
IPR002876, Transcrip_reg_TACO1-like
IPR026564, Transcrip_reg_TACO1-like_dom3
IPR029072, YebC-like

The PANTHER Classification System

More...PANTHERi		PTHR12532, PTHR12532, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF01709, Transcrip_reg, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF75625, SSF75625, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9BSH4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSAWAAASLS RAAARCLLAR GPGVRAAPPR DPRPSHPEPR GCGAAPGRTL 
        60         70         80         90        100
HFTAAVPAGH NKWSKVRHIK GPKDVERSRI FSKLCLNIRL AVKEGGPNPE 
       110        120        130        140        150
HNSNLANILE VCRSKHMPKS TIETALKMEK SKDTYLLYEG RGPGGSSLLI 
       160        170        180        190        200
EALSNSSHKC QADIRHILNK NGGVMAVGAR HSFDKKGVIV VEVEDREKKA 
       210        220        230        240        250
VNLERALEMA IEAGAEDVKE TEDEEERNVF KFICDASSLH QVRKKLDSLG 
       260        270        280        290 
LCSVSCALEF IPNSKVQLAE PDLEQAAHLI QALSNHEDVI HVYDNIE
Length:297
Mass (Da):32,477
Last modified:June 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i079C4716F32EE6FF
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti168L → M in AAF24044 (Ref. 5) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_052934145G → S. Corresponds to variant dbSNP:rs35252424EnsemblClinVar.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AK315375 mRNA Translation: BAG37768.1
CH471109 Genomic DNA Translation: EAW94304.1
BC005049 mRNA Translation: AAH05049.1
BC007744 mRNA Translation: AAH07744.1
AL833861 mRNA Translation: CAD38719.1
AF090929 mRNA Translation: AAF24044.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS11640.1

NCBI Reference Sequences

More...RefSeqi		NP_057444.2, NM_016360.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000258975; ENSP00000258975; ENSG00000136463

Database of genes from NCBI RefSeq genomes

More...GeneIDi		51204

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:51204

UCSC genome browser

More...UCSCi		uc002jbd.3, human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK315375 mRNA Translation: BAG37768.1
CH471109 Genomic DNA Translation: EAW94304.1
BC005049 mRNA Translation: AAH05049.1
BC007744 mRNA Translation: AAH07744.1
AL833861 mRNA Translation: CAD38719.1
AF090929 mRNA Translation: AAF24044.1
CCDSiCCDS11640.1
RefSeqiNP_057444.2, NM_016360.3

3D structure databases

SMRiQ9BSH4
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi119377, 33 interactors
IntActiQ9BSH4, 30 interactors
STRINGi9606.ENSP00000258975

PTM databases

iPTMnetiQ9BSH4
PhosphoSitePlusiQ9BSH4
SwissPalmiQ9BSH4

Polymorphism and mutation databases

BioMutaiTACO1
DMDMi33516968

Proteomic databases

EPDiQ9BSH4
jPOSTiQ9BSH4
MassIVEiQ9BSH4
MaxQBiQ9BSH4
PaxDbiQ9BSH4
PeptideAtlasiQ9BSH4
PRIDEiQ9BSH4
ProteomicsDBi78893

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		18674, 173 antibodies

The DNASU plasmid repository

More...DNASUi		51204

Genome annotation databases

EnsembliENST00000258975; ENSP00000258975; ENSG00000136463
GeneIDi51204
KEGGihsa:51204
UCSCiuc002jbd.3, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		51204
DisGeNETi51204
EuPathDBiHostDB:ENSG00000136463.7

GeneCards: human genes, protein and diseases

More...GeneCardsi		TACO1
HGNCiHGNC:24316, TACO1
HPAiENSG00000136463, Low tissue specificity
MalaCardsiTACO1
MIMi256000, phenotype
612958, gene
neXtProtiNX_Q9BSH4
OpenTargetsiENSG00000136463
Orphaneti255241, Leigh syndrome with leukodystrophy
PharmGKBiPA165433031

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG2972, Eukaryota
GeneTreeiENSGT00390000012820
HOGENOMiCLU_062974_3_0_1
InParanoidiQ9BSH4
OMAiETIMYEG
OrthoDBi1199273at2759
PhylomeDBiQ9BSH4
TreeFamiTF300070

Enzyme and pathway databases

PathwayCommonsiQ9BSH4
ReactomeiR-HSA-5628897, TP53 Regulates Metabolic Genes
R-HSA-611105, Respiratory electron transport

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		51204, 7 hits in 842 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		TACO1, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		51204
PharosiQ9BSH4, Tdark

Protein Ontology

More...PROi		PR:Q9BSH4
RNActiQ9BSH4, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000136463, Expressed in right lobe of liver and 217 other tissues
GenevisibleiQ9BSH4, HS

Family and domain databases

Gene3Di1.10.10.200, 1 hit
3.30.70.980, 2 hits
HAMAPiMF_00693, Transcrip_reg_TACO1, 1 hit
InterProiView protein in InterPro
IPR017856, Integrase-like_N
IPR002876, Transcrip_reg_TACO1-like
IPR026564, Transcrip_reg_TACO1-like_dom3
IPR029072, YebC-like
PANTHERiPTHR12532, PTHR12532, 1 hit
PfamiView protein in Pfam
PF01709, Transcrip_reg, 1 hit
SUPFAMiSSF75625, SSF75625, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTACO1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9BSH4
Secondary accession number(s): B2RD21, Q8N3N6, Q9UI60
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 4, 2003
Last sequence update: June 1, 2001
Last modified: December 2, 2020
This is version 149 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families
  5. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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