ZPBP

Functionⁱ

Plays a role in acrosome compaction and sperm morphogenesis (PubMed:21911476). Is implicated in sperm-oocyte interaction during fertilization (By similarity).By similarity1 Publication

GO - Biological processⁱ

binding of sperm to zona pellucida Source: InterPro

View the complete GO annotation on QuickGO ...

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Zona pellucida-binding protein 1 Alternative name(s): Inner acrosomal membrane IAM38By similarity Sp38
Gene namesⁱ	Name:ZPBP Synonyms:ZPBP1
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 7

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000042813.7
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:15662 ZPBP
MIMⁱ	608498 gene
neXtProtⁱ	NX_Q9BS86

Keywords - Cellular componentⁱ

Cytoplasmic vesicle, Membrane, Secreted

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	11055
Open Targets More...OpenTargetsⁱ	ENSG00000042813
PharmGKBⁱ	PA38013

Polymorphism and mutation databases

BioMutaⁱ	ZPBP
DMDMⁱ	54036652

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 44	Sequence analysisAdd BLAST		44
ChainⁱPRO_0000041598	45 – 351	Zona pellucida-binding protein 1Add BLAST		307

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Glycosylationⁱ	114	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	187	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	340	N-linked (GlcNAc...) asparagineSequence analysis	1

Post-translational modificationⁱ

N-glycosylated.By similarity

Keywords - PTMⁱ

Glycoprotein

Proteomic databases

PaxDbⁱ	Q9BS86
PeptideAtlas More...PeptideAtlasⁱ	Q9BS86
PRIDEⁱ	Q9BS86
ProteomicsDBⁱ	78866

PTM databases

iPTMnetⁱ	Q9BS86
PhosphoSitePlusⁱ	Q9BS86

Expressionⁱ

Tissue specificityⁱ

Expressed specifically in testis.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000042813
CleanExⁱ	HS_ZPBP
ExpressionAtlasⁱ	Q9BS86 baseline and differential
Genevisibleⁱ	Q9BS86 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA058673

HPAⁱ

HPA058673

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	116240, 2 interactors
IntActⁱ	Q9BS86, 1 interactor
STRINGⁱ	9606.ENSP00000046087

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9BS86
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the zona pellucida-binding protein Sp38 family.Curated

Keywords - Domainⁱ

Signal

Phylogenomic databases

eggNOGⁱ	ENOG410IEJM Eukaryota ENOG410YN9Q LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00520000055647
HOGENOMⁱ	HOG000230972
HOVERGENⁱ	HBG106672
InParanoidⁱ	Q9BS86
OMAⁱ	QCNSSLV
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0D27
PhylomeDBⁱ	Q9BS86
TreeFamⁱ	TF335677

Family and domain databases

Gene3Dⁱ	2.60.40.10, 1 hit
InterProⁱ	View protein in InterPro IPR007110 Ig-like_dom IPR036179 Ig-like_dom_sf IPR013783 Ig-like_fold IPR010857 Sp38-bd
PANTHERⁱ	PTHR15443 PTHR15443, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF07354 Sp38, 1 hit
SUPFAMⁱ	SSF48726 SSF48726, 1 hit

Sequences (2)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket Added to basket

Isoform 1 (identifier: Q9BS86-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEAFALGPAR RGRRRTRAAG SLLSRAAILL FISAFLVRVP SSVGHLVRLP 
        60         70         80         90        100
RAFRLTKDSV KIVGSTSFPV KAYVMLHQKS PHVLCVTQQL RNAELIDPSF 
       110        120        130        140        150
QWYGPKGKVV SVENRTAQIT STGSLVFQNF EESMSGIYTC FLEYKPTVEE 
       160        170        180        190        200
IVKRLQLKYA IYAYREPHYY YQFTARYHAA PCNSIYNISF EKKLLQILSK 
       210        220        230        240        250
LLLDLSCEIS LLKSECHRVK MQRAGLQNEL FFAFSVSSLD TEKGPKRCTD 
       260        270        280        290        300
HNCEPYKRLF KAKNLIERFF NQQVEILGRR AEQLPQIYYI EGTLQMVWIN 
       310        320        330        340        350
RCFPGYGMNV QQHPKCPECC VICSPGSYNP RDGIHCLQCN SSLVYGAKTC 

L

Length:351

Mass (Da):40,142

Last modified:June 1, 2001 - v1

Checksum:ⁱ8B57027FBE12E7DB

GO

Isoform 2 (identifier: Q9BS86-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
112-112: Missing.

« Hide

        10         20         30         40         50
MEAFALGPAR RGRRRTRAAG SLLSRAAILL FISAFLVRVP SSVGHLVRLP 
        60         70         80         90        100
RAFRLTKDSV KIVGSTSFPV KAYVMLHQKS PHVLCVTQQL RNAELIDPSF 
       110        120        130        140        150
QWYGPKGKVV SENRTAQITS TGSLVFQNFE ESMSGIYTCF LEYKPTVEEI 
       160        170        180        190        200
VKRLQLKYAI YAYREPHYYY QFTARYHAAP CNSIYNISFE KKLLQILSKL 
       210        220        230        240        250
LLDLSCEISL LKSECHRVKM QRAGLQNELF FAFSVSSLDT EKGPKRCTDH 
       260        270        280        290        300
NCEPYKRLFK AKNLIERFFN QQVEILGRRA EQLPQIYYIE GTLQMVWINR 
       310        320        330        340        350
CFPGYGMNVQ QHPKCPECCV ICSPGSYNPR DGIHCLQCNS SLVYGAKTCL

Note: No experimental confirmation available.

Show »

Length:350

Mass (Da):40,043

Checksum:ⁱ13D2B6ADB4408925

GO

Sequence cautionⁱ

The sequence AAS07517 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	180	A → V in BAA04495 (Ref. 1) Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_076826	17	R → P1 PublicationCorresponds to variant dbSNP:rs202231065Ensembl.	1
Natural variantⁱVAR_076827	25	R → P1 PublicationCorresponds to variant dbSNP:rs61696422Ensembl.	1
Natural variantⁱVAR_076828	184	S → G Found in an infertile patient with teratozoospermia; unknown pathological significance. 1 Publication	1
Natural variantⁱVAR_076829	217	H → L Found in an infertile patient with teratozoospermia; unknown pathological significance. 1 Publication	1
Natural variantⁱVAR_076830	225	G → S Found in an infertile patient with teratozoospermia; unknown pathological significance. 1 Publication	1
Natural variantⁱVAR_076831	252	N → S Found in an infertile patient with teratozoospermia; unknown pathological significance. 1 Publication	1
Natural variantⁱVAR_076832	287	I → T Found in an infertile patient with teratozoospermia; unknown pathological significance. 1 Publication	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_045491	112	Missing in isoform 2. 1 Publication		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	D17570 mRNA Translation: BAA04495.1 BT006822 mRNA Translation: AAP35468.1 AK312799 mRNA No translation available. AC020743 Genomic DNA No translation available. AC034145 Genomic DNA No translation available. AC096568 Genomic DNA Translation: AAS07517.1 Different initiation. AC034148 Genomic DNA Translation: AAS07558.1 CH236955 Genomic DNA Translation: EAL23903.1 CH471128 Genomic DNA Translation: EAW60984.1 BC005223 mRNA Translation: AAH05223.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS5509.1 [Q9BS86-1] CCDS55110.1 [Q9BS86-2]
NCBI Reference Sequences More...RefSeqⁱ	NP_001153350.1, NM_001159878.1 [Q9BS86-2] NP_008940.2, NM_007009.2 [Q9BS86-1]
UniGeneⁱ	Hs.388841

Genome annotation databases

Ensemblⁱ	ENST00000046087; ENSP00000046087; ENSG00000042813 [Q9BS86-1] ENST00000419417; ENSP00000402071; ENSG00000042813 [Q9BS86-2]
GeneIDⁱ	11055
KEGGⁱ	hsa:11055
UCSC genome browser More...UCSCⁱ	uc003tou.4 human [Q9BS86-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length
Q9BS86	UPI0005D00699		HUMAN		374
ZPBP isoform 2		PANTR		351
Zona pellucida binding protein		PANPA		351
Zona pellucida binding protein		GORGO		351
UPI0005D02D40		HUMAN		261
+8

Protein	Similar proteins		Species	Score	Length
Q9BS86	UPI0005D00699		HUMAN		374
ZPBP isoform 2		PANTR		351
Zona pellucida binding protein		PANPA		351
Zona pellucida binding protein		GORGO		351
Uncharacterized protein (Fragment)		TINGU		300
+62

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	D17570 mRNA Translation: BAA04495.1 BT006822 mRNA Translation: AAP35468.1 AK312799 mRNA No translation available. AC020743 Genomic DNA No translation available. AC034145 Genomic DNA No translation available. AC096568 Genomic DNA Translation: AAS07517.1 Different initiation. AC034148 Genomic DNA Translation: AAS07558.1 CH236955 Genomic DNA Translation: EAL23903.1 CH471128 Genomic DNA Translation: EAW60984.1 BC005223 mRNA Translation: AAH05223.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS5509.1 [Q9BS86-1] CCDS55110.1 [Q9BS86-2]
NCBI Reference Sequences More...RefSeqⁱ	NP_001153350.1, NM_001159878.1 [Q9BS86-2] NP_008940.2, NM_007009.2 [Q9BS86-1]
UniGeneⁱ	Hs.388841

3D structure databases

ProteinModelPortalⁱ	Q9BS86
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	116240, 2 interactors
IntActⁱ	Q9BS86, 1 interactor
STRINGⁱ	9606.ENSP00000046087

PTM databases

iPTMnetⁱ	Q9BS86
PhosphoSitePlusⁱ	Q9BS86

Polymorphism and mutation databases

BioMutaⁱ	ZPBP
DMDMⁱ	54036652

Proteomic databases

PaxDbⁱ	Q9BS86
PeptideAtlas More...PeptideAtlasⁱ	Q9BS86
PRIDEⁱ	Q9BS86
ProteomicsDBⁱ	78866

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	11055
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000046087; ENSP00000046087; ENSG00000042813 [Q9BS86-1] ENST00000419417; ENSP00000402071; ENSG00000042813 [Q9BS86-2]
GeneIDⁱ	11055
KEGGⁱ	hsa:11055
UCSC genome browser More...UCSCⁱ	uc003tou.4 human [Q9BS86-1]

Organism-specific databases

CTDⁱ	11055
DisGeNET More...DisGeNETⁱ	11055
EuPathDBⁱ	HostDB:ENSG00000042813.7
GeneCardsⁱ	ZPBP
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:15662 ZPBP
Human Protein Atlas More...HPAⁱ	HPA058673
MIMⁱ	608498 gene
neXtProtⁱ	NX_Q9BS86
Open Targets More...OpenTargetsⁱ	ENSG00000042813
PharmGKBⁱ	PA38013
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IEJM Eukaryota ENOG410YN9Q LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00520000055647
HOGENOMⁱ	HOG000230972
HOVERGENⁱ	HBG106672
InParanoidⁱ	Q9BS86
OMAⁱ	QCNSSLV
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0D27
PhylomeDBⁱ	Q9BS86
TreeFamⁱ	TF335677

Miscellaneous databases

ChiTaRSⁱ	ZPBP human
GenomeRNAiⁱ	11055
Protein Ontology More...PROⁱ	PR:Q9BS86
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000042813
CleanExⁱ	HS_ZPBP
ExpressionAtlasⁱ	Q9BS86 baseline and differential
Genevisibleⁱ	Q9BS86 HS

Family and domain databases

Gene3Dⁱ	2.60.40.10, 1 hit
InterProⁱ	View protein in InterPro IPR007110 Ig-like_dom IPR036179 Ig-like_dom_sf IPR013783 Ig-like_fold IPR010857 Sp38-bd
PANTHERⁱ	PTHR15443 PTHR15443, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF07354 Sp38, 1 hit
SUPFAMⁱ	SSF48726 SSF48726, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	ZPBP1_HUMAN
Accessionⁱ	Q9BS86Primary (citable) accession number: Q9BS86 Secondary accession number(s): A4D253 , C9JPU1, Q15941, Q75KX9, Q75MI3
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 11, 2004
	Last sequence update:	June 1, 2001
	Last modified:	June 20, 2018
	This is version 122 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human chromosome 7
Human chromosome 7: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
SIMILARITY comments
Index of protein domains and families

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UniProtKB - Q9BS86 (ZPBP1_HUMAN)

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Zona pellucida-binding protein 1

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted

Other locations

Extracellular region or secreted

Nucleus

Other locations

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

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Functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequence cautionⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ