Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 145 (16 Oct 2019)
Sequence version 3 (23 Nov 2004)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

Peroxiredoxin-like 2A

Gene

PRXL2A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in redox regulation of the cell (PubMed:26438880, PubMed:19951071). Acts as an antioxidant (PubMed:19951071, PubMed:26438880). Inhibits TNFSF11-induced NFKB1 and JUN activation and osteoclast differentiation (PubMed:19951071). May affect bone resorption and help to maintain bone mass (PubMed:19951071). Acts as a negative regulator of macrophage-mediated inflammation by inhibiting macrophage production of inflammatory cytokines, probably through suppression of the MAPK signaling pathway (PubMed:26438880).2 Publications

Miscellaneous

The active site cysteines correspond to the redox-active cysteines of peroxiredoxins.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei85Redox-activeBy similarity1
Active sitei88Redox-activeBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionAntioxidant

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Peroxiredoxin-like 2ACurated
Alternative name(s):
Peroxiredoxin-like 2 activated in M-CSF stimulated monocytes2 Publications
Short name:
Protein PAMM2 Publications
Redox-regulatory protein FAM213A
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PRXL2AImported
Synonyms:C10orf58, FAM213A, PAMM2 Publications
ORF Names:PRO2290, PSEC0139, UNQ611/PRO1198
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:28651 PRXL2A

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
617165 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9BRX8

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi85C → G: Decrease of about 38% in antioxidant activity in TNFSF11-stimulated osteoclasts and reduced inhibition of TNFSF11-induced osteoclast formation. Does not change anti-inflammatory properties. 2 Publications1
Mutagenesisi88C → G: Decrease of about 125% in antioxidant activity in TNFSF11-stimulated osteoclasts and reduced inhibition of TNFSF11-induced osteoclast formation. 1 Publication1

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000122378

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134969403

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9BRX8

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL3879824

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
FAM213A

Domain mapping of disease mutations (DMDM)

More...
DMDMi
73620080

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000195501 – 229Peroxiredoxin-like 2AAdd BLAST229

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9BRX8

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9BRX8

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9BRX8

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9BRX8

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9BRX8

PeptideAtlas

More...
PeptideAtlasi
Q9BRX8

PRoteomics IDEntifications database

More...
PRIDEi
Q9BRX8

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
78849 [Q9BRX8-1]
78850 [Q9BRX8-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9BRX8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9BRX8

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q9BRX8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in CSF1 and TNFSF11-stimulated CD14+ peripheral blood mononuclear cells (PBMCs).1 Publication

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Up-regulated by CSF1 in peripheral blood mononuclear cells (PBMCs). This induction is reduced in the presence of TNFSF11.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000122378 Expressed in 209 organ(s), highest expression level in adipose tissue

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9BRX8 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA009025
HPA024565

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
124020, 29 interactors

Protein interaction database and analysis system

More...
IntActi
Q9BRX8, 25 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000482445

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
Q9BRX8

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni14 – 112Thioredoxin foldBy similarityAdd BLAST99

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Redox-active center

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4498 Eukaryota
ENOG410YFY9 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000161199

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000293175

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9BRX8

Identification of Orthologs from Complete Genome Data

More...
OMAi
VWQNFFR

Database of Orthologous Groups

More...
OrthoDBi
1442607at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9BRX8

TreeFam database of animal gene trees

More...
TreeFami
TF313804

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR032801 PXL2A/B/C

The PANTHER Classification System

More...
PANTHERi
PTHR28630 PTHR28630, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13911 AhpC-TSA_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q9BRX8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSFLQDPSFF TMGMWSIGAG ALGAAALALL LANTDVFLSK PQKAALEYLE
60 70 80 90 100
DIDLKTLEKE PRTFKAKELW EKNGAVIMAV RRPGCFLCRE EAADLSSLKS
110 120 130 140 150
MLDQLGVPLY AVVKEHIRTE VKDFQPYFKG EIFLDEKKKF YGPQRRKMMF
160 170 180 190 200
MGFIRLGVWY NFFRAWNGGF SGNLEGEGFI LGGVFVVGSG KQGILLEHRE
210 220
KEFGDKVNLL SVLEAAKMIK PQTLASEKK
Length:229
Mass (Da):25,764
Last modified:November 23, 2004 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9ECE72DEF6C338D7
GO
Isoform 2 (identifier: Q9BRX8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-11: Missing.

Show »
Length:218
Mass (Da):24,463
Checksum:iC07A4C051DD19488
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAK55527 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence BAG37828 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti201K → N in BAC11108 (PubMed:14702039).Curated1
Sequence conflicti206K → R in BAC11627 (PubMed:16303743).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0422291 – 11Missing in isoform 2. 1 PublicationAdd BLAST11

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY359059 mRNA Translation: AAQ89418.1
AK315440 mRNA Translation: BAG37828.1 Different initiation.
AK074643 mRNA Translation: BAC11108.1
AK075447 mRNA Translation: BAC11627.1
AC021028 Genomic DNA No translation available.
BC005871 mRNA Translation: AAH05871.3
AF305824 mRNA Translation: AAK55527.1 Different initiation.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS58089.1 [Q9BRX8-2]
CCDS7368.1 [Q9BRX8-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001230707.1, NM_001243778.1 [Q9BRX8-1]
NP_001230708.1, NM_001243779.1 [Q9BRX8-1]
NP_001230709.1, NM_001243780.1 [Q9BRX8-1]
NP_001230710.1, NM_001243781.1 [Q9BRX8-2]
NP_001230711.1, NM_001243782.1
NP_115709.3, NM_032333.4 [Q9BRX8-1]
XP_011538567.1, XM_011540265.2 [Q9BRX8-1]
XP_011538568.1, XM_011540266.2 [Q9BRX8-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000372181; ENSP00000361254; ENSG00000122378 [Q9BRX8-1]
ENST00000372185; ENSP00000361259; ENSG00000122378 [Q9BRX8-2]
ENST00000372187; ENSP00000361261; ENSG00000122378 [Q9BRX8-1]
ENST00000372188; ENSP00000361262; ENSG00000122378 [Q9BRX8-1]
ENST00000606162; ENSP00000482445; ENSG00000122378 [Q9BRX8-1]
ENST00000615554; ENSP00000478152; ENSG00000122378 [Q9BRX8-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
84293

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:84293

UCSC genome browser

More...
UCSCi
uc001kcc.5 human [Q9BRX8-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY359059 mRNA Translation: AAQ89418.1
AK315440 mRNA Translation: BAG37828.1 Different initiation.
AK074643 mRNA Translation: BAC11108.1
AK075447 mRNA Translation: BAC11627.1
AC021028 Genomic DNA No translation available.
BC005871 mRNA Translation: AAH05871.3
AF305824 mRNA Translation: AAK55527.1 Different initiation.
CCDSiCCDS58089.1 [Q9BRX8-2]
CCDS7368.1 [Q9BRX8-1]
RefSeqiNP_001230707.1, NM_001243778.1 [Q9BRX8-1]
NP_001230708.1, NM_001243779.1 [Q9BRX8-1]
NP_001230709.1, NM_001243780.1 [Q9BRX8-1]
NP_001230710.1, NM_001243781.1 [Q9BRX8-2]
NP_001230711.1, NM_001243782.1
NP_115709.3, NM_032333.4 [Q9BRX8-1]
XP_011538567.1, XM_011540265.2 [Q9BRX8-1]
XP_011538568.1, XM_011540266.2 [Q9BRX8-1]

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi124020, 29 interactors
IntActiQ9BRX8, 25 interactors
STRINGi9606.ENSP00000482445

Chemistry databases

BindingDBiQ9BRX8
ChEMBLiCHEMBL3879824

PTM databases

iPTMnetiQ9BRX8
PhosphoSitePlusiQ9BRX8
SwissPalmiQ9BRX8

Polymorphism and mutation databases

BioMutaiFAM213A
DMDMi73620080

Proteomic databases

EPDiQ9BRX8
jPOSTiQ9BRX8
MassIVEiQ9BRX8
MaxQBiQ9BRX8
PaxDbiQ9BRX8
PeptideAtlasiQ9BRX8
PRIDEiQ9BRX8
ProteomicsDBi78849 [Q9BRX8-1]
78850 [Q9BRX8-2]

Genome annotation databases

EnsembliENST00000372181; ENSP00000361254; ENSG00000122378 [Q9BRX8-1]
ENST00000372185; ENSP00000361259; ENSG00000122378 [Q9BRX8-2]
ENST00000372187; ENSP00000361261; ENSG00000122378 [Q9BRX8-1]
ENST00000372188; ENSP00000361262; ENSG00000122378 [Q9BRX8-1]
ENST00000606162; ENSP00000482445; ENSG00000122378 [Q9BRX8-1]
ENST00000615554; ENSP00000478152; ENSG00000122378 [Q9BRX8-1]
GeneIDi84293
KEGGihsa:84293
UCSCiuc001kcc.5 human [Q9BRX8-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
84293

GeneCards: human genes, protein and diseases

More...
GeneCardsi
PRXL2A
HGNCiHGNC:28651 PRXL2A
HPAiHPA009025
HPA024565
MIMi617165 gene
neXtProtiNX_Q9BRX8
OpenTargetsiENSG00000122378
PharmGKBiPA134969403

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG4498 Eukaryota
ENOG410YFY9 LUCA
GeneTreeiENSGT00940000161199
HOGENOMiHOG000293175
InParanoidiQ9BRX8
OMAiVWQNFFR
OrthoDBi1442607at2759
PhylomeDBiQ9BRX8
TreeFamiTF313804

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
FAM213A human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
C10orf58

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
84293
PharosiQ9BRX8

Protein Ontology

More...
PROi
PR:Q9BRX8

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000122378 Expressed in 209 organ(s), highest expression level in adipose tissue
GenevisibleiQ9BRX8 HS

Family and domain databases

InterProiView protein in InterPro
IPR032801 PXL2A/B/C
PANTHERiPTHR28630 PTHR28630, 1 hit
PfamiView protein in Pfam
PF13911 AhpC-TSA_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPXL2A_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9BRX8
Secondary accession number(s): B2RD81
, Q6UW08, Q8N2K3, Q8NBK9, Q96JR0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: November 23, 2004
Last modified: October 16, 2019
This is version 145 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries
  2. SIMILARITY comments
    Index of protein domains and families
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again