AGMAT

Functionⁱ

Catalytic activityⁱ

Agmatine + H₂O = putrescine + urea.1 Publication

Cofactorⁱ

Mn²⁺PROSITE-ProRule annotation

Pathwayⁱ: putrescine biosynthesis via agmatine pathway

This protein is involved in step 1 of the subpathway that synthesizes putrescine from agmatine.1 Publication
Proteins known to be involved in this subpathway in this organism are:

Agmatinase, mitochondrial (AGMAT)

This subpathway is part of the pathway putrescine biosynthesis via agmatine pathway, which is itself part of Amine and polyamine biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes putrescine from agmatine, the pathway putrescine biosynthesis via agmatine pathway and in Amine and polyamine biosynthesis.

Sites

Feature key	Position(s)	DescriptionActions	Length
Metal bindingⁱ	162	Manganese 1PROSITE-ProRule annotation	1
Metal bindingⁱ	185	Manganese 1PROSITE-ProRule annotation	1
Metal bindingⁱ	185	Manganese 2PROSITE-ProRule annotation	1
Metal bindingⁱ	187	Manganese 2PROSITE-ProRule annotation	1
Metal bindingⁱ	189	Manganese 1PROSITE-ProRule annotation	1
Metal bindingⁱ	276	Manganese 1PROSITE-ProRule annotation	1
Metal bindingⁱ	276	Manganese 2PROSITE-ProRule annotation	1
Metal bindingⁱ	278	Manganese 2PROSITE-ProRule annotation	1

GO - Molecular functionⁱ

agmatinase activity Source: Reactome
metal ion binding Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

agmatine biosynthetic process Source: Reactome
putrescine biosynthetic process from arginine Source: UniProtKB-UniPathway
spermidine biosynthetic process Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Hydrolase
Biological process	Putrescine biosynthesis, Spermidine biosynthesis
Ligand	Manganese, Metal-binding

Enzyme and pathway databases

BioCycⁱ	MetaCyc:HS04051-MONOMER
BRENDAⁱ	3.5.3.11 2681
Reactomeⁱ	R-HSA-351143 Agmatine biosynthesis
UniPathwayⁱ	UPA00534;UER00287

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Agmatinase, mitochondrial (EC:3.5.3.111 Publication) Alternative name(s): Agmatine ureohydrolase Short name: AUH
Gene namesⁱ	Name:AGMAT
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 1

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000116771.5
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:18407 AGMAT
MIMⁱ	617887 gene
neXtProtⁱ	NX_Q9BSE5

Keywords - Cellular componentⁱ

Mitochondrion

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	79814
Open Targets More...OpenTargetsⁱ	ENSG00000116771
PharmGKBⁱ	PA24619

Polymorphism and mutation databases

BioMutaⁱ	AGMAT
DMDMⁱ	126302602

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Transit peptideⁱ	1 – 35	MitochondrionSequence analysisAdd BLAST		35
ChainⁱPRO_0000002089	36 – 352	Agmatinase, mitochondrialAdd BLAST		317

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	193	N6-acetyllysineBy similarity	1
Modified residueⁱ	217	N6-acetyllysine; alternateBy similarity	1
Modified residueⁱ	217	N6-succinyllysine; alternateBy similarity	1

Keywords - PTMⁱ

Acetylation

Proteomic databases

EPDⁱ	Q9BSE5
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q9BSE5
PaxDbⁱ	Q9BSE5
PeptideAtlas More...PeptideAtlasⁱ	Q9BSE5
PRIDEⁱ	Q9BSE5
ProteomicsDBⁱ	78882

PTM databases

iPTMnetⁱ	Q9BSE5
PhosphoSitePlusⁱ	Q9BSE5

Expressionⁱ

Tissue specificityⁱ

Highly expressed in liver and kidney. Also found in skeletal muscle, fetal liver, brain, testis, skin and the gastrointestinal tract. Within brain, expression is higher in the cerebral cortex with lower levels in the medulla and spinal cord.2 Publications

Gene expression databases

Bgeeⁱ	ENSG00000116771 Expressed in 147 organ(s), highest expression level in cortex of kidney
CleanExⁱ	HS_AGMAT
ExpressionAtlasⁱ	Q9BSE5 baseline and differential
Genevisibleⁱ	Q9BSE5 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA026443 HPA028321

HPAⁱ

HPA026443
HPA028321

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	122909, 25 interactors
STRINGⁱ	9606.ENSP00000364986

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9BSE5
SMRⁱ	Q9BSE5
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the arginase family. Agmatinase subfamily.PROSITE-ProRule annotation

Keywords - Domainⁱ

Transit peptide

Phylogenomic databases

eggNOGⁱ	KOG2964 Eukaryota COG0010 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000063082
HOGENOMⁱ	HOG000204320
HOVERGENⁱ	HBG023165
InParanoidⁱ	Q9BSE5
KEGG Orthology (KO) More...KOⁱ	K01480
OMAⁱ	DTYFGAE
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0HCM
PhylomeDBⁱ	Q9BSE5
TreeFamⁱ	TF328612

Family and domain databases

InterProⁱ	View protein in InterPro IPR005925 Agmatinase-rel IPR006035 Ureohydrolase IPR023696 Ureohydrolase_dom_sf IPR020855 Ureohydrolase_Mn_BS
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00491 Arginase, 1 hit
PIRSFⁱ	PIRSF036979 Arginase, 1 hit
PRINTSⁱ	PR00116 ARGINASE
SUPFAMⁱ	SSF52768 SSF52768, 1 hit
TIGRFAMsⁱ	TIGR01230 agmatinase, 1 hit
PROSITEⁱ	View protein in PROSITE PS01053 ARGINASE_1, 1 hit PS51409 ARGINASE_2, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

Q9BSE5-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MLRLLASGCA RGPGPGVGAR PAAGLFHPGR RQSRQASDAP RNQPPSPEFV 
        60         70         80         90        100
ARPVGVCSMM RLPVQTSPEG LDAAFIGVPL DTGTSNRPGA RFGPRRIREE 
       110        120        130        140        150
SVMLGTVNPS TGALPFQSLM VADLGDVNVN LYNLQDSCRR IQEAYEKIVA 
       160        170        180        190        200
AGCIPLTLGG DHTITYPILQ AMAKKHGPVG LLHVDAHTDT TDKALGEKLY 
       210        220        230        240        250
HGAPFRRCVD EGLLDCKRVV QIGIRGSSTT LDPYRYNRSQ GFRVVLAEDC 
       260        270        280        290        300
WMKSLVPLMG EVRQQMGGKP IYISFDIDAL DPAYAPGTGT PEIAGLTPSQ 
       310        320        330        340        350
ALEIIRGCQG LNVMGCDLVE VSPPYDLSGN TALLAANLLF EMLCALPKVT 

TV

Length:352

Mass (Da):37,660

Last modified:February 20, 2007 - v2

Checksum:ⁱ394738202353314A

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	145	Y → C in BAB15633 (PubMed:14702039).Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_023485	105	G → R3 PublicationsCorresponds to variant dbSNP:rs6429757Ensembl.		1
Natural variantⁱVAR_048332	140	R → Q1 PublicationCorresponds to variant dbSNP:rs11580170Ensembl.		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY057097 mRNA Translation: AAL24446.1 AK027037 mRNA Translation: BAB15633.1 AL121992 Genomic DNA No translation available. BC005090 mRNA Translation: AAH05090.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS160.1
NCBI Reference Sequences More...RefSeqⁱ	NP_079034.3, NM_024758.4
UniGeneⁱ	Hs.461532

Genome annotation databases

Ensemblⁱ	ENST00000375826; ENSP00000364986; ENSG00000116771
GeneIDⁱ	79814
KEGGⁱ	hsa:79814
UCSC genome browser More...UCSCⁱ	uc001awv.3 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9BSE5	Agmatine ureohydrolase (Agmatinase), isoform CRA_a		HUMAN		352	UniRef100_Q9BSE5

Protein	Similar proteins		Species	Score	Length	Source
Q9BSE5	Agmatine ureohydrolase (Agmatinase), isoform CRA_a		HUMAN		352	UniRef90_Q9BSE5
Agmatinase		SAIBB		352
Uncharacterized protein		Cebus capucinus imitator		352
AGMAT isoform 1		PANTR		352
Uncharacterized protein		CERAT		352
+19

Protein	Similar proteins		Species	Score	Length	Source
Q9BSE5	Guanidinobutyrase	)	PSEAE		319	UniRef50_Q9I3S3
Agmatinase, mitochondrial		RAT		353
Agmatinase, mitochondrial		MOUSE		358
Agmatinase		PSEAI		319
Agmatinase		Pseudomonas sp. HMSC059F05		319
+2428

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY057097 mRNA Translation: AAL24446.1 AK027037 mRNA Translation: BAB15633.1 AL121992 Genomic DNA No translation available. BC005090 mRNA Translation: AAH05090.1
CCDSⁱ	CCDS160.1
RefSeqⁱ	NP_079034.3, NM_024758.4
UniGeneⁱ	Hs.461532

3D structure databases

ProteinModelPortalⁱ	Q9BSE5
SMRⁱ	Q9BSE5
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	122909, 25 interactors
STRINGⁱ	9606.ENSP00000364986

PTM databases

iPTMnetⁱ	Q9BSE5
PhosphoSitePlusⁱ	Q9BSE5

Polymorphism and mutation databases

BioMutaⁱ	AGMAT
DMDMⁱ	126302602

Proteomic databases

EPDⁱ	Q9BSE5
MaxQBⁱ	Q9BSE5
PaxDbⁱ	Q9BSE5
PeptideAtlasⁱ	Q9BSE5
PRIDEⁱ	Q9BSE5
ProteomicsDBⁱ	78882

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	79814
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000375826; ENSP00000364986; ENSG00000116771
GeneIDⁱ	79814
KEGGⁱ	hsa:79814
UCSCⁱ	uc001awv.3 human

Organism-specific databases

CTDⁱ	79814
DisGeNETⁱ	79814
EuPathDBⁱ	HostDB:ENSG00000116771.5
GeneCardsⁱ	AGMAT
H-InvDBⁱ	HIX0000155
HGNCⁱ	HGNC:18407 AGMAT
HPAⁱ	HPA026443 HPA028321
MIMⁱ	617887 gene
neXtProtⁱ	NX_Q9BSE5
OpenTargetsⁱ	ENSG00000116771
PharmGKBⁱ	PA24619
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG2964 Eukaryota COG0010 LUCA
GeneTreeⁱ	ENSGT00530000063082
HOGENOMⁱ	HOG000204320
HOVERGENⁱ	HBG023165
InParanoidⁱ	Q9BSE5
KOⁱ	K01480
OMAⁱ	DTYFGAE
OrthoDBⁱ	EOG091G0HCM
PhylomeDBⁱ	Q9BSE5
TreeFamⁱ	TF328612

Enzyme and pathway databases

UniPathwayⁱ	UPA00534;UER00287
BioCycⁱ	MetaCyc:HS04051-MONOMER
BRENDAⁱ	3.5.3.11 2681
Reactomeⁱ	R-HSA-351143 Agmatine biosynthesis

Miscellaneous databases

ChiTaRSⁱ	AGMAT human
GeneWikiⁱ	Agmatinase
GenomeRNAiⁱ	79814
Protein Ontology More...PROⁱ	PR:Q9BSE5
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000116771 Expressed in 147 organ(s), highest expression level in cortex of kidney
CleanExⁱ	HS_AGMAT
ExpressionAtlasⁱ	Q9BSE5 baseline and differential
Genevisibleⁱ	Q9BSE5 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR005925 Agmatinase-rel IPR006035 Ureohydrolase IPR023696 Ureohydrolase_dom_sf IPR020855 Ureohydrolase_Mn_BS
Pfamⁱ	View protein in Pfam PF00491 Arginase, 1 hit
PIRSFⁱ	PIRSF036979 Arginase, 1 hit
PRINTSⁱ	PR00116 ARGINASE
SUPFAMⁱ	SSF52768 SSF52768, 1 hit
TIGRFAMsⁱ	TIGR01230 agmatinase, 1 hit
PROSITEⁱ	View protein in PROSITE PS01053 ARGINASE_1, 1 hit PS51409 ARGINASE_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	SPEB_HUMAN
Accessionⁱ	Q9BSE5Primary (citable) accession number: Q9BSE5 Secondary accession number(s): Q5TDH1, Q9H5J3
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	March 27, 2002
	Last sequence update:	February 20, 2007
	Last modified:	September 12, 2018
	This is version 154 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
SIMILARITY comments
Index of protein domains and families
PATHWAY comments
Index of metabolic and biosynthesis pathways
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q9BSE5 (SPEB_HUMAN)

Your basket is currently empty. i <p>When browsing through different UniProt proteins, you can use the ‘basket’ to save them, so that you can back to find or analyse them later.<p><a href='/help/basket' target='_top'>More...</a></p>

Agmatinase, mitochondrial

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: putrescine biosynthesis via agmatine pathway

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Mitochondrion

Mitochondrion

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

Your basket is currently empty. ⁱ

Functionⁱ

Pathwayⁱ: putrescine biosynthesis via agmatine pathway

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ