UniProtKB - Q9BSC4 (NOL10_HUMAN)
Protein
Nucleolar protein 10
Gene
NOL10
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- RNA binding Source: UniProtKB
GO - Biological processi
- maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Source: GO_Central
Enzyme and pathway databases
PathwayCommonsi | Q9BSC4 |
Names & Taxonomyi
Protein namesi | Recommended name: Nucleolar protein 10 |
Gene namesi | Name:NOL10 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:25862, NOL10 |
MIMi | 616197, gene |
neXtProti | NX_Q9BSC4 |
VEuPathDBi | HostDB:ENSG00000115761.15 |
Subcellular locationi
Nucleus
- nucleolus 1 Publication
Nucleus
- nucleolus Source: HPA
Other locations
- small-subunit processome Source: GO_Central
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 79954 |
OpenTargetsi | ENSG00000115761 |
PharmGKBi | PA142671257 |
Miscellaneous databases
Pharosi | Q9BSC4, Tdark |
Genetic variation databases
BioMutai | NOL10 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000051101 | 1 – 688 | Nucleolar protein 10Add BLAST | 688 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 1 | N-acetylmethionineCombined sources | 1 | |
Modified residuei | 25 | PhosphoserineCombined sources | 1 | |
Modified residuei | 475 | PhosphoserineCombined sources | 1 | |
Modified residuei | 481 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 514 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
EPDi | Q9BSC4 |
jPOSTi | Q9BSC4 |
MassIVEi | Q9BSC4 |
MaxQBi | Q9BSC4 |
PaxDbi | Q9BSC4 |
PeptideAtlasi | Q9BSC4 |
PRIDEi | Q9BSC4 |
ProteomicsDBi | 4565 78875 [Q9BSC4-1] 78876 [Q9BSC4-2] 78877 [Q9BSC4-3] |
2D gel databases
SWISS-2DPAGEi | Q9BSC4 |
PTM databases
iPTMneti | Q9BSC4 |
PhosphoSitePlusi | Q9BSC4 |
SwissPalmi | Q9BSC4 |
Expressioni
Gene expression databases
Bgeei | ENSG00000115761, Expressed in sperm and 216 other tissues |
ExpressionAtlasi | Q9BSC4, baseline and differential |
Genevisiblei | Q9BSC4, HS |
Organism-specific databases
HPAi | ENSG00000115761, Low tissue specificity |
Interactioni
Protein-protein interaction databases
BioGRIDi | 123023, 74 interactors |
CORUMi | Q9BSC4 |
IntActi | Q9BSC4, 28 interactors |
MINTi | Q9BSC4 |
STRINGi | 9606.ENSP00000371101 |
Miscellaneous databases
RNActi | Q9BSC4, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 44 – 82 | WD 1Add BLAST | 39 | |
Repeati | 88 – 124 | WD 2Add BLAST | 37 | |
Repeati | 127 – 163 | WD 3Add BLAST | 37 | |
Repeati | 170 – 205 | WD 4Add BLAST | 36 | |
Repeati | 219 – 258 | WD 5Add BLAST | 40 | |
Repeati | 262 – 300 | WD 6Add BLAST | 39 | |
Repeati | 304 – 341 | WD 7Add BLAST | 38 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 423 – 446 | Sequence analysisAdd BLAST | 24 | |
Coiled coili | 514 – 589 | Sequence analysisAdd BLAST | 76 | |
Coiled coili | 640 – 673 | Sequence analysisAdd BLAST | 34 |
Sequence similaritiesi
Belongs to the WD repeat NOL10/ENP2 family.Curated
Keywords - Domaini
Coiled coil, Repeat, WD repeatPhylogenomic databases
eggNOGi | KOG2321, Eukaryota |
GeneTreei | ENSGT00390000007900 |
HOGENOMi | CLU_009923_2_0_1 |
InParanoidi | Q9BSC4 |
OMAi | GEWVMST |
OrthoDBi | 1099332at2759 |
PhylomeDBi | Q9BSC4 |
TreeFami | TF105808 |
Family and domain databases
InterProi | View protein in InterPro IPR040382, NOL10/Enp2 IPR012580, NUC153 IPR001680, WD40_repeat IPR036322, WD40_repeat_dom_sf |
PANTHERi | PTHR14927, PTHR14927, 1 hit |
Pfami | View protein in Pfam PF08159, NUC153, 1 hit |
SMARTi | View protein in SMART SM00320, WD40, 5 hits |
SUPFAMi | SSF50978, SSF50978, 1 hit |
s (4+)i Sequence
Sequence statusi: Complete.
This entry describes 4 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 4 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
Isoform 1 (identifier: Q9BSC4-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MQVSSLNEVK IYSLSCGKSL PEWLSDRKKR ALQKKDVDVR RRIELIQDFE
60 70 80 90 100
MPTVCTTIKV SKDGQYILAT GTYKPRVRCY DTYQLSLKFE RCLDSEVVTF
110 120 130 140 150
EILSDDYSKI VFLHNDRYIE FHSQSGFYYK TRIPKFGRDF SYHYPSCDLY
160 170 180 190 200
FVGASSEVYR LNLEQGRYLN PLQTDAAENN VCDINSVHGL FATGTIEGRV
210 220 230 240 250
ECWDPRTRNR VGLLDCALNS VTADSEINSL PTISALKFNG ALTMAVGTTT
260 270 280 290 300
GQVLLYDLRS DKPLLVKDHQ YGLPIKSVHF QDSLDLILSA DSRIVKMWNK
310 320 330 340 350
NSGKIFTSLE PEHDLNDVCL YPNSGMLLTA NETPKMGIYY IPVLGPAPRW
360 370 380 390 400
CSFLDNLTEE LEENPESTVY DDYKFVTKKD LENLGLTHLI GSPFLRAYMH
410 420 430 440 450
GFFMDIRLYH KVKLMVNPFA YEEYRKDKIR QKIEETRAQR VQLKKLPKVN
460 470 480 490 500
KELALKLIEE EEEKQKSTWK KKVKSLPNIL TDDRFKVMFE NPDFQVDEES
510 520 530 540 550
EEFRLLNPLV SKISEKRKKK LRLLEQQELR EKEEEEEPEG KPSDAESSES
560 570 580 590 600
SDDEKAWVEE VRKQRRLLQQ EEKVKRQERL KEDQQTVLKP QFYEIKAGEE
610 620 630 640 650
FRSFKDSATK QKLMNKTLED RLKIEAKNGT LSVSDTTVGS KQLTFTLKRS
660 670 680
EQQKKQQEAE KLHRQERKRL RRSAGHLKSR HKRGRSFH
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketH7C1Z3 | H7C1Z3_HUMAN | Nucleolar protein 10 | NOL10 | 252 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 494 | F → L in BAB14836 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 570 | Q → R in BAB14836 (PubMed:14702039).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_060041 | 635 | D → N. Corresponds to variant dbSNP:rs2287059Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_015454 | 1 – 150 | Missing in isoform 3. 1 PublicationAdd BLAST | 150 | |
Alternative sequenceiVSP_045122 | 71 – 96 | Missing in isoform 4. 1 PublicationAdd BLAST | 26 | |
Alternative sequenceiVSP_015455 | 151 – 154 | FVGA → MTTQ in isoform 3. 1 Publication | 4 | |
Alternative sequenceiVSP_015456 | 253 – 302 | Missing in isoform 2. 1 PublicationAdd BLAST | 50 | |
Alternative sequenceiVSP_015457 | 343 – 345 | VLG → PSL in isoform 3. 1 Publication | 3 | |
Alternative sequenceiVSP_015458 | 346 – 688 | Missing in isoform 3. 1 PublicationAdd BLAST | 343 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK024000 mRNA Translation: BAB14765.1 AK024137 mRNA Translation: BAB14836.1 AK290680 mRNA Translation: BAF83369.1 AK297169 mRNA Translation: BAG59662.1 AC007314 Genomic DNA Translation: AAK52071.2 AC092687 Genomic DNA Translation: AAY24068.1 CH471053 Genomic DNA Translation: EAX00955.1 BC005125 mRNA Translation: AAH05125.1 |
CCDSi | CCDS1673.2 [Q9BSC4-1] CCDS58697.1 [Q9BSC4-4] CCDS58698.1 [Q9BSC4-2] |
RefSeqi | NP_001248321.1, NM_001261392.1 [Q9BSC4-4] NP_001248323.1, NM_001261394.1 [Q9BSC4-2] NP_079170.2, NM_024894.3 [Q9BSC4-1] |
Genome annotation databases
Ensembli | ENST00000345985; ENSP00000263837; ENSG00000115761 [Q9BSC4-2] ENST00000381685; ENSP00000371101; ENSG00000115761 [Q9BSC4-1] ENST00000538384; ENSP00000439663; ENSG00000115761 [Q9BSC4-4] |
GeneIDi | 79954 |
KEGGi | hsa:79954 |
UCSCi | uc002rap.4, human [Q9BSC4-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK024000 mRNA Translation: BAB14765.1 AK024137 mRNA Translation: BAB14836.1 AK290680 mRNA Translation: BAF83369.1 AK297169 mRNA Translation: BAG59662.1 AC007314 Genomic DNA Translation: AAK52071.2 AC092687 Genomic DNA Translation: AAY24068.1 CH471053 Genomic DNA Translation: EAX00955.1 BC005125 mRNA Translation: AAH05125.1 |
CCDSi | CCDS1673.2 [Q9BSC4-1] CCDS58697.1 [Q9BSC4-4] CCDS58698.1 [Q9BSC4-2] |
RefSeqi | NP_001248321.1, NM_001261392.1 [Q9BSC4-4] NP_001248323.1, NM_001261394.1 [Q9BSC4-2] NP_079170.2, NM_024894.3 [Q9BSC4-1] |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 123023, 74 interactors |
CORUMi | Q9BSC4 |
IntActi | Q9BSC4, 28 interactors |
MINTi | Q9BSC4 |
STRINGi | 9606.ENSP00000371101 |
PTM databases
iPTMneti | Q9BSC4 |
PhosphoSitePlusi | Q9BSC4 |
SwissPalmi | Q9BSC4 |
Genetic variation databases
BioMutai | NOL10 |
2D gel databases
SWISS-2DPAGEi | Q9BSC4 |
Proteomic databases
EPDi | Q9BSC4 |
jPOSTi | Q9BSC4 |
MassIVEi | Q9BSC4 |
MaxQBi | Q9BSC4 |
PaxDbi | Q9BSC4 |
PeptideAtlasi | Q9BSC4 |
PRIDEi | Q9BSC4 |
ProteomicsDBi | 4565 78875 [Q9BSC4-1] 78876 [Q9BSC4-2] 78877 [Q9BSC4-3] |
Protocols and materials databases
Antibodypediai | 26703, 95 antibodies |
Genome annotation databases
Ensembli | ENST00000345985; ENSP00000263837; ENSG00000115761 [Q9BSC4-2] ENST00000381685; ENSP00000371101; ENSG00000115761 [Q9BSC4-1] ENST00000538384; ENSP00000439663; ENSG00000115761 [Q9BSC4-4] |
GeneIDi | 79954 |
KEGGi | hsa:79954 |
UCSCi | uc002rap.4, human [Q9BSC4-1] |
Organism-specific databases
CTDi | 79954 |
DisGeNETi | 79954 |
GeneCardsi | NOL10 |
HGNCi | HGNC:25862, NOL10 |
HPAi | ENSG00000115761, Low tissue specificity |
MIMi | 616197, gene |
neXtProti | NX_Q9BSC4 |
OpenTargetsi | ENSG00000115761 |
PharmGKBi | PA142671257 |
VEuPathDBi | HostDB:ENSG00000115761.15 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG2321, Eukaryota |
GeneTreei | ENSGT00390000007900 |
HOGENOMi | CLU_009923_2_0_1 |
InParanoidi | Q9BSC4 |
OMAi | GEWVMST |
OrthoDBi | 1099332at2759 |
PhylomeDBi | Q9BSC4 |
TreeFami | TF105808 |
Enzyme and pathway databases
PathwayCommonsi | Q9BSC4 |
Miscellaneous databases
BioGRID-ORCSi | 79954, 750 hits in 971 CRISPR screens |
ChiTaRSi | NOL10, human |
GenomeRNAii | 79954 |
Pharosi | Q9BSC4, Tdark |
PROi | PR:Q9BSC4 |
RNActi | Q9BSC4, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000115761, Expressed in sperm and 216 other tissues |
ExpressionAtlasi | Q9BSC4, baseline and differential |
Genevisiblei | Q9BSC4, HS |
Family and domain databases
InterProi | View protein in InterPro IPR040382, NOL10/Enp2 IPR012580, NUC153 IPR001680, WD40_repeat IPR036322, WD40_repeat_dom_sf |
PANTHERi | PTHR14927, PTHR14927, 1 hit |
Pfami | View protein in Pfam PF08159, NUC153, 1 hit |
SMARTi | View protein in SMART SM00320, WD40, 5 hits |
SUPFAMi | SSF50978, SSF50978, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | NOL10_HUMAN | |
Accessioni | Q9BSC4Primary (citable) accession number: Q9BSC4 Secondary accession number(s): A8K3R5 Q9H855 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 30, 2005 |
Last sequence update: | June 1, 2001 | |
Last modified: | April 7, 2021 | |
This is version 159 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 2
Human chromosome 2: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families