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Protein

Suppressor of IKBKE 1

Gene

SIKE1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Physiological suppressor of IKK-epsilon and TBK1 that plays an inhibitory role in virus- and TLR3-triggered IRF3. Inhibits TLR3-mediated activation of interferon-stimulated response elements (ISRE) and the IFN-beta promoter. May act by disrupting the interactions of IKBKE or TBK1 with TICAM1/TRIF, IRF3 and DDX58/RIG-I. Does not inhibit NF-kappa-B activation pathways.1 Publication

GO - Molecular functioni

  • protein kinase binding Source: UniProtKB
  • Rho GTPase binding Source: UniProtKB

Enzyme and pathway databases

ReactomeiR-HSA-918233 TRAF3-dependent IRF activation pathway
R-HSA-933541 TRAF6 mediated IRF7 activation

Names & Taxonomyi

Protein namesi
Recommended name:
Suppressor of IKBKE 1
Alternative name(s):
Suppressor of IKK-epsilon
Gene namesi
Name:SIKE1
Synonyms:SIKE
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000052723.11
HGNCiHGNC:26119 SIKE1
MIMi611656 gene
neXtProtiNX_Q9BRV8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi80143
OpenTargetsiENSG00000052723
PharmGKBiPA165752371

Polymorphism and mutation databases

BioMutaiSIKE1
DMDMi74752290

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002990501 – 207Suppressor of IKBKE 1Add BLAST207

Proteomic databases

EPDiQ9BRV8
MaxQBiQ9BRV8
PaxDbiQ9BRV8
PeptideAtlasiQ9BRV8
PRIDEiQ9BRV8
ProteomicsDBi78843
78844 [Q9BRV8-2]

PTM databases

iPTMnetiQ9BRV8
PhosphoSitePlusiQ9BRV8

Expressioni

Tissue specificityi

Widely expressed. Expressed in brain, heart, skeletal muscle, colon, thymus, spleen, kidney, liver, small intestine, placenta, lung and leukocytes. Present in all cell lines tested (at protein level).1 Publication

Gene expression databases

BgeeiENSG00000052723
GenevisibleiQ9BRV8 HS

Organism-specific databases

HPAiHPA024177
HPA025726

Interactioni

Subunit structurei

Interacts with IKBKE and TBK1 via its coiled coil region. Interaction with TBK1 is disrupted upon viral infection or TLR3 stimulation (PubMed:16281057). Interacts with CDC42BPB (PubMed:25743393).2 Publications

Binary interactionsi

Show more details

GO - Molecular functioni

  • protein kinase binding Source: UniProtKB
  • Rho GTPase binding Source: UniProtKB

Protein-protein interaction databases

BioGridi123136, 40 interactors
CORUMiQ9BRV8
IntActiQ9BRV8, 43 interactors
STRINGi9606.ENSP00000358541

Structurei

3D structure databases

ProteinModelPortaliQ9BRV8
SMRiQ9BRV8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili70 – 102Sequence analysisAdd BLAST33
Coiled coili162 – 193Sequence analysisAdd BLAST32

Sequence similaritiesi

Belongs to the SIKE family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410II2X Eukaryota
ENOG4111HSR LUCA
GeneTreeiENSGT00390000018003
HOGENOMiHOG000294110
HOVERGENiHBG055808
InParanoidiQ9BRV8
KOiK12656
OMAiICEMGQV
OrthoDBiEOG091G0M4E
PhylomeDBiQ9BRV8
TreeFamiTF324337

Family and domain databases

InterProiView protein in InterPro
IPR008555 SIKE
PANTHERiPTHR12186 PTHR12186, 1 hit
PfamiView protein in Pfam
PF05769 SIKE, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9BRV8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSCTIEKILT DAKTLLERLR EHDAAAESLV DQSAALHRRV AAMREAGTAL
60 70 80 90 100
PDQYQEDASD MKDMSKYKPH ILLSQENTQI RDLQQENREL WISLEEHQDA
110 120 130 140 150
LELIMSKYRK QMLQLMVAKK AVDAEPVLKA HQSHSAEIES QIDRICEMGE
160 170 180 190 200
VMRKAVQVDD DQFCKIQEKL AQLELENKEL RELLSISSES LQARKENSMD

TASQAIK
Length:207
Mass (Da):23,721
Last modified:June 1, 2001 - v1
Checksum:i4C5598612F032988
GO
Isoform 2 (identifier: Q9BRV8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     53-53: Q → QVRQR

Note: No experimental confirmation available.
Show »
Length:211
Mass (Da):24,261
Checksum:i555B830504AE0EB7
GO

Sequence cautioni

The sequence CAI18824 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti127V → I in CAH18076 (PubMed:17974005).Curated1
Sequence conflicti169K → I in BAB15020 (PubMed:14702039).Curated1
Sequence conflicti191L → H in BAB15020 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_02754353Q → QVRQR in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK024821 mRNA Translation: BAB15020.1
CR749219 mRNA Translation: CAH18076.1
AL096773 Genomic DNA Translation: CAI18822.1
AL096773 Genomic DNA Translation: CAI18823.1
AL096773 Genomic DNA Translation: CAI18824.1 Sequence problems.
CH471122 Genomic DNA Translation: EAW56620.1
BC005934 mRNA Translation: AAH05934.1
CCDSiCCDS41371.1 [Q9BRV8-2]
CCDS878.1 [Q9BRV8-1]
RefSeqiNP_001095866.1, NM_001102396.1 [Q9BRV8-2]
NP_079349.2, NM_025073.2 [Q9BRV8-1]
UniGeneiHs.709277

Genome annotation databases

EnsembliENST00000060969; ENSP00000060969; ENSG00000052723 [Q9BRV8-1]
ENST00000369528; ENSP00000358541; ENSG00000052723 [Q9BRV8-2]
GeneIDi80143
KEGGihsa:80143
UCSCiuc001efo.5 human [Q9BRV8-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiSIKE1_HUMAN
AccessioniPrimary (citable) accession number: Q9BRV8
Secondary accession number(s): Q5TEZ7
, Q5TEZ9, Q68DZ4, Q9H778
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: June 1, 2001
Last modified: July 18, 2018
This is version 117 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

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