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Protein

Latexin

Gene

LXN

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Hardly reversible, non-competitive, and potent inhibitor of CPA1, CPA2 and CPA4. May play a role in inflammation.1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHeparin-binding, Metalloenzyme inhibitor, Metalloprotease inhibitor, Protease inhibitor
Biological processInflammatory response

Protein family/group databases

MEROPSiI47.001

Names & Taxonomyi

Protein namesi
Recommended name:
Latexin
Alternative name(s):
Endogenous carboxypeptidase inhibitor
Short name:
ECI
Protein MUM
Tissue carboxypeptidase inhibitor
Short name:
TCI
Gene namesi
Name:LXN
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000079257.7
HGNCiHGNC:13347 LXN
MIMi609305 gene
neXtProtiNX_Q9BS40

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi56925
OpenTargetsiENSG00000079257
PharmGKBiPA134991999

Polymorphism and mutation databases

BioMutaiLXN
DMDMi146345452

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001913431 – 222LatexinAdd BLAST222

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei55N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ9BS40
MaxQBiQ9BS40
PaxDbiQ9BS40
PeptideAtlasiQ9BS40
PRIDEiQ9BS40
ProteomicsDBi78864

PTM databases

iPTMnetiQ9BS40
PhosphoSitePlusiQ9BS40
SwissPalmiQ9BS40

Expressioni

Tissue specificityi

Highly expressed in heart, prostate, ovary, kidney, pancreas, and colon, moderate or low in other tissues including brain.1 Publication

Gene expression databases

BgeeiENSG00000079257 Expressed in 207 organ(s), highest expression level in left adrenal gland
CleanExiHS_LXN
ExpressionAtlasiQ9BS40 baseline and differential
GenevisibleiQ9BS40 HS

Organism-specific databases

HPAiCAB025128
HPA014179

Interactioni

Binary interactionsi

Protein-protein interaction databases

BioGridi121252, 15 interactors
IntActiQ9BS40, 26 interactors
STRINGi9606.ENSP00000264265

Structurei

Secondary structure

1222
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ9BS40
SMRiQ9BS40
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9BS40

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 97Cystatin-like fold 1By similarityAdd BLAST97
Regioni98 – 117Alpha-helical linkerBy similarityAdd BLAST20
Regioni118 – 222Cystatin-like fold 2By similarityAdd BLAST105

Sequence similaritiesi

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IHYK Eukaryota
ENOG4111KGW LUCA
GeneTreeiENSGT00530000063813
HOGENOMiHOG000113410
HOVERGENiHBG052373
InParanoidiQ9BS40
OMAiKYCLKFS
OrthoDBiEOG091G0I8X
PhylomeDBiQ9BS40
TreeFamiTF332787

Family and domain databases

InterProiView protein in InterPro
IPR009684 Prot_inh_latexin
PANTHERiPTHR28591 PTHR28591, 1 hit
PfamiView protein in Pfam
PF06907 Latexin, 1 hit
PIRSFiPIRSF011132 Prot_inh_latexin, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD023134 Prot_inh_latexin, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9BS40-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEIPPTNYPA SRAALVAQNY INYQQGTPHR VFEVQKVKQA SMEDIPGRGH
60 70 80 90 100
KYHLKFAVEE IIQKQVKVNC TAEVLYPSTG QETAPEVNFT FEGETGKNPD
110 120 130 140 150
EEDNTFYQRL KSMKEPLEAQ NIPDNFGNVS PEMTLVLHLA WVACGYIIWQ
160 170 180 190 200
NSTEDTWYKM VKIQTVKQVQ RNDDFIELDY TILLHNIASQ EIIPWQMQVL
210 220
WHPQYGTKVK HNSRLPKEVQ LE
Length:222
Mass (Da):25,750
Last modified:May 1, 2007 - v2
Checksum:i7D557BEDA0E1F60C
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H7C5A4H7C5A4_HUMAN
Latexin
LXN
157Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01911753H → R1 PublicationCorresponds to variant dbSNP:rs8455Ensembl.1
Natural variantiVAR_062139134T → M. Corresponds to variant dbSNP:rs59718588Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF087851 mRNA Translation: AAP97162.1
AF282626 mRNA Translation: AAF82807.1
AF303587 Genomic DNA Translation: AAL09331.1
AF282594 mRNA Translation: AAK69518.1
AC025033 Genomic DNA No translation available.
AC080013 Genomic DNA No translation available.
BC005346 mRNA Translation: AAH05346.1
BC008438 mRNA Translation: AAH08438.1
CCDSiCCDS3183.1
RefSeqiNP_064554.3, NM_020169.3
UniGeneiHs.478067

Genome annotation databases

EnsembliENST00000264265; ENSP00000264265; ENSG00000079257
GeneIDi56925
KEGGihsa:56925
UCSCiuc003fch.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF087851 mRNA Translation: AAP97162.1
AF282626 mRNA Translation: AAF82807.1
AF303587 Genomic DNA Translation: AAL09331.1
AF282594 mRNA Translation: AAK69518.1
AC025033 Genomic DNA No translation available.
AC080013 Genomic DNA No translation available.
BC005346 mRNA Translation: AAH05346.1
BC008438 mRNA Translation: AAH08438.1
CCDSiCCDS3183.1
RefSeqiNP_064554.3, NM_020169.3
UniGeneiHs.478067

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2BO9X-ray1.60B/D1-222[»]
ProteinModelPortaliQ9BS40
SMRiQ9BS40
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121252, 15 interactors
IntActiQ9BS40, 26 interactors
STRINGi9606.ENSP00000264265

Protein family/group databases

MEROPSiI47.001

PTM databases

iPTMnetiQ9BS40
PhosphoSitePlusiQ9BS40
SwissPalmiQ9BS40

Polymorphism and mutation databases

BioMutaiLXN
DMDMi146345452

Proteomic databases

EPDiQ9BS40
MaxQBiQ9BS40
PaxDbiQ9BS40
PeptideAtlasiQ9BS40
PRIDEiQ9BS40
ProteomicsDBi78864

Protocols and materials databases

DNASUi56925
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000264265; ENSP00000264265; ENSG00000079257
GeneIDi56925
KEGGihsa:56925
UCSCiuc003fch.3 human

Organism-specific databases

CTDi56925
DisGeNETi56925
EuPathDBiHostDB:ENSG00000079257.7
GeneCardsiLXN
HGNCiHGNC:13347 LXN
HPAiCAB025128
HPA014179
MIMi609305 gene
neXtProtiNX_Q9BS40
OpenTargetsiENSG00000079257
PharmGKBiPA134991999
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IHYK Eukaryota
ENOG4111KGW LUCA
GeneTreeiENSGT00530000063813
HOGENOMiHOG000113410
HOVERGENiHBG052373
InParanoidiQ9BS40
OMAiKYCLKFS
OrthoDBiEOG091G0I8X
PhylomeDBiQ9BS40
TreeFamiTF332787

Miscellaneous databases

EvolutionaryTraceiQ9BS40
GenomeRNAii56925
PROiPR:Q9BS40
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000079257 Expressed in 207 organ(s), highest expression level in left adrenal gland
CleanExiHS_LXN
ExpressionAtlasiQ9BS40 baseline and differential
GenevisibleiQ9BS40 HS

Family and domain databases

InterProiView protein in InterPro
IPR009684 Prot_inh_latexin
PANTHERiPTHR28591 PTHR28591, 1 hit
PfamiView protein in Pfam
PF06907 Latexin, 1 hit
PIRSFiPIRSF011132 Prot_inh_latexin, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD023134 Prot_inh_latexin, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiLXN_HUMAN
AccessioniPrimary (citable) accession number: Q9BS40
Secondary accession number(s): Q96PN2, Q9NQS6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 5, 2004
Last sequence update: May 1, 2007
Last modified: September 12, 2018
This is version 140 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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Main funding by: National Institutes of Health

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