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Entry version 151 (16 Oct 2019)
Sequence version 1 (01 Jun 2001)
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Protein

Nucleolar protein 10

Gene

NOL10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Nucleolar protein 10
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NOL10
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:25862 NOL10

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
616197 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9BSC4

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
79954

Open Targets

More...
OpenTargetsi
ENSG00000115761

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA142671257

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9BSC4

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
NOL10

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000511011 – 688Nucleolar protein 10Add BLAST688

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionineCombined sources1
Modified residuei25PhosphoserineCombined sources1
Modified residuei475PhosphoserineCombined sources1
Modified residuei481PhosphothreonineCombined sources1
Modified residuei514PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9BSC4

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9BSC4

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9BSC4

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9BSC4

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9BSC4

PeptideAtlas

More...
PeptideAtlasi
Q9BSC4

PRoteomics IDEntifications database

More...
PRIDEi
Q9BSC4

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
4565
78875 [Q9BSC4-1]
78876 [Q9BSC4-2]
78877 [Q9BSC4-3]

2D gel databases

Two-dimensional polyacrylamide gel electrophoresis database from the Geneva University Hospital

More...
SWISS-2DPAGEi
Q9BSC4

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9BSC4

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9BSC4

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q9BSC4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000115761 Expressed in 204 organ(s), highest expression level in sperm

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9BSC4 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9BSC4 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA035286
HPA043075

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
123023, 46 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
Q9BSC4

Protein interaction database and analysis system

More...
IntActi
Q9BSC4, 25 interactors

Molecular INTeraction database

More...
MINTi
Q9BSC4

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000371101

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati44 – 82WD 1Add BLAST39
Repeati88 – 124WD 2Add BLAST37
Repeati127 – 163WD 3Add BLAST37
Repeati170 – 205WD 4Add BLAST36
Repeati219 – 258WD 5Add BLAST40
Repeati262 – 300WD 6Add BLAST39
Repeati304 – 341WD 7Add BLAST38

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili423 – 446Sequence analysisAdd BLAST24
Coiled coili514 – 589Sequence analysisAdd BLAST76
Coiled coili640 – 673Sequence analysisAdd BLAST34

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the WD repeat NOL10/ENP2 family.Curated

Keywords - Domaini

Coiled coil, Repeat, WD repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2321 Eukaryota
ENOG410XQ2D LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000007900

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000182967

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9BSC4

KEGG Orthology (KO)

More...
KOi
K14788

Identification of Orthologs from Complete Genome Data

More...
OMAi
GEWVMST

Database of Orthologous Groups

More...
OrthoDBi
1099332at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9BSC4

TreeFam database of animal gene trees

More...
TreeFami
TF105808

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR040382 NOL10/Enp2
IPR012580 NUC153
IPR001680 WD40_repeat
IPR036322 WD40_repeat_dom_sf

The PANTHER Classification System

More...
PANTHERi
PTHR14927 PTHR14927, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08159 NUC153, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00320 WD40, 5 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50978 SSF50978, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9BSC4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MQVSSLNEVK IYSLSCGKSL PEWLSDRKKR ALQKKDVDVR RRIELIQDFE
60 70 80 90 100
MPTVCTTIKV SKDGQYILAT GTYKPRVRCY DTYQLSLKFE RCLDSEVVTF
110 120 130 140 150
EILSDDYSKI VFLHNDRYIE FHSQSGFYYK TRIPKFGRDF SYHYPSCDLY
160 170 180 190 200
FVGASSEVYR LNLEQGRYLN PLQTDAAENN VCDINSVHGL FATGTIEGRV
210 220 230 240 250
ECWDPRTRNR VGLLDCALNS VTADSEINSL PTISALKFNG ALTMAVGTTT
260 270 280 290 300
GQVLLYDLRS DKPLLVKDHQ YGLPIKSVHF QDSLDLILSA DSRIVKMWNK
310 320 330 340 350
NSGKIFTSLE PEHDLNDVCL YPNSGMLLTA NETPKMGIYY IPVLGPAPRW
360 370 380 390 400
CSFLDNLTEE LEENPESTVY DDYKFVTKKD LENLGLTHLI GSPFLRAYMH
410 420 430 440 450
GFFMDIRLYH KVKLMVNPFA YEEYRKDKIR QKIEETRAQR VQLKKLPKVN
460 470 480 490 500
KELALKLIEE EEEKQKSTWK KKVKSLPNIL TDDRFKVMFE NPDFQVDEES
510 520 530 540 550
EEFRLLNPLV SKISEKRKKK LRLLEQQELR EKEEEEEPEG KPSDAESSES
560 570 580 590 600
SDDEKAWVEE VRKQRRLLQQ EEKVKRQERL KEDQQTVLKP QFYEIKAGEE
610 620 630 640 650
FRSFKDSATK QKLMNKTLED RLKIEAKNGT LSVSDTTVGS KQLTFTLKRS
660 670 680
EQQKKQQEAE KLHRQERKRL RRSAGHLKSR HKRGRSFH
Length:688
Mass (Da):80,302
Last modified:June 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i27C3C9E0D7A4FA33
GO
Isoform 2 (identifier: Q9BSC4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     253-302: Missing.

Note: No experimental confirmation available.
Show »
Length:638
Mass (Da):74,509
Checksum:i13A71D5045CD8B2F
GO
Isoform 3 (identifier: Q9BSC4-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-150: Missing.
     151-154: FVGA → MTTQ
     343-345: VLG → PSL
     346-688: Missing.

Note: No experimental confirmation available.
Show »
Length:195
Mass (Da):21,578
Checksum:i106DF2BDCA17093A
GO
Isoform 4 (identifier: Q9BSC4-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     71-96: Missing.

Show »
Length:662
Mass (Da):77,148
Checksum:i63AD4D21BC5C50ED
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H7C1Z3H7C1Z3_HUMAN
Nucleolar protein 10
NOL10
252Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti494F → L in BAB14836 (PubMed:14702039).Curated1
Sequence conflicti570Q → R in BAB14836 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_060041635D → N. Corresponds to variant dbSNP:rs2287059Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0154541 – 150Missing in isoform 3. 1 PublicationAdd BLAST150
Alternative sequenceiVSP_04512271 – 96Missing in isoform 4. 1 PublicationAdd BLAST26
Alternative sequenceiVSP_015455151 – 154FVGA → MTTQ in isoform 3. 1 Publication4
Alternative sequenceiVSP_015456253 – 302Missing in isoform 2. 1 PublicationAdd BLAST50
Alternative sequenceiVSP_015457343 – 345VLG → PSL in isoform 3. 1 Publication3
Alternative sequenceiVSP_015458346 – 688Missing in isoform 3. 1 PublicationAdd BLAST343

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK024000 mRNA Translation: BAB14765.1
AK024137 mRNA Translation: BAB14836.1
AK290680 mRNA Translation: BAF83369.1
AK297169 mRNA Translation: BAG59662.1
AC007314 Genomic DNA Translation: AAK52071.2
AC092687 Genomic DNA Translation: AAY24068.1
CH471053 Genomic DNA Translation: EAX00955.1
BC005125 mRNA Translation: AAH05125.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS1673.2 [Q9BSC4-1]
CCDS58697.1 [Q9BSC4-4]
CCDS58698.1 [Q9BSC4-2]

NCBI Reference Sequences

More...
RefSeqi
NP_001248321.1, NM_001261392.1 [Q9BSC4-4]
NP_001248323.1, NM_001261394.1 [Q9BSC4-2]
NP_079170.2, NM_024894.3 [Q9BSC4-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000345985; ENSP00000263837; ENSG00000115761 [Q9BSC4-2]
ENST00000381685; ENSP00000371101; ENSG00000115761 [Q9BSC4-1]
ENST00000538384; ENSP00000439663; ENSG00000115761 [Q9BSC4-4]

Database of genes from NCBI RefSeq genomes

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GeneIDi
79954

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:79954

UCSC genome browser

More...
UCSCi
uc002rap.4 human [Q9BSC4-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK024000 mRNA Translation: BAB14765.1
AK024137 mRNA Translation: BAB14836.1
AK290680 mRNA Translation: BAF83369.1
AK297169 mRNA Translation: BAG59662.1
AC007314 Genomic DNA Translation: AAK52071.2
AC092687 Genomic DNA Translation: AAY24068.1
CH471053 Genomic DNA Translation: EAX00955.1
BC005125 mRNA Translation: AAH05125.1
CCDSiCCDS1673.2 [Q9BSC4-1]
CCDS58697.1 [Q9BSC4-4]
CCDS58698.1 [Q9BSC4-2]
RefSeqiNP_001248321.1, NM_001261392.1 [Q9BSC4-4]
NP_001248323.1, NM_001261394.1 [Q9BSC4-2]
NP_079170.2, NM_024894.3 [Q9BSC4-1]

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi123023, 46 interactors
CORUMiQ9BSC4
IntActiQ9BSC4, 25 interactors
MINTiQ9BSC4
STRINGi9606.ENSP00000371101

PTM databases

iPTMnetiQ9BSC4
PhosphoSitePlusiQ9BSC4
SwissPalmiQ9BSC4

Polymorphism and mutation databases

BioMutaiNOL10

2D gel databases

SWISS-2DPAGEiQ9BSC4

Proteomic databases

EPDiQ9BSC4
jPOSTiQ9BSC4
MassIVEiQ9BSC4
MaxQBiQ9BSC4
PaxDbiQ9BSC4
PeptideAtlasiQ9BSC4
PRIDEiQ9BSC4
ProteomicsDBi4565
78875 [Q9BSC4-1]
78876 [Q9BSC4-2]
78877 [Q9BSC4-3]

Genome annotation databases

EnsembliENST00000345985; ENSP00000263837; ENSG00000115761 [Q9BSC4-2]
ENST00000381685; ENSP00000371101; ENSG00000115761 [Q9BSC4-1]
ENST00000538384; ENSP00000439663; ENSG00000115761 [Q9BSC4-4]
GeneIDi79954
KEGGihsa:79954
UCSCiuc002rap.4 human [Q9BSC4-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
79954
DisGeNETi79954

GeneCards: human genes, protein and diseases

More...
GeneCardsi
NOL10
HGNCiHGNC:25862 NOL10
HPAiHPA035286
HPA043075
MIMi616197 gene
neXtProtiNX_Q9BSC4
OpenTargetsiENSG00000115761
PharmGKBiPA142671257

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2321 Eukaryota
ENOG410XQ2D LUCA
GeneTreeiENSGT00390000007900
HOGENOMiHOG000182967
InParanoidiQ9BSC4
KOiK14788
OMAiGEWVMST
OrthoDBi1099332at2759
PhylomeDBiQ9BSC4
TreeFamiTF105808

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
NOL10 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
79954
PharosiQ9BSC4

Protein Ontology

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PROi
PR:Q9BSC4

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000115761 Expressed in 204 organ(s), highest expression level in sperm
ExpressionAtlasiQ9BSC4 baseline and differential
GenevisibleiQ9BSC4 HS

Family and domain databases

InterProiView protein in InterPro
IPR040382 NOL10/Enp2
IPR012580 NUC153
IPR001680 WD40_repeat
IPR036322 WD40_repeat_dom_sf
PANTHERiPTHR14927 PTHR14927, 1 hit
PfamiView protein in Pfam
PF08159 NUC153, 1 hit
SMARTiView protein in SMART
SM00320 WD40, 5 hits
SUPFAMiSSF50978 SSF50978, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNOL10_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9BSC4
Secondary accession number(s): A8K3R5
, B4DLV0, Q53RC9, Q96TA5, Q9H7Y7, Q9H855
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: June 1, 2001
Last modified: October 16, 2019
This is version 151 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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