UniProtKB - Q9BSG5 (RTBDN_HUMAN)
Protein
Retbindin
Gene
RTBDN
Organism
Homo sapiens (Human)
Status
Functioni
Riboflavin-binding protein which might have a role in retinal flavin transport.By similarity
GO - Molecular functioni
- riboflavin binding Source: GO_Central
- riboflavin transmembrane transporter activity Source: GO_Central
- signaling receptor activity Source: GO_Central
Enzyme and pathway databases
PathwayCommonsi | Q9BSG5 |
Protein family/group databases
TCDBi | 9.B.92.2.1, the folate receptor (fr) family |
Names & Taxonomyi
Protein namesi | Recommended name: Retbindin |
Gene namesi | Name:RTBDN |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000132026.13 |
HGNCi | HGNC:30310, RTBDN |
MIMi | 609553, gene |
neXtProti | NX_Q9BSG5 |
Subcellular locationi
Plasma membrane
- Cell membrane ; Peripheral membrane protein By similarity
Extracellular region or secreted
- interphotoreceptor matrix By similarity
Extracellular region or secreted
- interphotoreceptor matrix Source: UniProtKB-SubCell
Plasma Membrane
- anchored component of external side of plasma membrane Source: GO_Central
Keywords - Cellular componenti
Cell membrane, Extracellular matrix, Membrane, SecretedPathology & Biotechi
Organism-specific databases
DisGeNETi | 83546 |
OpenTargetsi | ENSG00000132026 |
PharmGKBi | PA144596387 |
Miscellaneous databases
Pharosi | Q9BSG5, Tdark |
Polymorphism and mutation databases
BioMutai | RTBDN |
DMDMi | 83305682 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 30 | Sequence analysisAdd BLAST | 30 | |
ChainiPRO_0000043174 | 31 – 229 | RetbindinAdd BLAST | 199 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 79 ↔ 149 | By similarity | ||
Disulfide bondi | 86 ↔ 126 | By similarity | ||
Disulfide bondi | 119 ↔ 163 | By similarity | ||
Disulfide bondi | 132 ↔ 145 | By similarity |
Post-translational modificationi
Not N-glycosylated.By similarity
Keywords - PTMi
Disulfide bondProteomic databases
MassIVEi | Q9BSG5 |
PaxDbi | Q9BSG5 |
PeptideAtlasi | Q9BSG5 |
PRIDEi | Q9BSG5 |
ProteomicsDBi | 78889 [Q9BSG5-1] 78890 [Q9BSG5-2] |
PTM databases
iPTMneti | Q9BSG5 |
PhosphoSitePlusi | Q9BSG5 |
Expressioni
Tissue specificityi
Expressed in peripheral retina (at protein level).1 Publication
Gene expression databases
Bgeei | ENSG00000132026, Expressed in adenohypophysis and 91 other tissues |
ExpressionAtlasi | Q9BSG5, baseline and differential |
Genevisiblei | Q9BSG5, HS |
Organism-specific databases
HPAi | ENSG00000132026, Group enriched (brain, pituitary gland, retina) |
Interactioni
Protein-protein interaction databases
BioGRIDi | 123678, 9 interactors |
IntActi | Q9BSG5, 7 interactors |
STRINGi | 9606.ENSP00000326253 |
Miscellaneous databases
RNActi | Q9BSG5, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the folate receptor family.Curated
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | ENOG502RYYP, Eukaryota |
GeneTreei | ENSGT00950000183144 |
InParanoidi | Q9BSG5 |
OMAi | WFATCES |
OrthoDBi | 1534387at2759 |
PhylomeDBi | Q9BSG5 |
TreeFami | TF337710 |
Family and domain databases
InterProi | View protein in InterPro IPR004269, Folate_rcpt IPR018143, Folate_rcpt-like |
PANTHERi | PTHR10517, PTHR10517, 1 hit |
Pfami | View protein in Pfam PF03024, Folate_rec, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 9 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q9BSG5-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MDCRVHMRPI GLTWVLQLTL AWILLEACGG SRPLQARSQQ HHGLAADLGK
60 70 80 90 100
GKLHLAGPCC PSEMDTTETS GPGNHPERCG VPSPECESFL EHLQRALRSR
110 120 130 140 150
FRLRLLGVRQ AQPLCEELCQ AWFANCEDDI TCGPTWLPLS EKRGCEPSCL
160 170 180 190 200
TYGQTFADGT DLCRSALGHA LPVAAPGARH CFNISISAVP RPRPGRRGRE
210 220
APSRRSRSPR TSILDAAGSG SGSGSGSGP
Computationally mapped potential isoform sequencesi
There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketK7ENA4 | K7ENA4_HUMAN | Retbindin | RTBDN | 174 | Annotation score: | ||
K7EIS2 | K7EIS2_HUMAN | Retbindin | RTBDN | 214 | Annotation score: | ||
K7EM70 | K7EM70_HUMAN | Retbindin | RTBDN | 193 | Annotation score: | ||
K7EN64 | K7EN64_HUMAN | Retbindin | RTBDN | 130 | Annotation score: | ||
K7EKV3 | K7EKV3_HUMAN | Retbindin | RTBDN | 186 | Annotation score: | ||
K7EQL9 | K7EQL9_HUMAN | Retbindin | RTBDN | 184 | Annotation score: | ||
K7ESL8 | K7ESL8_HUMAN | Retbindin | RTBDN | 113 | Annotation score: | ||
K7ES48 | K7ES48_HUMAN | Retbindin | RTBDN | 70 | Annotation score: | ||
K7ESG0 | K7ESG0_HUMAN | Retbindin | RTBDN | 205 | Annotation score: |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_049053 | 198 | G → A. Corresponds to variant dbSNP:rs13628Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_037666 | 1 | M → MDEALETQLKTSRGRFSATE SLPTLELLSQVDM in isoform 2. 1 Publication | 1 | |
Alternative sequenceiVSP_046903 | 1 | M → MARQLLSQVDM in isoform 3. 1 Publication | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY028917 mRNA Translation: AAK26169.1 AB593122 mRNA Translation: BAJ84062.1 AC020934 Genomic DNA No translation available. BC005063 mRNA Translation: AAH05063.1 |
CCDSi | CCDS12283.1 [Q9BSG5-2] CCDS45994.1 [Q9BSG5-1] CCDS59355.1 [Q9BSG5-1] |
RefSeqi | NP_001074466.1, NM_001080997.2 [Q9BSG5-1] NP_001257370.1, NM_001270441.1 [Q9BSG5-1] NP_001257371.1, NM_001270442.1 NP_001257372.1, NM_001270443.1 [Q9BSG5-1] NP_001257373.1, NM_001270444.1 [Q9BSG5-1] NP_001257374.1, NM_001270445.1 NP_113617.1, NM_031429.2 [Q9BSG5-2] |
Genome annotation databases
Ensembli | ENST00000322912; ENSP00000326253; ENSG00000132026 [Q9BSG5-2] ENST00000393233; ENSP00000376925; ENSG00000132026 [Q9BSG5-1] ENST00000458671; ENSP00000416375; ENSG00000132026 [Q9BSG5-1] ENST00000592204; ENSP00000466765; ENSG00000132026 [Q9BSG5-3] ENST00000674343; ENSP00000501410; ENSG00000132026 [Q9BSG5-1] |
GeneIDi | 83546 |
KEGGi | hsa:83546 |
UCSCi | uc002mvi.5, human [Q9BSG5-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY028917 mRNA Translation: AAK26169.1 AB593122 mRNA Translation: BAJ84062.1 AC020934 Genomic DNA No translation available. BC005063 mRNA Translation: AAH05063.1 |
CCDSi | CCDS12283.1 [Q9BSG5-2] CCDS45994.1 [Q9BSG5-1] CCDS59355.1 [Q9BSG5-1] |
RefSeqi | NP_001074466.1, NM_001080997.2 [Q9BSG5-1] NP_001257370.1, NM_001270441.1 [Q9BSG5-1] NP_001257371.1, NM_001270442.1 NP_001257372.1, NM_001270443.1 [Q9BSG5-1] NP_001257373.1, NM_001270444.1 [Q9BSG5-1] NP_001257374.1, NM_001270445.1 NP_113617.1, NM_031429.2 [Q9BSG5-2] |
3D structure databases
SMRi | Q9BSG5 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 123678, 9 interactors |
IntActi | Q9BSG5, 7 interactors |
STRINGi | 9606.ENSP00000326253 |
Protein family/group databases
TCDBi | 9.B.92.2.1, the folate receptor (fr) family |
PTM databases
iPTMneti | Q9BSG5 |
PhosphoSitePlusi | Q9BSG5 |
Polymorphism and mutation databases
BioMutai | RTBDN |
DMDMi | 83305682 |
Proteomic databases
MassIVEi | Q9BSG5 |
PaxDbi | Q9BSG5 |
PeptideAtlasi | Q9BSG5 |
PRIDEi | Q9BSG5 |
ProteomicsDBi | 78889 [Q9BSG5-1] 78890 [Q9BSG5-2] |
Protocols and materials databases
Antibodypediai | 65265, 45 antibodies |
DNASUi | 83546 |
Genome annotation databases
Ensembli | ENST00000322912; ENSP00000326253; ENSG00000132026 [Q9BSG5-2] ENST00000393233; ENSP00000376925; ENSG00000132026 [Q9BSG5-1] ENST00000458671; ENSP00000416375; ENSG00000132026 [Q9BSG5-1] ENST00000592204; ENSP00000466765; ENSG00000132026 [Q9BSG5-3] ENST00000674343; ENSP00000501410; ENSG00000132026 [Q9BSG5-1] |
GeneIDi | 83546 |
KEGGi | hsa:83546 |
UCSCi | uc002mvi.5, human [Q9BSG5-1] |
Organism-specific databases
CTDi | 83546 |
DisGeNETi | 83546 |
EuPathDBi | HostDB:ENSG00000132026.13 |
GeneCardsi | RTBDN |
HGNCi | HGNC:30310, RTBDN |
HPAi | ENSG00000132026, Group enriched (brain, pituitary gland, retina) |
MIMi | 609553, gene |
neXtProti | NX_Q9BSG5 |
OpenTargetsi | ENSG00000132026 |
PharmGKBi | PA144596387 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502RYYP, Eukaryota |
GeneTreei | ENSGT00950000183144 |
InParanoidi | Q9BSG5 |
OMAi | WFATCES |
OrthoDBi | 1534387at2759 |
PhylomeDBi | Q9BSG5 |
TreeFami | TF337710 |
Enzyme and pathway databases
PathwayCommonsi | Q9BSG5 |
Miscellaneous databases
BioGRID-ORCSi | 83546, 9 hits in 844 CRISPR screens |
ChiTaRSi | RTBDN, human |
GenomeRNAii | 83546 |
Pharosi | Q9BSG5, Tdark |
PROi | PR:Q9BSG5 |
RNActi | Q9BSG5, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000132026, Expressed in adenohypophysis and 91 other tissues |
ExpressionAtlasi | Q9BSG5, baseline and differential |
Genevisiblei | Q9BSG5, HS |
Family and domain databases
InterProi | View protein in InterPro IPR004269, Folate_rcpt IPR018143, Folate_rcpt-like |
PANTHERi | PTHR10517, PTHR10517, 1 hit |
Pfami | View protein in Pfam PF03024, Folate_rec, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | RTBDN_HUMAN | |
Accessioni | Q9BSG5Primary (citable) accession number: Q9BSG5 Secondary accession number(s): F1T0I8, Q9BWT5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 6, 2005 |
Last sequence update: | December 6, 2005 | |
Last modified: | December 2, 2020 | |
This is version 133 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations