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Protein

Zona pellucida-binding protein 1

Gene

ZPBP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Plays a role in acrosome compaction and sperm morphogenesis (PubMed:21911476). Is implicated in sperm-oocyte interaction during fertilization (By similarity).By similarity1 Publication

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Zona pellucida-binding protein 1
Alternative name(s):
Inner acrosomal membrane IAM38By similarity
Sp38
Gene namesi
Name:ZPBP
Synonyms:ZPBP1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000042813.7
HGNCiHGNC:15662 ZPBP
MIMi608498 gene
neXtProtiNX_Q9BS86

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasmic vesicle, Membrane, Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi11055
OpenTargetsiENSG00000042813
PharmGKBiPA38013

Polymorphism and mutation databases

BioMutaiZPBP
DMDMi54036652

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 44Sequence analysisAdd BLAST44
ChainiPRO_000004159845 – 351Zona pellucida-binding protein 1Add BLAST307

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi114N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi187N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi340N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

N-glycosylated.By similarity

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9BS86
PeptideAtlasiQ9BS86
PRIDEiQ9BS86
ProteomicsDBi78866

PTM databases

iPTMnetiQ9BS86
PhosphoSitePlusiQ9BS86

Expressioni

Tissue specificityi

Expressed specifically in testis.1 Publication

Gene expression databases

BgeeiENSG00000042813
CleanExiHS_ZPBP
ExpressionAtlasiQ9BS86 baseline and differential
GenevisibleiQ9BS86 HS

Organism-specific databases

HPAiHPA058673

Interactioni

Protein-protein interaction databases

BioGridi116240, 2 interactors
IntActiQ9BS86, 1 interactor
STRINGi9606.ENSP00000046087

Structurei

3D structure databases

ProteinModelPortaliQ9BS86
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IEJM Eukaryota
ENOG410YN9Q LUCA
GeneTreeiENSGT00520000055647
HOGENOMiHOG000230972
HOVERGENiHBG106672
InParanoidiQ9BS86
OMAiQCNSSLV
OrthoDBiEOG091G0D27
PhylomeDBiQ9BS86
TreeFamiTF335677

Family and domain databases

Gene3Di2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR010857 Sp38-bd
PANTHERiPTHR15443 PTHR15443, 1 hit
PfamiView protein in Pfam
PF07354 Sp38, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9BS86-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEAFALGPAR RGRRRTRAAG SLLSRAAILL FISAFLVRVP SSVGHLVRLP
60 70 80 90 100
RAFRLTKDSV KIVGSTSFPV KAYVMLHQKS PHVLCVTQQL RNAELIDPSF
110 120 130 140 150
QWYGPKGKVV SVENRTAQIT STGSLVFQNF EESMSGIYTC FLEYKPTVEE
160 170 180 190 200
IVKRLQLKYA IYAYREPHYY YQFTARYHAA PCNSIYNISF EKKLLQILSK
210 220 230 240 250
LLLDLSCEIS LLKSECHRVK MQRAGLQNEL FFAFSVSSLD TEKGPKRCTD
260 270 280 290 300
HNCEPYKRLF KAKNLIERFF NQQVEILGRR AEQLPQIYYI EGTLQMVWIN
310 320 330 340 350
RCFPGYGMNV QQHPKCPECC VICSPGSYNP RDGIHCLQCN SSLVYGAKTC

L
Length:351
Mass (Da):40,142
Last modified:June 1, 2001 - v1
Checksum:i8B57027FBE12E7DB
GO
Isoform 2 (identifier: Q9BS86-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     112-112: Missing.

Note: No experimental confirmation available.
Show »
Length:350
Mass (Da):40,043
Checksum:i13D2B6ADB4408925
GO

Sequence cautioni

The sequence AAS07517 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti180A → V in BAA04495 (Ref. 1) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_07682617R → P1 PublicationCorresponds to variant dbSNP:rs202231065Ensembl.1
Natural variantiVAR_07682725R → P1 PublicationCorresponds to variant dbSNP:rs61696422Ensembl.1
Natural variantiVAR_076828184S → G Found in an infertile patient with teratozoospermia; unknown pathological significance. 1 Publication1
Natural variantiVAR_076829217H → L Found in an infertile patient with teratozoospermia; unknown pathological significance. 1 Publication1
Natural variantiVAR_076830225G → S Found in an infertile patient with teratozoospermia; unknown pathological significance. 1 Publication1
Natural variantiVAR_076831252N → S Found in an infertile patient with teratozoospermia; unknown pathological significance. 1 Publication1
Natural variantiVAR_076832287I → T Found in an infertile patient with teratozoospermia; unknown pathological significance. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_045491112Missing in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D17570 mRNA Translation: BAA04495.1
BT006822 mRNA Translation: AAP35468.1
AK312799 mRNA No translation available.
AC020743 Genomic DNA No translation available.
AC034145 Genomic DNA No translation available.
AC096568 Genomic DNA Translation: AAS07517.1 Different initiation.
AC034148 Genomic DNA Translation: AAS07558.1
CH236955 Genomic DNA Translation: EAL23903.1
CH471128 Genomic DNA Translation: EAW60984.1
BC005223 mRNA Translation: AAH05223.1
CCDSiCCDS5509.1 [Q9BS86-1]
CCDS55110.1 [Q9BS86-2]
RefSeqiNP_001153350.1, NM_001159878.1 [Q9BS86-2]
NP_008940.2, NM_007009.2 [Q9BS86-1]
UniGeneiHs.388841

Genome annotation databases

EnsembliENST00000046087; ENSP00000046087; ENSG00000042813 [Q9BS86-1]
ENST00000419417; ENSP00000402071; ENSG00000042813 [Q9BS86-2]
GeneIDi11055
KEGGihsa:11055
UCSCiuc003tou.4 human [Q9BS86-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiZPBP1_HUMAN
AccessioniPrimary (citable) accession number: Q9BS86
Secondary accession number(s): A4D253
, C9JPU1, Q15941, Q75KX9, Q75MI3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: June 1, 2001
Last modified: June 20, 2018
This is version 122 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

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