ZKSCAN3

Functionⁱ

Transcriptional factor that binds to the consensus sequence 5'-[GT][AG][AGT]GGGG-3' and acts as a repressor of autophagy. Specifically represses expression of genes involved in autophagy and lysosome biogenesis/function such as MAP1LC3B, ULK1 or WIPI2. Associates with chromatin at the ITGB4 and VEGF promoters. Also acts as a transcription activator and promotes cancer cell progression and/or migration in various tumors and myelomas.4 Publications

Regions

Feature key	Position(s)	DescriptionActions	Length
Zinc fingerⁱ	314 – 336	C2H2-type 1PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	342 – 364	C2H2-type 2PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	370 – 392	C2H2-type 3PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	398 – 420	C2H2-type 4PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	426 – 448	C2H2-type 5PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	480 – 502	C2H2-type 6PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	508 – 530	C2H2-type 7PROSITE-ProRule annotationAdd BLAST	23

GO - Molecular functionⁱ

chromatin binding
Source: UniProtKB
Inferred from direct assayⁱ
- 18940803
DNA binding
Source: UniProtKB
Inferred from direct assayⁱ
- 18940803
DNA-binding transcription factor activity
Source: UniProtKB
Inferred from direct assayⁱ
- 23434374
metal ion binding Source: UniProtKB-KW
RNA polymerase II proximal promoter sequence-specific DNA binding
Source: NTNU_SB
Inferred from direct assayⁱ
- 18940803
RNA polymerase II transcription factor activity, sequence-specific DNA binding Source: NTNU_SB
sequence-specific DNA binding
Source: UniProtKB
Inferred from direct assayⁱ
- 23434374
transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding
Source: NTNU_SB
Inferred from direct assayⁱ
- 18940803

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

autophagy Source: UniProtKB-KW
lysosome organization
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 23434374
negative regulation of autophagy
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 23434374
negative regulation of cellular senescence
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 23434374
negative regulation of transcription, DNA-templated
Source: UniProtKB
Inferred from direct assayⁱ
- 23434374
negative regulation of transcription by RNA polymerase II
Source: NTNU_SB
Inferred from direct assayⁱ
- 18940803
positive regulation of transcription, DNA-templated
Source: UniProtKB
Inferred from direct assayⁱ
- 18940803
transcription, DNA-templated Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	DNA-binding, Repressor
Biological process	Autophagy, Transcription, Transcription regulation
Ligand	Metal-binding, Zinc

Enzyme and pathway databases

Reactomeⁱ	R-HSA-212436 Generic Transcription Pathway

Reactomeⁱ

R-HSA-212436 Generic Transcription Pathway

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Zinc finger protein with KRAB and SCAN domains 3 Alternative name(s): Zinc finger and SCAN domain-containing protein 13 Zinc finger protein 306 Zinc finger protein 309 Zinc finger protein 47 homolog Short name: Zf47 Short name: Zfp-47
Gene namesⁱ	Name:ZKSCAN3 Synonyms:ZFP47, ZNF306, ZNF309, ZSCAN13
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 6

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000189298.13
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:13853 ZKSCAN3
MIMⁱ	612791 gene
neXtProtⁱ	NX_Q9BRR0

Keywords - Cellular componentⁱ

Cytoplasm, Nucleus

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	80317
Open Targets More...OpenTargetsⁱ	ENSG00000189298
PharmGKBⁱ	PA37821

Polymorphism and mutation databases

BioMutaⁱ	ZKSCAN3
DMDMⁱ	116242859

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000047524	1 – 538	Zinc finger protein with KRAB and SCAN domains 3Add BLAST		538

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	42	PhosphoserineBy similarity	1
Cross-linkⁱ	171	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residueⁱ	207	PhosphothreonineCombined sources	1
Modified residueⁱ	449	PhosphothreonineCombined sources	1

Keywords - PTMⁱ

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDⁱ	Q9BRR0
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q9BRR0
PaxDbⁱ	Q9BRR0
PeptideAtlas More...PeptideAtlasⁱ	Q9BRR0
PRIDEⁱ	Q9BRR0
ProteomicsDBⁱ	78810

PTM databases

iPTMnetⁱ	Q9BRR0
PhosphoSitePlusⁱ	Q9BRR0

Expressionⁱ

Inductionⁱ

Overexpressed in various tumors, such as multiple myeloma, colorectal and prostate cancers (at protein level).3 Publications

Gene expression databases

Bgeeⁱ	ENSG00000189298 Expressed in 146 organ(s), highest expression level in heart
CleanExⁱ	HS_ZKSCAN3
Genevisibleⁱ	Q9BRR0 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA009637 HPA060116

HPAⁱ

HPA009637
HPA060116

Interactionⁱ

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
LZTS2	Q9BRK4	3	EBI-1965777,EBI-741037
SCAND1	P57086	4	EBI-1965777,EBI-745846

Protein-protein interaction databases

BioGridⁱ	123230, 14 interactors
IntActⁱ	Q9BRR0, 10 interactors
STRINGⁱ	9606.ENSP00000252211

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9BRR0
SMRⁱ	Q9BRR0
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	46 – 128	SCAN boxPROSITE-ProRule annotationAdd BLAST		83
Domainⁱ	214 – 274	KRABAdd BLAST		61

Sequence similaritiesⁱ

Belongs to the krueppel C2H2-type zinc-finger protein family.Curated

Zinc finger

Feature key	Position(s)	DescriptionActions	Length
Zinc fingerⁱ	314 – 336	C2H2-type 1PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	342 – 364	C2H2-type 2PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	370 – 392	C2H2-type 3PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	398 – 420	C2H2-type 4PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	426 – 448	C2H2-type 5PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	480 – 502	C2H2-type 6PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	508 – 530	C2H2-type 7PROSITE-ProRule annotationAdd BLAST	23

Keywords - Domainⁱ

Repeat, Zinc-finger

Phylogenomic databases

eggNOGⁱ	KOG1721 Eukaryota COG5048 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118881
HOGENOMⁱ	HOG000234619
HOVERGENⁱ	HBG018163
InParanoidⁱ	Q9BRR0
KEGG Orthology (KO) More...KOⁱ	K09229
OMAⁱ	NVETPMS
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G040B
PhylomeDBⁱ	Q9BRR0
TreeFamⁱ	TF350830

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd07765 KRAB_A-box, 1 hit cd07936 SCAN, 1 hit
Gene3Dⁱ	1.10.4020.10, 1 hit
InterProⁱ	View protein in InterPro IPR001909 KRAB IPR036051 KRAB_dom_sf IPR003309 SCAN_dom IPR038269 SCAN_sf IPR036236 Znf_C2H2_sf IPR013087 Znf_C2H2_type
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01352 KRAB, 1 hit PF02023 SCAN, 1 hit PF00096 zf-C2H2, 7 hits
SMARTⁱ	View protein in SMART SM00349 KRAB, 1 hit SM00431 SCAN, 1 hit SM00355 ZnF_C2H2, 7 hits
SUPFAMⁱ	SSF109640 SSF109640, 1 hit SSF57667 SSF57667, 4 hits
PROSITEⁱ	View protein in PROSITE PS50804 SCAN_BOX, 1 hit PS00028 ZINC_FINGER_C2H2_1, 7 hits PS50157 ZINC_FINGER_C2H2_2, 7 hits

Sequences (2)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

Isoform 1 (identifier: Q9BRR0-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MARELSESTA LDAQSTEDQM ELLVIKVEEE EAGFPSSPDL GSEGSRERFR 
        60         70         80         90        100
GFRYPEAAGP REALSRLREL CRQWLQPEMH SKEQILELLV LEQFLTILPG 
       110        120        130        140        150
NLQSWVREQH PESGEEVVVL LEYLERQLDE PAPQVSGVDQ GQELLCCKMA 
       160        170        180        190        200
LLTPAPGSQS SQFQLMKALL KHESVGSQPL QDRVLQVPVL AHGGCCREDK 
       210        220        230        240        250
VVASRLTPES QGLLKVEDVA LTLTPEWTQQ DSSQGNLCRD EKQENHGSLV 
       260        270        280        290        300
SLGDEKQTKS RDLPPAEELP EKEHGKISCH LREDIAQIPT CAEAGEQEGR 
       310        320        330        340        350
LQRKQKNATG GRRHICHECG KSFAQSSGLS KHRRIHTGEK PYECEECGKA 
       360        370        380        390        400
FIGSSALVIH QRVHTGEKPY ECEECGKAFS HSSDLIKHQR THTGEKPYEC 
       410        420        430        440        450
DDCGKTFSQS CSLLEHHRIH TGEKPYQCSM CGKAFRRSSH LLRHQRIHTG 
       460        470        480        490        500
DKNVQEPEQG EAWKSRMESQ LENVETPMSY KCNECERSFT QNTGLIEHQK 
       510        520        530 
IHTGEKPYQC NACGKGFTRI SYLVQHQRSH VGKNILSQ

Length:538

Mass (Da):60,641

Last modified:October 17, 2006 - v2

Checksum:ⁱ0D8F706F1B2F888F

GO

Isoform 2 (identifier: Q9BRR0-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-148: Missing.

« Hide

        10         20         30         40         50
MALLTPAPGS QSSQFQLMKA LLKHESVGSQ PLQDRVLQVP VLAHGGCCRE 
        60         70         80         90        100
DKVVASRLTP ESQGLLKVED VALTLTPEWT QQDSSQGNLC RDEKQENHGS 
       110        120        130        140        150
LVSLGDEKQT KSRDLPPAEE LPEKEHGKIS CHLREDIAQI PTCAEAGEQE 
       160        170        180        190        200
GRLQRKQKNA TGGRRHICHE CGKSFAQSSG LSKHRRIHTG EKPYECEECG 
       210        220        230        240        250
KAFIGSSALV IHQRVHTGEK PYECEECGKA FSHSSDLIKH QRTHTGEKPY 
       260        270        280        290        300
ECDDCGKTFS QSCSLLEHHR IHTGEKPYQC SMCGKAFRRS SHLLRHQRIH 
       310        320        330        340        350
TGDKNVQEPE QGEAWKSRME SQLENVETPM SYKCNECERS FTQNTGLIEH 
       360        370        380        390
QKIHTGEKPY QCNACGKGFT RISYLVQHQR SHVGKNILSQ

Note: No experimental confirmation available.

Show »

Length:390

Mass (Da):43,793

Checksum:ⁱBE2B599E4BE6A684

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	206 – 207	LT → IP in AAB16813 (PubMed:10520746).Curated	2
Sequence conflictⁱ	348 – 350	GKA → AKP in AAB16813 (PubMed:10520746).Curated	3
Sequence conflictⁱ	437	R → D in AAB16813 (PubMed:10520746).Curated	1
Sequence conflictⁱ	459 – 479	QGEAW…ETPMS → TGRGWKVGWKASWKMLKLPC P in AAB16813 (PubMed:10520746).CuratedAdd BLAST	21

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_024208	3	R → T. Corresponds to variant dbSNP:rs733743Ensembl.	1
Natural variantⁱVAR_028313	33	G → V. Corresponds to variant dbSNP:rs3857554Ensembl.	1
Natural variantⁱVAR_028314	34	F → L. Corresponds to variant dbSNP:rs3857555Ensembl.	1
Natural variantⁱVAR_028315	189	V → M1 PublicationCorresponds to variant dbSNP:rs17856167Ensembl.	1
Natural variantⁱVAR_059950	200	K → A Requires 2 nucleotide substitutions. 3 PublicationsCorresponds to variant dbSNP:rs371085669Ensembl.	1
Natural variantⁱVAR_028316	200	K → E1 PublicationCorresponds to variant dbSNP:rs13201752Ensembl.	1
Natural variantⁱVAR_028317	200	K → T. Corresponds to variant dbSNP:rs13201753Ensembl.	1
Natural variantⁱVAR_028318	246	H → Q. Corresponds to variant dbSNP:rs213227Ensembl.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_045908	1 – 148	Missing in isoform 2. 1 PublicationAdd BLAST		148

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	BT007427 mRNA Translation: AAP36095.1 AK122790 mRNA Translation: BAG53732.1 AK313532 mRNA Translation: BAG36309.1 AL358785 Genomic DNA No translation available. AL021997 Genomic DNA No translation available. CH471081 Genomic DNA Translation: EAX03157.1 BC006118 mRNA Translation: AAH06118.1 U71601 mRNA Translation: AAB16813.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS4650.1 [Q9BRR0-1] CCDS56408.1 [Q9BRR0-2]
NCBI Reference Sequences More...RefSeqⁱ	NP_001229823.1, NM_001242894.1 [Q9BRR0-1] NP_001229824.1, NM_001242895.1 [Q9BRR0-2] NP_077819.2, NM_024493.3 [Q9BRR0-1] XP_006715278.1, XM_006715215.2 [Q9BRR0-1] XP_006715281.1, XM_006715218.3 [Q9BRR0-2]
UniGeneⁱ	Hs.380930 Hs.485004

Genome annotation databases

Ensemblⁱ	ENST00000252211; ENSP00000252211; ENSG00000189298 [Q9BRR0-1] ENST00000341464; ENSP00000341883; ENSG00000189298 [Q9BRR0-2] ENST00000377255; ENSP00000366465; ENSG00000189298 [Q9BRR0-1]
GeneIDⁱ	80317
KEGGⁱ	hsa:80317
UCSC genome browser More...UCSCⁱ	uc003nle.4 human [Q9BRR0-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9BRR0	Isoform 2 of Zinc finger protein with KRAB and SCAN domains 3		HUMAN		390	UniRef90_Q9BRR0
ZKSCAN3 isoform 1		PANTR		538
ZKSCAN3 isoform 1		PONAB		538
Zinc finger with KRAB and SCAN domains 3		SAIBB		538
Zinc finger protein 306		MACMU		538
+28

Protein	Similar proteins		Species	Score	Length	Source
Q9BRR0	Zinc finger protein with KRAB and SCAN domains 4		HUMAN		545	UniRef50_Q9BRR0
Zinc finger protein with KRAB and SCAN domains 3		MOUSE		553
Uncharacterized protein		CHLSB		538
Uncharacterized protein		MANLE		538
Uncharacterized protein		CERAT		538
+250

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	BT007427 mRNA Translation: AAP36095.1 AK122790 mRNA Translation: BAG53732.1 AK313532 mRNA Translation: BAG36309.1 AL358785 Genomic DNA No translation available. AL021997 Genomic DNA No translation available. CH471081 Genomic DNA Translation: EAX03157.1 BC006118 mRNA Translation: AAH06118.1 U71601 mRNA Translation: AAB16813.1
CCDSⁱ	CCDS4650.1 [Q9BRR0-1] CCDS56408.1 [Q9BRR0-2]
RefSeqⁱ	NP_001229823.1, NM_001242894.1 [Q9BRR0-1] NP_001229824.1, NM_001242895.1 [Q9BRR0-2] NP_077819.2, NM_024493.3 [Q9BRR0-1] XP_006715278.1, XM_006715215.2 [Q9BRR0-1] XP_006715281.1, XM_006715218.3 [Q9BRR0-2]
UniGeneⁱ	Hs.380930 Hs.485004

3D structure databases

ProteinModelPortalⁱ	Q9BRR0
SMRⁱ	Q9BRR0
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	123230, 14 interactors
IntActⁱ	Q9BRR0, 10 interactors
STRINGⁱ	9606.ENSP00000252211

PTM databases

iPTMnetⁱ	Q9BRR0
PhosphoSitePlusⁱ	Q9BRR0

Polymorphism and mutation databases

BioMutaⁱ	ZKSCAN3
DMDMⁱ	116242859

Proteomic databases

EPDⁱ	Q9BRR0
MaxQBⁱ	Q9BRR0
PaxDbⁱ	Q9BRR0
PeptideAtlasⁱ	Q9BRR0
PRIDEⁱ	Q9BRR0
ProteomicsDBⁱ	78810

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	80317
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000252211; ENSP00000252211; ENSG00000189298 [Q9BRR0-1] ENST00000341464; ENSP00000341883; ENSG00000189298 [Q9BRR0-2] ENST00000377255; ENSP00000366465; ENSG00000189298 [Q9BRR0-1]
GeneIDⁱ	80317
KEGGⁱ	hsa:80317
UCSCⁱ	uc003nle.4 human [Q9BRR0-1]

Organism-specific databases

CTDⁱ	80317
DisGeNETⁱ	80317
EuPathDBⁱ	HostDB:ENSG00000189298.13
GeneCardsⁱ	ZKSCAN3
HGNCⁱ	HGNC:13853 ZKSCAN3
HPAⁱ	HPA009637 HPA060116
MIMⁱ	612791 gene
neXtProtⁱ	NX_Q9BRR0
OpenTargetsⁱ	ENSG00000189298
PharmGKBⁱ	PA37821
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG1721 Eukaryota COG5048 LUCA
GeneTreeⁱ	ENSGT00760000118881
HOGENOMⁱ	HOG000234619
HOVERGENⁱ	HBG018163
InParanoidⁱ	Q9BRR0
KOⁱ	K09229
OMAⁱ	NVETPMS
OrthoDBⁱ	EOG091G040B
PhylomeDBⁱ	Q9BRR0
TreeFamⁱ	TF350830

Enzyme and pathway databases

Reactomeⁱ	R-HSA-212436 Generic Transcription Pathway

Reactomeⁱ

R-HSA-212436 Generic Transcription Pathway

Miscellaneous databases

ChiTaRSⁱ	ZKSCAN3 human
GenomeRNAiⁱ	80317
Protein Ontology More...PROⁱ	PR:Q9BRR0
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000189298 Expressed in 146 organ(s), highest expression level in heart
CleanExⁱ	HS_ZKSCAN3
Genevisibleⁱ	Q9BRR0 HS

Family and domain databases

CDDⁱ	cd07765 KRAB_A-box, 1 hit cd07936 SCAN, 1 hit
Gene3Dⁱ	1.10.4020.10, 1 hit
InterProⁱ	View protein in InterPro IPR001909 KRAB IPR036051 KRAB_dom_sf IPR003309 SCAN_dom IPR038269 SCAN_sf IPR036236 Znf_C2H2_sf IPR013087 Znf_C2H2_type
Pfamⁱ	View protein in Pfam PF01352 KRAB, 1 hit PF02023 SCAN, 1 hit PF00096 zf-C2H2, 7 hits
SMARTⁱ	View protein in SMART SM00349 KRAB, 1 hit SM00431 SCAN, 1 hit SM00355 ZnF_C2H2, 7 hits
SUPFAMⁱ	SSF109640 SSF109640, 1 hit SSF57667 SSF57667, 4 hits
PROSITEⁱ	View protein in PROSITE PS50804 SCAN_BOX, 1 hit PS00028 ZINC_FINGER_C2H2_1, 7 hits PS50157 ZINC_FINGER_C2H2_2, 7 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	ZKSC3_HUMAN
Accessionⁱ	Q9BRR0Primary (citable) accession number: Q9BRR0 Secondary accession number(s): B2R8W2 , B3KVC0, H7BXX1, Q5VXH3, Q92972, Q9H4T3
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	September 19, 2002
	Last sequence update:	October 17, 2006
	Last modified:	October 10, 2018
	This is version 161 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human chromosome 6
Human chromosome 6: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
SIMILARITY comments
Index of protein domains and families
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q9BRR0 (ZKSC3_HUMAN)

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Zinc finger protein with KRAB and SCAN domains 3

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Other locations

Cytosol

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

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Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

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<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ