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Protein

rRNA-processing protein UTP23 homolog

Gene

UTP23

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in rRNA-processing and ribosome biogenesis.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processRibosome biogenesis, rRNA processing

Names & Taxonomyi

Protein namesi
Recommended name:
rRNA-processing protein UTP23 homolog
Gene namesi
Name:UTP23
Synonyms:C8orf53
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

EuPathDBiHostDB:ENSG00000147679.11
HGNCiHGNC:28224 UTP23
neXtProtiNX_Q9BRU9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi84294
OpenTargetsiENSG00000147679
PharmGKBiPA162408778

Polymorphism and mutation databases

BioMutaiUTP23
DMDMi296452859

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002856341 – 249rRNA-processing protein UTP23 homologAdd BLAST249

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei174PhosphoserineCombined sources1
Cross-linki179Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ9BRU9
MaxQBiQ9BRU9
PaxDbiQ9BRU9
PeptideAtlasiQ9BRU9
PRIDEiQ9BRU9
ProteomicsDBi78838
78839 [Q9BRU9-2]

PTM databases

iPTMnetiQ9BRU9
PhosphoSitePlusiQ9BRU9

Expressioni

Gene expression databases

BgeeiENSG00000147679 Expressed in 214 organ(s), highest expression level in kidney epithelium
CleanExiHS_UTP23
ExpressionAtlasiQ9BRU9 baseline and differential
GenevisibleiQ9BRU9 HS

Organism-specific databases

HPAiHPA044418

Interactioni

Binary interactionsi

Protein-protein interaction databases

BioGridi124021, 42 interactors
IntActiQ9BRU9, 32 interactors
STRINGi9606.ENSP00000308332

Structurei

3D structure databases

ProteinModelPortaliQ9BRU9
SMRiQ9BRU9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi209 – 213Poly-Lys5

Sequence similaritiesi

Belongs to the UTP23/FCF1 family. UTP23 subfamily.Curated

Phylogenomic databases

eggNOGiKOG3164 Eukaryota
COG1412 LUCA
GeneTreeiENSGT00550000074848
HOGENOMiHOG000239062
HOVERGENiHBG054456
InParanoidiQ9BRU9
KOiK14773
OMAiYMKEKQG
OrthoDBiEOG091G176S
PhylomeDBiQ9BRU9
TreeFamiTF105804

Family and domain databases

InterProiView protein in InterPro
IPR006984 Fcf1/Utp23
IPR029060 PIN-like_dom_sf
PfamiView protein in Pfam
PF04900 Fcf1, 1 hit
SUPFAMiSSF88723 SSF88723, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9BRU9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MKITRQKHAK KHLGFFRNNF GVREPYQILL DGTFCQAALR GRIQLREQLP
60 70 80 90 100
RYLMGETQLC TTRCVLKELE TLGKDLYGAK LIAQKCQVRN CPHFKNAVSG
110 120 130 140 150
SECLLSMVEE GNPHHYFVAT QDQNLSVKVK KKPGVPLMFI IQNTMVLDKP
160 170 180 190 200
SPKTIAFVKA VESGQLVSVH EKESIKHLKE EQGLVKNTEQ SRRKKRKKIS
210 220 230 240
GPNPLSCLKK KKKAPDTQSS ASEKKRKRKR IRNRSNPKVL SEKQNAEGE
Length:249
Mass (Da):28,402
Last modified:May 18, 2010 - v2
Checksum:i5DBFD9D7D64D96EE
GO
Isoform 2 (identifier: Q9BRU9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     122-145: DQNLSVKVKKKPGVPLMFIIQNTM → YIPRMYTFCTNYGGQQYVIDALIG
     146-249: Missing.

Note: No experimental confirmation available.
Show »
Length:145
Mass (Da):16,680
Checksum:iF26E100DD5996164
GO

Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E5RGP0E5RGP0_HUMAN
rRNA-processing protein UTP23 homol...
UTP23
155Annotation score:
G3XAM4G3XAM4_HUMAN
Chromosome 8 open reading frame 53,...
UTP23 C8orf53, hCG_1640093
105Annotation score:
E5RIC4E5RIC4_HUMAN
rRNA-processing protein UTP23 homol...
UTP23
80Annotation score:
E5RH13E5RH13_HUMAN
rRNA-processing protein UTP23 homol...
UTP23
69Annotation score:
E5RIM0E5RIM0_HUMAN
rRNA-processing protein UTP23 homol...
UTP23
64Annotation score:
E5RG01E5RG01_HUMAN
rRNA-processing protein UTP23 homol...
UTP23
67Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti225K → R in AAH05955 (PubMed:15489334).Curated1
Sequence conflicti225K → R in AAH22441 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_032031170H → R. Corresponds to variant dbSNP:rs16888722Ensembl.1
Natural variantiVAR_032032195K → Q. Corresponds to variant dbSNP:rs1133950Ensembl.1
Natural variantiVAR_032033215P → L. Corresponds to variant dbSNP:rs16888728Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_024874122 – 145DQNLS…IQNTM → YIPRMYTFCTNYGGQQYVID ALIG in isoform 2. 1 PublicationAdd BLAST24
Alternative sequenceiVSP_024875146 – 249Missing in isoform 2. 1 PublicationAdd BLAST104

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK055279 mRNA Translation: BAB70896.1
AK315770 mRNA Translation: BAG38122.1
AC087350 Genomic DNA No translation available.
AP002905 Genomic DNA No translation available.
CH471060 Genomic DNA Translation: EAW91960.1
BC005955 mRNA Translation: AAH05955.1
BC022441 mRNA Translation: AAH22441.1
CCDSiCCDS6320.1 [Q9BRU9-1]
RefSeqiNP_115710.2, NM_032334.2 [Q9BRU9-1]
UniGeneiHs.86970

Genome annotation databases

EnsembliENST00000309822; ENSP00000308332; ENSG00000147679 [Q9BRU9-1]
GeneIDi84294
KEGGihsa:84294
UCSCiuc003yoc.4 human [Q9BRU9-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK055279 mRNA Translation: BAB70896.1
AK315770 mRNA Translation: BAG38122.1
AC087350 Genomic DNA No translation available.
AP002905 Genomic DNA No translation available.
CH471060 Genomic DNA Translation: EAW91960.1
BC005955 mRNA Translation: AAH05955.1
BC022441 mRNA Translation: AAH22441.1
CCDSiCCDS6320.1 [Q9BRU9-1]
RefSeqiNP_115710.2, NM_032334.2 [Q9BRU9-1]
UniGeneiHs.86970

3D structure databases

ProteinModelPortaliQ9BRU9
SMRiQ9BRU9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124021, 42 interactors
IntActiQ9BRU9, 32 interactors
STRINGi9606.ENSP00000308332

PTM databases

iPTMnetiQ9BRU9
PhosphoSitePlusiQ9BRU9

Polymorphism and mutation databases

BioMutaiUTP23
DMDMi296452859

Proteomic databases

EPDiQ9BRU9
MaxQBiQ9BRU9
PaxDbiQ9BRU9
PeptideAtlasiQ9BRU9
PRIDEiQ9BRU9
ProteomicsDBi78838
78839 [Q9BRU9-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000309822; ENSP00000308332; ENSG00000147679 [Q9BRU9-1]
GeneIDi84294
KEGGihsa:84294
UCSCiuc003yoc.4 human [Q9BRU9-1]

Organism-specific databases

CTDi84294
DisGeNETi84294
EuPathDBiHostDB:ENSG00000147679.11
GeneCardsiUTP23
HGNCiHGNC:28224 UTP23
HPAiHPA044418
neXtProtiNX_Q9BRU9
OpenTargetsiENSG00000147679
PharmGKBiPA162408778
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3164 Eukaryota
COG1412 LUCA
GeneTreeiENSGT00550000074848
HOGENOMiHOG000239062
HOVERGENiHBG054456
InParanoidiQ9BRU9
KOiK14773
OMAiYMKEKQG
OrthoDBiEOG091G176S
PhylomeDBiQ9BRU9
TreeFamiTF105804

Miscellaneous databases

ChiTaRSiUTP23 human
GenomeRNAii84294
PROiPR:Q9BRU9

Gene expression databases

BgeeiENSG00000147679 Expressed in 214 organ(s), highest expression level in kidney epithelium
CleanExiHS_UTP23
ExpressionAtlasiQ9BRU9 baseline and differential
GenevisibleiQ9BRU9 HS

Family and domain databases

InterProiView protein in InterPro
IPR006984 Fcf1/Utp23
IPR029060 PIN-like_dom_sf
PfamiView protein in Pfam
PF04900 Fcf1, 1 hit
SUPFAMiSSF88723 SSF88723, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiUTP23_HUMAN
AccessioniPrimary (citable) accession number: Q9BRU9
Secondary accession number(s): B2RE25, Q96NJ8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: May 18, 2010
Last modified: September 12, 2018
This is version 124 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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