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Protein

Zinc finger protein 2

Gene

ZNF2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri174 – 196C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri202 – 224C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri230 – 252C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri258 – 280C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri286 – 308C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri314 – 336C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri342 – 364C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri370 – 392C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri398 – 420C2H2-type 9; degeneratePROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 2
Alternative name(s):
Zinc finger protein 2.2
Zinc finger protein 661
Gene namesi
Name:ZNF2
Synonyms:ZNF661
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000275111.4
HGNCiHGNC:12991 ZNF2
MIMi194500 gene
neXtProtiNX_Q9BSG1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi7549
OpenTargetsiENSG00000275111
PharmGKBiPA37571

Polymorphism and mutation databases

BioMutaiZNF2
DMDMi527504091

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002740491 – 426Zinc finger protein 2Add BLAST426

Proteomic databases

MaxQBiQ9BSG1
PaxDbiQ9BSG1
PeptideAtlasiQ9BSG1
PRIDEiQ9BSG1
ProteomicsDBi78888

PTM databases

iPTMnetiQ9BSG1
PhosphoSitePlusiQ9BSG1

Expressioni

Gene expression databases

BgeeiENSG00000275111 Expressed in 152 organ(s), highest expression level in female gonad
CleanExiHS_ZNF2
ExpressionAtlasiQ9BSG1 baseline and differential
GenevisibleiQ9BSG1 HS

Organism-specific databases

HPAiHPA041358

Interactioni

Binary interactionsi

Protein-protein interaction databases

BioGridi113381, 84 interactors
IntActiQ9BSG1, 6 interactors
MINTiQ9BSG1
STRINGi9606.ENSP00000345392

Structurei

3D structure databases

ProteinModelPortaliQ9BSG1
SMRiQ9BSG1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini14 – 85KRABPROSITE-ProRule annotationAdd BLAST72

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri174 – 196C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri202 – 224C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri230 – 252C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri258 – 280C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri286 – 308C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri314 – 336C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri342 – 364C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri370 – 392C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri398 – 420C2H2-type 9; degeneratePROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00920000149024
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiQ9BSG1
KOiK09228
TreeFamiTF340946

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
PF00096 zf-C2H2, 9 hits
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 9 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 5 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 8 hits
PS50157 ZINC_FINGER_C2H2_2, 9 hits

Sequences (4+)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9BSG1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAAVSPTTRC QESVTFEDVA VVFTDEEWSR LVPIQRDLYK EVMLENYNSI
60 70 80 90 100
VSLGLPVPQP DVIFQLKRGD KPWMVDLHGS EEREWPESVS LDWETKPEIH
110 120 130 140 150
DASDKKSEGS LRECLGRQSP LCPKFEVHTP NGRMGTEKQS PSGETRKKSL
160 170 180 190 200
SRDKGLRRRR SALSREILTK ERHQECSDCG KTFFDHSSLT RHQRTHTGEK
210 220 230 240 250
PYDCRECGKA FSHRSSLSRH LMSHTGESPY ECSVCSKAFF DRSSLTVHQR
260 270 280 290 300
IHTGEKPFQC NECGKAFFDR SSLTRHQRIH TGESPYECHQ CGKAFSQKSI
310 320 330 340 350
LTRHQLIHTG RKPYECNECG KAFYGVSSLN RHQKAHAGDP RYQCNECGKA
360 370 380 390 400
FFDRSSLTQH QKIHTGDKPY ECSECGKAFS QRCRLTRHQR VHTGEKPFEC
410 420
TVCGKVFSSK SSVIQHQRRY AKQGID
Length:426
Mass (Da):48,863
Last modified:July 24, 2013 - v4
Checksum:i3392DBC6FC250843
GO
Isoform 2 (identifier: Q9BSG1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     157-157: Missing.

Show »
Length:425
Mass (Da):48,707
Checksum:i8CB40D3EDB62147E
GO
Isoform 3 (identifier: Q9BSG1-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-42: Missing.

Note: No experimental confirmation available.
Show »
Length:384
Mass (Da):44,034
Checksum:i589958B82B6E1F9D
GO
Isoform 4 (identifier: Q9BSG1-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     51-88: Missing.

Note: No experimental confirmation available.
Show »
Length:388
Mass (Da):44,508
Checksum:iFF9497523DAEA39B
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B0AZN8B0AZN8_HUMAN
Zinc finger protein 2, isoform CRA_...
ZNF2 hCG_1746204
383Annotation score:
A0A087WYR5A0A087WYR5_HUMAN
Zinc finger protein 2
ZNF2
438Annotation score:
A0A087X063A0A087X063_HUMAN
Zinc finger protein 2
ZNF2
387Annotation score:
Q68CY6Q68CY6_HUMAN
Zinc finger protein 2
ZNF2 DKFZp686D2168
345Annotation score:

Sequence cautioni

The sequence AAX88982 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti1 – 11MAAVSPTTRCQ → RGAVFPGPEHSVPE in CAB52138 (PubMed:1945843).CuratedAdd BLAST11
Sequence conflicti370Y → H in AAH05068 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0476581 – 42Missing in isoform 3. CuratedAdd BLAST42
Alternative sequenceiVSP_05436951 – 88Missing in isoform 4. 1 PublicationAdd BLAST38
Alternative sequenceiVSP_047659157Missing in isoform 2. 2 Publications1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK295739 mRNA Translation: BAG58576.1
AC092835 Genomic DNA Translation: AAX88982.1 Sequence problems.
BC005068 mRNA Translation: AAH05068.2
BC009976 mRNA Translation: AAH09976.2
X60152 mRNA Translation: CAB52138.1
CCDSiCCDS42712.1 [Q9BSG1-2]
RefSeqiNP_001017396.1, NM_001017396.2
NP_001269327.1, NM_001282398.1
NP_066574.2, NM_021088.3 [Q9BSG1-2]
UniGeneiHs.590916

Genome annotation databases

EnsembliENST00000614034; ENSP00000480297; ENSG00000275111 [Q9BSG1-2]
GeneIDi7549
KEGGihsa:7549
UCSCiuc032nuy.2 human [Q9BSG1-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK295739 mRNA Translation: BAG58576.1
AC092835 Genomic DNA Translation: AAX88982.1 Sequence problems.
BC005068 mRNA Translation: AAH05068.2
BC009976 mRNA Translation: AAH09976.2
X60152 mRNA Translation: CAB52138.1
CCDSiCCDS42712.1 [Q9BSG1-2]
RefSeqiNP_001017396.1, NM_001017396.2
NP_001269327.1, NM_001282398.1
NP_066574.2, NM_021088.3 [Q9BSG1-2]
UniGeneiHs.590916

3D structure databases

ProteinModelPortaliQ9BSG1
SMRiQ9BSG1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113381, 84 interactors
IntActiQ9BSG1, 6 interactors
MINTiQ9BSG1
STRINGi9606.ENSP00000345392

PTM databases

iPTMnetiQ9BSG1
PhosphoSitePlusiQ9BSG1

Polymorphism and mutation databases

BioMutaiZNF2
DMDMi527504091

Proteomic databases

MaxQBiQ9BSG1
PaxDbiQ9BSG1
PeptideAtlasiQ9BSG1
PRIDEiQ9BSG1
ProteomicsDBi78888

Protocols and materials databases

DNASUi7549
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000614034; ENSP00000480297; ENSG00000275111 [Q9BSG1-2]
GeneIDi7549
KEGGihsa:7549
UCSCiuc032nuy.2 human [Q9BSG1-1]

Organism-specific databases

CTDi7549
DisGeNETi7549
EuPathDBiHostDB:ENSG00000275111.4
GeneCardsiZNF2
HGNCiHGNC:12991 ZNF2
HPAiHPA041358
MIMi194500 gene
neXtProtiNX_Q9BSG1
OpenTargetsiENSG00000275111
PharmGKBiPA37571
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00920000149024
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiQ9BSG1
KOiK09228
TreeFamiTF340946

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway

Miscellaneous databases

ChiTaRSiZNF2 human
GenomeRNAii7549
PROiPR:Q9BSG1
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000275111 Expressed in 152 organ(s), highest expression level in female gonad
CleanExiHS_ZNF2
ExpressionAtlasiQ9BSG1 baseline and differential
GenevisibleiQ9BSG1 HS

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
PF00096 zf-C2H2, 9 hits
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 9 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 5 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 8 hits
PS50157 ZINC_FINGER_C2H2_2, 9 hits
ProtoNetiSearch...

Entry informationi

Entry nameiZNF2_HUMAN
AccessioniPrimary (citable) accession number: Q9BSG1
Secondary accession number(s): A8MWV7
, B4DIR4, Q4ZFY6, Q96G44, Q9UMC5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: July 24, 2013
Last modified: November 7, 2018
This is version 150 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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