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Entry version 138 (16 Jan 2019)
Sequence version 1 (01 Jun 2001)
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Protein

COBW domain-containing protein 1

Gene

CBWD1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi49 – 56ATPSequence analysis8
Nucleotide bindingi110 – 114ATPSequence analysis5
Nucleotide bindingi203 – 206ATPSequence analysis4

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandATP-binding, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
COBW domain-containing protein 1
Alternative name(s):
Cobalamin synthase W domain-containing protein 1
Short name:
COBP
NPC-A-6 COBW domain-containing protein 1
Short name:
NPC-A-6
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CBWD1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000172785.18

Human Gene Nomenclature Database

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HGNCi
HGNC:17134 CBWD1

Online Mendelian Inheritance in Man (OMIM)

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MIMi
611078 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9BRT8

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000172785

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA26124

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
CBWD1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74752288

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002455231 – 395COBW domain-containing protein 1Add BLAST395

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q9BRT8

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q9BRT8

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9BRT8

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9BRT8

PeptideAtlas

More...
PeptideAtlasi
Q9BRT8

PRoteomics IDEntifications database

More...
PRIDEi
Q9BRT8

ProteomicsDB human proteome resource

More...
ProteomicsDBi
78831
78832 [Q9BRT8-2]
78833 [Q9BRT8-3]
78834 [Q9BRT8-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9BRT8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9BRT8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitously expressed. Up-regulated in cultured astrocytes treated with dopamine.1 Publication

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Increased expression in response to dopamine treatment. Down-regulated by ZNF658 in response to zinc.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000172785 Expressed in 90 organ(s), highest expression level in adrenal tissue

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q9BRT8 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q9BRT8 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA042759
HPA042813

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
120970, 106 interactors

Protein interaction database and analysis system

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IntActi
Q9BRT8, 9 interactors

STRING: functional protein association networks

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STRINGi
9606.ENSP00000348915

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q9BRT8

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q9BRT8

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini274 – 377CobW C-terminalAdd BLAST104

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG2743 Eukaryota
COG0523 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000164995

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG056297

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q9BRT8

Identification of Orthologs from Complete Genome Data

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OMAi
HDCHDHH

Database of Orthologous Groups

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OrthoDBi
1144889at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q9BRT8

TreeFam database of animal gene trees

More...
TreeFami
TF332679

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
3.30.1220.10, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR011629 Cbl_biosynth_CobW-like_C
IPR036627 CobW-likC_sf
IPR003495 CobW/HypB/UreG_dom
IPR027417 P-loop_NTPase

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02492 cobW, 1 hit
PF07683 CobW_C, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540 SSF52540, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 11 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9BRT8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLPAVGSADE EEDPAEEDCP ELVPIETTQS EEEEKSGLGA KIPVTIITGY
60 70 80 90 100
LGAGKTTLLN YILTEQHSKR VAVILNEFGE GSALEKSLAV SQGGELYEEW
110 120 130 140 150
LELRNGCLCC SVKDSGLRAI ENLMQKKGKF DYILLETTGL ADPGAVASMF
160 170 180 190 200
WVDAELGSDI YLDGIITIVD SKYGLKHLTE EKPDGLINEA TRQVALADAI
210 220 230 240 250
LINKTDLVPE EDVKKLRTTI RSINGLGQIL ETQRSRVDLS NVLDLHAFDS
260 270 280 290 300
LSGISLQKKL QHVPGTQPHL DQSIVTITFE VPGNAKEEHL NMFIQNLLWE
310 320 330 340 350
KNVRNKDNHC MEVIRLKGLV SIKDKSQQVI VQGVHELYDL EETPVSWKDD
360 370 380 390
TERTNRLVLL GRNLDKDILK QLFIATVTET EKQWTTRFQE DQVCT
Length:395
Mass (Da):44,068
Last modified:June 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA3E04537A6698C6E
GO
Isoform 2 (identifier: Q9BRT8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-36: Missing.
     37-51: GLGAKIPVTIITGYL → MYFKRAARAFPVLLT

Show »
Length:359
Mass (Da):40,420
Checksum:i9928D6FBA10020A9
GO
Isoform 3 (identifier: Q9BRT8-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     236-254: Missing.

Note: No experimental confirmation available.
Show »
Length:376
Mass (Da):42,015
Checksum:iCA0A21FFE9F924F4
GO
Isoform 4 (identifier: Q9BRT8-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     114-395: Missing.

Note: No experimental confirmation available.
Show »
Length:113
Mass (Da):12,172
Checksum:i52695BDF92C6CFD9
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 11 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087X140A0A087X140_HUMAN
COBW domain-containing protein 1
CBWD1
347Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F2Z2T4F2Z2T4_HUMAN
COBW domain-containing protein 1
CBWD1
250Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WZQ3A0A087WZQ3_HUMAN
COBW domain-containing protein 1
CBWD1
180Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0B4J1T6A0A0B4J1T6_HUMAN
COBW domain-containing protein 1
CBWD1
77Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WVU7A0A087WVU7_HUMAN
COBW domain-containing protein 1
CBWD1
50Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WTC0A0A087WTC0_HUMAN
COBW domain-containing protein 1
CBWD1
160Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WY70A0A087WY70_HUMAN
COBW domain-containing protein 1
CBWD1
58Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WU37A0A087WU37_HUMAN
COBW domain-containing protein 1
CBWD1
93Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087X0Y9A0A087X0Y9_HUMAN
COBW domain-containing protein 1
CBWD1
28Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WWK6A0A087WWK6_HUMAN
COBW domain-containing protein 1
CBWD1
38Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There is more potential isoformShow all

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti25I → M in AAF68990 (PubMed:11489251).Curated1
Sequence conflicti25I → M in AAK14935 (PubMed:10931946).Curated1
Sequence conflicti115S → N in AAF68990 (PubMed:11489251).Curated1
Sequence conflicti387 – 389RFQ → HFK in AAK14935 (PubMed:10931946).Curated3

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0269798A → V2 PublicationsCorresponds to variant dbSNP:rs16925054Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0197311 – 36Missing in isoform 2. 2 PublicationsAdd BLAST36
Alternative sequenceiVSP_01973237 – 51GLGAK…ITGYL → MYFKRAARAFPVLLT in isoform 2. 2 PublicationsAdd BLAST15
Alternative sequenceiVSP_019733114 – 395Missing in isoform 4. 1 PublicationAdd BLAST282
Alternative sequenceiVSP_019734236 – 254Missing in isoform 3. 1 PublicationAdd BLAST19

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF257330 mRNA Translation: AAF68990.2
AY343911 mRNA Translation: AAQ76869.1
AY320414 mRNA Translation: AAP73813.1
AF212253 mRNA Translation: AAK14935.1
AK315855 mRNA Translation: BAF98746.1
AK290648 mRNA Translation: BAF83337.1
AL356244 Genomic DNA No translation available.
AL449043 Genomic DNA No translation available.
BC005996 mRNA Translation: AAH05996.1
BC009573 mRNA Translation: AAH09573.1
BC013432 mRNA Translation: AAH13432.1
BC132759 mRNA Translation: AAI32760.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS47947.1 [Q9BRT8-3]
CCDS47948.1 [Q9BRT8-2]
CCDS6438.1 [Q9BRT8-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001138827.1, NM_001145355.1 [Q9BRT8-2]
NP_001138828.1, NM_001145356.1 [Q9BRT8-3]
NP_060961.3, NM_018491.3 [Q9BRT8-1]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.531330
Hs.567539
Hs.645337

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000314367; ENSP00000323433; ENSG00000172785 [Q9BRT8-2]
ENST00000356521; ENSP00000348915; ENSG00000172785 [Q9BRT8-1]
ENST00000377400; ENSP00000366617; ENSG00000172785 [Q9BRT8-1]
ENST00000382393; ENSP00000371830; ENSG00000172785 [Q9BRT8-4]
ENST00000382447; ENSP00000371885; ENSG00000172785 [Q9BRT8-3]

Database of genes from NCBI RefSeq genomes

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GeneIDi
55871

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:55871

UCSC genome browser

More...
UCSCi
uc003zga.5 human [Q9BRT8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF257330 mRNA Translation: AAF68990.2
AY343911 mRNA Translation: AAQ76869.1
AY320414 mRNA Translation: AAP73813.1
AF212253 mRNA Translation: AAK14935.1
AK315855 mRNA Translation: BAF98746.1
AK290648 mRNA Translation: BAF83337.1
AL356244 Genomic DNA No translation available.
AL449043 Genomic DNA No translation available.
BC005996 mRNA Translation: AAH05996.1
BC009573 mRNA Translation: AAH09573.1
BC013432 mRNA Translation: AAH13432.1
BC132759 mRNA Translation: AAI32760.1
CCDSiCCDS47947.1 [Q9BRT8-3]
CCDS47948.1 [Q9BRT8-2]
CCDS6438.1 [Q9BRT8-1]
RefSeqiNP_001138827.1, NM_001145355.1 [Q9BRT8-2]
NP_001138828.1, NM_001145356.1 [Q9BRT8-3]
NP_060961.3, NM_018491.3 [Q9BRT8-1]
UniGeneiHs.531330
Hs.567539
Hs.645337

3D structure databases

ProteinModelPortaliQ9BRT8
SMRiQ9BRT8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120970, 106 interactors
IntActiQ9BRT8, 9 interactors
STRINGi9606.ENSP00000348915

PTM databases

iPTMnetiQ9BRT8
PhosphoSitePlusiQ9BRT8

Polymorphism and mutation databases

BioMutaiCBWD1
DMDMi74752288

Proteomic databases

EPDiQ9BRT8
jPOSTiQ9BRT8
MaxQBiQ9BRT8
PaxDbiQ9BRT8
PeptideAtlasiQ9BRT8
PRIDEiQ9BRT8
ProteomicsDBi78831
78832 [Q9BRT8-2]
78833 [Q9BRT8-3]
78834 [Q9BRT8-4]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
55871
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000314367; ENSP00000323433; ENSG00000172785 [Q9BRT8-2]
ENST00000356521; ENSP00000348915; ENSG00000172785 [Q9BRT8-1]
ENST00000377400; ENSP00000366617; ENSG00000172785 [Q9BRT8-1]
ENST00000382393; ENSP00000371830; ENSG00000172785 [Q9BRT8-4]
ENST00000382447; ENSP00000371885; ENSG00000172785 [Q9BRT8-3]
GeneIDi55871
KEGGihsa:55871
UCSCiuc003zga.5 human [Q9BRT8-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
55871
EuPathDBiHostDB:ENSG00000172785.18

GeneCards: human genes, protein and diseases

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GeneCardsi
CBWD1
HGNCiHGNC:17134 CBWD1
HPAiHPA042759
HPA042813
MIMi611078 gene
neXtProtiNX_Q9BRT8
OpenTargetsiENSG00000172785
PharmGKBiPA26124

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2743 Eukaryota
COG0523 LUCA
GeneTreeiENSGT00940000164995
HOVERGENiHBG056297
InParanoidiQ9BRT8
OMAiHDCHDHH
OrthoDBi1144889at2759
PhylomeDBiQ9BRT8
TreeFamiTF332679

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
CBWD1 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
CBWD1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
55871

Protein Ontology

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PROi
PR:Q9BRT8

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000172785 Expressed in 90 organ(s), highest expression level in adrenal tissue
ExpressionAtlasiQ9BRT8 baseline and differential
GenevisibleiQ9BRT8 HS

Family and domain databases

Gene3Di3.30.1220.10, 1 hit
InterProiView protein in InterPro
IPR011629 Cbl_biosynth_CobW-like_C
IPR036627 CobW-likC_sf
IPR003495 CobW/HypB/UreG_dom
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF02492 cobW, 1 hit
PF07683 CobW_C, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCBWD1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9BRT8
Secondary accession number(s): A2RU55
, A8K3N3, B0AZR4, Q49AJ1, Q5VVK2, Q6VBU6, Q7Z5Z0, Q7Z652, Q9BY38, Q9NYD0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: June 1, 2001
Last modified: January 16, 2019
This is version 138 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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