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UniProtKB - Q9BSE5 (SPEB_HUMAN)
Protein
Agmatinase, mitochondrial
Gene
AGMAT
Organism
Homo sapiens (Human)
Status
Functioni
Catalytic activityi
- EC:3.5.3.111 Publication
Cofactori
Mn2+PROSITE-ProRule annotation
: putrescine biosynthesis via agmatine pathway Pathwayi
This protein is involved in step 1 of the subpathway that synthesizes putrescine from agmatine.1 Publication This subpathway is part of the pathway putrescine biosynthesis via agmatine pathway, which is itself part of Amine and polyamine biosynthesis.View all proteins of this organism that are known to be involved in the subpathway that synthesizes putrescine from agmatine, the pathway putrescine biosynthesis via agmatine pathway and in Amine and polyamine biosynthesis.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 162 | Manganese 1PROSITE-ProRule annotation | 1 | |
Metal bindingi | 185 | Manganese 1PROSITE-ProRule annotation | 1 | |
Metal bindingi | 185 | Manganese 2PROSITE-ProRule annotation | 1 | |
Metal bindingi | 187 | Manganese 2PROSITE-ProRule annotation | 1 | |
Metal bindingi | 189 | Manganese 1PROSITE-ProRule annotation | 1 | |
Metal bindingi | 276 | Manganese 1PROSITE-ProRule annotation | 1 | |
Metal bindingi | 276 | Manganese 2PROSITE-ProRule annotation | 1 | |
Metal bindingi | 278 | Manganese 2PROSITE-ProRule annotation | 1 |
GO - Molecular functioni
- agmatinase activity Source: GO_Central
- metal ion binding Source: UniProtKB-KW
GO - Biological processi
- agmatine biosynthetic process Source: Reactome
- putrescine biosynthetic process from arginine, using agmatinase Source: GO_Central
- spermidine biosynthetic process Source: UniProtKB-KW
Keywordsi
Molecular function | Hydrolase |
Biological process | Putrescine biosynthesis, Spermidine biosynthesis |
Ligand | Manganese, Metal-binding |
Enzyme and pathway databases
BRENDAi | 3.5.3.11, 2681 |
PathwayCommonsi | Q9BSE5 |
Reactomei | R-HSA-351143, Agmatine biosynthesis |
SignaLinki | Q9BSE5 |
UniPathwayi | UPA00534;UER00287 |
Names & Taxonomyi
Protein namesi | Recommended name: Agmatinase, mitochondrial (EC:3.5.3.111 Publication)Alternative name(s): Agmatine ureohydrolase Short name: AUH |
Gene namesi | Name:AGMAT |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:18407, AGMAT |
MIMi | 617887, gene |
neXtProti | NX_Q9BSE5 |
VEuPathDBi | HostDB:ENSG00000116771 |
Subcellular locationi
Mitochondrion
Mitochondrion
- mitochondrion Source: Reactome
Keywords - Cellular componenti
MitochondrionPathology & Biotechi
Organism-specific databases
DisGeNETi | 79814 |
OpenTargetsi | ENSG00000116771 |
PharmGKBi | PA24619 |
Miscellaneous databases
Pharosi | Q9BSE5, Tbio |
Genetic variation databases
BioMutai | AGMAT |
DMDMi | 126302602 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transit peptidei | 1 – 35 | MitochondrionSequence analysisAdd BLAST | 35 | |
ChainiPRO_0000002089 | 36 – 352 | Agmatinase, mitochondrialAdd BLAST | 317 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 193 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 217 | N6-acetyllysine; alternateBy similarity | 1 | |
Modified residuei | 217 | N6-succinyllysine; alternateBy similarity | 1 |
Keywords - PTMi
AcetylationProteomic databases
EPDi | Q9BSE5 |
jPOSTi | Q9BSE5 |
MassIVEi | Q9BSE5 |
MaxQBi | Q9BSE5 |
PaxDbi | Q9BSE5 |
PeptideAtlasi | Q9BSE5 |
PRIDEi | Q9BSE5 |
ProteomicsDBi | 78882 |
PTM databases
iPTMneti | Q9BSE5 |
PhosphoSitePlusi | Q9BSE5 |
Expressioni
Tissue specificityi
Highly expressed in liver and kidney. Also found in skeletal muscle, fetal liver, brain, testis, skin and the gastrointestinal tract. Within brain, expression is higher in the cerebral cortex with lower levels in the medulla and spinal cord.2 Publications
Gene expression databases
Bgeei | ENSG00000116771, Expressed in cortex of kidney and 164 other tissues |
ExpressionAtlasi | Q9BSE5, baseline and differential |
Genevisiblei | Q9BSE5, HS |
Organism-specific databases
HPAi | ENSG00000116771, Group enriched (kidney, liver, skeletal muscle) |
Interactioni
Protein-protein interaction databases
BioGRIDi | 122909, 44 interactors |
IntActi | Q9BSE5, 5 interactors |
STRINGi | 9606.ENSP00000364986 |
Miscellaneous databases
RNActi | Q9BSE5, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 11 – 49 | DisorderedSequence analysisAdd BLAST | 39 |
Sequence similaritiesi
Keywords - Domaini
Transit peptidePhylogenomic databases
eggNOGi | KOG2964, Eukaryota |
GeneTreei | ENSGT00950000183195 |
HOGENOMi | CLU_039478_0_0_1 |
InParanoidi | Q9BSE5 |
OMAi | YELTTIM |
OrthoDBi | 921352at2759 |
PhylomeDBi | Q9BSE5 |
TreeFami | TF328612 |
Family and domain databases
InterProi | View protein in InterPro IPR005925, Agmatinase-rel IPR006035, Ureohydrolase IPR023696, Ureohydrolase_dom_sf IPR020855, Ureohydrolase_Mn_BS |
PANTHERi | PTHR11358, PTHR11358, 1 hit |
Pfami | View protein in Pfam PF00491, Arginase, 1 hit |
PIRSFi | PIRSF036979, Arginase, 1 hit |
PRINTSi | PR00116, ARGINASE |
SUPFAMi | SSF52768, SSF52768, 1 hit |
TIGRFAMsi | TIGR01230, agmatinase, 1 hit |
PROSITEi | View protein in PROSITE PS01053, ARGINASE_1, 1 hit PS51409, ARGINASE_2, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q9BSE5-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLRLLASGCA RGPGPGVGAR PAAGLFHPGR RQSRQASDAP RNQPPSPEFV
60 70 80 90 100
ARPVGVCSMM RLPVQTSPEG LDAAFIGVPL DTGTSNRPGA RFGPRRIREE
110 120 130 140 150
SVMLGTVNPS TGALPFQSLM VADLGDVNVN LYNLQDSCRR IQEAYEKIVA
160 170 180 190 200
AGCIPLTLGG DHTITYPILQ AMAKKHGPVG LLHVDAHTDT TDKALGEKLY
210 220 230 240 250
HGAPFRRCVD EGLLDCKRVV QIGIRGSSTT LDPYRYNRSQ GFRVVLAEDC
260 270 280 290 300
WMKSLVPLMG EVRQQMGGKP IYISFDIDAL DPAYAPGTGT PEIAGLTPSQ
310 320 330 340 350
ALEIIRGCQG LNVMGCDLVE VSPPYDLSGN TALLAANLLF EMLCALPKVT
TV
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 145 | Y → C in BAB15633 (PubMed:14702039).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_023485 | 105 | G → R3 PublicationsCorresponds to variant dbSNP:rs6429757Ensembl. | 1 | |
Natural variantiVAR_048332 | 140 | R → Q1 PublicationCorresponds to variant dbSNP:rs11580170Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY057097 mRNA Translation: AAL24446.1 AK027037 mRNA Translation: BAB15633.1 AL121992 Genomic DNA No translation available. BC005090 mRNA Translation: AAH05090.1 |
CCDSi | CCDS160.1 |
RefSeqi | NP_079034.3, NM_024758.4 |
Genome annotation databases
Ensembli | ENST00000375826; ENSP00000364986; ENSG00000116771 |
GeneIDi | 79814 |
KEGGi | hsa:79814 |
MANE-Selecti | ENST00000375826.4; ENSP00000364986.3; NM_024758.5; NP_079034.3 |
UCSCi | uc001awv.3, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY057097 mRNA Translation: AAL24446.1 AK027037 mRNA Translation: BAB15633.1 AL121992 Genomic DNA No translation available. BC005090 mRNA Translation: AAH05090.1 |
CCDSi | CCDS160.1 |
RefSeqi | NP_079034.3, NM_024758.4 |
3D structure databases
SMRi | Q9BSE5 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 122909, 44 interactors |
IntActi | Q9BSE5, 5 interactors |
STRINGi | 9606.ENSP00000364986 |
PTM databases
iPTMneti | Q9BSE5 |
PhosphoSitePlusi | Q9BSE5 |
Genetic variation databases
BioMutai | AGMAT |
DMDMi | 126302602 |
Proteomic databases
EPDi | Q9BSE5 |
jPOSTi | Q9BSE5 |
MassIVEi | Q9BSE5 |
MaxQBi | Q9BSE5 |
PaxDbi | Q9BSE5 |
PeptideAtlasi | Q9BSE5 |
PRIDEi | Q9BSE5 |
ProteomicsDBi | 78882 |
Protocols and materials databases
Antibodypediai | 14379, 92 antibodies from 20 providers |
DNASUi | 79814 |
Genome annotation databases
Ensembli | ENST00000375826; ENSP00000364986; ENSG00000116771 |
GeneIDi | 79814 |
KEGGi | hsa:79814 |
MANE-Selecti | ENST00000375826.4; ENSP00000364986.3; NM_024758.5; NP_079034.3 |
UCSCi | uc001awv.3, human |
Organism-specific databases
CTDi | 79814 |
DisGeNETi | 79814 |
GeneCardsi | AGMAT |
HGNCi | HGNC:18407, AGMAT |
HPAi | ENSG00000116771, Group enriched (kidney, liver, skeletal muscle) |
MIMi | 617887, gene |
neXtProti | NX_Q9BSE5 |
OpenTargetsi | ENSG00000116771 |
PharmGKBi | PA24619 |
VEuPathDBi | HostDB:ENSG00000116771 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG2964, Eukaryota |
GeneTreei | ENSGT00950000183195 |
HOGENOMi | CLU_039478_0_0_1 |
InParanoidi | Q9BSE5 |
OMAi | YELTTIM |
OrthoDBi | 921352at2759 |
PhylomeDBi | Q9BSE5 |
TreeFami | TF328612 |
Enzyme and pathway databases
UniPathwayi | UPA00534;UER00287 |
BRENDAi | 3.5.3.11, 2681 |
PathwayCommonsi | Q9BSE5 |
Reactomei | R-HSA-351143, Agmatine biosynthesis |
SignaLinki | Q9BSE5 |
Miscellaneous databases
BioGRID-ORCSi | 79814, 11 hits in 1037 CRISPR screens |
ChiTaRSi | AGMAT, human |
GeneWikii | Agmatinase |
GenomeRNAii | 79814 |
Pharosi | Q9BSE5, Tbio |
PROi | PR:Q9BSE5 |
RNActi | Q9BSE5, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000116771, Expressed in cortex of kidney and 164 other tissues |
ExpressionAtlasi | Q9BSE5, baseline and differential |
Genevisiblei | Q9BSE5, HS |
Family and domain databases
InterProi | View protein in InterPro IPR005925, Agmatinase-rel IPR006035, Ureohydrolase IPR023696, Ureohydrolase_dom_sf IPR020855, Ureohydrolase_Mn_BS |
PANTHERi | PTHR11358, PTHR11358, 1 hit |
Pfami | View protein in Pfam PF00491, Arginase, 1 hit |
PIRSFi | PIRSF036979, Arginase, 1 hit |
PRINTSi | PR00116, ARGINASE |
SUPFAMi | SSF52768, SSF52768, 1 hit |
TIGRFAMsi | TIGR01230, agmatinase, 1 hit |
PROSITEi | View protein in PROSITE PS01053, ARGINASE_1, 1 hit PS51409, ARGINASE_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | SPEB_HUMAN | |
Accessioni | Q9BSE5Primary (citable) accession number: Q9BSE5 Secondary accession number(s): Q5TDH1, Q9H5J3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 27, 2002 |
Last sequence update: | February 20, 2007 | |
Last modified: | February 23, 2022 | |
This is version 175 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families