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Protein

La-related protein 6

Gene

LARP6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regulates the coordinated translation of type I collagen alpha-1 and alpha-2 mRNAs, CO1A1 and CO1A2. Stabilizes mRNAs through high-affinity binding of a stem-loop structure in their 5' UTR. This regulation requires VIM and MYH10 filaments, and the helicase DHX9.3 Publications

GO - Molecular functioni

  • mRNA 5'-UTR binding Source: UniProtKB
  • myosin binding Source: UniProtKB
  • RNA stem-loop binding Source: UniProtKB
  • sequence-specific mRNA binding Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionRNA-binding
Biological processTranslation regulation

Names & Taxonomyi

Protein namesi
Recommended name:
La-related protein 6
Alternative name(s):
Acheron
Short name:
Achn
La ribonucleoprotein domain family member 6
Gene namesi
Name:LARP6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

EuPathDBiHostDB:ENSG00000166173.10
HGNCiHGNC:24012 LARP6
MIMi611300 gene
neXtProtiNX_Q9BRS8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi55323
OpenTargetsiENSG00000166173
PharmGKBiPA142671568

Polymorphism and mutation databases

BioMutaiLARP6
DMDMi74752287

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00002811412 – 491La-related protein 6Add BLAST490

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei56PhosphoserineCombined sources1
Modified residuei58PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9BRS8
MaxQBiQ9BRS8
PaxDbiQ9BRS8
PeptideAtlasiQ9BRS8
PRIDEiQ9BRS8
ProteomicsDBi78825
78826 [Q9BRS8-2]

PTM databases

iPTMnetiQ9BRS8
PhosphoSitePlusiQ9BRS8

Expressioni

Tissue specificityi

Expressed in numerous tissues.1 Publication

Gene expression databases

BgeeiENSG00000166173 Expressed in 215 organ(s), highest expression level in left testis
CleanExiHS_LARP6
ExpressionAtlasiQ9BRS8 baseline and differential
GenevisibleiQ9BRS8 HS

Organism-specific databases

HPAiHPA020338
HPA049029

Interactioni

Subunit structurei

Interacts (via the HTH domain) with VIM/vimentin. Interacts (via C-terminus) with non-muscle myosin MYH10. Interacts (via C-terminus) with DHX9.3 Publications

GO - Molecular functioni

Protein-protein interaction databases

BioGridi120604, 5 interactors
STRINGi9606.ENSP00000299213

Structurei

Secondary structure

1491
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ9BRS8
SMRiQ9BRS8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini86 – 177HTH La-type RNA-bindingPROSITE-ProRule annotationAdd BLAST92
Domaini184 – 296RRMAdd BLAST113

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi186 – 193Nuclear export signal8
Motifi296 – 302Nuclear localization signal7

Domaini

The RRM domain mediates the association with collagen mRNAs stem-loops.

Phylogenomic databases

eggNOGiKOG1855 Eukaryota
ENOG4110VUA LUCA
GeneTreeiENSGT00830000128323
HOGENOMiHOG000010108
HOVERGENiHBG070244
InParanoidiQ9BRS8
KOiK18733
OMAiHERGRAC
OrthoDBiEOG091G09LP
PhylomeDBiQ9BRS8
TreeFamiTF326594

Family and domain databases

CDDicd12289 RRM_LARP6, 1 hit
Gene3Di1.10.10.10, 1 hit
3.30.70.330, 1 hit
InterProiView protein in InterPro
IPR006630 La_HTH
IPR034886 LARP6
IPR034880 LARP6_RRM
IPR002344 Lupus_La
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR024642 SUZ-C
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PANTHERiPTHR22792:SF71 PTHR22792:SF71, 1 hit
PfamiView protein in Pfam
PF05383 La, 1 hit
PF12901 SUZ-C, 1 hit
PRINTSiPR00302 LUPUSLA
SMARTiView protein in SMART
SM00715 LA, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
SSF54928 SSF54928, 1 hit
PROSITEiView protein in PROSITE
PS50961 HTH_LA, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9BRS8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAQSGGEARP GPKTAVQIRV AIQEAEDVDE LEDEEEGAET RGAGDPARYL
60 70 80 90 100
SPGWGSASEE EPSRGHSGTT ASGGENERED LEQEWKPPDE ELIKKLVDQI
110 120 130 140 150
EFYFSDENLE KDAFLLKHVR RNKLGYVSVK LLTSFKKVKH LTRDWRTTAH
160 170 180 190 200
ALKYSVVLEL NEDHRKVRRT TPVPLFPNEN LPSKMLLVYD LYLSPKLWAL
210 220 230 240 250
ATPQKNGRVQ EKVMEHLLKL FGTFGVISSV RILKPGRELP PDIRRISSRY
260 270 280 290 300
SQVGTQECAI VEFEEVEAAI KAHEFMITES QGKENMKAVL IGMKPPKKKP
310 320 330 340 350
AKDKNHDEEP TASIHLNKSL NKRVEELQYM GDESSANSSS DPESNPTSPM
360 370 380 390 400
AGRRHAATNK LSPSGHQNLF LSPNASPCTS PWSSPLAQRK GVSRKSPLAE
410 420 430 440 450
EGRLNCSTSP EIFRKCMDYS SDSSVTPSGS PWVRRRRQAE MGTQEKSPGT
460 470 480 490
SPLLSRKMQT ADGLPVGVLR LPRGPDNTRG FHGHERSRAC V
Length:491
Mass (Da):54,737
Last modified:June 1, 2001 - v1
Checksum:i2CF3AFFFD69BDD07
GO
Isoform 2 (identifier: Q9BRS8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     67-491: SGTTASGGEN...HGHERSRACV → RNRSSVNSRTMLASFIVSSAPSTAPST

Note: No experimental confirmation available.
Show »
Length:93
Mass (Da):9,773
Checksum:i88CB7691294B6FD8
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YMC6H0YMC6_HUMAN
La-related protein 6
LARP6
78Annotation score:
K7EPD2K7EPD2_HUMAN
La-related protein 6
LARP6
31Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti103Y → C in BAA92061 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_04256567 – 491SGTTA…SRACV → RNRSSVNSRTMLASFIVSSA PSTAPST in isoform 2. 1 PublicationAdd BLAST425

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF443828 mRNA Translation: AAN76710.1
AF443829 mRNA Translation: AAN76711.1
AK002058 mRNA Translation: BAA92061.1
AL833876 mRNA Translation: CAD38733.2
AC009269 Genomic DNA No translation available.
AC090868 Genomic DNA No translation available.
BC006082 mRNA Translation: AAH06082.1
BC009446 mRNA Translation: AAH09446.1
BC014018 mRNA Translation: AAH14018.1
BC039153 mRNA Translation: AAH39153.1
CCDSiCCDS10236.1 [Q9BRS8-2]
CCDS32281.1 [Q9BRS8-1]
RefSeqiNP_001273608.1, NM_001286679.1
NP_060827.2, NM_018357.3 [Q9BRS8-1]
NP_932062.1, NM_197958.2 [Q9BRS8-2]
UniGeneiHs.416755

Genome annotation databases

EnsembliENST00000299213; ENSP00000299213; ENSG00000166173 [Q9BRS8-1]
ENST00000344870; ENSP00000343869; ENSG00000166173 [Q9BRS8-2]
GeneIDi55323
KEGGihsa:55323
UCSCiuc002ass.5 human [Q9BRS8-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF443828 mRNA Translation: AAN76710.1
AF443829 mRNA Translation: AAN76711.1
AK002058 mRNA Translation: BAA92061.1
AL833876 mRNA Translation: CAD38733.2
AC009269 Genomic DNA No translation available.
AC090868 Genomic DNA No translation available.
BC006082 mRNA Translation: AAH06082.1
BC009446 mRNA Translation: AAH09446.1
BC014018 mRNA Translation: AAH14018.1
BC039153 mRNA Translation: AAH39153.1
CCDSiCCDS10236.1 [Q9BRS8-2]
CCDS32281.1 [Q9BRS8-1]
RefSeqiNP_001273608.1, NM_001286679.1
NP_060827.2, NM_018357.3 [Q9BRS8-1]
NP_932062.1, NM_197958.2 [Q9BRS8-2]
UniGeneiHs.416755

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2MTFNMR-A70-183[»]
2MTGNMR-A178-295[»]
ProteinModelPortaliQ9BRS8
SMRiQ9BRS8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120604, 5 interactors
STRINGi9606.ENSP00000299213

PTM databases

iPTMnetiQ9BRS8
PhosphoSitePlusiQ9BRS8

Polymorphism and mutation databases

BioMutaiLARP6
DMDMi74752287

Proteomic databases

EPDiQ9BRS8
MaxQBiQ9BRS8
PaxDbiQ9BRS8
PeptideAtlasiQ9BRS8
PRIDEiQ9BRS8
ProteomicsDBi78825
78826 [Q9BRS8-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000299213; ENSP00000299213; ENSG00000166173 [Q9BRS8-1]
ENST00000344870; ENSP00000343869; ENSG00000166173 [Q9BRS8-2]
GeneIDi55323
KEGGihsa:55323
UCSCiuc002ass.5 human [Q9BRS8-1]

Organism-specific databases

CTDi55323
DisGeNETi55323
EuPathDBiHostDB:ENSG00000166173.10
GeneCardsiLARP6
HGNCiHGNC:24012 LARP6
HPAiHPA020338
HPA049029
MIMi611300 gene
neXtProtiNX_Q9BRS8
OpenTargetsiENSG00000166173
PharmGKBiPA142671568
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1855 Eukaryota
ENOG4110VUA LUCA
GeneTreeiENSGT00830000128323
HOGENOMiHOG000010108
HOVERGENiHBG070244
InParanoidiQ9BRS8
KOiK18733
OMAiHERGRAC
OrthoDBiEOG091G09LP
PhylomeDBiQ9BRS8
TreeFamiTF326594

Miscellaneous databases

ChiTaRSiLARP6 human
GeneWikiiLARP6
GenomeRNAii55323
PROiPR:Q9BRS8
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000166173 Expressed in 215 organ(s), highest expression level in left testis
CleanExiHS_LARP6
ExpressionAtlasiQ9BRS8 baseline and differential
GenevisibleiQ9BRS8 HS

Family and domain databases

CDDicd12289 RRM_LARP6, 1 hit
Gene3Di1.10.10.10, 1 hit
3.30.70.330, 1 hit
InterProiView protein in InterPro
IPR006630 La_HTH
IPR034886 LARP6
IPR034880 LARP6_RRM
IPR002344 Lupus_La
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR024642 SUZ-C
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PANTHERiPTHR22792:SF71 PTHR22792:SF71, 1 hit
PfamiView protein in Pfam
PF05383 La, 1 hit
PF12901 SUZ-C, 1 hit
PRINTSiPR00302 LUPUSLA
SMARTiView protein in SMART
SM00715 LA, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
SSF54928 SSF54928, 1 hit
PROSITEiView protein in PROSITE
PS50961 HTH_LA, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiLARP6_HUMAN
AccessioniPrimary (citable) accession number: Q9BRS8
Secondary accession number(s): Q5XKE4, Q8N3N2, Q9NUR0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: June 1, 2001
Last modified: November 7, 2018
This is version 146 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
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