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Protein

WD repeat domain-containing protein 83

Gene

WDR83

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Molecular scaffold protein for various multimeric protein complexes. Acts as a module in the assembly of a multicomponent scaffold for the ERK pathway, linking ERK responses to specific agonists. At low concentrations it enhances ERK activation, whereas high concentrations lead to the inhibition of ERK activation. Also involved in response to hypoxia by acting as a negative regulator of HIF1A/HIF-1-alpha via its interaction with EGLN3/PHD3. May promote degradation of HIF1A. May act by recruiting signaling complexes to a specific upstream activator (By similarity). May also be involved in pre-mRNA splicing.By similarity

GO - Biological processi

Keywordsi

Biological processmRNA processing, mRNA splicing

Enzyme and pathway databases

ReactomeiR-HSA-5674135 MAP2K and MAPK activation
SignaLinkiQ9BRX9
SIGNORiQ9BRX9

Names & Taxonomyi

Protein namesi
Recommended name:
WD repeat domain-containing protein 83
Alternative name(s):
Mitogen-activated protein kinase organizer 1
Short name:
MAPK organizer 1
Gene namesi
Name:WDR83
Synonyms:MORG1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000123154.11
HGNCiHGNC:32672 WDR83
neXtProtiNX_Q9BRX9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus, Spliceosome

Pathology & Biotechi

Organism-specific databases

DisGeNETi84292
OpenTargetsiENSG00000123154
PharmGKBiPA165394765

Polymorphism and mutation databases

BioMutaiWDR83
DMDMi74761224

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002352631 – 315WD repeat domain-containing protein 83Add BLAST315

Proteomic databases

EPDiQ9BRX9
MaxQBiQ9BRX9
PaxDbiQ9BRX9
PeptideAtlasiQ9BRX9
PRIDEiQ9BRX9
ProteomicsDBi78851

PTM databases

iPTMnetiQ9BRX9
PhosphoSitePlusiQ9BRX9

Expressioni

Gene expression databases

BgeeiENSG00000123154 Expressed in 143 organ(s), highest expression level in cerebellum
ExpressionAtlasiQ9BRX9 baseline and differential
GenevisibleiQ9BRX9 HS

Organism-specific databases

HPAiHPA042629
HPA042838

Interactioni

Subunit structurei

Interacts with EGLN3/PHD3. Interacts with ERK signaling proteins MAP2K1/MEK1, MAP2K2/MEK2, LAMTOR3, ARAF/Raf-1, MAPK1/ERK2 and MAPK3/ERK1 (By similarity). Identified in the spliceosome C complex.By similarity1 Publication

Binary interactionsi

Protein-protein interaction databases

BioGridi124019, 137 interactors
CORUMiQ9BRX9
IntActiQ9BRX9, 63 interactors
MINTiQ9BRX9
STRINGi9606.ENSP00000242796

Structurei

3D structure databases

ProteinModelPortaliQ9BRX9
SMRiQ9BRX9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati23 – 62WD 1Add BLAST40
Repeati65 – 104WD 2Add BLAST40
Repeati107 – 146WD 3Add BLAST40
Repeati151 – 188WD 4Add BLAST38
Repeati190 – 228WD 5Add BLAST39
Repeati231 – 272WD 6Add BLAST42
Repeati275 – 313WD 7Add BLAST39

Sequence similaritiesi

Belongs to the WD repeat MORG1 family.Curated

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG0316 Eukaryota
ENOG410XRZ0 LUCA
GeneTreeiENSGT00930000150962
HOGENOMiHOG000091642
HOVERGENiHBG105288
InParanoidiQ9BRX9
KOiK13124
OMAiMCWDIRT
OrthoDBiEOG091G0G62
PhylomeDBiQ9BRX9
TreeFamiTF314828

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR020472 G-protein_beta_WD-40_rep
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PfamiView protein in Pfam
PF00400 WD40, 4 hits
PRINTSiPR00320 GPROTEINBRPT
SMARTiView protein in SMART
SM00320 WD40, 7 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS00678 WD_REPEATS_1, 2 hits
PS50082 WD_REPEATS_2, 3 hits
PS50294 WD_REPEATS_REGION, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

Q9BRX9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAFPEPKPRP PELPQKRLKT LDCGQGAVRA VRFNVDGNYC LTCGSDKTLK
60 70 80 90 100
LWNPLRGTLL RTYSGHGYEV LDAAGSFDNS SLCSGGGDKA VVLWDVASGQ
110 120 130 140 150
VVRKFRGHAG KVNTVQFNEE ATVILSGSID SSIRCWDCRS RRPEPVQTLD
160 170 180 190 200
EARDGVSSVK VSDHEILAGS VDGRVRRYDL RMGQLFSDYV GSPITCTCFS
210 220 230 240 250
RDGQCTLVSS LDSTLRLLDK DTGELLGEYK GHKNQEYKLD CCLSERDTHV
260 270 280 290 300
VSCSEDGKVF FWDLVEGALA LALPVGSGVV QSLAYHPTEP CLLTAMGGSV
310
QCWREEAYEA EDGAG
Length:315
Mass (Da):34,343
Last modified:June 1, 2001 - v1
Checksum:iCF5F59C1FAA432FE
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3V221G3V221_HUMAN
Mitogen-activated protein kinase or...
WDR83 MORG1, hCG_172499
71Annotation score:
F8VSE4F8VSE4_HUMAN
WD repeat domain-containing protein...
WDR83
153Annotation score:
H0YIE8H0YIE8_HUMAN
WD repeat domain-containing protein...
WDR83
211Annotation score:
H7C0S9H7C0S9_HUMAN
WD repeat domain-containing protein...
WDR83
74Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti162S → L in BAD96915 (Ref. 2) Curated1
Sequence conflicti278G → D in BAD96915 (Ref. 2) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_053410278G → S. Corresponds to variant dbSNP:rs34373915Ensembl.1
Natural variantiVAR_053411304R → Q. Corresponds to variant dbSNP:rs35092999Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK223195 mRNA Translation: BAD96915.1
AK314164 mRNA Translation: BAG36848.1
CH471106 Genomic DNA Translation: EAW84282.1
BC005870 mRNA Translation: AAH05870.1
CCDSiCCDS12275.1
RefSeqiNP_001093207.1, NM_001099737.2
NP_115708.1, NM_032332.3
UniGeneiHs.657204

Genome annotation databases

EnsembliENST00000418543; ENSP00000402653; ENSG00000123154
GeneIDi84292
KEGGihsa:84292
UCSCiuc002mue.5 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK223195 mRNA Translation: BAD96915.1
AK314164 mRNA Translation: BAG36848.1
CH471106 Genomic DNA Translation: EAW84282.1
BC005870 mRNA Translation: AAH05870.1
CCDSiCCDS12275.1
RefSeqiNP_001093207.1, NM_001099737.2
NP_115708.1, NM_032332.3
UniGeneiHs.657204

3D structure databases

ProteinModelPortaliQ9BRX9
SMRiQ9BRX9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124019, 137 interactors
CORUMiQ9BRX9
IntActiQ9BRX9, 63 interactors
MINTiQ9BRX9
STRINGi9606.ENSP00000242796

PTM databases

iPTMnetiQ9BRX9
PhosphoSitePlusiQ9BRX9

Polymorphism and mutation databases

BioMutaiWDR83
DMDMi74761224

Proteomic databases

EPDiQ9BRX9
MaxQBiQ9BRX9
PaxDbiQ9BRX9
PeptideAtlasiQ9BRX9
PRIDEiQ9BRX9
ProteomicsDBi78851

Protocols and materials databases

DNASUi84292
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000418543; ENSP00000402653; ENSG00000123154
GeneIDi84292
KEGGihsa:84292
UCSCiuc002mue.5 human

Organism-specific databases

CTDi84292
DisGeNETi84292
EuPathDBiHostDB:ENSG00000123154.11
GeneCardsiWDR83
HGNCiHGNC:32672 WDR83
HPAiHPA042629
HPA042838
neXtProtiNX_Q9BRX9
OpenTargetsiENSG00000123154
PharmGKBiPA165394765
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0316 Eukaryota
ENOG410XRZ0 LUCA
GeneTreeiENSGT00930000150962
HOGENOMiHOG000091642
HOVERGENiHBG105288
InParanoidiQ9BRX9
KOiK13124
OMAiMCWDIRT
OrthoDBiEOG091G0G62
PhylomeDBiQ9BRX9
TreeFamiTF314828

Enzyme and pathway databases

ReactomeiR-HSA-5674135 MAP2K and MAPK activation
SignaLinkiQ9BRX9
SIGNORiQ9BRX9

Miscellaneous databases

ChiTaRSiWDR83 human
GenomeRNAii84292
PROiPR:Q9BRX9

Gene expression databases

BgeeiENSG00000123154 Expressed in 143 organ(s), highest expression level in cerebellum
ExpressionAtlasiQ9BRX9 baseline and differential
GenevisibleiQ9BRX9 HS

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR020472 G-protein_beta_WD-40_rep
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PfamiView protein in Pfam
PF00400 WD40, 4 hits
PRINTSiPR00320 GPROTEINBRPT
SMARTiView protein in SMART
SM00320 WD40, 7 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS00678 WD_REPEATS_1, 2 hits
PS50082 WD_REPEATS_2, 3 hits
PS50294 WD_REPEATS_REGION, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiWDR83_HUMAN
AccessioniPrimary (citable) accession number: Q9BRX9
Secondary accession number(s): B2RAF1, Q53FT6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: June 1, 2001
Last modified: November 7, 2018
This is version 148 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
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