UniProtKB - Q9BS40 (LXN_HUMAN)

BLAST

>sp|Q9BS40|LXN_HUMAN Latexin OS=Homo sapiens OX=9606 GN=LXN PE=1 SV=2
MEIPPTNYPASRAALVAQNYINYQQGTPHRVFEVQKVKQASMEDIPGRGHKYHLKFAVEE
IIQKQVKVNCTAEVLYPSTGQETAPEVNFTFEGETGKNPDEEDNTFYQRLKSMKEPLEAQ
NIPDNFGNVSPEMTLVLHLAWVACGYIIWQNSTEDTWYKMVKIQTVKQVQRNDDFIELDY
TILLHNIASQEIIPWQMQVLWHPQYGTKVKHNSRLPKEVQLE

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History
Entry version 140 (12 Sep 2018)
Sequence version 2 (01 May 2007)
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Protein

Latexin

Gene

LXN

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Hardly reversible, non-competitive, and potent inhibitor of CPA1, CPA2 and CPA4. May play a role in inflammation.1 Publication

GO - Molecular functionⁱ

heparin binding Source: UniProtKB-KW
metalloendopeptidase inhibitor activity Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

detection of temperature stimulus involved in sensory perception of pain Source: Ensembl
inflammatory response Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Heparin-binding, Metalloenzyme inhibitor, Metalloprotease inhibitor, Protease inhibitor
Biological process	Inflammatory response

Protein family/group databases

MEROPS protease database More...MEROPSⁱ	I47.001

MEROPSⁱ

I47.001

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Latexin Alternative name(s): Endogenous carboxypeptidase inhibitor Short name: ECI Protein MUM Tissue carboxypeptidase inhibitor Short name: TCI
Gene namesⁱ	Name:LXN
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 3

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000079257.7
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:13347 LXN
MIMⁱ	609305 gene
neXtProtⁱ	NX_Q9BS40

Keywords - Cellular componentⁱ

Cytoplasm

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	56925
Open Targets More...OpenTargetsⁱ	ENSG00000079257
PharmGKBⁱ	PA134991999

Polymorphism and mutation databases

BioMutaⁱ	LXN
DMDMⁱ	146345452

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000191343	1 – 222	LatexinAdd BLAST		222

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	55	N6-acetyllysineCombined sources		1

Keywords - PTMⁱ

Acetylation

Proteomic databases

EPDⁱ	Q9BS40
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q9BS40
PaxDbⁱ	Q9BS40
PeptideAtlas More...PeptideAtlasⁱ	Q9BS40
PRIDEⁱ	Q9BS40
ProteomicsDBⁱ	78864

PTM databases

iPTMnetⁱ	Q9BS40
PhosphoSitePlusⁱ	Q9BS40
SwissPalmⁱ	Q9BS40

Expressionⁱ

Tissue specificityⁱ

Highly expressed in heart, prostate, ovary, kidney, pancreas, and colon, moderate or low in other tissues including brain.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000079257 Expressed in 207 organ(s), highest expression level in left adrenal gland
CleanExⁱ	HS_LXN
ExpressionAtlasⁱ	Q9BS40 baseline and differential
Genevisibleⁱ	Q9BS40 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB025128 HPA014179

HPAⁱ

CAB025128
HPA014179

Interactionⁱ

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
DPYD	Q12882	3	EBI-1044504,EBI-2839838
GSG1L	Q6UXU4	3	EBI-1044504,EBI-10297401
MAGEA8	P43361	3	EBI-1044504,EBI-10182930
TMEM14A	Q9Y6G1	3	EBI-1044504,EBI-2800360
TRIM39	Q9HCM9	3	EBI-1044504,EBI-739510
ZKSCAN4	Q969J2	5	EBI-1044504,EBI-2818641

Protein-protein interaction databases

BioGridⁱ	121252, 15 interactors
IntActⁱ	Q9BS40, 26 interactors
STRINGⁱ	9606.ENSP00000264265

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	8 – 25	Combined sources	18
Beta strandⁱ	32 – 45	Combined sources	14
Turnⁱ	46 – 48	Combined sources	3
Beta strandⁱ	49 – 60	Combined sources	12
Turnⁱ	61 – 63	Combined sources	3
Beta strandⁱ	67 – 77	Combined sources	11
Beta strandⁱ	86 – 93	Combined sources	8
Helixⁱ	100 – 112	Combined sources	13
Beta strandⁱ	118 – 123	Combined sources	6
Helixⁱ	131 – 151	Combined sources	21
Beta strandⁱ	158 – 169	Combined sources	12
Beta strandⁱ	172 – 174	Combined sources	3
Beta strandⁱ	176 – 186	Combined sources	11
Turnⁱ	187 – 189	Combined sources	3
Beta strandⁱ	192 – 202	Combined sources	11
Turnⁱ	203 – 205	Combined sources	3
Beta strandⁱ	206 – 214	Combined sources	9

Show more details

3D structure databases

ProteinModelPortalⁱ	Q9BS40
SMRⁱ	Q9BS40
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ

Q9BS40

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Length
Regionⁱ	1 – 97	Cystatin-like fold 1By similarityAdd BLAST	97
Regionⁱ	98 – 117	Alpha-helical linkerBy similarityAdd BLAST	20
Regionⁱ	118 – 222	Cystatin-like fold 2By similarityAdd BLAST	105

Sequence similaritiesⁱ

Belongs to the protease inhibitor I47 (latexin) family. [View classification]Curated

Keywords - Domainⁱ

Repeat

Phylogenomic databases

eggNOGⁱ	ENOG410IHYK Eukaryota ENOG4111KGW LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000063813
HOGENOMⁱ	HOG000113410
HOVERGENⁱ	HBG052373
InParanoidⁱ	Q9BS40
OMAⁱ	KYCLKFS
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0I8X
PhylomeDBⁱ	Q9BS40
TreeFamⁱ	TF332787

Family and domain databases

InterProⁱ	View protein in InterPro IPR009684 Prot_inh_latexin
PANTHERⁱ	PTHR28591 PTHR28591, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF06907 Latexin, 1 hit
PIRSFⁱ	PIRSF011132 Prot_inh_latexin, 1 hit
ProDomⁱ	View protein in ProDom or Entries sharing at least one domain PD023134 Prot_inh_latexin, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show all Align All

Q9BS40-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MEIPPTNYPA SRAALVAQNY INYQQGTPHR VFEVQKVKQA SMEDIPGRGH 
        60         70         80         90        100
KYHLKFAVEE IIQKQVKVNC TAEVLYPSTG QETAPEVNFT FEGETGKNPD 
       110        120        130        140        150
EEDNTFYQRL KSMKEPLEAQ NIPDNFGNVS PEMTLVLHLA WVACGYIIWQ 
       160        170        180        190        200
NSTEDTWYKM VKIQTVKQVQ RNDDFIELDY TILLHNIASQ EIIPWQMQVL 
       210        220 
WHPQYGTKVK HNSRLPKEVQ LE

Length:222

Mass (Da):25,750

Last modified:May 1, 2007 - v2

Checksum:ⁱ7D557BEDA0E1F60C

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	H7C5A4	H7C5A4_HUMAN		Latexin Latexin	LXN	157	Annotation score:

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_019117	53	H → R1 PublicationCorresponds to variant dbSNP:rs8455Ensembl.		1
Natural variantⁱVAR_062139	134	T → M. Corresponds to variant dbSNP:rs59718588Ensembl.		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF087851 mRNA Translation: AAP97162.1 AF282626 mRNA Translation: AAF82807.1 AF303587 Genomic DNA Translation: AAL09331.1 AF282594 mRNA Translation: AAK69518.1 AC025033 Genomic DNA No translation available. AC080013 Genomic DNA No translation available. BC005346 mRNA Translation: AAH05346.1 BC008438 mRNA Translation: AAH08438.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS3183.1
NCBI Reference Sequences More...RefSeqⁱ	NP_064554.3, NM_020169.3
UniGeneⁱ	Hs.478067

Genome annotation databases

Ensemblⁱ	ENST00000264265; ENSP00000264265; ENSG00000079257
GeneIDⁱ	56925
KEGGⁱ	hsa:56925
UCSC genome browser More...UCSCⁱ	uc003fch.3 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9BS40	Latexin		CALJA		222	UniRef90_Q9BS40
LXN isoform 1		PANTR		222
Uncharacterized protein		PANPA		222
Uncharacterized protein		NOMLE		222
Latexin		MACMU		222
+16

Protein	Similar proteins		Species	Score	Length	Source
Q9BS40	Latexin	)	MOUSE		222	UniRef50_Q9BS40
Latexin		RAT		223
LXN isoform 2		PONAB		222
LXN isoform 1		PANTR		222
Uncharacterized protein		PANPA		222
+47

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF087851 mRNA Translation: AAP97162.1 AF282626 mRNA Translation: AAF82807.1 AF303587 Genomic DNA Translation: AAL09331.1 AF282594 mRNA Translation: AAK69518.1 AC025033 Genomic DNA No translation available. AC080013 Genomic DNA No translation available. BC005346 mRNA Translation: AAH05346.1 BC008438 mRNA Translation: AAH08438.1
CCDSⁱ	CCDS3183.1
RefSeqⁱ	NP_064554.3, NM_020169.3
UniGeneⁱ	Hs.478067

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2BO9	X-ray	1.60	B/D	1-222	[»]
ProteinModelPortalⁱ	Q9BS40
SMRⁱ	Q9BS40
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	121252, 15 interactors
IntActⁱ	Q9BS40, 26 interactors
STRINGⁱ	9606.ENSP00000264265

Protein family/group databases

MEROPSⁱ	I47.001

MEROPSⁱ

I47.001

PTM databases

iPTMnetⁱ	Q9BS40
PhosphoSitePlusⁱ	Q9BS40
SwissPalmⁱ	Q9BS40

Polymorphism and mutation databases

BioMutaⁱ	LXN
DMDMⁱ	146345452

Proteomic databases

EPDⁱ	Q9BS40
MaxQBⁱ	Q9BS40
PaxDbⁱ	Q9BS40
PeptideAtlasⁱ	Q9BS40
PRIDEⁱ	Q9BS40
ProteomicsDBⁱ	78864

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	56925
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000264265; ENSP00000264265; ENSG00000079257
GeneIDⁱ	56925
KEGGⁱ	hsa:56925
UCSCⁱ	uc003fch.3 human

Organism-specific databases

CTDⁱ	56925
DisGeNETⁱ	56925
EuPathDBⁱ	HostDB:ENSG00000079257.7
GeneCardsⁱ	LXN
HGNCⁱ	HGNC:13347 LXN
HPAⁱ	CAB025128 HPA014179
MIMⁱ	609305 gene
neXtProtⁱ	NX_Q9BS40
OpenTargetsⁱ	ENSG00000079257
PharmGKBⁱ	PA134991999
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IHYK Eukaryota ENOG4111KGW LUCA
GeneTreeⁱ	ENSGT00530000063813
HOGENOMⁱ	HOG000113410
HOVERGENⁱ	HBG052373
InParanoidⁱ	Q9BS40
OMAⁱ	KYCLKFS
OrthoDBⁱ	EOG091G0I8X
PhylomeDBⁱ	Q9BS40
TreeFamⁱ	TF332787

Miscellaneous databases

EvolutionaryTraceⁱ	Q9BS40
GenomeRNAiⁱ	56925
Protein Ontology More...PROⁱ	PR:Q9BS40
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000079257 Expressed in 207 organ(s), highest expression level in left adrenal gland
CleanExⁱ	HS_LXN
ExpressionAtlasⁱ	Q9BS40 baseline and differential
Genevisibleⁱ	Q9BS40 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR009684 Prot_inh_latexin
PANTHERⁱ	PTHR28591 PTHR28591, 1 hit
Pfamⁱ	View protein in Pfam PF06907 Latexin, 1 hit
PIRSFⁱ	PIRSF011132 Prot_inh_latexin, 1 hit
ProDomⁱ	View protein in ProDom or Entries sharing at least one domain PD023134 Prot_inh_latexin, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	LXN_HUMAN
Accessionⁱ	Q9BS40Primary (citable) accession number: Q9BS40 Secondary accession number(s): Q96PN2, Q9NQS6
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 5, 2004
	Last sequence update:	May 1, 2007
	Last modified:	September 12, 2018
	This is version 140 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human chromosome 3
Human chromosome 3: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

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UniParc

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UniRef

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Annotation systems

Supporting data

UniProtKB - Q9BS40 (LXN_HUMAN)

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Latexin

LXN

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ