UniProtKB - Q9BRX2 (PELO_HUMAN)
Protein
Protein pelota homolog
Gene
PELO
Organism
Homo sapiens (Human)
Status
Functioni
Required for normal chromosome segregation during cell division and genomic stability (By similarity). May function in recognizing stalled ribosomes and triggering endonucleolytic cleavage of the mRNA, a mechanism to release non-functional ribosomes and degrade damaged mRNAs. May have ribonuclease activity (Potential).By similarityCurated
Cofactori
a divalent metal cationCurated
GO - Molecular functioni
- endonuclease activity Source: UniProtKB-KW
- metal ion binding Source: UniProtKB-KW
GO - Biological processi
- cell cycle Source: UniProtKB-KW
- cell division Source: UniProtKB-KW
- chromosome organization Source: Ensembl
- endoderm development Source: Ensembl
- inner cell mass cell proliferation Source: Ensembl
- mesenchymal to epithelial transition Source: Ensembl
- nonfunctional rRNA decay Source: GO_Central
- nuclear-transcribed mRNA catabolic process, no-go decay Source: GO_Central
- nuclear-transcribed mRNA catabolic process, non-stop decay Source: InterPro
- positive regulation of BMP signaling pathway Source: Ensembl
- ribosome disassembly Source: GO_Central
- RNA surveillance Source: InterPro
- stem cell population maintenance Source: Ensembl
Keywordsi
Molecular function | Endonuclease, Hydrolase, Nuclease |
Biological process | Cell cycle, Cell division |
Ligand | Metal-binding |
Enzyme and pathway databases
PathwayCommonsi | Q9BRX2 |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:PELO ORF Names:CGI-17 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000152684.10 |
HGNCi | HGNC:8829, PELO |
MIMi | 605757, gene |
neXtProti | NX_Q9BRX2 |
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 53918 |
OpenTargetsi | ENSG00000152684 |
PharmGKBi | PA33174 |
Miscellaneous databases
Pharosi | Q9BRX2, Tbio |
Polymorphism and mutation databases
BioMutai | PELO |
DMDMi | 322510057 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000143188 | 1 – 385 | Protein pelota homologAdd BLAST | 385 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Cross-linki | 162 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 374 | PhosphoserineCombined sources | 1 | |
Modified residuei | 380 | PhosphoserineCombined sources | 1 | |
Modified residuei | 381 | PhosphoserineCombined sources | 1 | |
Modified residuei | 382 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | Q9BRX2 |
jPOSTi | Q9BRX2 |
MassIVEi | Q9BRX2 |
MaxQBi | Q9BRX2 |
PaxDbi | Q9BRX2 |
PeptideAtlasi | Q9BRX2 |
PRIDEi | Q9BRX2 |
ProteomicsDBi | 78846 |
PTM databases
iPTMneti | Q9BRX2 |
MetOSitei | Q9BRX2 |
PhosphoSitePlusi | Q9BRX2 |
Expressioni
Tissue specificityi
Ubiquitously expressed.1 Publication
Gene expression databases
Bgeei | ENSG00000152684, Expressed in islet of Langerhans and 231 other tissues |
Genevisiblei | Q9BRX2, HS |
Organism-specific databases
HPAi | ENSG00000152684, Low tissue specificity |
Interactioni
Binary interactionsi
Hide detailsQ9BRX2
Protein-protein interaction databases
BioGRIDi | 119818, 99 interactors |
IntActi | Q9BRX2, 30 interactors |
MINTi | Q9BRX2 |
STRINGi | 9606.ENSP00000274311 |
Miscellaneous databases
RNActi | Q9BRX2, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | Q9BRX2 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q9BRX2 |
Family & Domainsi
Domaini
The N-terminal domain has the RNA-binding Sm fold. It may harbor the endoribonuclease activity (Potential).Curated
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG2869, Eukaryota |
GeneTreei | ENSGT00390000016326 |
HOGENOMi | CLU_023334_3_1_1 |
InParanoidi | Q9BRX2 |
OMAi | DNLFRCQ |
PhylomeDBi | Q9BRX2 |
TreeFami | TF105733 |
Family and domain databases
Gene3Di | 2.30.30.870, 1 hit 3.30.1330.30, 1 hit 3.30.420.60, 1 hit |
InterProi | View protein in InterPro IPR042226, eFR1_2_sf IPR005140, eRF1_1_Pelota IPR005141, eRF1_2 IPR005142, eRF1_3 IPR029064, L30e-like IPR038069, Pelota/DOM34_N IPR004405, Transl-rel_pelota |
PANTHERi | PTHR10853, PTHR10853, 1 hit |
Pfami | View protein in Pfam PF03463, eRF1_1, 1 hit PF03464, eRF1_2, 1 hit PF03465, eRF1_3, 1 hit |
SMARTi | View protein in SMART SM01194, eRF1_1, 1 hit |
SUPFAMi | SSF159065, SSF159065, 1 hit SSF55315, SSF55315, 1 hit |
TIGRFAMsi | TIGR00111, pelota, 1 hit |
i Sequence
Sequence statusi: Complete.
Q9BRX2-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKLVRKNIEK DNAGQVTLVP EEPEDMWHTY NLVQVGDSLR ASTIRKVQTE
60 70 80 90 100
SSTGSVGSNR VRTTLTLCVE AIDFDSQACQ LRVKGTNIQE NEYVKMGAYH
110 120 130 140 150
TIELEPNRQF TLAKKQWDSV VLERIEQACD PAWSADVAAV VMQEGLAHIC
160 170 180 190 200
LVTPSMTLTR AKVEVNIPRK RKGNCSQHDR ALERFYEQVV QAIQRHIHFD
210 220 230 240 250
VVKCILVASP GFVREQFCDY LFQQAVKTDN KLLLENRSKF LQVHASSGHK
260 270 280 290 300
YSLKEALCDP TVASRLSDTK AAGEVKALDD FYKMLQHEPD RAFYGLKQVE
310 320 330 340 350
KANEAMAIDT LLISDELFRH QDVATRSRYV RLVDSVKENA GTVRIFSSLH
360 370 380
VSGEQLSQLT GVAAILRFPV PELSDQEGDS SSEED
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 135 | A → D in AAG22574 (PubMed:11060452).Curated | 1 | |
Sequence conflicti | 135 | A → D in AAG22575 (PubMed:11060452).Curated | 1 | |
Sequence conflicti | 235 | E → G in AAD27726 (PubMed:10810093).Curated | 1 | |
Sequence conflicti | 263 – 264 | AS → LA in AAD27726 (PubMed:10810093).Curated | 2 | |
Sequence conflicti | 281 | F → S in AAD27726 (PubMed:10810093).Curated | 1 | |
Sequence conflicti | 352 | S → Y in AAG22574 (PubMed:11060452).Curated | 1 | |
Sequence conflicti | 352 | S → Y in AAG22575 (PubMed:11060452).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_019777 | 221 | L → M4 PublicationsCorresponds to variant dbSNP:rs1499280Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF139828 mRNA Translation: AAG22574.1 AF143952 Genomic DNA Translation: AAG22575.1 AY117399 mRNA Translation: AAM89414.1 AF132951 mRNA Translation: AAD27726.1 AC026230 Genomic DNA No translation available. BC005889 mRNA Translation: AAH05889.1 BC007249 mRNA Translation: AAH07249.1 BC007650 mRNA Translation: AAH07650.1 BC022789 mRNA Translation: AAH22789.1 |
CCDSi | CCDS3956.1 |
RefSeqi | NP_057030.3, NM_015946.4 |
Genome annotation databases
Ensembli | ENST00000274311; ENSP00000274311; ENSG00000152684 |
GeneIDi | 53918 |
KEGGi | hsa:53918 |
UCSCi | uc003jos.5, human |
Keywords - Coding sequence diversityi
PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF139828 mRNA Translation: AAG22574.1 AF143952 Genomic DNA Translation: AAG22575.1 AY117399 mRNA Translation: AAM89414.1 AF132951 mRNA Translation: AAD27726.1 AC026230 Genomic DNA No translation available. BC005889 mRNA Translation: AAH05889.1 BC007249 mRNA Translation: AAH07249.1 BC007650 mRNA Translation: AAH07650.1 BC022789 mRNA Translation: AAH22789.1 |
CCDSi | CCDS3956.1 |
RefSeqi | NP_057030.3, NM_015946.4 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1X52 | NMR | - | A | 261-371 | [»] | |
5EO3 | X-ray | 2.60 | A/B | 265-385 | [»] | |
5LZW | electron microscopy | 3.53 | ii | 1-385 | [»] | |
5LZX | electron microscopy | 3.67 | ii | 1-385 | [»] | |
5LZY | electron microscopy | 3.99 | ii | 1-385 | [»] | |
5LZZ | electron microscopy | 3.47 | ii | 1-385 | [»] | |
SMRi | Q9BRX2 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 119818, 99 interactors |
IntActi | Q9BRX2, 30 interactors |
MINTi | Q9BRX2 |
STRINGi | 9606.ENSP00000274311 |
PTM databases
iPTMneti | Q9BRX2 |
MetOSitei | Q9BRX2 |
PhosphoSitePlusi | Q9BRX2 |
Polymorphism and mutation databases
BioMutai | PELO |
DMDMi | 322510057 |
Proteomic databases
EPDi | Q9BRX2 |
jPOSTi | Q9BRX2 |
MassIVEi | Q9BRX2 |
MaxQBi | Q9BRX2 |
PaxDbi | Q9BRX2 |
PeptideAtlasi | Q9BRX2 |
PRIDEi | Q9BRX2 |
ProteomicsDBi | 78846 |
Protocols and materials databases
Antibodypediai | 23309, 136 antibodies |
DNASUi | 53918 |
Genome annotation databases
Ensembli | ENST00000274311; ENSP00000274311; ENSG00000152684 |
GeneIDi | 53918 |
KEGGi | hsa:53918 |
UCSCi | uc003jos.5, human |
Organism-specific databases
CTDi | 53918 |
DisGeNETi | 53918 |
EuPathDBi | HostDB:ENSG00000152684.10 |
GeneCardsi | PELO |
HGNCi | HGNC:8829, PELO |
HPAi | ENSG00000152684, Low tissue specificity |
MIMi | 605757, gene |
neXtProti | NX_Q9BRX2 |
OpenTargetsi | ENSG00000152684 |
PharmGKBi | PA33174 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG2869, Eukaryota |
GeneTreei | ENSGT00390000016326 |
HOGENOMi | CLU_023334_3_1_1 |
InParanoidi | Q9BRX2 |
OMAi | DNLFRCQ |
PhylomeDBi | Q9BRX2 |
TreeFami | TF105733 |
Enzyme and pathway databases
PathwayCommonsi | Q9BRX2 |
Miscellaneous databases
BioGRID-ORCSi | 53918, 552 hits in 852 CRISPR screens |
EvolutionaryTracei | Q9BRX2 |
GeneWikii | PELO |
GenomeRNAii | 53918 |
Pharosi | Q9BRX2, Tbio |
PROi | PR:Q9BRX2 |
RNActi | Q9BRX2, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000152684, Expressed in islet of Langerhans and 231 other tissues |
Genevisiblei | Q9BRX2, HS |
Family and domain databases
Gene3Di | 2.30.30.870, 1 hit 3.30.1330.30, 1 hit 3.30.420.60, 1 hit |
InterProi | View protein in InterPro IPR042226, eFR1_2_sf IPR005140, eRF1_1_Pelota IPR005141, eRF1_2 IPR005142, eRF1_3 IPR029064, L30e-like IPR038069, Pelota/DOM34_N IPR004405, Transl-rel_pelota |
PANTHERi | PTHR10853, PTHR10853, 1 hit |
Pfami | View protein in Pfam PF03463, eRF1_1, 1 hit PF03464, eRF1_2, 1 hit PF03465, eRF1_3, 1 hit |
SMARTi | View protein in SMART SM01194, eRF1_1, 1 hit |
SUPFAMi | SSF159065, SSF159065, 1 hit SSF55315, SSF55315, 1 hit |
TIGRFAMsi | TIGR00111, pelota, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | PELO_HUMAN | |
Accessioni | Q9BRX2Primary (citable) accession number: Q9BRX2 Secondary accession number(s): Q9GZS6, Q9Y306 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 11, 2004 |
Last sequence update: | February 8, 2011 | |
Last modified: | December 2, 2020 | |
This is version 162 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 5
Human chromosome 5: entries, gene names and cross-references to MIM - Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations