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Protein

Probable UDP-sugar transporter protein SLC35A5

Gene

SLC35A5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processSugar transport, Transport

Protein family/group databases

TCDBi2.A.7.12.14 the drug/metabolite transporter (dmt) superfamily

Names & Taxonomyi

Protein namesi
Recommended name:
Probable UDP-sugar transporter protein SLC35A5
Alternative name(s):
Solute carrier family 35 member A5
Gene namesi
Name:SLC35A5
ORF Names:UNQ164/PRO190
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000138459.8
HGNCiHGNC:20792 SLC35A5
neXtProtiNX_Q9BS91

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei9 – 29HelicalSequence analysisAdd BLAST21
Transmembranei54 – 74HelicalSequence analysisAdd BLAST21
Transmembranei94 – 116HelicalSequence analysisAdd BLAST23
Transmembranei120 – 142HelicalSequence analysisAdd BLAST23
Transmembranei148 – 168HelicalSequence analysisAdd BLAST21
Transmembranei229 – 249HelicalSequence analysisAdd BLAST21
Transmembranei264 – 284HelicalSequence analysisAdd BLAST21
Transmembranei304 – 324HelicalSequence analysisAdd BLAST21
Transmembranei331 – 351HelicalSequence analysisAdd BLAST21
Transmembranei355 – 375HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000138459
PharmGKBiPA134947136

Polymorphism and mutation databases

DMDMi160358743

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003093551 – 424Probable UDP-sugar transporter protein SLC35A5Add BLAST424

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi204N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei394PhosphoserineCombined sources1
Modified residuei416PhosphoserineCombined sources1
Modified residuei419PhosphoserineCombined sources1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

EPDiQ9BS91
MaxQBiQ9BS91
PaxDbiQ9BS91
PeptideAtlasiQ9BS91
PRIDEiQ9BS91
ProteomicsDBi78867

PTM databases

iPTMnetiQ9BS91
PhosphoSitePlusiQ9BS91

Expressioni

Gene expression databases

BgeeiENSG00000138459 Expressed in 214 organ(s), highest expression level in C1 segment of cervical spinal cord
CleanExiHS_SLC35A5
ExpressionAtlasiQ9BS91 baseline and differential
GenevisibleiQ9BS91 HS

Organism-specific databases

HPAiHPA035519
HPA057964

Interactioni

Protein-protein interaction databases

BioGridi120361, 8 interactors
IntActiQ9BS91, 3 interactors
STRINGi9606.ENSP00000417654

Structurei

3D structure databases

ProteinModelPortaliQ9BS91
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2234 Eukaryota
COG0697 LUCA
GeneTreeiENSGT00550000074563
HOGENOMiHOG000154236
HOVERGENiHBG056977
InParanoidiQ9BS91
KOiK15274
OMAiLLFRSEC
OrthoDBiEOG091G08HH
PhylomeDBiQ9BS91
TreeFamiTF354304

Family and domain databases

InterProiView protein in InterPro
IPR007271 Nuc_sug_transpt
PANTHERiPTHR10231 PTHR10231, 1 hit
PfamiView protein in Pfam
PF04142 Nuc_sug_transp, 1 hit
PIRSFiPIRSF005799 UDP-gal_transpt, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

Q9BS91-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEKQCCSHPV ICSLSTMYTF LLGAIFIALS SSRILLVKYS ANEENKYDYL
60 70 80 90 100
PTTVNVCSEL VKLVFCVLVS FCVIKKDHQS RNLKYASWKE FSDFMKWSIP
110 120 130 140 150
AFLYFLDNLI VFYVLSYLQP AMAVIFSNFS IITTALLFRI VLKRRLNWIQ
160 170 180 190 200
WASLLTLFLS IVALTAGTKT LQHNLAGRGF HHDAFFSPSN SCLLFRSECP
210 220 230 240 250
RKDNCTAKEW TFPEAKWNTT ARVFSHIRLG MGHVLIIVQC FISSMANIYN
260 270 280 290 300
EKILKEGNQL TESIFIQNSK LYFFGILFNG LTLGLQRSNR DQIKNCGFFY
310 320 330 340 350
GHSAFSVALI FVTAFQGLSV AFILKFLDNM FHVLMAQVTT VIITTVSVLV
360 370 380 390 400
FDFRPSLEFF LEAPSVLLSI FIYNASKPQV PEYAPRQERI RDLSGNLWER
410 420
SSGDGEELER LTKPKSDESD EDTF
Length:424
Mass (Da):48,500
Last modified:November 13, 2007 - v2
Checksum:i120D1E650D736F60
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H7BXF8H7BXF8_HUMAN
Probable UDP-sugar transporter prot...
SLC35A5
235Annotation score:
C9JXZ8C9JXZ8_HUMAN
Probable UDP-sugar transporter prot...
SLC35A5
147Annotation score:
F8WDF8F8WDF8_HUMAN
Probable UDP-sugar transporter prot...
SLC35A5
119Annotation score:
C9J7U8C9J7U8_HUMAN
Probable UDP-sugar transporter prot...
SLC35A5
88Annotation score:

Sequence cautioni

The sequence BAD18792 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_036945247N → I1 PublicationCorresponds to variant dbSNP:rs17849939Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358994 mRNA Translation: AAQ89353.1
AK000737 mRNA Translation: BAA91350.1
AK172825 mRNA Translation: BAD18792.1 Different initiation.
CH471052 Genomic DNA Translation: EAW79666.1
CH471052 Genomic DNA Translation: EAW79667.1
BC005207 mRNA Translation: AAH05207.1
BC010307 mRNA Translation: AAH10307.1
BC013046 mRNA Translation: AAH13046.1
AL117531 mRNA Translation: CAH10717.1
CCDSiCCDS2967.1
RefSeqiNP_060415.1, NM_017945.3
XP_011511250.1, XM_011512948.1
UniGeneiHs.237480

Genome annotation databases

EnsembliENST00000492406; ENSP00000417654; ENSG00000138459
GeneIDi55032
KEGGihsa:55032
UCSCiuc003dze.5 human

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358994 mRNA Translation: AAQ89353.1
AK000737 mRNA Translation: BAA91350.1
AK172825 mRNA Translation: BAD18792.1 Different initiation.
CH471052 Genomic DNA Translation: EAW79666.1
CH471052 Genomic DNA Translation: EAW79667.1
BC005207 mRNA Translation: AAH05207.1
BC010307 mRNA Translation: AAH10307.1
BC013046 mRNA Translation: AAH13046.1
AL117531 mRNA Translation: CAH10717.1
CCDSiCCDS2967.1
RefSeqiNP_060415.1, NM_017945.3
XP_011511250.1, XM_011512948.1
UniGeneiHs.237480

3D structure databases

ProteinModelPortaliQ9BS91
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120361, 8 interactors
IntActiQ9BS91, 3 interactors
STRINGi9606.ENSP00000417654

Protein family/group databases

TCDBi2.A.7.12.14 the drug/metabolite transporter (dmt) superfamily

PTM databases

iPTMnetiQ9BS91
PhosphoSitePlusiQ9BS91

Polymorphism and mutation databases

DMDMi160358743

Proteomic databases

EPDiQ9BS91
MaxQBiQ9BS91
PaxDbiQ9BS91
PeptideAtlasiQ9BS91
PRIDEiQ9BS91
ProteomicsDBi78867

Protocols and materials databases

DNASUi55032
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000492406; ENSP00000417654; ENSG00000138459
GeneIDi55032
KEGGihsa:55032
UCSCiuc003dze.5 human

Organism-specific databases

CTDi55032
EuPathDBiHostDB:ENSG00000138459.8
GeneCardsiSLC35A5
HGNCiHGNC:20792 SLC35A5
HPAiHPA035519
HPA057964
neXtProtiNX_Q9BS91
OpenTargetsiENSG00000138459
PharmGKBiPA134947136
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2234 Eukaryota
COG0697 LUCA
GeneTreeiENSGT00550000074563
HOGENOMiHOG000154236
HOVERGENiHBG056977
InParanoidiQ9BS91
KOiK15274
OMAiLLFRSEC
OrthoDBiEOG091G08HH
PhylomeDBiQ9BS91
TreeFamiTF354304

Miscellaneous databases

ChiTaRSiSLC35A5 human
GenomeRNAii55032
PROiPR:Q9BS91

Gene expression databases

BgeeiENSG00000138459 Expressed in 214 organ(s), highest expression level in C1 segment of cervical spinal cord
CleanExiHS_SLC35A5
ExpressionAtlasiQ9BS91 baseline and differential
GenevisibleiQ9BS91 HS

Family and domain databases

InterProiView protein in InterPro
IPR007271 Nuc_sug_transpt
PANTHERiPTHR10231 PTHR10231, 1 hit
PfamiView protein in Pfam
PF04142 Nuc_sug_transp, 1 hit
PIRSFiPIRSF005799 UDP-gal_transpt, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiS35A5_HUMAN
AccessioniPrimary (citable) accession number: Q9BS91
Secondary accession number(s): D3DN66
, Q69YY6, Q6ZMD6, Q9NWM9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: November 13, 2007
Last modified: November 7, 2018
This is version 116 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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Main funding by: National Institutes of Health

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