UniProtKB - Q9BRY0 (S39A3_HUMAN)
Protein
Zinc transporter ZIP3
Gene
SLC39A3
Organism
Homo sapiens (Human)
Status
Functioni
Acts as a zinc-influx transporter.Curated
GO - Molecular functioni
- zinc ion transmembrane transporter activity Source: GO_Central
GO - Biological processi
- zinc ion transmembrane transport Source: GO_Central
Keywordsi
Biological process | Ion transport, Transport, Zinc transport |
Ligand | Zinc |
Enzyme and pathway databases
PathwayCommonsi | Q9BRY0 |
Reactomei | R-HSA-442380, Zinc influx into cells by the SLC39 gene family |
Protein family/group databases
TCDBi | 2.A.5.3.3, the zinc (zn(2+))-iron (fe(2+)) permease (zip) family |
Names & Taxonomyi
Protein namesi | Recommended name: Zinc transporter ZIP3Alternative name(s): Solute carrier family 39 member 3 Zrt- and Irt-like protein 3 Short name: ZIP-3 |
Gene namesi | Name:SLC39A3 Synonyms:ZIP3 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000141873.10 |
HGNCi | HGNC:17128, SLC39A3 |
MIMi | 612168, gene |
neXtProti | NX_Q9BRY0 |
Subcellular locationi
Other locations
- Membrane Curated; Multi-pass membrane protein Curated
Plasma Membrane
- plasma membrane Source: GO_Central
Other locations
- integral component of membrane Source: UniProtKB-KW
- membrane Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 3 | ExtracellularSequence analysis | 3 | |
Transmembranei | 4 – 24 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 25 – 42 | CytoplasmicSequence analysisAdd BLAST | 18 | |
Transmembranei | 43 – 63 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 64 – 85 | ExtracellularSequence analysisAdd BLAST | 22 | |
Transmembranei | 86 – 106 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 107 – 169 | CytoplasmicSequence analysisAdd BLAST | 63 | |
Transmembranei | 170 – 190 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 191 – 196 | ExtracellularSequence analysis | 6 | |
Transmembranei | 197 – 217 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 218 – 229 | CytoplasmicSequence analysisAdd BLAST | 12 | |
Transmembranei | 230 – 250 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 251 – 262 | ExtracellularSequence analysisAdd BLAST | 12 | |
Transmembranei | 263 – 283 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 284 – 292 | CytoplasmicSequence analysis | 9 | |
Transmembranei | 293 – 313 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 314 | ExtracellularSequence analysis | 1 |
Keywords - Cellular componenti
MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 29985 |
OpenTargetsi | ENSG00000141873 |
PharmGKBi | PA38203 |
Miscellaneous databases
Pharosi | Q9BRY0, Tbio |
Chemistry databases
DrugBanki | DB14533, Zinc chloride DB14548, Zinc sulfate, unspecified form |
Polymorphism and mutation databases
BioMutai | SLC39A3 |
DMDMi | 74732942 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000312868 | 1 – 314 | Zinc transporter ZIP3Add BLAST | 314 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 125 | PhosphoserineCombined sources | 1 | |
Modified residuei | 129 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q9BRY0 |
jPOSTi | Q9BRY0 |
MassIVEi | Q9BRY0 |
MaxQBi | Q9BRY0 |
PaxDbi | Q9BRY0 |
PeptideAtlasi | Q9BRY0 |
PRIDEi | Q9BRY0 |
ProteomicsDBi | 78852 [Q9BRY0-1] 78853 [Q9BRY0-2] |
PTM databases
iPTMneti | Q9BRY0 |
PhosphoSitePlusi | Q9BRY0 |
Expressioni
Gene expression databases
Bgeei | ENSG00000141873, Expressed in muscle tissue and 188 other tissues |
ExpressionAtlasi | Q9BRY0, baseline and differential |
Genevisiblei | Q9BRY0, HS |
Organism-specific databases
HPAi | ENSG00000141873, Low tissue specificity |
Interactioni
Binary interactionsi
Isoform 2 [Q9BRY0-2]
With | #Exp. | IntAct |
---|---|---|
YIPF2 [Q9BWQ6] | 3 | EBI-17714201,EBI-751204 |
Protein-protein interaction databases
BioGRIDi | 119011, 42 interactors |
IntActi | Q9BRY0, 8 interactors |
STRINGi | 9606.ENSP00000269740 |
Miscellaneous databases
RNActi | Q9BRY0, protein |
Family & Domainsi
Sequence similaritiesi
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG1558, Eukaryota |
GeneTreei | ENSGT00940000160231 |
HOGENOMi | CLU_040462_4_1_1 |
InParanoidi | Q9BRY0 |
OrthoDBi | 981397at2759 |
PhylomeDBi | Q9BRY0 |
TreeFami | TF317098 |
Family and domain databases
InterProi | View protein in InterPro IPR003689, ZIP |
Pfami | View protein in Pfam PF02535, Zip, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q9BRY0-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MVKLLVAKIL CMVGVFFFML LGSLLPVKII ETDFEKAHRS KKILSLCNTF
60 70 80 90 100
GGGVFLATCF NALLPAVREK LQKVLSLGHI STDYPLAETI LLLGFFMTVF
110 120 130 140 150
LEQLILTFRK EKPSFIDLET FNAGSDVGSD SEYESPFMGG ARGHALYVEP
160 170 180 190 200
HGHGPSLSVQ GLSRASPVRL LSLAFALSAH SVFEGLALGL QEEGEKVVSL
210 220 230 240 250
FVGVAVHETL VAVALGISMA RSAMPLRDAA KLAVTVSAMI PLGIGLGLGI
260 270 280 290 300
ESAQGVPGSV ASVLLQGLAG GTFLFITFLE ILAKELEEKS DRLLKVLFLV
310
LGYTVLAGMV FLKW
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketF5H385 | F5H385_HUMAN | Zinc transporter ZIP3 | SLC39A3 | 323 | Annotation score: | ||
K7EJZ1 | K7EJZ1_HUMAN | Zinc transporter ZIP3 | SLC39A3 | 136 | Annotation score: | ||
K7ENJ1 | K7ENJ1_HUMAN | Zinc transporter ZIP3 | SLC39A3 | 107 | Annotation score: |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_037599 | 100 | F → L. Corresponds to variant dbSNP:rs11539244Ensembl. | 1 | |
Natural variantiVAR_037600 | 257 | P → L. Corresponds to variant dbSNP:rs35594294Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_029920 | 71 – 105 | LQKVL…LEQLI → VRAPWALAAALGTLWPRDSD AFSTLMPSSVKALML in isoform 2. 2 PublicationsAdd BLAST | 35 | |
Alternative sequenceiVSP_029921 | 106 – 314 | Missing in isoform 2. 2 PublicationsAdd BLAST | 209 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK002044 mRNA Translation: BAG51005.1 BC005869 mRNA Translation: AAH05869.2 BC020571 mRNA Translation: AAH20571.1 |
CCDSi | CCDS12093.1 [Q9BRY0-1] CCDS45909.1 [Q9BRY0-2] |
RefSeqi | NP_653165.2, NM_144564.4 [Q9BRY0-1] NP_998733.1, NM_213568.1 [Q9BRY0-2] |
Genome annotation databases
Ensembli | ENST00000269740; ENSP00000269740; ENSG00000141873 [Q9BRY0-1] ENST00000455372; ENSP00000393715; ENSG00000141873 [Q9BRY0-2] |
GeneIDi | 29985 |
KEGGi | hsa:29985 |
UCSCi | uc002lwg.4, human [Q9BRY0-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK002044 mRNA Translation: BAG51005.1 BC005869 mRNA Translation: AAH05869.2 BC020571 mRNA Translation: AAH20571.1 |
CCDSi | CCDS12093.1 [Q9BRY0-1] CCDS45909.1 [Q9BRY0-2] |
RefSeqi | NP_653165.2, NM_144564.4 [Q9BRY0-1] NP_998733.1, NM_213568.1 [Q9BRY0-2] |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 119011, 42 interactors |
IntActi | Q9BRY0, 8 interactors |
STRINGi | 9606.ENSP00000269740 |
Chemistry databases
DrugBanki | DB14533, Zinc chloride DB14548, Zinc sulfate, unspecified form |
Protein family/group databases
TCDBi | 2.A.5.3.3, the zinc (zn(2+))-iron (fe(2+)) permease (zip) family |
PTM databases
iPTMneti | Q9BRY0 |
PhosphoSitePlusi | Q9BRY0 |
Polymorphism and mutation databases
BioMutai | SLC39A3 |
DMDMi | 74732942 |
Proteomic databases
EPDi | Q9BRY0 |
jPOSTi | Q9BRY0 |
MassIVEi | Q9BRY0 |
MaxQBi | Q9BRY0 |
PaxDbi | Q9BRY0 |
PeptideAtlasi | Q9BRY0 |
PRIDEi | Q9BRY0 |
ProteomicsDBi | 78852 [Q9BRY0-1] 78853 [Q9BRY0-2] |
Protocols and materials databases
Antibodypediai | 23039, 112 antibodies |
Genome annotation databases
Ensembli | ENST00000269740; ENSP00000269740; ENSG00000141873 [Q9BRY0-1] ENST00000455372; ENSP00000393715; ENSG00000141873 [Q9BRY0-2] |
GeneIDi | 29985 |
KEGGi | hsa:29985 |
UCSCi | uc002lwg.4, human [Q9BRY0-1] |
Organism-specific databases
CTDi | 29985 |
DisGeNETi | 29985 |
EuPathDBi | HostDB:ENSG00000141873.10 |
GeneCardsi | SLC39A3 |
HGNCi | HGNC:17128, SLC39A3 |
HPAi | ENSG00000141873, Low tissue specificity |
MIMi | 612168, gene |
neXtProti | NX_Q9BRY0 |
OpenTargetsi | ENSG00000141873 |
PharmGKBi | PA38203 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1558, Eukaryota |
GeneTreei | ENSGT00940000160231 |
HOGENOMi | CLU_040462_4_1_1 |
InParanoidi | Q9BRY0 |
OrthoDBi | 981397at2759 |
PhylomeDBi | Q9BRY0 |
TreeFami | TF317098 |
Enzyme and pathway databases
PathwayCommonsi | Q9BRY0 |
Reactomei | R-HSA-442380, Zinc influx into cells by the SLC39 gene family |
Miscellaneous databases
BioGRID-ORCSi | 29985, 5 hits in 842 CRISPR screens |
ChiTaRSi | SLC39A3, human |
GeneWikii | SLC39A3 |
GenomeRNAii | 29985 |
Pharosi | Q9BRY0, Tbio |
PROi | PR:Q9BRY0 |
RNActi | Q9BRY0, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000141873, Expressed in muscle tissue and 188 other tissues |
ExpressionAtlasi | Q9BRY0, baseline and differential |
Genevisiblei | Q9BRY0, HS |
Family and domain databases
InterProi | View protein in InterPro IPR003689, ZIP |
Pfami | View protein in Pfam PF02535, Zip, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | S39A3_HUMAN | |
Accessioni | Q9BRY0Primary (citable) accession number: Q9BRY0 Secondary accession number(s): B3KMJ3, Q8WUG1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 4, 2007 |
Last sequence update: | March 1, 2004 | |
Last modified: | December 2, 2020 | |
This is version 145 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations