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Entry version 163 (07 Apr 2021)
Sequence version 1 (01 Jun 2001)
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Protein

WD repeat domain-containing protein 83

Gene

WDR83

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Molecular scaffold protein for various multimeric protein complexes. Acts as a module in the assembly of a multicomponent scaffold for the ERK pathway, linking ERK responses to specific agonists. At low concentrations it enhances ERK activation, whereas high concentrations lead to the inhibition of ERK activation. Also involved in response to hypoxia by acting as a negative regulator of HIF1A/HIF-1-alpha via its interaction with EGLN3/PHD3. May promote degradation of HIF1A. May act by recruiting signaling complexes to a specific upstream activator (By similarity). May also be involved in pre-mRNA splicing.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processmRNA processing, mRNA splicing

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q9BRX9

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-5674135, MAP2K and MAPK activation

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q9BRX9

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q9BRX9

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
WD repeat domain-containing protein 83
Alternative name(s):
Mitogen-activated protein kinase organizer 1
Short name:
MAPK organizer 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:WDR83
Synonyms:MORG1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:32672, WDR83

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9BRX9

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000123154.11

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Nucleus, Spliceosome

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
84292

Open Targets

More...
OpenTargetsi
ENSG00000123154

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA165394765

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9BRX9, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
WDR83

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74761224

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002352631 – 315WD repeat domain-containing protein 83Add BLAST315

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9BRX9

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9BRX9

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9BRX9

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9BRX9

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9BRX9

PeptideAtlas

More...
PeptideAtlasi
Q9BRX9

PRoteomics IDEntifications database

More...
PRIDEi
Q9BRX9

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
78851

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9BRX9

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9BRX9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000123154, Expressed in cerebellum and 161 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9BRX9, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9BRX9, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000123154, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with EGLN3/PHD3.

Interacts with ERK signaling proteins MAP2K1/MEK1, MAP2K2/MEK2, LAMTOR3, ARAF/Raf-1, MAPK1/ERK2 and MAPK3/ERK1 (By similarity). Identified in the spliceosome C complex.

By similarity1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details
Q9BRX9
With#Exp.IntAct
ATXN1 [P54253]6EBI-7705033,EBI-930964
BCL6 [P41182]3EBI-7705033,EBI-765407
COL26A1 - isoform 2 [Q96A83-2]3EBI-7705033,EBI-21553822
DMWD [G5E9A7]3EBI-7705033,EBI-10976677
DNAJB6 - isoform B [O75190-2]3EBI-7705033,EBI-12593112
DNALI1 [O14645]3EBI-7705033,EBI-395638
FAM124B - isoform 2 [Q9H5Z6-2]3EBI-7705033,EBI-11986315
FLNA - isoform 2 [P21333-2]3EBI-7705033,EBI-9641086
FRS3 [O43559]3EBI-7705033,EBI-725515
GFAP [P14136]3EBI-7705033,EBI-744302
GNE - isoform 2 [Q9Y223-2]3EBI-7705033,EBI-11975289
HOXA1 [P49639]3EBI-7705033,EBI-740785
HSPB1 [P04792]4EBI-7705033,EBI-352682
JPH3 [Q8WXH2]3EBI-7705033,EBI-1055254
KCTD9 [Q7L273]3EBI-7705033,EBI-4397613
KEAP1 [Q14145]7EBI-7705033,EBI-751001
KIF1B - isoform 2 [O60333-2]3EBI-7705033,EBI-10975473
KLF11 [O14901]3EBI-7705033,EBI-948266
LONRF1 [Q17RB8]3EBI-7705033,EBI-2341787
NDUFV2 [P19404]3EBI-7705033,EBI-713665
NOXA1 - isoform 2 [Q86UR1-2]3EBI-7705033,EBI-12025760
PMP22 [D3DTS7]3EBI-7705033,EBI-25882629
PPIL1 [Q9Y3C6]2EBI-7705033,EBI-2557649
PRKAB2 [O43741]3EBI-7705033,EBI-1053424
PRPF8 [Q6P2Q9]2EBI-7705033,EBI-538479
PRPS1 [P60891]3EBI-7705033,EBI-749195
RNF11 [Q9Y3C5]3EBI-7705033,EBI-396669
SF3B4 [Q15427]2EBI-7705033,EBI-348469
SNRPC [P09234]2EBI-7705033,EBI-766589
SPRED1 [Q7Z699]3EBI-7705033,EBI-5235340
TARDBP [Q13148]6EBI-7705033,EBI-372899
TLX3 [O43711]3EBI-7705033,EBI-3939165
TTR [P02766]3EBI-7705033,EBI-711909
UBL5 [Q9BZL1]2EBI-7705033,EBI-607755
VAC14 [Q08AM6]3EBI-7705033,EBI-2107455
WFS1 [O76024]3EBI-7705033,EBI-720609
ZNF76 [P36508]3EBI-7705033,EBI-7254550

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
124019, 158 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
Q9BRX9

Protein interaction database and analysis system

More...
IntActi
Q9BRX9, 153 interactors

Molecular INTeraction database

More...
MINTi
Q9BRX9

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000402653

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9BRX9, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9BRX9

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati23 – 62WD 1Add BLAST40
Repeati65 – 104WD 2Add BLAST40
Repeati107 – 146WD 3Add BLAST40
Repeati151 – 188WD 4Add BLAST38
Repeati190 – 228WD 5Add BLAST39
Repeati231 – 272WD 6Add BLAST42
Repeati275 – 313WD 7Add BLAST39

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the WD repeat MORG1 family.Curated

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0316, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000159016

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9BRX9

Identification of Orthologs from Complete Genome Data

More...
OMAi
MCWDIRT

Database of Orthologous Groups

More...
OrthoDBi
1090342at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9BRX9

TreeFam database of animal gene trees

More...
TreeFami
TF314828

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.130.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR020472, G-protein_beta_WD-40_rep
IPR015943, WD40/YVTN_repeat-like_dom_sf
IPR001680, WD40_repeat
IPR019775, WD40_repeat_CS
IPR017986, WD40_repeat_dom
IPR036322, WD40_repeat_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00400, WD40, 4 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00320, GPROTEINBRPT

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00320, WD40, 7 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50978, SSF50978, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00678, WD_REPEATS_1, 2 hits
PS50082, WD_REPEATS_2, 3 hits
PS50294, WD_REPEATS_REGION, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

Q9BRX9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAFPEPKPRP PELPQKRLKT LDCGQGAVRA VRFNVDGNYC LTCGSDKTLK
60 70 80 90 100
LWNPLRGTLL RTYSGHGYEV LDAAGSFDNS SLCSGGGDKA VVLWDVASGQ
110 120 130 140 150
VVRKFRGHAG KVNTVQFNEE ATVILSGSID SSIRCWDCRS RRPEPVQTLD
160 170 180 190 200
EARDGVSSVK VSDHEILAGS VDGRVRRYDL RMGQLFSDYV GSPITCTCFS
210 220 230 240 250
RDGQCTLVSS LDSTLRLLDK DTGELLGEYK GHKNQEYKLD CCLSERDTHV
260 270 280 290 300
VSCSEDGKVF FWDLVEGALA LALPVGSGVV QSLAYHPTEP CLLTAMGGSV
310
QCWREEAYEA EDGAG
Length:315
Mass (Da):34,343
Last modified:June 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCF5F59C1FAA432FE
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3V221G3V221_HUMAN
Mitogen-activated protein kinase or...
WDR83 MORG1, hCG_172499
71Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YIE8H0YIE8_HUMAN
WD repeat domain-containing protein...
WDR83
211Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8VSE4F8VSE4_HUMAN
WD repeat domain-containing protein...
WDR83
153Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C0S9H7C0S9_HUMAN
WD repeat domain-containing protein...
WDR83
74Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti162S → L in BAD96915 (Ref. 2) Curated1
Sequence conflicti278G → D in BAD96915 (Ref. 2) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_053410278G → S. Corresponds to variant dbSNP:rs34373915Ensembl.1
Natural variantiVAR_053411304R → Q. Corresponds to variant dbSNP:rs35092999Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK223195 mRNA Translation: BAD96915.1
AK314164 mRNA Translation: BAG36848.1
CH471106 Genomic DNA Translation: EAW84282.1
BC005870 mRNA Translation: AAH05870.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS12275.1

NCBI Reference Sequences

More...
RefSeqi
NP_001093207.1, NM_001099737.2
NP_115708.1, NM_032332.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000418543; ENSP00000402653; ENSG00000123154

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
84292

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:84292

UCSC genome browser

More...
UCSCi
uc002mue.5, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK223195 mRNA Translation: BAD96915.1
AK314164 mRNA Translation: BAG36848.1
CH471106 Genomic DNA Translation: EAW84282.1
BC005870 mRNA Translation: AAH05870.1
CCDSiCCDS12275.1
RefSeqiNP_001093207.1, NM_001099737.2
NP_115708.1, NM_032332.3

3D structure databases

SMRiQ9BRX9
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi124019, 158 interactors
CORUMiQ9BRX9
IntActiQ9BRX9, 153 interactors
MINTiQ9BRX9
STRINGi9606.ENSP00000402653

PTM databases

iPTMnetiQ9BRX9
PhosphoSitePlusiQ9BRX9

Genetic variation databases

BioMutaiWDR83
DMDMi74761224

Proteomic databases

EPDiQ9BRX9
jPOSTiQ9BRX9
MassIVEiQ9BRX9
MaxQBiQ9BRX9
PaxDbiQ9BRX9
PeptideAtlasiQ9BRX9
PRIDEiQ9BRX9
ProteomicsDBi78851

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
26076, 210 antibodies

The DNASU plasmid repository

More...
DNASUi
84292

Genome annotation databases

EnsembliENST00000418543; ENSP00000402653; ENSG00000123154
GeneIDi84292
KEGGihsa:84292
UCSCiuc002mue.5, human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
84292
DisGeNETi84292

GeneCards: human genes, protein and diseases

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GeneCardsi
WDR83
HGNCiHGNC:32672, WDR83
HPAiENSG00000123154, Low tissue specificity
neXtProtiNX_Q9BRX9
OpenTargetsiENSG00000123154
PharmGKBiPA165394765
VEuPathDBiHostDB:ENSG00000123154.11

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG0316, Eukaryota
GeneTreeiENSGT00940000159016
InParanoidiQ9BRX9
OMAiMCWDIRT
OrthoDBi1090342at2759
PhylomeDBiQ9BRX9
TreeFamiTF314828

Enzyme and pathway databases

PathwayCommonsiQ9BRX9
ReactomeiR-HSA-5674135, MAP2K and MAPK activation
SignaLinkiQ9BRX9
SIGNORiQ9BRX9

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
84292, 298 hits in 1004 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
WDR83, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
84292
PharosiQ9BRX9, Tbio

Protein Ontology

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PROi
PR:Q9BRX9
RNActiQ9BRX9, protein

Gene expression databases

BgeeiENSG00000123154, Expressed in cerebellum and 161 other tissues
ExpressionAtlasiQ9BRX9, baseline and differential
GenevisibleiQ9BRX9, HS

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR020472, G-protein_beta_WD-40_rep
IPR015943, WD40/YVTN_repeat-like_dom_sf
IPR001680, WD40_repeat
IPR019775, WD40_repeat_CS
IPR017986, WD40_repeat_dom
IPR036322, WD40_repeat_dom_sf
PfamiView protein in Pfam
PF00400, WD40, 4 hits
PRINTSiPR00320, GPROTEINBRPT
SMARTiView protein in SMART
SM00320, WD40, 7 hits
SUPFAMiSSF50978, SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS00678, WD_REPEATS_1, 2 hits
PS50082, WD_REPEATS_2, 3 hits
PS50294, WD_REPEATS_REGION, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiWDR83_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9BRX9
Secondary accession number(s): B2RAF1, Q53FT6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: June 1, 2001
Last modified: April 7, 2021
This is version 163 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. SIMILARITY comments
    Index of protein domains and families
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