UniProtKB - Q9BS40 (LXN_HUMAN)
Protein
Latexin
Gene
LXN
Organism
Homo sapiens (Human)
Status
Functioni
Hardly reversible, non-competitive, and potent inhibitor of CPA1, CPA2 and CPA4. May play a role in inflammation.1 Publication
GO - Molecular functioni
- heparin binding Source: UniProtKB-KW
- metalloendopeptidase inhibitor activity Source: GO_Central
GO - Biological processi
- detection of temperature stimulus involved in sensory perception of pain Source: Ensembl
- inflammatory response Source: UniProtKB-KW
Keywordsi
Molecular function | Heparin-binding, Metalloenzyme inhibitor, Metalloprotease inhibitor, Protease inhibitor |
Biological process | Inflammatory response |
Enzyme and pathway databases
PathwayCommonsi | Q9BS40 |
Protein family/group databases
MEROPSi | I47.001 |
Names & Taxonomyi
Protein namesi | Recommended name: LatexinAlternative name(s): Endogenous carboxypeptidase inhibitor Short name: ECI Protein MUM Tissue carboxypeptidase inhibitor Short name: TCI |
Gene namesi | Name:LXN |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000079257.7 |
HGNCi | HGNC:13347, LXN |
MIMi | 609305, gene |
neXtProti | NX_Q9BS40 |
Subcellular locationi
Other locations
- Cytoplasm Curated
Extracellular region or secreted
- extracellular space Source: GO_Central
Other locations
- cytoplasm Source: UniProtKB-SubCell
Keywords - Cellular componenti
CytoplasmPathology & Biotechi
Organism-specific databases
DisGeNETi | 56925 |
OpenTargetsi | ENSG00000079257 |
PharmGKBi | PA134991999 |
Miscellaneous databases
Pharosi | Q9BS40, Tbio |
Polymorphism and mutation databases
BioMutai | LXN |
DMDMi | 146345452 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000191343 | 1 – 222 | LatexinAdd BLAST | 222 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 55 | N6-acetyllysineCombined sources | 1 |
Keywords - PTMi
AcetylationProteomic databases
EPDi | Q9BS40 |
jPOSTi | Q9BS40 |
MassIVEi | Q9BS40 |
MaxQBi | Q9BS40 |
PaxDbi | Q9BS40 |
PeptideAtlasi | Q9BS40 |
PRIDEi | Q9BS40 |
ProteomicsDBi | 78864 |
PTM databases
iPTMneti | Q9BS40 |
MetOSitei | Q9BS40 |
PhosphoSitePlusi | Q9BS40 |
SwissPalmi | Q9BS40 |
Expressioni
Tissue specificityi
Highly expressed in heart, prostate, ovary, kidney, pancreas, and colon, moderate or low in other tissues including brain.1 Publication
Gene expression databases
Bgeei | ENSG00000079257, Expressed in left adrenal gland and 218 other tissues |
ExpressionAtlasi | Q9BS40, baseline and differential |
Genevisiblei | Q9BS40, HS |
Organism-specific databases
HPAi | ENSG00000079257, Low tissue specificity |
Interactioni
Binary interactionsi
Hide detailsQ9BS40
Protein-protein interaction databases
BioGRIDi | 121252, 35 interactors |
IntActi | Q9BS40, 26 interactors |
STRINGi | 9606.ENSP00000264265 |
Miscellaneous databases
RNActi | Q9BS40, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | Q9BS40 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q9BS40 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 97 | Cystatin-like fold 1By similarityAdd BLAST | 97 | |
Regioni | 98 – 117 | Alpha-helical linkerBy similarityAdd BLAST | 20 | |
Regioni | 118 – 222 | Cystatin-like fold 2By similarityAdd BLAST | 105 |
Sequence similaritiesi
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | ENOG502RYUY, Eukaryota |
GeneTreei | ENSGT00530000063813 |
HOGENOMi | CLU_083048_0_0_1 |
InParanoidi | Q9BS40 |
OMAi | MWQNSTE |
OrthoDBi | 1129396at2759 |
PhylomeDBi | Q9BS40 |
TreeFami | TF332787 |
Family and domain databases
InterProi | View protein in InterPro IPR009684, Prot_inh_latexin |
PANTHERi | PTHR28591, PTHR28591, 1 hit |
Pfami | View protein in Pfam PF06907, Latexin, 1 hit |
PIRSFi | PIRSF011132, Prot_inh_latexin, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q9BS40-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MEIPPTNYPA SRAALVAQNY INYQQGTPHR VFEVQKVKQA SMEDIPGRGH
60 70 80 90 100
KYHLKFAVEE IIQKQVKVNC TAEVLYPSTG QETAPEVNFT FEGETGKNPD
110 120 130 140 150
EEDNTFYQRL KSMKEPLEAQ NIPDNFGNVS PEMTLVLHLA WVACGYIIWQ
160 170 180 190 200
NSTEDTWYKM VKIQTVKQVQ RNDDFIELDY TILLHNIASQ EIIPWQMQVL
210 220
WHPQYGTKVK HNSRLPKEVQ LE
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketH7C5A4 | H7C5A4_HUMAN | Latexin | LXN | 157 | Annotation score: |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_019117 | 53 | H → R1 PublicationCorresponds to variant dbSNP:rs8455Ensembl. | 1 | |
Natural variantiVAR_062139 | 134 | T → M. Corresponds to variant dbSNP:rs59718588Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF087851 mRNA Translation: AAP97162.1 AF282626 mRNA Translation: AAF82807.1 AF303587 Genomic DNA Translation: AAL09331.1 AF282594 mRNA Translation: AAK69518.1 AC025033 Genomic DNA No translation available. AC080013 Genomic DNA No translation available. BC005346 mRNA Translation: AAH05346.1 BC008438 mRNA Translation: AAH08438.1 |
CCDSi | CCDS3183.1 |
RefSeqi | NP_064554.3, NM_020169.3 |
Genome annotation databases
Ensembli | ENST00000264265; ENSP00000264265; ENSG00000079257 |
GeneIDi | 56925 |
KEGGi | hsa:56925 |
UCSCi | uc003fch.3, human |
Keywords - Coding sequence diversityi
PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF087851 mRNA Translation: AAP97162.1 AF282626 mRNA Translation: AAF82807.1 AF303587 Genomic DNA Translation: AAL09331.1 AF282594 mRNA Translation: AAK69518.1 AC025033 Genomic DNA No translation available. AC080013 Genomic DNA No translation available. BC005346 mRNA Translation: AAH05346.1 BC008438 mRNA Translation: AAH08438.1 |
CCDSi | CCDS3183.1 |
RefSeqi | NP_064554.3, NM_020169.3 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2BO9 | X-ray | 1.60 | B/D | 1-222 | [»] | |
SMRi | Q9BS40 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 121252, 35 interactors |
IntActi | Q9BS40, 26 interactors |
STRINGi | 9606.ENSP00000264265 |
Protein family/group databases
MEROPSi | I47.001 |
PTM databases
iPTMneti | Q9BS40 |
MetOSitei | Q9BS40 |
PhosphoSitePlusi | Q9BS40 |
SwissPalmi | Q9BS40 |
Polymorphism and mutation databases
BioMutai | LXN |
DMDMi | 146345452 |
Proteomic databases
EPDi | Q9BS40 |
jPOSTi | Q9BS40 |
MassIVEi | Q9BS40 |
MaxQBi | Q9BS40 |
PaxDbi | Q9BS40 |
PeptideAtlasi | Q9BS40 |
PRIDEi | Q9BS40 |
ProteomicsDBi | 78864 |
Protocols and materials databases
Antibodypediai | 2121, 586 antibodies |
DNASUi | 56925 |
Genome annotation databases
Ensembli | ENST00000264265; ENSP00000264265; ENSG00000079257 |
GeneIDi | 56925 |
KEGGi | hsa:56925 |
UCSCi | uc003fch.3, human |
Organism-specific databases
CTDi | 56925 |
DisGeNETi | 56925 |
EuPathDBi | HostDB:ENSG00000079257.7 |
GeneCardsi | LXN |
HGNCi | HGNC:13347, LXN |
HPAi | ENSG00000079257, Low tissue specificity |
MIMi | 609305, gene |
neXtProti | NX_Q9BS40 |
OpenTargetsi | ENSG00000079257 |
PharmGKBi | PA134991999 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502RYUY, Eukaryota |
GeneTreei | ENSGT00530000063813 |
HOGENOMi | CLU_083048_0_0_1 |
InParanoidi | Q9BS40 |
OMAi | MWQNSTE |
OrthoDBi | 1129396at2759 |
PhylomeDBi | Q9BS40 |
TreeFami | TF332787 |
Enzyme and pathway databases
PathwayCommonsi | Q9BS40 |
Miscellaneous databases
BioGRID-ORCSi | 56925, 6 hits in 840 CRISPR screens |
ChiTaRSi | LXN, human |
EvolutionaryTracei | Q9BS40 |
GenomeRNAii | 56925 |
Pharosi | Q9BS40, Tbio |
PROi | PR:Q9BS40 |
RNActi | Q9BS40, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000079257, Expressed in left adrenal gland and 218 other tissues |
ExpressionAtlasi | Q9BS40, baseline and differential |
Genevisiblei | Q9BS40, HS |
Family and domain databases
InterProi | View protein in InterPro IPR009684, Prot_inh_latexin |
PANTHERi | PTHR28591, PTHR28591, 1 hit |
Pfami | View protein in Pfam PF06907, Latexin, 1 hit |
PIRSFi | PIRSF011132, Prot_inh_latexin, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | LXN_HUMAN | |
Accessioni | Q9BS40Primary (citable) accession number: Q9BS40 Secondary accession number(s): Q96PN2, Q9NQS6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 5, 2004 |
Last sequence update: | May 1, 2007 | |
Last modified: | December 2, 2020 | |
This is version 154 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 3
Human chromosome 3: entries, gene names and cross-references to MIM - Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations