TACO1

Functionⁱ

Acts as a translational activator of mitochondrially-encoded cytochrome c oxidase 1.1 Publication

GO - Biological processⁱ

regulation of translation Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Activator
Biological process	Translation regulation

Enzyme and pathway databases

Reactomeⁱ	R-HSA-5628897 TP53 Regulates Metabolic Genes R-HSA-611105 Respiratory electron transport

Reactomeⁱ

R-HSA-5628897 TP53 Regulates Metabolic Genes
R-HSA-611105 Respiratory electron transport

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Translational activator of cytochrome c oxidase 1 Alternative name(s): Coiled-coil domain-containing protein 44 Translational activator of mitochondrially-encoded cytochrome c oxidase I
Gene namesⁱ	Name:TACO1 Synonyms:CCDC44 ORF Names:PRO0477
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 17

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000136463.7
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:24316 TACO1
MIMⁱ	612958 gene
neXtProtⁱ	NX_Q9BSH4

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Mitochondrion

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Leigh syndrome (LS)

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionAn early-onset progressive neurodegenerative disorder characterized by the presence of focal, bilateral lesions in one or more areas of the central nervous system including the brainstem, thalamus, basal ganglia, cerebellum and spinal cord. Clinical features depend on which areas of the central nervous system are involved and include subacute onset of psychomotor retardation, hypotonia, ataxia, weakness, vision loss, eye movement abnormalities, seizures, and dysphagia.

Keywords - Diseaseⁱ

Leigh syndrome, Primary mitochondrial disease

Organism-specific databases

DisGeNET More...DisGeNETⁱ	51204
MalaCards human disease database More...MalaCardsⁱ	TACO1
MIMⁱ	256000 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000136463
Orphanetⁱ	255241 Leigh syndrome with leukodystrophy
PharmGKBⁱ	PA165433031

Polymorphism and mutation databases

BioMutaⁱ	TACO1
DMDMⁱ	33516968

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000175942	1 – 297	Translational activator of cytochrome c oxidase 1Add BLAST		297

Proteomic databases

EPDⁱ	Q9BSH4
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q9BSH4
PaxDbⁱ	Q9BSH4
PeptideAtlas More...PeptideAtlasⁱ	Q9BSH4
PRIDEⁱ	Q9BSH4
ProteomicsDBⁱ	78893

PTM databases

iPTMnetⁱ	Q9BSH4
PhosphoSitePlusⁱ	Q9BSH4
SwissPalmⁱ	Q9BSH4

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000136463 Expressed in 203 organ(s), highest expression level in right lobe of liver
CleanExⁱ	HS_CCDC44
Genevisibleⁱ	Q9BSH4 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA021626 HPA021643 HPA024294

HPAⁱ

HPA021626
HPA021643
HPA024294

Interactionⁱ

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
SAT1	P21673	3	EBI-747797,EBI-711613

With

Entry

#Exp.

IntAct

Notes

SAT1

P21673

3

EBI-747797,EBI-711613

Protein-protein interaction databases

BioGridⁱ	119377, 8 interactors
IntActⁱ	Q9BSH4, 25 interactors
STRINGⁱ	9606.ENSP00000258975

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9BSH4
SMRⁱ	Q9BSH4
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Coiled coil

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Coiled coilⁱ	191 – 227	Sequence analysisAdd BLAST		37

Sequence similaritiesⁱ

Belongs to the TACO1 family.Curated

Keywords - Domainⁱ

Coiled coil

Phylogenomic databases

eggNOGⁱ	KOG2972 Eukaryota COG0217 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000012820
HOGENOMⁱ	HOG000228370
InParanoidⁱ	Q9BSH4
KEGG Orthology (KO) More...KOⁱ	K18189
OMAⁱ	GNPTLFD
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0I1M
PhylomeDBⁱ	Q9BSH4
TreeFamⁱ	TF300070

Family and domain databases

Gene3Dⁱ	1.10.10.200, 1 hit 3.30.70.980, 2 hits
HAMAPⁱ	MF_00693 Transcrip_reg_TACO1, 1 hit
InterProⁱ	View protein in InterPro IPR017856 Integrase-like_N IPR002876 Transcrip_reg_TACO1-like IPR026564 Transcrip_reg_TACO1-like_dom3 IPR029072 YebC-like
PANTHERⁱ	PTHR12532 PTHR12532, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01709 Transcrip_reg, 1 hit
SUPFAMⁱ	SSF75625 SSF75625, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Q9BSH4-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MSAWAAASLS RAAARCLLAR GPGVRAAPPR DPRPSHPEPR GCGAAPGRTL 
        60         70         80         90        100
HFTAAVPAGH NKWSKVRHIK GPKDVERSRI FSKLCLNIRL AVKEGGPNPE 
       110        120        130        140        150
HNSNLANILE VCRSKHMPKS TIETALKMEK SKDTYLLYEG RGPGGSSLLI 
       160        170        180        190        200
EALSNSSHKC QADIRHILNK NGGVMAVGAR HSFDKKGVIV VEVEDREKKA 
       210        220        230        240        250
VNLERALEMA IEAGAEDVKE TEDEEERNVF KFICDASSLH QVRKKLDSLG 
       260        270        280        290 
LCSVSCALEF IPNSKVQLAE PDLEQAAHLI QALSNHEDVI HVYDNIE

Length:297

Mass (Da):32,477

Last modified:June 1, 2001 - v1

Checksum:ⁱ079C4716F32EE6FF

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	168	L → M in AAF24044 (Ref. 5) Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_052934	145	G → S. Corresponds to variant dbSNP:rs35252424EnsemblClinVar.		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK315375 mRNA Translation: BAG37768.1 CH471109 Genomic DNA Translation: EAW94304.1 BC005049 mRNA Translation: AAH05049.1 BC007744 mRNA Translation: AAH07744.1 AL833861 mRNA Translation: CAD38719.1 AF090929 mRNA Translation: AAF24044.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS11640.1
NCBI Reference Sequences More...RefSeqⁱ	NP_057444.2, NM_016360.3
UniGeneⁱ	Hs.174134

Genome annotation databases

Ensemblⁱ	ENST00000258975; ENSP00000258975; ENSG00000136463
GeneIDⁱ	51204
KEGGⁱ	hsa:51204
UCSC genome browser More...UCSCⁱ	uc002jbd.3 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Protein	Similar proteins		Species	Score	Length	Source
Q9BSH4	Coiled-coil domain containing 44, isoform CRA_a		HUMAN		172	UniRef100_Q9BSH4

Protein	Similar proteins		Species	Score	Length	Source
Q9BSH4	Coiled-coil domain containing 44, isoform CRA_a		HUMAN		172	UniRef90_Q9BSH4
Translational activator of cytochrome c oxidase 1		MACMU		297
Translational activator of cytochrome c oxidase I		MACFA		297
TACO1 isoform 1		PANTR		297
Uncharacterized protein		PANPA		297
+16

Protein	Similar proteins		Species	Score	Length	Source
Q9BSH4	Translational activator of cytochrome c oxidase 1		RAT		295	UniRef50_Q9BSH4
Translational activator of cytochrome c oxidase 1	)	MOUSE		294
Coiled-coil domain containing 44, isoform CRA_a		HUMAN		172
Uncharacterized protein		MACNE		297
Uncharacterized protein		CERAT		297
+96

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK315375 mRNA Translation: BAG37768.1 CH471109 Genomic DNA Translation: EAW94304.1 BC005049 mRNA Translation: AAH05049.1 BC007744 mRNA Translation: AAH07744.1 AL833861 mRNA Translation: CAD38719.1 AF090929 mRNA Translation: AAF24044.1
CCDSⁱ	CCDS11640.1
RefSeqⁱ	NP_057444.2, NM_016360.3
UniGeneⁱ	Hs.174134

3D structure databases

ProteinModelPortalⁱ	Q9BSH4
SMRⁱ	Q9BSH4
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	119377, 8 interactors
IntActⁱ	Q9BSH4, 25 interactors
STRINGⁱ	9606.ENSP00000258975

PTM databases

iPTMnetⁱ	Q9BSH4
PhosphoSitePlusⁱ	Q9BSH4
SwissPalmⁱ	Q9BSH4

Polymorphism and mutation databases

BioMutaⁱ	TACO1
DMDMⁱ	33516968

Proteomic databases

EPDⁱ	Q9BSH4
MaxQBⁱ	Q9BSH4
PaxDbⁱ	Q9BSH4
PeptideAtlasⁱ	Q9BSH4
PRIDEⁱ	Q9BSH4
ProteomicsDBⁱ	78893

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	51204
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000258975; ENSP00000258975; ENSG00000136463
GeneIDⁱ	51204
KEGGⁱ	hsa:51204
UCSCⁱ	uc002jbd.3 human

Organism-specific databases

CTDⁱ	51204
DisGeNETⁱ	51204
EuPathDBⁱ	HostDB:ENSG00000136463.7
GeneCardsⁱ	TACO1
HGNCⁱ	HGNC:24316 TACO1
HPAⁱ	HPA021626 HPA021643 HPA024294
MalaCardsⁱ	TACO1
MIMⁱ	256000 phenotype 612958 gene
neXtProtⁱ	NX_Q9BSH4
OpenTargetsⁱ	ENSG00000136463
Orphanetⁱ	255241 Leigh syndrome with leukodystrophy
PharmGKBⁱ	PA165433031
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG2972 Eukaryota COG0217 LUCA
GeneTreeⁱ	ENSGT00390000012820
HOGENOMⁱ	HOG000228370
InParanoidⁱ	Q9BSH4
KOⁱ	K18189
OMAⁱ	GNPTLFD
OrthoDBⁱ	EOG091G0I1M
PhylomeDBⁱ	Q9BSH4
TreeFamⁱ	TF300070

Enzyme and pathway databases

Reactomeⁱ	R-HSA-5628897 TP53 Regulates Metabolic Genes R-HSA-611105 Respiratory electron transport

Reactomeⁱ

R-HSA-5628897 TP53 Regulates Metabolic Genes
R-HSA-611105 Respiratory electron transport

Miscellaneous databases

ChiTaRSⁱ	TACO1 human
GenomeRNAiⁱ	51204
Protein Ontology More...PROⁱ	PR:Q9BSH4
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000136463 Expressed in 203 organ(s), highest expression level in right lobe of liver
CleanExⁱ	HS_CCDC44
Genevisibleⁱ	Q9BSH4 HS

Family and domain databases

Gene3Dⁱ	1.10.10.200, 1 hit 3.30.70.980, 2 hits
HAMAPⁱ	MF_00693 Transcrip_reg_TACO1, 1 hit
InterProⁱ	View protein in InterPro IPR017856 Integrase-like_N IPR002876 Transcrip_reg_TACO1-like IPR026564 Transcrip_reg_TACO1-like_dom3 IPR029072 YebC-like
PANTHERⁱ	PTHR12532 PTHR12532, 1 hit
Pfamⁱ	View protein in Pfam PF01709 Transcrip_reg, 1 hit
SUPFAMⁱ	SSF75625 SSF75625, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	TACO1_HUMAN
Accessionⁱ	Q9BSH4Primary (citable) accession number: Q9BSH4 Secondary accession number(s): B2RD21, Q8N3N6, Q9UI60
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	August 4, 2003
	Last sequence update:	June 1, 2001
	Last modified:	November 7, 2018
	This is version 136 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Uncharacterized protein families (UPF)
List of uncharacterized protein family (UPF) entries
Human chromosome 17
Human chromosome 17: entries, gene names and cross-references to MIM

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UniProtKB - Q9BSH4 (TACO1_HUMAN)

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Translational activator of cytochrome c oxidase 1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Mitochondrion

Mitochondrion

Nucleus

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Leigh syndrome (LS)

Keywords - Diseasei

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ