UniProtKB - Q9BRS8 (LARP6_HUMAN)
Protein
La-related protein 6
Gene
LARP6
Organism
Homo sapiens (Human)
Status
Functioni
Regulates the coordinated translation of type I collagen alpha-1 and alpha-2 mRNAs, CO1A1 and CO1A2. Stabilizes mRNAs through high-affinity binding of a stem-loop structure in their 5' UTR. This regulation requires VIM and MYH10 filaments, and the helicase DHX9.3 Publications
GO - Molecular functioni
- mRNA 5'-UTR binding Source: UniProtKB
- myosin binding Source: UniProtKB
- RNA stem-loop binding Source: UniProtKB
- sequence-specific mRNA binding Source: UniProtKB
GO - Biological processi
- positive regulation of collagen biosynthetic process Source: UniProtKB
- positive regulation of mRNA binding Source: UniProtKB
- positive regulation of translation Source: UniProtKB
- RNA processing Source: InterPro
Keywordsi
Molecular function | RNA-binding |
Biological process | Translation regulation |
Enzyme and pathway databases
PathwayCommonsi | Q9BRS8 |
Names & Taxonomyi
Protein namesi | Recommended name: La-related protein 6Alternative name(s): Acheron Short name: Achn La ribonucleoprotein domain family member 6 |
Gene namesi | Name:LARP6 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:24012, LARP6 |
MIMi | 611300, gene |
neXtProti | NX_Q9BRS8 |
VEuPathDBi | HostDB:ENSG00000166173.10 |
Subcellular locationi
Nucleus
- nucleus Source: UniProtKB
Other locations
- cytoplasm Source: UniProtKB-SubCell
- polysome Source: UniProtKB
- ribonucleoprotein complex Source: UniProtKB
Keywords - Cellular componenti
Cytoplasm, NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 55323 |
OpenTargetsi | ENSG00000166173 |
PharmGKBi | PA142671568 |
Miscellaneous databases
Pharosi | Q9BRS8, Tbio |
Genetic variation databases
BioMutai | LARP6 |
DMDMi | 74752287 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedCombined sources | |||
ChainiPRO_0000281141 | 2 – 491 | La-related protein 6Add BLAST | 490 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylalanineCombined sources | 1 | |
Modified residuei | 56 | PhosphoserineCombined sources | 1 | |
Modified residuei | 58 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
EPDi | Q9BRS8 |
jPOSTi | Q9BRS8 |
MassIVEi | Q9BRS8 |
MaxQBi | Q9BRS8 |
PaxDbi | Q9BRS8 |
PeptideAtlasi | Q9BRS8 |
PRIDEi | Q9BRS8 |
ProteomicsDBi | 78825 [Q9BRS8-1] 78826 [Q9BRS8-2] |
PTM databases
GlyConnecti | 1953, 5 N-Linked glycans (1 site) |
GlyGeni | Q9BRS8, 1 site |
iPTMneti | Q9BRS8 |
PhosphoSitePlusi | Q9BRS8 |
Expressioni
Tissue specificityi
Expressed in numerous tissues.1 Publication
Gene expression databases
Bgeei | ENSG00000166173, Expressed in left testis and 227 other tissues |
ExpressionAtlasi | Q9BRS8, baseline and differential |
Genevisiblei | Q9BRS8, HS |
Organism-specific databases
HPAi | ENSG00000166173, Low tissue specificity |
Interactioni
Subunit structurei
Interacts (via the HTH domain) with VIM/vimentin.
Interacts (via C-terminus) with non-muscle myosin MYH10.
Interacts (via C-terminus) with DHX9.
3 PublicationsGO - Molecular functioni
- myosin binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 120604, 5 interactors |
IntActi | Q9BRS8, 1 interactor |
STRINGi | 9606.ENSP00000299213 |
Miscellaneous databases
RNActi | Q9BRS8, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
BMRBi | Q9BRS8 |
SMRi | Q9BRS8 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 86 – 177 | HTH La-type RNA-bindingPROSITE-ProRule annotationAdd BLAST | 92 | |
Domaini | 184 – 296 | RRMAdd BLAST | 113 | |
Domaini | 427 – 485 | SUZ-CPROSITE-ProRule annotationAdd BLAST | 59 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 186 – 193 | Nuclear export signal | 8 | |
Motifi | 296 – 302 | Nuclear localization signal | 7 |
Domaini
The RRM domain mediates the association with collagen mRNAs stem-loops.
Phylogenomic databases
eggNOGi | KOG1855, Eukaryota |
GeneTreei | ENSGT00940000159103 |
HOGENOMi | CLU_015330_1_0_1 |
InParanoidi | Q9BRS8 |
OMAi | PHSHKSP |
OrthoDBi | 1179659at2759 |
PhylomeDBi | Q9BRS8 |
TreeFami | TF326594 |
Family and domain databases
CDDi | cd12289, RRM_LARP6, 1 hit |
Gene3Di | 1.10.10.10, 1 hit 3.30.70.330, 1 hit |
InterProi | View protein in InterPro IPR006630, La_HTH IPR034886, LARP6 IPR034880, LARP6_RRM IPR002344, Lupus_La IPR012677, Nucleotide-bd_a/b_plait_sf IPR035979, RBD_domain_sf IPR024642, SUZ-C IPR036388, WH-like_DNA-bd_sf IPR036390, WH_DNA-bd_sf |
PANTHERi | PTHR22792:SF71, PTHR22792:SF71, 1 hit |
Pfami | View protein in Pfam PF05383, La, 1 hit PF12901, SUZ-C, 1 hit |
PRINTSi | PR00302, LUPUSLA |
SMARTi | View protein in SMART SM00715, LA, 1 hit |
SUPFAMi | SSF46785, SSF46785, 1 hit SSF54928, SSF54928, 1 hit |
PROSITEi | View protein in PROSITE PS50961, HTH_LA, 1 hit PS51938, SUZ_C, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q9BRS8-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAQSGGEARP GPKTAVQIRV AIQEAEDVDE LEDEEEGAET RGAGDPARYL
60 70 80 90 100
SPGWGSASEE EPSRGHSGTT ASGGENERED LEQEWKPPDE ELIKKLVDQI
110 120 130 140 150
EFYFSDENLE KDAFLLKHVR RNKLGYVSVK LLTSFKKVKH LTRDWRTTAH
160 170 180 190 200
ALKYSVVLEL NEDHRKVRRT TPVPLFPNEN LPSKMLLVYD LYLSPKLWAL
210 220 230 240 250
ATPQKNGRVQ EKVMEHLLKL FGTFGVISSV RILKPGRELP PDIRRISSRY
260 270 280 290 300
SQVGTQECAI VEFEEVEAAI KAHEFMITES QGKENMKAVL IGMKPPKKKP
310 320 330 340 350
AKDKNHDEEP TASIHLNKSL NKRVEELQYM GDESSANSSS DPESNPTSPM
360 370 380 390 400
AGRRHAATNK LSPSGHQNLF LSPNASPCTS PWSSPLAQRK GVSRKSPLAE
410 420 430 440 450
EGRLNCSTSP EIFRKCMDYS SDSSVTPSGS PWVRRRRQAE MGTQEKSPGT
460 470 480 490
SPLLSRKMQT ADGLPVGVLR LPRGPDNTRG FHGHERSRAC V
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketH0YMC6 | H0YMC6_HUMAN | La-related protein 6 | LARP6 | 78 | Annotation score: | ||
K7EPD2 | K7EPD2_HUMAN | La-related protein 6 | LARP6 | 31 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 103 | Y → C in BAA92061 (PubMed:14702039).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_042565 | 67 – 491 | SGTTA…SRACV → RNRSSVNSRTMLASFIVSSA PSTAPST in isoform 2. 1 PublicationAdd BLAST | 425 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF443828 mRNA Translation: AAN76710.1 AF443829 mRNA Translation: AAN76711.1 AK002058 mRNA Translation: BAA92061.1 AL833876 mRNA Translation: CAD38733.2 AC009269 Genomic DNA No translation available. AC090868 Genomic DNA No translation available. BC006082 mRNA Translation: AAH06082.1 BC009446 mRNA Translation: AAH09446.1 BC014018 mRNA Translation: AAH14018.1 BC039153 mRNA Translation: AAH39153.1 |
CCDSi | CCDS10236.1 [Q9BRS8-2] CCDS32281.1 [Q9BRS8-1] |
RefSeqi | NP_001273608.1, NM_001286679.1 NP_060827.2, NM_018357.3 [Q9BRS8-1] NP_932062.1, NM_197958.2 [Q9BRS8-2] |
Genome annotation databases
Ensembli | ENST00000299213; ENSP00000299213; ENSG00000166173 [Q9BRS8-1] ENST00000344870; ENSP00000343869; ENSG00000166173 [Q9BRS8-2] |
GeneIDi | 55323 |
KEGGi | hsa:55323 |
UCSCi | uc002ass.5, human [Q9BRS8-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF443828 mRNA Translation: AAN76710.1 AF443829 mRNA Translation: AAN76711.1 AK002058 mRNA Translation: BAA92061.1 AL833876 mRNA Translation: CAD38733.2 AC009269 Genomic DNA No translation available. AC090868 Genomic DNA No translation available. BC006082 mRNA Translation: AAH06082.1 BC009446 mRNA Translation: AAH09446.1 BC014018 mRNA Translation: AAH14018.1 BC039153 mRNA Translation: AAH39153.1 |
CCDSi | CCDS10236.1 [Q9BRS8-2] CCDS32281.1 [Q9BRS8-1] |
RefSeqi | NP_001273608.1, NM_001286679.1 NP_060827.2, NM_018357.3 [Q9BRS8-1] NP_932062.1, NM_197958.2 [Q9BRS8-2] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2MTF | NMR | - | A | 70-183 | [»] | |
2MTG | NMR | - | A | 178-295 | [»] | |
BMRBi | Q9BRS8 | |||||
SMRi | Q9BRS8 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 120604, 5 interactors |
IntActi | Q9BRS8, 1 interactor |
STRINGi | 9606.ENSP00000299213 |
PTM databases
GlyConnecti | 1953, 5 N-Linked glycans (1 site) |
GlyGeni | Q9BRS8, 1 site |
iPTMneti | Q9BRS8 |
PhosphoSitePlusi | Q9BRS8 |
Genetic variation databases
BioMutai | LARP6 |
DMDMi | 74752287 |
Proteomic databases
EPDi | Q9BRS8 |
jPOSTi | Q9BRS8 |
MassIVEi | Q9BRS8 |
MaxQBi | Q9BRS8 |
PaxDbi | Q9BRS8 |
PeptideAtlasi | Q9BRS8 |
PRIDEi | Q9BRS8 |
ProteomicsDBi | 78825 [Q9BRS8-1] 78826 [Q9BRS8-2] |
Protocols and materials databases
Antibodypediai | 14073, 126 antibodies |
Genome annotation databases
Ensembli | ENST00000299213; ENSP00000299213; ENSG00000166173 [Q9BRS8-1] ENST00000344870; ENSP00000343869; ENSG00000166173 [Q9BRS8-2] |
GeneIDi | 55323 |
KEGGi | hsa:55323 |
UCSCi | uc002ass.5, human [Q9BRS8-1] |
Organism-specific databases
CTDi | 55323 |
DisGeNETi | 55323 |
GeneCardsi | LARP6 |
HGNCi | HGNC:24012, LARP6 |
HPAi | ENSG00000166173, Low tissue specificity |
MIMi | 611300, gene |
neXtProti | NX_Q9BRS8 |
OpenTargetsi | ENSG00000166173 |
PharmGKBi | PA142671568 |
VEuPathDBi | HostDB:ENSG00000166173.10 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1855, Eukaryota |
GeneTreei | ENSGT00940000159103 |
HOGENOMi | CLU_015330_1_0_1 |
InParanoidi | Q9BRS8 |
OMAi | PHSHKSP |
OrthoDBi | 1179659at2759 |
PhylomeDBi | Q9BRS8 |
TreeFami | TF326594 |
Enzyme and pathway databases
PathwayCommonsi | Q9BRS8 |
Miscellaneous databases
BioGRID-ORCSi | 55323, 9 hits in 991 CRISPR screens |
ChiTaRSi | LARP6, human |
GeneWikii | LARP6 |
GenomeRNAii | 55323 |
Pharosi | Q9BRS8, Tbio |
PROi | PR:Q9BRS8 |
RNActi | Q9BRS8, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000166173, Expressed in left testis and 227 other tissues |
ExpressionAtlasi | Q9BRS8, baseline and differential |
Genevisiblei | Q9BRS8, HS |
Family and domain databases
CDDi | cd12289, RRM_LARP6, 1 hit |
Gene3Di | 1.10.10.10, 1 hit 3.30.70.330, 1 hit |
InterProi | View protein in InterPro IPR006630, La_HTH IPR034886, LARP6 IPR034880, LARP6_RRM IPR002344, Lupus_La IPR012677, Nucleotide-bd_a/b_plait_sf IPR035979, RBD_domain_sf IPR024642, SUZ-C IPR036388, WH-like_DNA-bd_sf IPR036390, WH_DNA-bd_sf |
PANTHERi | PTHR22792:SF71, PTHR22792:SF71, 1 hit |
Pfami | View protein in Pfam PF05383, La, 1 hit PF12901, SUZ-C, 1 hit |
PRINTSi | PR00302, LUPUSLA |
SMARTi | View protein in SMART SM00715, LA, 1 hit |
SUPFAMi | SSF46785, SSF46785, 1 hit SSF54928, SSF54928, 1 hit |
PROSITEi | View protein in PROSITE PS50961, HTH_LA, 1 hit PS51938, SUZ_C, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | LARP6_HUMAN | |
Accessioni | Q9BRS8Primary (citable) accession number: Q9BRS8 Secondary accession number(s): Q5XKE4, Q8N3N2, Q9NUR0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 20, 2007 |
Last sequence update: | June 1, 2001 | |
Last modified: | April 7, 2021 | |
This is version 161 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 15
Human chromosome 15: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references