UniProtKB - Q9BRS8 (LARP6_HUMAN)

BLAST

>sp|Q9BRS8|LARP6_HUMAN La-related protein 6 OS=Homo sapiens OX=9606 GN=LARP6 PE=1 SV=1
MAQSGGEARPGPKTAVQIRVAIQEAEDVDELEDEEEGAETRGAGDPARYLSPGWGSASEE
EPSRGHSGTTASGGENEREDLEQEWKPPDEELIKKLVDQIEFYFSDENLEKDAFLLKHVR
RNKLGYVSVKLLTSFKKVKHLTRDWRTTAHALKYSVVLELNEDHRKVRRTTPVPLFPNEN
LPSKMLLVYDLYLSPKLWALATPQKNGRVQEKVMEHLLKLFGTFGVISSVRILKPGRELP
PDIRRISSRYSQVGTQECAIVEFEEVEAAIKAHEFMITESQGKENMKAVLIGMKPPKKKP
AKDKNHDEEPTASIHLNKSLNKRVEELQYMGDESSANSSSDPESNPTSPMAGRRHAATNK
LSPSGHQNLFLSPNASPCTSPWSSPLAQRKGVSRKSPLAEEGRLNCSTSPEIFRKCMDYS
SDSSVTPSGSPWVRRRRQAEMGTQEKSPGTSPLLSRKMQTADGLPVGVLRLPRGPDNTRG
FHGHERSRACV

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History
Entry version 146 (07 Nov 2018)
Sequence version 1 (01 Jun 2001)
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Protein

La-related protein 6

Gene

LARP6

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Regulates the coordinated translation of type I collagen alpha-1 and alpha-2 mRNAs, CO1A1 and CO1A2. Stabilizes mRNAs through high-affinity binding of a stem-loop structure in their 5' UTR. This regulation requires VIM and MYH10 filaments, and the helicase DHX9.3 Publications

GO - Molecular functionⁱ

mRNA 5'-UTR binding
Source: UniProtKB
Inferred from direct assayⁱ
- 20603131
- 22190748
myosin binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 20603131
RNA stem-loop binding
Source: UniProtKB
Inferred from direct assayⁱ
- 20603131
sequence-specific mRNA binding
Source: UniProtKB
Inferred from direct assayⁱ
- 22190748

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

positive regulation of collagen biosynthetic process
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 21746880
positive regulation of mRNA binding
Source: UniProtKB
Inferred from direct assayⁱ
- 22190748
positive regulation of translation
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 21746880
RNA processing Source: InterPro

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	RNA-binding
Biological process	Translation regulation

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: La-related protein 6 Alternative name(s): Acheron Short name: Achn La ribonucleoprotein domain family member 6
Gene namesⁱ	Name:LARP6
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 15

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000166173.10
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:24012 LARP6
MIMⁱ	611300 gene
neXtProtⁱ	NX_Q9BRS8

Keywords - Cellular componentⁱ

Cytoplasm, Nucleus

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	55323
Open Targets More...OpenTargetsⁱ	ENSG00000166173
PharmGKBⁱ	PA142671568

Polymorphism and mutation databases

BioMutaⁱ	LARP6
DMDMⁱ	74752287

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Initiator methionineⁱ		RemovedCombined sources
ChainⁱPRO_0000281141	2 – 491	La-related protein 6Add BLAST		490

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	2	N-acetylalanineCombined sources	1
Modified residueⁱ	56	PhosphoserineCombined sources	1
Modified residueⁱ	58	PhosphoserineBy similarity	1

Keywords - PTMⁱ

Acetylation, Phosphoprotein

Proteomic databases

EPDⁱ	Q9BRS8
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q9BRS8
PaxDbⁱ	Q9BRS8
PeptideAtlas More...PeptideAtlasⁱ	Q9BRS8
PRIDEⁱ	Q9BRS8
ProteomicsDBⁱ	78825 78826 [Q9BRS8-2]

PTM databases

iPTMnetⁱ	Q9BRS8
PhosphoSitePlusⁱ	Q9BRS8

Expressionⁱ

Tissue specificityⁱ

Expressed in numerous tissues.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000166173 Expressed in 215 organ(s), highest expression level in left testis
CleanExⁱ	HS_LARP6
ExpressionAtlasⁱ	Q9BRS8 baseline and differential
Genevisibleⁱ	Q9BRS8 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA020338 HPA049029

HPAⁱ

HPA020338
HPA049029

Interactionⁱ

Subunit structureⁱ

Interacts (via the HTH domain) with VIM/vimentin. Interacts (via C-terminus) with non-muscle myosin MYH10. Interacts (via C-terminus) with DHX9.3 Publications

GO - Molecular functionⁱ

myosin binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 20603131

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	120604, 5 interactors
STRINGⁱ	9606.ENSP00000299213

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	78 – 80	Combined sources	3
Helixⁱ	90 – 103	Combined sources	14
Helixⁱ	106 – 109	Combined sources	4
Turnⁱ	113 – 115	Combined sources	3
Helixⁱ	116 – 119	Combined sources	4
Beta strandⁱ	122 – 124	Combined sources	3
Helixⁱ	129 – 133	Combined sources	5
Turnⁱ	136 – 140	Combined sources	5
Helixⁱ	145 – 153	Combined sources	9
Beta strandⁱ	157 – 159	Combined sources	3
Turnⁱ	162 – 165	Combined sources	4
Turnⁱ	177 – 179	Combined sources	3
Beta strandⁱ	185 – 189	Combined sources	5
Turnⁱ	195 – 199	Combined sources	5
Helixⁱ	209 – 224	Combined sources	16
Beta strandⁱ	227 – 233	Combined sources	7
Turnⁱ	235 – 237	Combined sources	3
Helixⁱ	241 – 246	Combined sources	6
Turnⁱ	247 – 249	Combined sources	3
Beta strandⁱ	253 – 255	Combined sources	3
Beta strandⁱ	258 – 264	Combined sources	7
Helixⁱ	266 – 279	Combined sources	14
Turnⁱ	280 – 284	Combined sources	5
Beta strandⁱ	287 – 291	Combined sources	5

Show more details

3D structure databases

ProteinModelPortalⁱ	Q9BRS8
SMRⁱ	Q9BRS8
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	86 – 177	HTH La-type RNA-bindingPROSITE-ProRule annotationAdd BLAST		92
Domainⁱ	184 – 296	RRMAdd BLAST		113

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	186 – 193	Nuclear export signal		8
Motifⁱ	296 – 302	Nuclear localization signal		7

Domainⁱ

The RRM domain mediates the association with collagen mRNAs stem-loops.

Phylogenomic databases

eggNOGⁱ	KOG1855 Eukaryota ENOG4110VUA LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00830000128323
HOGENOMⁱ	HOG000010108
HOVERGENⁱ	HBG070244
InParanoidⁱ	Q9BRS8
KEGG Orthology (KO) More...KOⁱ	K18733
OMAⁱ	HERGRAC
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G09LP
PhylomeDBⁱ	Q9BRS8
TreeFamⁱ	TF326594

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd12289 RRM_LARP6, 1 hit
Gene3Dⁱ	1.10.10.10, 1 hit 3.30.70.330, 1 hit
InterProⁱ	View protein in InterPro IPR006630 La_HTH IPR034886 LARP6 IPR034880 LARP6_RRM IPR002344 Lupus_La IPR012677 Nucleotide-bd_a/b_plait_sf IPR035979 RBD_domain_sf IPR024642 SUZ-C IPR036388 WH-like_DNA-bd_sf IPR036390 WH_DNA-bd_sf
PANTHERⁱ	PTHR22792:SF71 PTHR22792:SF71, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF05383 La, 1 hit PF12901 SUZ-C, 1 hit
PRINTSⁱ	PR00302 LUPUSLA
SMARTⁱ	View protein in SMART SM00715 LA, 1 hit
SUPFAMⁱ	SSF46785 SSF46785, 1 hit SSF54928 SSF54928, 1 hit
PROSITEⁱ	View protein in PROSITE PS50961 HTH_LA, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q9BRS8-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAQSGGEARP GPKTAVQIRV AIQEAEDVDE LEDEEEGAET RGAGDPARYL 
        60         70         80         90        100
SPGWGSASEE EPSRGHSGTT ASGGENERED LEQEWKPPDE ELIKKLVDQI 
       110        120        130        140        150
EFYFSDENLE KDAFLLKHVR RNKLGYVSVK LLTSFKKVKH LTRDWRTTAH 
       160        170        180        190        200
ALKYSVVLEL NEDHRKVRRT TPVPLFPNEN LPSKMLLVYD LYLSPKLWAL 
       210        220        230        240        250
ATPQKNGRVQ EKVMEHLLKL FGTFGVISSV RILKPGRELP PDIRRISSRY 
       260        270        280        290        300
SQVGTQECAI VEFEEVEAAI KAHEFMITES QGKENMKAVL IGMKPPKKKP 
       310        320        330        340        350
AKDKNHDEEP TASIHLNKSL NKRVEELQYM GDESSANSSS DPESNPTSPM 
       360        370        380        390        400
AGRRHAATNK LSPSGHQNLF LSPNASPCTS PWSSPLAQRK GVSRKSPLAE 
       410        420        430        440        450
EGRLNCSTSP EIFRKCMDYS SDSSVTPSGS PWVRRRRQAE MGTQEKSPGT 
       460        470        480        490 
SPLLSRKMQT ADGLPVGVLR LPRGPDNTRG FHGHERSRAC V

Length:491

Mass (Da):54,737

Last modified:June 1, 2001 - v1

Checksum:ⁱ2CF3AFFFD69BDD07

Isoform 2 (identifier: Q9BRS8-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
67-491: SGTTASGGEN...HGHERSRACV → RNRSSVNSRTMLASFIVSSAPSTAPST

« Hide

        10         20         30         40         50
MAQSGGEARP GPKTAVQIRV AIQEAEDVDE LEDEEEGAET RGAGDPARYL 
        60         70         80         90 
SPGWGSASEE EPSRGHRNRS SVNSRTMLAS FIVSSAPSTA PST

Note: No experimental confirmation available.

Show »

Length:93

Mass (Da):9,773

Checksum:ⁱ88CB7691294B6FD8

Computationally mapped potential isoform sequencesⁱ

There are 2 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

H0YMC6	H0YMC6_HUMAN	La-related protein 6 La-related protein 6	LARP6	78	Annotation score:
K7EPD2	K7EPD2_HUMAN	La-related protein 6 La-related protein 6	LARP6	31	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	103	Y → C in BAA92061 (PubMed:14702039).Curated		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_042565	67 – 491	SGTTA…SRACV → RNRSSVNSRTMLASFIVSSA PSTAPST in isoform 2. 1 PublicationAdd BLAST		425

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF443828 mRNA Translation: AAN76710.1 AF443829 mRNA Translation: AAN76711.1 AK002058 mRNA Translation: BAA92061.1 AL833876 mRNA Translation: CAD38733.2 AC009269 Genomic DNA No translation available. AC090868 Genomic DNA No translation available. BC006082 mRNA Translation: AAH06082.1 BC009446 mRNA Translation: AAH09446.1 BC014018 mRNA Translation: AAH14018.1 BC039153 mRNA Translation: AAH39153.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS10236.1 [Q9BRS8-2] CCDS32281.1 [Q9BRS8-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_001273608.1, NM_001286679.1 NP_060827.2, NM_018357.3 [Q9BRS8-1] NP_932062.1, NM_197958.2 [Q9BRS8-2]
UniGeneⁱ	Hs.416755

Genome annotation databases

Ensemblⁱ	ENST00000299213; ENSP00000299213; ENSG00000166173 [Q9BRS8-1] ENST00000344870; ENSP00000343869; ENSG00000166173 [Q9BRS8-2]
GeneIDⁱ	55323
KEGGⁱ	hsa:55323
UCSC genome browser More...UCSCⁱ	uc002ass.5 human [Q9BRS8-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9BRS8	Acheron isoform 1		PANTR		491	UniRef100_Q9BRS8
Uncharacterized protein		PANPA		424
La ribonucleoprotein domain family member 6		GORGO		424
UPI0003C401ED		HUMAN		307
Q9BRS8-2	LARP6 isoform 2		PANTR		93	UniRef100_K7AUT8

Protein	Similar proteins		Species	Score	Length	Source
Q9BRS8	Acheron isoform 1		PANTR		491	UniRef90_Q9BRS8
Uncharacterized protein		PANPA		424
La ribonucleoprotein domain family member 6		GORGO		424
Uncharacterized protein		RHIRO		491
Uncharacterized protein		AOTNA		491
+46
Q9BRS8-2	LARP6 isoform 2		PANTR		93	UniRef90_K7AUT8
Uncharacterized protein		PAPAN		112
Uncharacterized protein		CERAT		112
LARP6 isoform 3 (Fragment)		PONAB		94
Uncharacterized protein		CALJA		94
+6

Protein	Similar proteins		Species	Score	Length	Source
Q9BRS8	La-related protein 6		MOUSE		492	UniRef50_Q9BRS8
Acheron isoform 1		PANTR		491
Uncharacterized protein		PANPA		424
La ribonucleoprotein domain family member 6		GORGO		424
La-related protein 6 isoform 1		MACMU		491
+253
Q9BRS8-2	LARP6 isoform 2		PANTR		93	UniRef50_K7AUT8
Uncharacterized protein		PAPAN		112
Uncharacterized protein		CERAT		112
Uncharacterized protein		CALJA		94
LARP6 isoform 3 (Fragment)		PONAB		94
+9

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF443828 mRNA Translation: AAN76710.1 AF443829 mRNA Translation: AAN76711.1 AK002058 mRNA Translation: BAA92061.1 AL833876 mRNA Translation: CAD38733.2 AC009269 Genomic DNA No translation available. AC090868 Genomic DNA No translation available. BC006082 mRNA Translation: AAH06082.1 BC009446 mRNA Translation: AAH09446.1 BC014018 mRNA Translation: AAH14018.1 BC039153 mRNA Translation: AAH39153.1
CCDSⁱ	CCDS10236.1 [Q9BRS8-2] CCDS32281.1 [Q9BRS8-1]
RefSeqⁱ	NP_001273608.1, NM_001286679.1 NP_060827.2, NM_018357.3 [Q9BRS8-1] NP_932062.1, NM_197958.2 [Q9BRS8-2]
UniGeneⁱ	Hs.416755

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2MTF	NMR	-	A	70-183	[»]
	2MTG	NMR	-	A	178-295	[»]
ProteinModelPortalⁱ	Q9BRS8
SMRⁱ	Q9BRS8
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	120604, 5 interactors
STRINGⁱ	9606.ENSP00000299213

PTM databases

iPTMnetⁱ	Q9BRS8
PhosphoSitePlusⁱ	Q9BRS8

Polymorphism and mutation databases

BioMutaⁱ	LARP6
DMDMⁱ	74752287

Proteomic databases

EPDⁱ	Q9BRS8
MaxQBⁱ	Q9BRS8
PaxDbⁱ	Q9BRS8
PeptideAtlasⁱ	Q9BRS8
PRIDEⁱ	Q9BRS8
ProteomicsDBⁱ	78825 78826 [Q9BRS8-2]

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000299213; ENSP00000299213; ENSG00000166173 [Q9BRS8-1] ENST00000344870; ENSP00000343869; ENSG00000166173 [Q9BRS8-2]
GeneIDⁱ	55323
KEGGⁱ	hsa:55323
UCSCⁱ	uc002ass.5 human [Q9BRS8-1]

Organism-specific databases

CTDⁱ	55323
DisGeNETⁱ	55323
EuPathDBⁱ	HostDB:ENSG00000166173.10
GeneCardsⁱ	LARP6
HGNCⁱ	HGNC:24012 LARP6
HPAⁱ	HPA020338 HPA049029
MIMⁱ	611300 gene
neXtProtⁱ	NX_Q9BRS8
OpenTargetsⁱ	ENSG00000166173
PharmGKBⁱ	PA142671568
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG1855 Eukaryota ENOG4110VUA LUCA
GeneTreeⁱ	ENSGT00830000128323
HOGENOMⁱ	HOG000010108
HOVERGENⁱ	HBG070244
InParanoidⁱ	Q9BRS8
KOⁱ	K18733
OMAⁱ	HERGRAC
OrthoDBⁱ	EOG091G09LP
PhylomeDBⁱ	Q9BRS8
TreeFamⁱ	TF326594

Miscellaneous databases

ChiTaRSⁱ	LARP6 human
GeneWikiⁱ	LARP6
GenomeRNAiⁱ	55323
Protein Ontology More...PROⁱ	PR:Q9BRS8
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000166173 Expressed in 215 organ(s), highest expression level in left testis
CleanExⁱ	HS_LARP6
ExpressionAtlasⁱ	Q9BRS8 baseline and differential
Genevisibleⁱ	Q9BRS8 HS

Family and domain databases

CDDⁱ	cd12289 RRM_LARP6, 1 hit
Gene3Dⁱ	1.10.10.10, 1 hit 3.30.70.330, 1 hit
InterProⁱ	View protein in InterPro IPR006630 La_HTH IPR034886 LARP6 IPR034880 LARP6_RRM IPR002344 Lupus_La IPR012677 Nucleotide-bd_a/b_plait_sf IPR035979 RBD_domain_sf IPR024642 SUZ-C IPR036388 WH-like_DNA-bd_sf IPR036390 WH_DNA-bd_sf
PANTHERⁱ	PTHR22792:SF71 PTHR22792:SF71, 1 hit
Pfamⁱ	View protein in Pfam PF05383 La, 1 hit PF12901 SUZ-C, 1 hit
PRINTSⁱ	PR00302 LUPUSLA
SMARTⁱ	View protein in SMART SM00715 LA, 1 hit
SUPFAMⁱ	SSF46785 SSF46785, 1 hit SSF54928 SSF54928, 1 hit
PROSITEⁱ	View protein in PROSITE PS50961 HTH_LA, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	LARP6_HUMAN
Accessionⁱ	Q9BRS8Primary (citable) accession number: Q9BRS8 Secondary accession number(s): Q5XKE4, Q8N3N2, Q9NUR0
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	March 20, 2007
	Last sequence update:	June 1, 2001
	Last modified:	November 7, 2018
	This is version 146 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human chromosome 15
Human chromosome 15: entries, gene names and cross-references to MIM

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UniProtKB - Q9BRS8 (LARP6_HUMAN)

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La-related protein 6

LARP6

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Other locations

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Motif

Phylogenomic databases

Family and domain databases

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ