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Protein

Endoplasmic reticulum resident protein 44

Gene

ERP44

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Mediates thiol-dependent retention in the early secretory pathway, forming mixed disulfides with substrate proteins through its conserved CRFS motif. Inhibits the calcium channel activity of ITPR1. May have a role in the control of oxidative protein folding in the endoplasmic reticulum. Required to retain ERO1A and ERO1B in the endoplasmic reticulum.2 Publications

GO - Molecular functioni

  • protein disulfide isomerase activity Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionChaperone
Biological processStress response

Enzyme and pathway databases

ReactomeiR-HSA-6798695 Neutrophil degranulation

Names & Taxonomyi

Protein namesi
Recommended name:
Endoplasmic reticulum resident protein 44
Short name:
ER protein 44
Short name:
ERp44
Alternative name(s):
Thioredoxin domain-containing protein 4
Gene namesi
Name:ERP44
Synonyms:KIAA0573, TXNDC4
ORF Names:UNQ532/PRO1075
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000023318.7
HGNCiHGNC:18311 ERP44
MIMi609170 gene
neXtProtiNX_Q9BS26

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum

Pathology & Biotechi

Organism-specific databases

DisGeNETi23071
OpenTargetsiENSG00000023318
PharmGKBiPA164719295

Polymorphism and mutation databases

BioMutaiERP44
DMDMi31077035

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 29Add BLAST29
ChainiPRO_000003418030 – 406Endoplasmic reticulum resident protein 44Add BLAST377

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi58Interchain (with ERO1A)1 Publication
Disulfide bondi189 ↔ 2411 Publication
Disulfide bondi301 ↔ 3181 Publication

Keywords - PTMi

Disulfide bond

Proteomic databases

EPDiQ9BS26
MaxQBiQ9BS26
PaxDbiQ9BS26
PeptideAtlasiQ9BS26
PRIDEiQ9BS26
ProteomicsDBi78861

2D gel databases

REPRODUCTION-2DPAGEiIPI00401264

PTM databases

iPTMnetiQ9BS26
PhosphoSitePlusiQ9BS26
SwissPalmiQ9BS26

Expressioni

Inductioni

Up-regulated by inducers of the unfolded protein response (UPR), including tunicamycin and dithiothreitol.1 Publication

Gene expression databases

BgeeiENSG00000023318 Expressed in 239 organ(s), highest expression level in type B pancreatic cell
CleanExiHS_TXNDC4
GenevisibleiQ9BS26 HS

Organism-specific databases

HPAiHPA001318

Interactioni

Subunit structurei

Forms mixed disulfides with both ERO1A and ERO1B and cargo folding intermediates. Directly interacts with ITPR1 in a pH-, redox state- and calcium-dependent manner, but not with ITPR2 or ITPR3. The strength of this interaction inversely correlates with calcium concentration (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
LMAN1P492573EBI-541644,EBI-1057738

Protein-protein interaction databases

BioGridi116704, 83 interactors
IntActiQ9BS26, 31 interactors
MINTiQ9BS26
STRINGi9606.ENSP00000262455

Structurei

Secondary structure

1406
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ9BS26
SMRiQ9BS26
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9BS26

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini30 – 138ThioredoxinPROSITE-ProRule annotationAdd BLAST109

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni236 – 285Interaction with ITPR1By similarityAdd BLAST50

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi403 – 406Prevents secretion from ERPROSITE-ProRule annotation4

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG0912 Eukaryota
COG0526 LUCA
GeneTreeiENSGT00930000151031
HOGENOMiHOG000007707
InParanoidiQ9BS26
KOiK17264
OMAiKLGPCVA
OrthoDBiEOG091G08L8
PhylomeDBiQ9BS26
TreeFamiTF106378

Family and domain databases

InterProiView protein in InterPro
IPR036249 Thioredoxin-like_sf
IPR013766 Thioredoxin_domain
PfamiView protein in Pfam
PF00085 Thioredoxin, 1 hit
SUPFAMiSSF52833 SSF52833, 3 hits
PROSITEiView protein in PROSITE
PS00014 ER_TARGET, 1 hit
PS51352 THIOREDOXIN_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9BS26-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MHPAVFLSLP DLRCSLLLLV TWVFTPVTTE ITSLDTENID EILNNADVAL
60 70 80 90 100
VNFYADWCRF SQMLHPIFEE ASDVIKEEFP NENQVVFARV DCDQHSDIAQ
110 120 130 140 150
RYRISKYPTL KLFRNGMMMK REYRGQRSVK ALADYIRQQK SDPIQEIRDL
160 170 180 190 200
AEITTLDRSK RNIIGYFEQK DSDNYRVFER VANILHDDCA FLSAFGDVSK
210 220 230 240 250
PERYSGDNII YKPPGHSAPD MVYLGAMTNF DVTYNWIQDK CVPLVREITF
260 270 280 290 300
ENGEELTEEG LPFLILFHMK EDTESLEIFQ NEVARQLISE KGTINFLHAD
310 320 330 340 350
CDKFRHPLLH IQKTPADCPV IAIDSFRHMY VFGDFKDVLI PGKLKQFVFD
360 370 380 390 400
LHSGKLHREF HHGPDPTDTA PGEQAQDVAS SPPESSFQKL APSEYRYTLL

RDRDEL
Length:406
Mass (Da):46,971
Last modified:June 1, 2001 - v1
Checksum:i3865DCF3811BC263
GO

Sequence cautioni

The sequence BAA25499 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti35D → A in AAQ89407 (PubMed:12975309).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ344330 mRNA Translation: CAC87611.1
AB011145 mRNA Translation: BAA25499.1 Different initiation.
AY359048 mRNA Translation: AAQ89407.1
AK075024 mRNA Translation: BAG52054.1
AL360084 Genomic DNA No translation available.
AL137072 Genomic DNA No translation available.
AL358937 Genomic DNA No translation available.
BC005374 mRNA Translation: AAH05374.1
CCDSiCCDS35082.1
RefSeqiNP_055866.1, NM_015051.2
UniGeneiHs.154023

Genome annotation databases

EnsembliENST00000262455; ENSP00000262455; ENSG00000023318
GeneIDi23071
KEGGihsa:23071
UCSCiuc004bam.4 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ344330 mRNA Translation: CAC87611.1
AB011145 mRNA Translation: BAA25499.1 Different initiation.
AY359048 mRNA Translation: AAQ89407.1
AK075024 mRNA Translation: BAG52054.1
AL360084 Genomic DNA No translation available.
AL137072 Genomic DNA No translation available.
AL358937 Genomic DNA No translation available.
BC005374 mRNA Translation: AAH05374.1
CCDSiCCDS35082.1
RefSeqiNP_055866.1, NM_015051.2
UniGeneiHs.154023

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2R2JX-ray2.60A30-406[»]
5GU6X-ray2.00A30-402[»]
5GU7X-ray2.05C30-402[»]
5HQPX-ray2.60C/D30-406[»]
ProteinModelPortaliQ9BS26
SMRiQ9BS26
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116704, 83 interactors
IntActiQ9BS26, 31 interactors
MINTiQ9BS26
STRINGi9606.ENSP00000262455

PTM databases

iPTMnetiQ9BS26
PhosphoSitePlusiQ9BS26
SwissPalmiQ9BS26

Polymorphism and mutation databases

BioMutaiERP44
DMDMi31077035

2D gel databases

REPRODUCTION-2DPAGEiIPI00401264

Proteomic databases

EPDiQ9BS26
MaxQBiQ9BS26
PaxDbiQ9BS26
PeptideAtlasiQ9BS26
PRIDEiQ9BS26
ProteomicsDBi78861

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000262455; ENSP00000262455; ENSG00000023318
GeneIDi23071
KEGGihsa:23071
UCSCiuc004bam.4 human

Organism-specific databases

CTDi23071
DisGeNETi23071
EuPathDBiHostDB:ENSG00000023318.7
GeneCardsiERP44
HGNCiHGNC:18311 ERP44
HPAiHPA001318
MIMi609170 gene
neXtProtiNX_Q9BS26
OpenTargetsiENSG00000023318
PharmGKBiPA164719295
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0912 Eukaryota
COG0526 LUCA
GeneTreeiENSGT00930000151031
HOGENOMiHOG000007707
InParanoidiQ9BS26
KOiK17264
OMAiKLGPCVA
OrthoDBiEOG091G08L8
PhylomeDBiQ9BS26
TreeFamiTF106378

Enzyme and pathway databases

ReactomeiR-HSA-6798695 Neutrophil degranulation

Miscellaneous databases

ChiTaRSiERP44 human
EvolutionaryTraceiQ9BS26
GeneWikiiERP44
GenomeRNAii23071
PROiPR:Q9BS26
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000023318 Expressed in 239 organ(s), highest expression level in type B pancreatic cell
CleanExiHS_TXNDC4
GenevisibleiQ9BS26 HS

Family and domain databases

InterProiView protein in InterPro
IPR036249 Thioredoxin-like_sf
IPR013766 Thioredoxin_domain
PfamiView protein in Pfam
PF00085 Thioredoxin, 1 hit
SUPFAMiSSF52833 SSF52833, 3 hits
PROSITEiView protein in PROSITE
PS00014 ER_TARGET, 1 hit
PS51352 THIOREDOXIN_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiERP44_HUMAN
AccessioniPrimary (citable) accession number: Q9BS26
Secondary accession number(s): O60319
, Q4VXC1, Q5VWZ7, Q6UW14, Q8WX67
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 23, 2003
Last sequence update: June 1, 2001
Last modified: November 7, 2018
This is version 168 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
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