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Protein

Autophagy-related protein 101

Gene

ATG101

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Autophagy factor required for autophagosome formation. Stabilizes ATG13, protecting it from proteasomal degradation.2 Publications

GO - Molecular functioni

  • identical protein binding Source: IntAct
  • protein-containing complex binding Source: UniProtKB

GO - Biological processi

  • autophagosome assembly Source: UniProtKB
  • macroautophagy Source: Reactome
  • regulation of macroautophagy Source: Reactome

Keywordsi

Biological processAutophagy

Enzyme and pathway databases

ReactomeiR-HSA-1632852 Macroautophagy
SIGNORiQ9BSB4

Protein family/group databases

TCDBi9.A.15.2.1 the autophagy-related phagophore-formation transporter (apt) family

Names & Taxonomyi

Protein namesi
Recommended name:
Autophagy-related protein 101
Gene namesi
Name:ATG101
Synonyms:C12orf44
ORF Names:PP894
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000123395.14
HGNCiHGNC:25679 ATG101
MIMi615089 gene
neXtProtiNX_Q9BSB4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi31H → S: Impairs interaction with ATG13; when associated with R-54. 1 Publication1
Mutagenesisi54D → R: Impairs interaction with ATG13; when associated with S-31. 1 Publication1
Mutagenesisi152I → D: Abolishes interaction with ATG13; when associated with D-153 and D-156. 1 Publication1
Mutagenesisi153I → D: Abolishes interaction with ATG13; when associated with D-152 and D-156. 1 Publication1
Mutagenesisi156V → D: Abolishes interaction with ATG13; when associated with D-152 and D-152. 1 Publication1

Organism-specific databases

OpenTargetsiENSG00000123395
PharmGKBiPA143485374

Polymorphism and mutation databases

BioMutaiATG101
DMDMi74732983

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002943221 – 218Autophagy-related protein 101Add BLAST218

Proteomic databases

EPDiQ9BSB4
MaxQBiQ9BSB4
PaxDbiQ9BSB4
PeptideAtlasiQ9BSB4
PRIDEiQ9BSB4
ProteomicsDBi78873

PTM databases

iPTMnetiQ9BSB4
PhosphoSitePlusiQ9BSB4

Expressioni

Gene expression databases

BgeeiENSG00000123395 Expressed in 219 organ(s), highest expression level in testis
CleanExiHS_C12orf44
ExpressionAtlasiQ9BSB4 baseline and differential
GenevisibleiQ9BSB4 HS

Organism-specific databases

HPAiHPA039904

Interactioni

Subunit structurei

Interacts with ATG13 (PubMed:19287211, PubMed:19597335, PubMed:26299944). Associates with a complex composed of ATG13, ULK1 and RB1CC1; the association with this complex requires the presence of ATG13 (PubMed:19287211, PubMed:19597335).3 Publications

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi121948, 51 interactors
ComplexPortaliCPX-373 ULK1-ATG13-RB1CC1-ATG101 autophagy initiation complex
CORUMiQ9BSB4
DIPiDIP-60653N
IntActiQ9BSB4, 43 interactors
MINTiQ9BSB4
STRINGi9606.ENSP00000338990

Structurei

Secondary structure

1218
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ9BSB4
SMRiQ9BSB4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni152 – 156Important for interaction with ATG131 Publication5

Sequence similaritiesi

Belongs to the ATG101 family.Curated

Phylogenomic databases

eggNOGiKOG4493 Eukaryota
ENOG410XP6A LUCA
GeneTreeiENSGT00390000016511
HOGENOMiHOG000008086
InParanoidiQ9BSB4
KOiK19730
OMAiIDCDFID
OrthoDBiEOG091G076X
PhylomeDBiQ9BSB4
TreeFamiTF320996

Family and domain databases

InterProiView protein in InterPro
IPR012445 ATG101
PANTHERiPTHR13292 PTHR13292, 1 hit
PfamiView protein in Pfam
PF07855 ATG101, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q9BSB4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNCRSEVLEV SVEGRQVEEA MLAVLHTVLL HRSTGKFHYK KEGTYSIGTV
60 70 80 90 100
GTQDVDCDFI DFTYVRVSSE ELDRALRKVV GEFKDALRNS GGDGLGQMSL
110 120 130 140 150
EFYQKKKSRW PFSDECIPWE VWTVKVHVVA LATEQERQIC REKVGEKLCE
160 170 180 190 200
KIINIVEVMN RHEYLPKMPT QSEVDNVFDT GLRDVQPYLY KISFQITDAL
210
GTSVTTTMRR LIKDTLAL
Length:218
Mass (Da):25,003
Last modified:June 1, 2001 - v1
Checksum:i69A881EAF9A07659
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H3BMZ4H3BMZ4_HUMAN
Autophagy-related protein 101
ATG101
84Annotation score:
F8VQD9F8VQD9_HUMAN
Autophagy-related protein 101
ATG101
190Annotation score:
F8VVA0F8VVA0_HUMAN
Autophagy-related protein 101
ATG101
141Annotation score:

Sequence cautioni

The sequence AAG17273 differs from that shown. Reason: Frameshift at position 110.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti47I → T in BAB13907 (PubMed:14702039).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK021835 mRNA Translation: BAB13907.1
AF218031 mRNA Translation: AAG17273.1 Frameshift.
AC025259 Genomic DNA No translation available.
BC005151 mRNA Translation: AAH05151.1
BC009937 mRNA Translation: AAH09937.1
CCDSiCCDS8820.1
RefSeqiNP_001092143.1, NM_001098673.1
NP_068753.2, NM_021934.4
UniGeneiHs.9911

Genome annotation databases

EnsembliENST00000336854; ENSP00000338990; ENSG00000123395
GeneIDi60673
KEGGihsa:60673
UCSCiuc001rzu.5 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK021835 mRNA Translation: BAB13907.1
AF218031 mRNA Translation: AAG17273.1 Frameshift.
AC025259 Genomic DNA No translation available.
BC005151 mRNA Translation: AAH05151.1
BC009937 mRNA Translation: AAH09937.1
CCDSiCCDS8820.1
RefSeqiNP_001092143.1, NM_001098673.1
NP_068753.2, NM_021934.4
UniGeneiHs.9911

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4WZGX-ray1.90A1-218[»]
5C50X-ray1.63A1-198[»]
5XUYX-ray2.20B/D1-218[»]
5XV1X-ray2.51B/D1-218[»]
5XV3X-ray2.57B/D1-218[»]
5XV4X-ray2.95B/D/F/H/J/L/N/P1-218[»]
5XV6X-ray2.46B1-218[»]
ProteinModelPortaliQ9BSB4
SMRiQ9BSB4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121948, 51 interactors
ComplexPortaliCPX-373 ULK1-ATG13-RB1CC1-ATG101 autophagy initiation complex
CORUMiQ9BSB4
DIPiDIP-60653N
IntActiQ9BSB4, 43 interactors
MINTiQ9BSB4
STRINGi9606.ENSP00000338990

Protein family/group databases

TCDBi9.A.15.2.1 the autophagy-related phagophore-formation transporter (apt) family

PTM databases

iPTMnetiQ9BSB4
PhosphoSitePlusiQ9BSB4

Polymorphism and mutation databases

BioMutaiATG101
DMDMi74732983

Proteomic databases

EPDiQ9BSB4
MaxQBiQ9BSB4
PaxDbiQ9BSB4
PeptideAtlasiQ9BSB4
PRIDEiQ9BSB4
ProteomicsDBi78873

Protocols and materials databases

DNASUi60673
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000336854; ENSP00000338990; ENSG00000123395
GeneIDi60673
KEGGihsa:60673
UCSCiuc001rzu.5 human

Organism-specific databases

CTDi60673
EuPathDBiHostDB:ENSG00000123395.14
GeneCardsiATG101
H-InvDBiHIX0010645
HGNCiHGNC:25679 ATG101
HPAiHPA039904
MIMi615089 gene
neXtProtiNX_Q9BSB4
OpenTargetsiENSG00000123395
PharmGKBiPA143485374
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4493 Eukaryota
ENOG410XP6A LUCA
GeneTreeiENSGT00390000016511
HOGENOMiHOG000008086
InParanoidiQ9BSB4
KOiK19730
OMAiIDCDFID
OrthoDBiEOG091G076X
PhylomeDBiQ9BSB4
TreeFamiTF320996

Enzyme and pathway databases

ReactomeiR-HSA-1632852 Macroautophagy
SIGNORiQ9BSB4

Miscellaneous databases

GeneWikiiAutophagy-related_protein_101
GenomeRNAii60673
PROiPR:Q9BSB4
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000123395 Expressed in 219 organ(s), highest expression level in testis
CleanExiHS_C12orf44
ExpressionAtlasiQ9BSB4 baseline and differential
GenevisibleiQ9BSB4 HS

Family and domain databases

InterProiView protein in InterPro
IPR012445 ATG101
PANTHERiPTHR13292 PTHR13292, 1 hit
PfamiView protein in Pfam
PF07855 ATG101, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiATGA1_HUMAN
AccessioniPrimary (citable) accession number: Q9BSB4
Secondary accession number(s): Q9HAE2, Q9HBN1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: June 1, 2001
Last modified: November 7, 2018
This is version 126 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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