UniProtKB - Q9BRV8 (SIKE1_HUMAN)
Protein
Suppressor of IKBKE 1
Gene
SIKE1
Organism
Homo sapiens (Human)
Status
Functioni
Physiological suppressor of IKK-epsilon and TBK1 that plays an inhibitory role in virus- and TLR3-triggered IRF3. Inhibits TLR3-mediated activation of interferon-stimulated response elements (ISRE) and the IFN-beta promoter. May act by disrupting the interactions of IKBKE or TBK1 with TICAM1/TRIF, IRF3 and DDX58/RIG-I. Does not inhibit NF-kappa-B activation pathways.1 Publication
GO - Molecular functioni
- protein kinase binding Source: UniProtKB
- small GTPase binding Source: UniProtKB
Enzyme and pathway databases
PathwayCommonsi | Q9BRV8 |
Reactomei | R-HSA-918233, TRAF3-dependent IRF activation pathway R-HSA-933541, TRAF6 mediated IRF7 activation |
Names & Taxonomyi
Protein namesi | Recommended name: Suppressor of IKBKE 1Alternative name(s): Suppressor of IKK-epsilon |
Gene namesi | Name:SIKE1 Synonyms:SIKE |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:26119, SIKE1 |
MIMi | 611656, gene |
neXtProti | NX_Q9BRV8 |
VEuPathDBi | HostDB:ENSG00000052723.11 |
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm 1 Publication
Cytosol
- cytosol Source: Reactome
Keywords - Cellular componenti
CytoplasmPathology & Biotechi
Organism-specific databases
DisGeNETi | 80143 |
OpenTargetsi | ENSG00000052723 |
PharmGKBi | PA165752371 |
Miscellaneous databases
Pharosi | Q9BRV8, Tdark |
Genetic variation databases
BioMutai | SIKE1 |
DMDMi | 74752290 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000299050 | 1 – 207 | Suppressor of IKBKE 1Add BLAST | 207 |
Proteomic databases
EPDi | Q9BRV8 |
jPOSTi | Q9BRV8 |
MassIVEi | Q9BRV8 |
MaxQBi | Q9BRV8 |
PaxDbi | Q9BRV8 |
PeptideAtlasi | Q9BRV8 |
PRIDEi | Q9BRV8 |
ProteomicsDBi | 78843 [Q9BRV8-1] 78844 [Q9BRV8-2] |
PTM databases
iPTMneti | Q9BRV8 |
PhosphoSitePlusi | Q9BRV8 |
Expressioni
Tissue specificityi
Widely expressed. Expressed in brain, heart, skeletal muscle, colon, thymus, spleen, kidney, liver, small intestine, placenta, lung and leukocytes. Present in all cell lines tested (at protein level).1 Publication
Gene expression databases
Bgeei | ENSG00000052723, Expressed in buccal mucosa cell and 229 other tissues |
Genevisiblei | Q9BRV8, HS |
Organism-specific databases
HPAi | ENSG00000052723, Low tissue specificity |
Interactioni
Subunit structurei
Binary interactionsi
Hide detailsQ9BRV8
GO - Molecular functioni
- protein kinase binding Source: UniProtKB
- small GTPase binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 123136, 50 interactors |
CORUMi | Q9BRV8 |
IntActi | Q9BRV8, 52 interactors |
STRINGi | 9606.ENSP00000358541 |
Miscellaneous databases
RNActi | Q9BRV8, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | Q9BRV8 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 70 – 102 | Sequence analysisAdd BLAST | 33 | |
Coiled coili | 162 – 193 | Sequence analysisAdd BLAST | 32 |
Sequence similaritiesi
Belongs to the SIKE family.Curated
Keywords - Domaini
Coiled coilPhylogenomic databases
eggNOGi | ENOG502QTKS, Eukaryota |
GeneTreei | ENSGT00390000018003 |
HOGENOMi | CLU_073167_1_0_1 |
InParanoidi | Q9BRV8 |
OMAi | HYCSVRE |
OrthoDBi | 1368908at2759 |
PhylomeDBi | Q9BRV8 |
TreeFami | TF324337 |
Family and domain databases
InterProi | View protein in InterPro IPR008555, SIKE |
PANTHERi | PTHR12186, PTHR12186, 1 hit |
Pfami | View protein in Pfam PF05769, SIKE, 1 hit |
s (2)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketIsoform 1 (identifier: Q9BRV8-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSCTIEKILT DAKTLLERLR EHDAAAESLV DQSAALHRRV AAMREAGTAL
60 70 80 90 100
PDQYQEDASD MKDMSKYKPH ILLSQENTQI RDLQQENREL WISLEEHQDA
110 120 130 140 150
LELIMSKYRK QMLQLMVAKK AVDAEPVLKA HQSHSAEIES QIDRICEMGE
160 170 180 190 200
VMRKAVQVDD DQFCKIQEKL AQLELENKEL RELLSISSES LQARKENSMD
TASQAIK
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 127 | V → I in CAH18076 (PubMed:17974005).Curated | 1 | |
Sequence conflicti | 169 | K → I in BAB15020 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 191 | L → H in BAB15020 (PubMed:14702039).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_027543 | 53 | Q → QVRQR in isoform 2. 1 Publication | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK024821 mRNA Translation: BAB15020.1 CR749219 mRNA Translation: CAH18076.1 AL096773 Genomic DNA No translation available. CH471122 Genomic DNA Translation: EAW56620.1 BC005934 mRNA Translation: AAH05934.1 |
CCDSi | CCDS41371.1 [Q9BRV8-2] CCDS878.1 [Q9BRV8-1] |
RefSeqi | NP_001095866.1, NM_001102396.1 [Q9BRV8-2] NP_079349.2, NM_025073.2 [Q9BRV8-1] |
Genome annotation databases
Ensembli | ENST00000060969; ENSP00000060969; ENSG00000052723 [Q9BRV8-1] ENST00000369528; ENSP00000358541; ENSG00000052723 [Q9BRV8-2] |
GeneIDi | 80143 |
KEGGi | hsa:80143 |
UCSCi | uc001efo.5, human [Q9BRV8-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK024821 mRNA Translation: BAB15020.1 CR749219 mRNA Translation: CAH18076.1 AL096773 Genomic DNA No translation available. CH471122 Genomic DNA Translation: EAW56620.1 BC005934 mRNA Translation: AAH05934.1 |
CCDSi | CCDS41371.1 [Q9BRV8-2] CCDS878.1 [Q9BRV8-1] |
RefSeqi | NP_001095866.1, NM_001102396.1 [Q9BRV8-2] NP_079349.2, NM_025073.2 [Q9BRV8-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
6AKK | X-ray | 1.50 | A/B | 72-121 | [»] | |
6AKL | X-ray | 1.75 | A/B | 72-121 | [»] | |
6AKM | X-ray | 2.30 | A | 5-65 | [»] | |
SMRi | Q9BRV8 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 123136, 50 interactors |
CORUMi | Q9BRV8 |
IntActi | Q9BRV8, 52 interactors |
STRINGi | 9606.ENSP00000358541 |
PTM databases
iPTMneti | Q9BRV8 |
PhosphoSitePlusi | Q9BRV8 |
Genetic variation databases
BioMutai | SIKE1 |
DMDMi | 74752290 |
Proteomic databases
EPDi | Q9BRV8 |
jPOSTi | Q9BRV8 |
MassIVEi | Q9BRV8 |
MaxQBi | Q9BRV8 |
PaxDbi | Q9BRV8 |
PeptideAtlasi | Q9BRV8 |
PRIDEi | Q9BRV8 |
ProteomicsDBi | 78843 [Q9BRV8-1] 78844 [Q9BRV8-2] |
Protocols and materials databases
Antibodypediai | 20165, 120 antibodies |
DNASUi | 80143 |
Genome annotation databases
Ensembli | ENST00000060969; ENSP00000060969; ENSG00000052723 [Q9BRV8-1] ENST00000369528; ENSP00000358541; ENSG00000052723 [Q9BRV8-2] |
GeneIDi | 80143 |
KEGGi | hsa:80143 |
UCSCi | uc001efo.5, human [Q9BRV8-1] |
Organism-specific databases
CTDi | 80143 |
DisGeNETi | 80143 |
GeneCardsi | SIKE1 |
HGNCi | HGNC:26119, SIKE1 |
HPAi | ENSG00000052723, Low tissue specificity |
MIMi | 611656, gene |
neXtProti | NX_Q9BRV8 |
OpenTargetsi | ENSG00000052723 |
PharmGKBi | PA165752371 |
VEuPathDBi | HostDB:ENSG00000052723.11 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QTKS, Eukaryota |
GeneTreei | ENSGT00390000018003 |
HOGENOMi | CLU_073167_1_0_1 |
InParanoidi | Q9BRV8 |
OMAi | HYCSVRE |
OrthoDBi | 1368908at2759 |
PhylomeDBi | Q9BRV8 |
TreeFami | TF324337 |
Enzyme and pathway databases
PathwayCommonsi | Q9BRV8 |
Reactomei | R-HSA-918233, TRAF3-dependent IRF activation pathway R-HSA-933541, TRAF6 mediated IRF7 activation |
Miscellaneous databases
BioGRID-ORCSi | 80143, 10 hits in 994 CRISPR screens |
ChiTaRSi | SIKE1, human |
GenomeRNAii | 80143 |
Pharosi | Q9BRV8, Tdark |
PROi | PR:Q9BRV8 |
RNActi | Q9BRV8, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000052723, Expressed in buccal mucosa cell and 229 other tissues |
Genevisiblei | Q9BRV8, HS |
Family and domain databases
InterProi | View protein in InterPro IPR008555, SIKE |
PANTHERi | PTHR12186, PTHR12186, 1 hit |
Pfami | View protein in Pfam PF05769, SIKE, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | SIKE1_HUMAN | |
Accessioni | Q9BRV8Primary (citable) accession number: Q9BRV8 Secondary accession number(s): Q5TEZ7 Q9H778 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 11, 2007 |
Last sequence update: | June 1, 2001 | |
Last modified: | April 7, 2021 | |
This is version 133 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families