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Entry version 140 (17 Jun 2020)
Sequence version 3 (18 May 2010)
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Protein

Protein tweety homolog 2

Gene

TTYH2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Probable large-conductance Ca2+-activated chloride channel. May play a role in Ca2+ signal transduction. May be involved in cell proliferation and cell aggregation.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionChloride channel, Ion channel
Biological processIon transport, Transport
LigandCalcium, Chloride

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-2672351 Stimuli-sensing channels

Protein family/group databases

Transport Classification Database

More...
TCDBi
1.A.48.1.3 the anion channel tweety (tweety) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein tweety homolog 2
Short name:
hTTY2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TTYH2
Synonyms:C17orf29
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000141540.10

Human Gene Nomenclature Database

More...
HGNCi
HGNC:13877 TTYH2

Online Mendelian Inheritance in Man (OMIM)

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MIMi
608855 gene

neXtProt; the human protein knowledge platform

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neXtProti
NX_Q9BSA4

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 44ExtracellularSequence analysisAdd BLAST44
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei45 – 65Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini66 – 87CytoplasmicSequence analysisAdd BLAST22
Transmembranei88 – 108Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini109 – 213ExtracellularSequence analysisAdd BLAST105
Transmembranei214 – 234Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini235 – 240CytoplasmicSequence analysis6
Transmembranei241 – 261Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini262 – 388ExtracellularSequence analysisAdd BLAST127
Transmembranei389 – 409Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini410 – 534CytoplasmicSequence analysisAdd BLAST125

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
94015

Open Targets

More...
OpenTargetsi
ENSG00000141540

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA37823

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9BSA4 Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
TTYH2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
296453009

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003122461 – 534Protein tweety homolog 2Add BLAST534

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi31N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei199PhosphothreonineCombined sources1
Glycosylationi283N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei504PhosphoserineBy similarity1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9BSA4

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q9BSA4

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q9BSA4

PeptideAtlas

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PeptideAtlasi
Q9BSA4

PRoteomics IDEntifications database

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PRIDEi
Q9BSA4

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
78869 [Q9BSA4-1]
78870 [Q9BSA4-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9BSA4

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9BSA4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed at higher level in brain and testis and at lower levels in heart, ovary, spleen and peripheral blood leukocytes. Up-regulated in 13 of 16 renal cell carcinoma samples examined. Up-regulated in colon carcinoma.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000141540 Expressed in subthalamic nucleus and 198 other tissues

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q9BSA4 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9BSA4 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000141540 Tissue enriched (brain)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
125087, 17 interactors

Protein interaction database and analysis system

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IntActi
Q9BSA4, 7 interactors

Molecular INTeraction database

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MINTi
Q9BSA4

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000269346

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

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RNActi
Q9BSA4 protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi423 – 431Poly-Asp9

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the tweety family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG4433 Eukaryota
ENOG410ZNTN LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00950000183060

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
CLU_023758_0_1_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q9BSA4

KEGG Orthology (KO)

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KOi
K22641

Identification of Orthologs from Complete Genome Data

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OMAi
EYMNQAA

Database for complete collections of gene phylogenies

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PhylomeDBi
Q9BSA4

TreeFam database of animal gene trees

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TreeFami
TF319025

Family and domain databases

Conserved Domains Database

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CDDi
cd07912 Tweety_N, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR006990 Tweety

The PANTHER Classification System

More...
PANTHERi
PTHR12424 PTHR12424, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF04906 Tweety, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9BSA4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MQAARVDYIA PWWVVWLHSV PHVGLRLQPV NSTFSPGDES YQESLLFLGL
60 70 80 90 100
VAAVCLGLNL IFLVAYLVCA CHCRRDDAVQ TKQHHSCCIT WTAVVAGLIC
110 120 130 140 150
CAAVGVGFYG NSETNDGAYQ LMYSLDDANH TFSGIDALVS GTTQKMKVDL
160 170 180 190 200
EQHLARLSEI FAARGDYLQT LKFIQQMAGS VVVQLSGLPV WREVTMELTK
210 220 230 240 250
LSDQTGYVEY YRWLSYLLLF ILDLVICLIA CLGLAKRSKC LLASMLCCGA
260 270 280 290 300
LSLLLSWASL AADGSAAVAT SDFCVAPDTF ILNVTEGQIS TEVTRYYLYC
310 320 330 340 350
SQSGSSPFQQ TLTTFQRALT TMQIQVAGLL QFAVPLFSTA EEDLLAIQLL
360 370 380 390 400
LNSSESSLHQ LTAMVDCRGL HKDYLDALAG ICYDGLQGLL YLGLFSFLAA
410 420 430 440 450
LAFSTMICAG PRAWKHFTTR NRDYDDIDDD DPFNPQAWRM AAHSPPRGQL
460 470 480 490 500
HSFCSYSSGL GSQTSLQPPA QTISNAPVSE YMNQAMLFGR NPRYENVPLI
510 520 530
GRASPPPTYS PSMRATYLSV ADEHLRHYGN QFPA
Length:534
Mass (Da):58,772
Last modified:May 18, 2010 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCD59065DD53B309C
GO
Isoform 2 (identifier: Q9BSA4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-321: Missing.

Show »
Length:213
Mass (Da):23,562
Checksum:i433E2A4DFD0DA7DC
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B4DKD1B4DKD1_HUMAN
Protein tweety homolog
TTYH2
513Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3KRY9J3KRY9_HUMAN
Protein tweety homolog
TTYH2
138Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3KSH7J3KSH7_HUMAN
Protein tweety homolog
TTYH2
137Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH05168 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
The sequence BAC03579 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti4A → S in AAL16784 (PubMed:11597145).Curated1
Sequence conflicti181V → I in AAL16784 (PubMed:11597145).Curated1
Sequence conflicti181V → I in BAC03579 (PubMed:14702039).Curated1
Sequence conflicti388G → V in BAG54409 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_03746011P → H. Corresponds to variant dbSNP:rs11538875Ensembl.1
Natural variantiVAR_03746185H → D. Corresponds to variant dbSNP:rs11538876Ensembl.1
Natural variantiVAR_037462262A → T1 PublicationCorresponds to variant dbSNP:rs35682745Ensembl.1
Natural variantiVAR_037463265S → A2 PublicationsCorresponds to variant dbSNP:rs35999669Ensembl.1
Natural variantiVAR_057791409A → E. Corresponds to variant dbSNP:rs9892705Ensembl.1
Natural variantiVAR_037464419T → I. Corresponds to variant dbSNP:rs12600564Ensembl.1
Natural variantiVAR_037465423D → E2 PublicationsCorresponds to variant dbSNP:rs9899862Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0405671 – 321Missing in isoform 2. 1 PublicationAdd BLAST321

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF319952 mRNA Translation: AAL16784.1
AK126955 mRNA Translation: BAG54409.1
AK091085 mRNA Translation: BAC03579.1 Different initiation.
AC100786 Genomic DNA No translation available.
BC005168 mRNA Translation: AAH05168.1 Different initiation.
BC107492 mRNA Translation: AAI07493.1
BC107602 mRNA Translation: AAI07603.1
BX647912 mRNA Translation: CAH10576.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS32717.1 [Q9BSA4-1]
CCDS45770.1 [Q9BSA4-2]

NCBI Reference Sequences

More...
RefSeqi
NP_116035.5, NM_032646.5 [Q9BSA4-1]
NP_443101.1, NM_052869.1 [Q9BSA4-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000269346; ENSP00000269346; ENSG00000141540 [Q9BSA4-1]
ENST00000441391; ENSP00000394576; ENSG00000141540 [Q9BSA4-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
94015

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:94015

UCSC genome browser

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UCSCi
uc002jkc.4 human [Q9BSA4-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF319952 mRNA Translation: AAL16784.1
AK126955 mRNA Translation: BAG54409.1
AK091085 mRNA Translation: BAC03579.1 Different initiation.
AC100786 Genomic DNA No translation available.
BC005168 mRNA Translation: AAH05168.1 Different initiation.
BC107492 mRNA Translation: AAI07493.1
BC107602 mRNA Translation: AAI07603.1
BX647912 mRNA Translation: CAH10576.1
CCDSiCCDS32717.1 [Q9BSA4-1]
CCDS45770.1 [Q9BSA4-2]
RefSeqiNP_116035.5, NM_032646.5 [Q9BSA4-1]
NP_443101.1, NM_052869.1 [Q9BSA4-2]

3D structure databases

Database of comparative protein structure models

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ModBasei
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SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi125087, 17 interactors
IntActiQ9BSA4, 7 interactors
MINTiQ9BSA4
STRINGi9606.ENSP00000269346

Protein family/group databases

TCDBi1.A.48.1.3 the anion channel tweety (tweety) family

PTM databases

iPTMnetiQ9BSA4
PhosphoSitePlusiQ9BSA4

Polymorphism and mutation databases

BioMutaiTTYH2
DMDMi296453009

Proteomic databases

jPOSTiQ9BSA4
MassIVEiQ9BSA4
PaxDbiQ9BSA4
PeptideAtlasiQ9BSA4
PRIDEiQ9BSA4
ProteomicsDBi78869 [Q9BSA4-1]
78870 [Q9BSA4-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
61709 21 antibodies

Genome annotation databases

EnsembliENST00000269346; ENSP00000269346; ENSG00000141540 [Q9BSA4-1]
ENST00000441391; ENSP00000394576; ENSG00000141540 [Q9BSA4-2]
GeneIDi94015
KEGGihsa:94015
UCSCiuc002jkc.4 human [Q9BSA4-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
94015
DisGeNETi94015
EuPathDBiHostDB:ENSG00000141540.10

GeneCards: human genes, protein and diseases

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GeneCardsi
TTYH2
HGNCiHGNC:13877 TTYH2
HPAiENSG00000141540 Tissue enriched (brain)
MIMi608855 gene
neXtProtiNX_Q9BSA4
OpenTargetsiENSG00000141540
PharmGKBiPA37823

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG4433 Eukaryota
ENOG410ZNTN LUCA
GeneTreeiENSGT00950000183060
HOGENOMiCLU_023758_0_1_1
InParanoidiQ9BSA4
KOiK22641
OMAiEYMNQAA
PhylomeDBiQ9BSA4
TreeFamiTF319025

Enzyme and pathway databases

ReactomeiR-HSA-2672351 Stimuli-sensing channels

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
94015 4 hits in 788 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
TTYH2 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
94015
PharosiQ9BSA4 Tdark

Protein Ontology

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PROi
PR:Q9BSA4
RNActiQ9BSA4 protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000141540 Expressed in subthalamic nucleus and 198 other tissues
ExpressionAtlasiQ9BSA4 baseline and differential
GenevisibleiQ9BSA4 HS

Family and domain databases

CDDicd07912 Tweety_N, 1 hit
InterProiView protein in InterPro
IPR006990 Tweety
PANTHERiPTHR12424 PTHR12424, 1 hit
PfamiView protein in Pfam
PF04906 Tweety, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTTYH2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9BSA4
Secondary accession number(s): B3KX97
, Q3B7H8, Q3B7R9, Q6AWB4, Q8NBB7, Q96PK1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: May 18, 2010
Last modified: June 17, 2020
This is version 140 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
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