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Protein

Sugar transporter SWEET1

Gene

SLC50A1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Mediates sugar transport across membranes. May stimulate V(D)J recombination by the activation of RAG1.1 Publication

GO - Molecular functioni

  • glucoside transmembrane transporter activity Source: UniProtKB
  • sugar transmembrane transporter activity Source: GO_Central

GO - Biological processi

  • hexose transmembrane transport Source: Reactome
  • positive regulation of gene expression, epigenetic Source: HGNC

Keywordsi

Biological processSugar transport, Transport

Enzyme and pathway databases

ReactomeiR-HSA-189200 Cellular hexose transport

Protein family/group databases

TCDBi2.A.123.1.4 the sweet, pq-loop, saliva, mtn3 (sweet) family

Names & Taxonomyi

Protein namesi
Recommended name:
Sugar transporter SWEET1
Short name:
HsSWEET1
Alternative name(s):
RAG1-activating protein 1
Solute carrier family 50 member 1
Stromal cell protein
Gene namesi
Name:SLC50A1
Synonyms:RAG1AP1, SCP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000169241.17
HGNCiHGNC:30657 SLC50A1
MIMi613683 gene
neXtProtiNX_Q9BRV3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei3 – 23Helical; Name=1Sequence analysisAdd BLAST21
Transmembranei42 – 62Helical; Name=2Sequence analysisAdd BLAST21
Transmembranei68 – 88Helical; Name=3Sequence analysisAdd BLAST21
Transmembranei96 – 116Helical; Name=4Sequence analysisAdd BLAST21
Transmembranei129 – 149Helical; Name=5Sequence analysisAdd BLAST21
Transmembranei160 – 180Helical; Name=6Sequence analysisAdd BLAST21
Transmembranei186 – 206Helical; Name=7Sequence analysisAdd BLAST21

Keywords - Cellular componenti

Cell membrane, Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi55974
OpenTargetsiENSG00000169241
PharmGKBiPA142671099

Polymorphism and mutation databases

BioMutaiSLC50A1
DMDMi74752289

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003451161 – 221Sugar transporter SWEET1Add BLAST221

Proteomic databases

PaxDbiQ9BRV3
PeptideAtlasiQ9BRV3
PRIDEiQ9BRV3
ProteomicsDBi78840
78841 [Q9BRV3-2]
78842 [Q9BRV3-3]

PTM databases

iPTMnetiQ9BRV3
PhosphoSitePlusiQ9BRV3

Expressioni

Tissue specificityi

Ubiquitously expressed with highest expression in oviduct, epididymis and intestine.1 Publication

Gene expression databases

BgeeiENSG00000169241 Expressed in 224 organ(s), highest expression level in right lobe of liver
CleanExiHS_RAG1AP1
ExpressionAtlasiQ9BRV3 baseline and differential
GenevisibleiQ9BRV3 HS

Organism-specific databases

HPAiHPA018095

Interactioni

Subunit structurei

Interacts with TRPV2; the interaction probably occurs intracellularly and depends on TRPV2 N-glycosylation.By similarity

Protein-protein interaction databases

BioGridi121020, 2 interactors
IntActiQ9BRV3, 5 interactors
MINTiQ9BRV3
STRINGi9606.ENSP00000357389

Structurei

3D structure databases

ProteinModelPortaliQ9BRV3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini10 – 94MtN3/slv 1Add BLAST85
Domaini127 – 212MtN3/slv 2Add BLAST86

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni149 – 221Mediates interaction with TRPV2By similarityAdd BLAST73

Sequence similaritiesi

Belongs to the SWEET sugar transporter family.Curated

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1623 Eukaryota
ENOG4111M4R LUCA
GeneTreeiENSGT00390000007801
HOVERGENiHBG055287
InParanoidiQ9BRV3
KOiK15382
OMAiVSMYLSP
OrthoDBiEOG091G0J82
PhylomeDBiQ9BRV3
TreeFamiTF313635

Family and domain databases

InterProiView protein in InterPro
IPR004316 SWEET_sugar_transpr
PfamiView protein in Pfam
PF03083 MtN3_slv, 2 hits

Sequences (3+)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9BRV3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEAGGFLDSL IYGACVVFTL GMFSAGLSDL RHMRMTRSVD NVQFLPFLTT
60 70 80 90 100
EVNNLGWLSY GALKGDGILI VVNTVGAALQ TLYILAYLHY CPRKRVVLLQ
110 120 130 140 150
TATLLGVLLL GYGYFWLLVP NPEARLQQLG LFCSVFTISM YLSPLADLAK
160 170 180 190 200
VIQTKSTQCL SYPLTIATLL TSASWCLYGF RLRDPYIMVS NFPGIVTSFI
210 220
RFWLFWKYPQ EQDRNYWLLQ T
Length:221
Mass (Da):25,030
Last modified:June 1, 2001 - v1
Checksum:iFEC35396C28EA9F0
GO
Isoform 2 (identifier: Q9BRV3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-55: Missing.
     56-94: GWLSYGALKG...LAYLHYCPRK → MRGLHPWHVL...VPALSHHGSQ

Show »
Length:166
Mass (Da):19,050
Checksum:i04F7A714A75C3BDF
GO
Isoform 3 (identifier: Q9BRV3-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     95-148: Missing.

Show »
Length:167
Mass (Da):19,020
Checksum:iCCCDF3750BB71D12
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5SR67Q5SR67_HUMAN
Sugar transporter SWEET1
SLC50A1
156Annotation score:
A0A087WXX5A0A087WXX5_HUMAN
Sugar transporter SWEET1
SLC50A1
175Annotation score:

Sequence cautioni

Isoform 2 : The sequence AAF17233 differs from that shown. Reason: Frameshift at positions 29 and 30.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti43Q → R in AAF17232 (PubMed:10931946).Curated1
Sequence conflicti130G → A in CAG33429 (Ref. 3) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0349161 – 55Missing in isoform 2. 1 PublicationAdd BLAST55
Alternative sequenceiVSP_03491756 – 94GWLSY…YCPRK → MRGLHPWHVLRRPLGPQAHA NDPECGQRPVPALSHHGSQ in isoform 2. 1 PublicationAdd BLAST39
Alternative sequenceiVSP_03491895 – 148Missing in isoform 3. 1 PublicationAdd BLAST54

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF126023 mRNA Translation: AAF17232.1
AF126024 mRNA Translation: AAF17233.1 Frameshift.
AK289551 mRNA Translation: BAF82240.1
CR457148 mRNA Translation: CAG33429.1
AL691442 Genomic DNA No translation available.
BC005943 mRNA Translation: AAH05943.1
BC009621 mRNA Translation: AAH09621.1
CCDSiCCDS1093.1 [Q9BRV3-1]
CCDS44238.1 [Q9BRV3-3]
CCDS44239.1 [Q9BRV3-2]
RefSeqiNP_001116309.1, NM_001122837.1 [Q9BRV3-2]
NP_001116311.1, NM_001122839.1 [Q9BRV3-3]
NP_001274515.1, NM_001287586.1
NP_001274516.1, NM_001287587.1
NP_001274517.1, NM_001287588.1
NP_001274519.1, NM_001287590.1
NP_001274520.1, NM_001287591.1
NP_001274521.1, NM_001287592.1
NP_061333.2, NM_018845.3 [Q9BRV3-1]
UniGeneiHs.292154

Genome annotation databases

EnsembliENST00000303343; ENSP00000306146; ENSG00000169241 [Q9BRV3-3]
ENST00000368401; ENSP00000357386; ENSG00000169241 [Q9BRV3-2]
ENST00000368404; ENSP00000357389; ENSG00000169241 [Q9BRV3-1]
GeneIDi55974
KEGGihsa:55974
UCSCiuc001fhj.5 human [Q9BRV3-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF126023 mRNA Translation: AAF17232.1
AF126024 mRNA Translation: AAF17233.1 Frameshift.
AK289551 mRNA Translation: BAF82240.1
CR457148 mRNA Translation: CAG33429.1
AL691442 Genomic DNA No translation available.
BC005943 mRNA Translation: AAH05943.1
BC009621 mRNA Translation: AAH09621.1
CCDSiCCDS1093.1 [Q9BRV3-1]
CCDS44238.1 [Q9BRV3-3]
CCDS44239.1 [Q9BRV3-2]
RefSeqiNP_001116309.1, NM_001122837.1 [Q9BRV3-2]
NP_001116311.1, NM_001122839.1 [Q9BRV3-3]
NP_001274515.1, NM_001287586.1
NP_001274516.1, NM_001287587.1
NP_001274517.1, NM_001287588.1
NP_001274519.1, NM_001287590.1
NP_001274520.1, NM_001287591.1
NP_001274521.1, NM_001287592.1
NP_061333.2, NM_018845.3 [Q9BRV3-1]
UniGeneiHs.292154

3D structure databases

ProteinModelPortaliQ9BRV3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121020, 2 interactors
IntActiQ9BRV3, 5 interactors
MINTiQ9BRV3
STRINGi9606.ENSP00000357389

Protein family/group databases

TCDBi2.A.123.1.4 the sweet, pq-loop, saliva, mtn3 (sweet) family

PTM databases

iPTMnetiQ9BRV3
PhosphoSitePlusiQ9BRV3

Polymorphism and mutation databases

BioMutaiSLC50A1
DMDMi74752289

Proteomic databases

PaxDbiQ9BRV3
PeptideAtlasiQ9BRV3
PRIDEiQ9BRV3
ProteomicsDBi78840
78841 [Q9BRV3-2]
78842 [Q9BRV3-3]

Protocols and materials databases

DNASUi55974
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000303343; ENSP00000306146; ENSG00000169241 [Q9BRV3-3]
ENST00000368401; ENSP00000357386; ENSG00000169241 [Q9BRV3-2]
ENST00000368404; ENSP00000357389; ENSG00000169241 [Q9BRV3-1]
GeneIDi55974
KEGGihsa:55974
UCSCiuc001fhj.5 human [Q9BRV3-1]

Organism-specific databases

CTDi55974
DisGeNETi55974
EuPathDBiHostDB:ENSG00000169241.17
GeneCardsiSLC50A1
H-InvDBiHIX0199799
HGNCiHGNC:30657 SLC50A1
HPAiHPA018095
MIMi613683 gene
neXtProtiNX_Q9BRV3
OpenTargetsiENSG00000169241
PharmGKBiPA142671099
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1623 Eukaryota
ENOG4111M4R LUCA
GeneTreeiENSGT00390000007801
HOVERGENiHBG055287
InParanoidiQ9BRV3
KOiK15382
OMAiVSMYLSP
OrthoDBiEOG091G0J82
PhylomeDBiQ9BRV3
TreeFamiTF313635

Enzyme and pathway databases

ReactomeiR-HSA-189200 Cellular hexose transport

Miscellaneous databases

ChiTaRSiSLC50A1 human
GenomeRNAii55974
PROiPR:Q9BRV3
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000169241 Expressed in 224 organ(s), highest expression level in right lobe of liver
CleanExiHS_RAG1AP1
ExpressionAtlasiQ9BRV3 baseline and differential
GenevisibleiQ9BRV3 HS

Family and domain databases

InterProiView protein in InterPro
IPR004316 SWEET_sugar_transpr
PfamiView protein in Pfam
PF03083 MtN3_slv, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiSWET1_HUMAN
AccessioniPrimary (citable) accession number: Q9BRV3
Secondary accession number(s): Q5SR64
, Q6IAK6, Q96DC5, Q9UHQ2, Q9UHQ3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 22, 2008
Last sequence update: June 1, 2001
Last modified: November 7, 2018
This is version 126 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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