UniProtKB - Q9BS86 (ZPBP1_HUMAN)
Protein
Zona pellucida-binding protein 1
Gene
ZPBP
Organism
Homo sapiens (Human)
Status
Functioni
Plays a role in acrosome compaction and sperm morphogenesis (PubMed:21911476). Is implicated in sperm-oocyte interaction during fertilization (By similarity).By similarity1 Publication
GO - Biological processi
- acrosome assembly Source: GO_Central
- binding of sperm to zona pellucida Source: GO_Central
Enzyme and pathway databases
PathwayCommonsi | Q9BS86 |
Names & Taxonomyi
Protein namesi | Recommended name: Zona pellucida-binding protein 1Alternative name(s): Inner acrosomal membrane IAM38By similarity Sp38 |
Gene namesi | Name:ZPBP Synonyms:ZPBP1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:15662, ZPBP |
MIMi | 608498, gene |
neXtProti | NX_Q9BS86 |
VEuPathDBi | HostDB:ENSG00000042813.7 |
Subcellular locationi
Extracellular region or secreted
- Secreted Curated
Other locations
- acrosome membrane By similarity; Peripheral membrane protein By similarity
Note: First localized in acrosome granule, later migrates to the inner and outer acrosomal membrane. Released after the acrosomal reaction.By similarity
Extracellular region or secreted
- extracellular region Source: UniProtKB-SubCell
Nucleus
- nucleus Source: UniProtKB
Other locations
- acrosomal membrane Source: UniProtKB-SubCell
- acrosomal vesicle Source: GO_Central
- zona pellucida receptor complex Source: GO_Central
Keywords - Cellular componenti
Cytoplasmic vesicle, Membrane, SecretedPathology & Biotechi
Organism-specific databases
DisGeNETi | 11055 |
OpenTargetsi | ENSG00000042813 |
PharmGKBi | PA38013 |
Miscellaneous databases
Pharosi | Q9BS86, Tdark |
Genetic variation databases
BioMutai | ZPBP |
DMDMi | 54036652 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 44 | Sequence analysisAdd BLAST | 44 | |
ChainiPRO_0000041598 | 45 – 351 | Zona pellucida-binding protein 1Add BLAST | 307 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 114 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 187 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 340 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Post-translational modificationi
N-glycosylated.By similarity
Keywords - PTMi
GlycoproteinProteomic databases
MassIVEi | Q9BS86 |
PaxDbi | Q9BS86 |
PeptideAtlasi | Q9BS86 |
PRIDEi | Q9BS86 |
ProteomicsDBi | 11161 78866 [Q9BS86-1] |
PTM databases
GlyGeni | Q9BS86, 3 sites |
iPTMneti | Q9BS86 |
PhosphoSitePlusi | Q9BS86 |
Expressioni
Tissue specificityi
Expressed specifically in testis.1 Publication
Gene expression databases
Bgeei | ENSG00000042813, Expressed in testis and 96 other tissues |
ExpressionAtlasi | Q9BS86, baseline and differential |
Genevisiblei | Q9BS86, HS |
Organism-specific databases
HPAi | ENSG00000042813, Tissue enriched (testis) |
Interactioni
Protein-protein interaction databases
BioGRIDi | 116240, 4 interactors |
IntActi | Q9BS86, 2 interactors |
STRINGi | 9606.ENSP00000046087 |
Miscellaneous databases
RNActi | Q9BS86, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the zona pellucida-binding protein Sp38 family.Curated
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | ENOG502RJ20, Eukaryota |
GeneTreei | ENSGT00520000055647 |
HOGENOMi | CLU_056016_0_1_1 |
InParanoidi | Q9BS86 |
OMAi | GIHCLPC |
OrthoDBi | 1069241at2759 |
PhylomeDBi | Q9BS86 |
TreeFami | TF335677 |
Family and domain databases
Gene3Di | 2.60.40.10, 1 hit |
InterProi | View protein in InterPro IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR010857, Sp38-bd |
PANTHERi | PTHR15443, PTHR15443, 1 hit |
Pfami | View protein in Pfam PF07354, Sp38, 1 hit |
SUPFAMi | SSF48726, SSF48726, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q9BS86-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MEAFALGPAR RGRRRTRAAG SLLSRAAILL FISAFLVRVP SSVGHLVRLP
60 70 80 90 100
RAFRLTKDSV KIVGSTSFPV KAYVMLHQKS PHVLCVTQQL RNAELIDPSF
110 120 130 140 150
QWYGPKGKVV SVENRTAQIT STGSLVFQNF EESMSGIYTC FLEYKPTVEE
160 170 180 190 200
IVKRLQLKYA IYAYREPHYY YQFTARYHAA PCNSIYNISF EKKLLQILSK
210 220 230 240 250
LLLDLSCEIS LLKSECHRVK MQRAGLQNEL FFAFSVSSLD TEKGPKRCTD
260 270 280 290 300
HNCEPYKRLF KAKNLIERFF NQQVEILGRR AEQLPQIYYI EGTLQMVWIN
310 320 330 340 350
RCFPGYGMNV QQHPKCPECC VICSPGSYNP RDGIHCLQCN SSLVYGAKTC
L
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketC9JIS7 | C9JIS7_HUMAN | Zona pellucida-binding protein 1 | ZPBP | 72 | Annotation score: | ||
F8WDW2 | F8WDW2_HUMAN | Zona pellucida-binding protein 1 | ZPBP | 75 | Annotation score: |
Sequence cautioni
The sequence AAS07517 differs from that shown. Reason: Erroneous initiation.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 180 | A → V in BAA04495 (Ref. 1) Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_076826 | 17 | R → P1 PublicationCorresponds to variant dbSNP:rs202231065EnsemblClinVar. | 1 | |
Natural variantiVAR_076827 | 25 | R → P1 PublicationCorresponds to variant dbSNP:rs61696422Ensembl. | 1 | |
Natural variantiVAR_076828 | 184 | S → G Found in an infertile patient with teratozoospermia; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs1299521157Ensembl. | 1 | |
Natural variantiVAR_076829 | 217 | H → L Found in an infertile patient with teratozoospermia; unknown pathological significance. 1 Publication | 1 | |
Natural variantiVAR_076830 | 225 | G → S Found in an infertile patient with teratozoospermia; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs1468321681Ensembl. | 1 | |
Natural variantiVAR_076831 | 252 | N → S Found in an infertile patient with teratozoospermia; unknown pathological significance. 1 Publication | 1 | |
Natural variantiVAR_076832 | 287 | I → T Found in an infertile patient with teratozoospermia; unknown pathological significance. 1 Publication | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_045491 | 112 | Missing in isoform 2. 1 Publication | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D17570 mRNA Translation: BAA04495.1 BT006822 mRNA Translation: AAP35468.1 AK312799 mRNA No translation available. AC020743 Genomic DNA No translation available. AC034145 Genomic DNA No translation available. AC096568 Genomic DNA Translation: AAS07517.1 Different initiation. AC034148 Genomic DNA Translation: AAS07558.1 CH236955 Genomic DNA Translation: EAL23903.1 CH471128 Genomic DNA Translation: EAW60984.1 BC005223 mRNA Translation: AAH05223.1 |
CCDSi | CCDS5509.1 [Q9BS86-1] CCDS55110.1 [Q9BS86-2] |
RefSeqi | NP_001153350.1, NM_001159878.1 [Q9BS86-2] NP_008940.2, NM_007009.2 [Q9BS86-1] |
Genome annotation databases
Ensembli | ENST00000046087; ENSP00000046087; ENSG00000042813 [Q9BS86-1] ENST00000419417; ENSP00000402071; ENSG00000042813 [Q9BS86-2] |
GeneIDi | 11055 |
KEGGi | hsa:11055 |
UCSCi | uc003tou.4, human [Q9BS86-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D17570 mRNA Translation: BAA04495.1 BT006822 mRNA Translation: AAP35468.1 AK312799 mRNA No translation available. AC020743 Genomic DNA No translation available. AC034145 Genomic DNA No translation available. AC096568 Genomic DNA Translation: AAS07517.1 Different initiation. AC034148 Genomic DNA Translation: AAS07558.1 CH236955 Genomic DNA Translation: EAL23903.1 CH471128 Genomic DNA Translation: EAW60984.1 BC005223 mRNA Translation: AAH05223.1 |
CCDSi | CCDS5509.1 [Q9BS86-1] CCDS55110.1 [Q9BS86-2] |
RefSeqi | NP_001153350.1, NM_001159878.1 [Q9BS86-2] NP_008940.2, NM_007009.2 [Q9BS86-1] |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 116240, 4 interactors |
IntActi | Q9BS86, 2 interactors |
STRINGi | 9606.ENSP00000046087 |
PTM databases
GlyGeni | Q9BS86, 3 sites |
iPTMneti | Q9BS86 |
PhosphoSitePlusi | Q9BS86 |
Genetic variation databases
BioMutai | ZPBP |
DMDMi | 54036652 |
Proteomic databases
MassIVEi | Q9BS86 |
PaxDbi | Q9BS86 |
PeptideAtlasi | Q9BS86 |
PRIDEi | Q9BS86 |
ProteomicsDBi | 11161 78866 [Q9BS86-1] |
Protocols and materials databases
Antibodypediai | 55139, 68 antibodies |
DNASUi | 11055 |
Genome annotation databases
Ensembli | ENST00000046087; ENSP00000046087; ENSG00000042813 [Q9BS86-1] ENST00000419417; ENSP00000402071; ENSG00000042813 [Q9BS86-2] |
GeneIDi | 11055 |
KEGGi | hsa:11055 |
UCSCi | uc003tou.4, human [Q9BS86-1] |
Organism-specific databases
CTDi | 11055 |
DisGeNETi | 11055 |
GeneCardsi | ZPBP |
HGNCi | HGNC:15662, ZPBP |
HPAi | ENSG00000042813, Tissue enriched (testis) |
MIMi | 608498, gene |
neXtProti | NX_Q9BS86 |
OpenTargetsi | ENSG00000042813 |
PharmGKBi | PA38013 |
VEuPathDBi | HostDB:ENSG00000042813.7 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502RJ20, Eukaryota |
GeneTreei | ENSGT00520000055647 |
HOGENOMi | CLU_056016_0_1_1 |
InParanoidi | Q9BS86 |
OMAi | GIHCLPC |
OrthoDBi | 1069241at2759 |
PhylomeDBi | Q9BS86 |
TreeFami | TF335677 |
Enzyme and pathway databases
PathwayCommonsi | Q9BS86 |
Miscellaneous databases
BioGRID-ORCSi | 11055, 8 hits in 872 CRISPR screens |
ChiTaRSi | ZPBP, human |
GenomeRNAii | 11055 |
Pharosi | Q9BS86, Tdark |
PROi | PR:Q9BS86 |
RNActi | Q9BS86, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000042813, Expressed in testis and 96 other tissues |
ExpressionAtlasi | Q9BS86, baseline and differential |
Genevisiblei | Q9BS86, HS |
Family and domain databases
Gene3Di | 2.60.40.10, 1 hit |
InterProi | View protein in InterPro IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR010857, Sp38-bd |
PANTHERi | PTHR15443, PTHR15443, 1 hit |
Pfami | View protein in Pfam PF07354, Sp38, 1 hit |
SUPFAMi | SSF48726, SSF48726, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ZPBP1_HUMAN | |
Accessioni | Q9BS86Primary (citable) accession number: Q9BS86 Secondary accession number(s): A4D253 Q75MI3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 11, 2004 |
Last sequence update: | June 1, 2001 | |
Last modified: | February 10, 2021 | |
This is version 139 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human chromosome 7
Human chromosome 7: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants