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Protein

Pygopus homolog 2

Gene

PYGO2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in signal transduction through the Wnt pathway.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri327 – 385PHD-typePROSITE-ProRule annotationAdd BLAST59

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processWnt signaling pathway
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-201722 Formation of the beta-catenin:TCF transactivating complex
R-HSA-3769402 Deactivation of the beta-catenin transactivating complex

Names & Taxonomyi

Protein namesi
Recommended name:
Pygopus homolog 2
Gene namesi
Name:PYGO2
ORF Names:PP7910
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000163348.3
HGNCiHGNC:30257 PYGO2
MIMi606903 gene
neXtProtiNX_Q9BRQ0

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi90780
OpenTargetsiENSG00000163348
PharmGKBiPA134881185

Polymorphism and mutation databases

BioMutaiPYGO2
DMDMi23396825

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00000971232 – 406Pygopus homolog 2Add BLAST405

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei40PhosphoserineCombined sources1
Modified residuei302PhosphothreonineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9BRQ0
MaxQBiQ9BRQ0
PaxDbiQ9BRQ0
PeptideAtlasiQ9BRQ0
PRIDEiQ9BRQ0
ProteomicsDBi78801

PTM databases

iPTMnetiQ9BRQ0
PhosphoSitePlusiQ9BRQ0

Expressioni

Gene expression databases

BgeeiENSG00000163348 Expressed in 196 organ(s), highest expression level in nasal cavity epithelium
CleanExiHS_PYGO2
ExpressionAtlasiQ9BRQ0 baseline and differential
GenevisibleiQ9BRQ0 HS

Organism-specific databases

HPAiHPA023689

Interactioni

Subunit structurei

Binds to BCL9 via the PHD-type zinc finger motif, and thereby becomes part of the nuclear beta-catenin/TCF complex.

Binary interactionsi

WithEntry#Exp.IntActNotes
BCL9O005122EBI-932471,EBI-533127

GO - Molecular functioni

Protein-protein interaction databases

BioGridi124760, 21 interactors
IntActiQ9BRQ0, 5 interactors
MINTiQ9BRQ0
STRINGi9606.ENSP00000357442

Structurei

Secondary structure

1406
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ9BRQ0
SMRiQ9BRQ0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi41 – 47Nuclear localization signalSequence analysis7

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi6 – 329Pro-richAdd BLAST324

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri327 – 385PHD-typePROSITE-ProRule annotationAdd BLAST59

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiENOG410IKQ3 Eukaryota
ENOG41128HN LUCA
GeneTreeiENSGT00530000063948
HOGENOMiHOG000001580
HOVERGENiHBG053774
InParanoidiQ9BRQ0
OMAiNHMGNNL
OrthoDBiEOG091G0KKH
PhylomeDBiQ9BRQ0
TreeFamiTF333020

Family and domain databases

Gene3Di3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR019786 Zinc_finger_PHD-type_CS
IPR011011 Znf_FYVE_PHD
IPR001965 Znf_PHD
IPR019787 Znf_PHD-finger
IPR013083 Znf_RING/FYVE/PHD
PfamiView protein in Pfam
PF00628 PHD, 1 hit
SMARTiView protein in SMART
SM00249 PHD, 1 hit
SUPFAMiSSF57903 SSF57903, 1 hit
PROSITEiView protein in PROSITE
PS01359 ZF_PHD_1, 1 hit
PS50016 ZF_PHD_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9BRQ0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAASAPPPPD KLEGGGGPAP PPAPPSTGRK QGKAGLQMKS PEKKRRKSNT
60 70 80 90 100
QGPAYSHLTE FAPPPTPMVD HLVASNPFED DFGAPKVGVA APPFLGSPVP
110 120 130 140 150
FGGFRVQGGM AGQVPPGYST GGGGGPQPLR RQPPPFPPNP MGPAFNMPPQ
160 170 180 190 200
GPGYPPPGNM NFPSQPFNQP LGQNFSPPSG QMMPGPVGGF GPMISPTMGQ
210 220 230 240 250
PPRAELGPPS LSQRFAQPGA PFGPSPLQRP GQGLPSLPPN TSPFPGPDPG
260 270 280 290 300
FPGPGGEDGG KPLNPPASTA FPQEPHSGSP AAAVNGNQPS FPPNSSGRGG
310 320 330 340 350
GTPDANSLAP PGKAGGGSGP QPPPGLVYPC GACRSEVNDD QDAILCEASC
360 370 380 390 400
QKWFHRECTG MTESAYGLLT TEASAVWACD LCLKTKEIQS VYIREGMGQL

VAANDG
Length:406
Mass (Da):41,244
Last modified:September 19, 2002 - v2
Checksum:iCA002A5447767CD9
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5T171Q5T171_HUMAN
Pygopus homolog 2 (Drosophila), iso...
PYGO2 hCG_2039581
369Annotation score:

Sequence cautioni

The sequence AAL55782 differs from that shown. Sequencing errors.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti157P → Q in AAL55782 (PubMed:15498874).Curated1
Sequence conflicti170P → L in AAL55782 (PubMed:15498874).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF457208 mRNA Translation: AAL91371.1
BC006132 mRNA Translation: AAH06132.2
BC013725 mRNA Translation: AAH13725.1
BC032099 mRNA Translation: AAH32099.1
AF289598 mRNA Translation: AAL55782.1 Sequence problems.
CCDSiCCDS1075.1
RefSeqiNP_612157.1, NM_138300.3
UniGeneiHs.533597

Genome annotation databases

EnsembliENST00000368457; ENSP00000357442; ENSG00000163348
GeneIDi90780
KEGGihsa:90780
UCSCiuc001fft.4 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF457208 mRNA Translation: AAL91371.1
BC006132 mRNA Translation: AAH06132.2
BC013725 mRNA Translation: AAH13725.1
BC032099 mRNA Translation: AAH32099.1
AF289598 mRNA Translation: AAL55782.1 Sequence problems.
CCDSiCCDS1075.1
RefSeqiNP_612157.1, NM_138300.3
UniGeneiHs.533597

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2XB1X-ray1.90A/C325-387[»]
4UP0X-ray1.28A327-387[»]
4UP5X-ray1.65A327-387[»]
ProteinModelPortaliQ9BRQ0
SMRiQ9BRQ0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124760, 21 interactors
IntActiQ9BRQ0, 5 interactors
MINTiQ9BRQ0
STRINGi9606.ENSP00000357442

PTM databases

iPTMnetiQ9BRQ0
PhosphoSitePlusiQ9BRQ0

Polymorphism and mutation databases

BioMutaiPYGO2
DMDMi23396825

Proteomic databases

EPDiQ9BRQ0
MaxQBiQ9BRQ0
PaxDbiQ9BRQ0
PeptideAtlasiQ9BRQ0
PRIDEiQ9BRQ0
ProteomicsDBi78801

Protocols and materials databases

DNASUi90780
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000368457; ENSP00000357442; ENSG00000163348
GeneIDi90780
KEGGihsa:90780
UCSCiuc001fft.4 human

Organism-specific databases

CTDi90780
DisGeNETi90780
EuPathDBiHostDB:ENSG00000163348.3
GeneCardsiPYGO2
HGNCiHGNC:30257 PYGO2
HPAiHPA023689
MIMi606903 gene
neXtProtiNX_Q9BRQ0
OpenTargetsiENSG00000163348
PharmGKBiPA134881185
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IKQ3 Eukaryota
ENOG41128HN LUCA
GeneTreeiENSGT00530000063948
HOGENOMiHOG000001580
HOVERGENiHBG053774
InParanoidiQ9BRQ0
OMAiNHMGNNL
OrthoDBiEOG091G0KKH
PhylomeDBiQ9BRQ0
TreeFamiTF333020

Enzyme and pathway databases

ReactomeiR-HSA-201722 Formation of the beta-catenin:TCF transactivating complex
R-HSA-3769402 Deactivation of the beta-catenin transactivating complex

Miscellaneous databases

ChiTaRSiPYGO2 human
GeneWikiiPYGO2
GenomeRNAii90780
PROiPR:Q9BRQ0
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000163348 Expressed in 196 organ(s), highest expression level in nasal cavity epithelium
CleanExiHS_PYGO2
ExpressionAtlasiQ9BRQ0 baseline and differential
GenevisibleiQ9BRQ0 HS

Family and domain databases

Gene3Di3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR019786 Zinc_finger_PHD-type_CS
IPR011011 Znf_FYVE_PHD
IPR001965 Znf_PHD
IPR019787 Znf_PHD-finger
IPR013083 Znf_RING/FYVE/PHD
PfamiView protein in Pfam
PF00628 PHD, 1 hit
SMARTiView protein in SMART
SM00249 PHD, 1 hit
SUPFAMiSSF57903 SSF57903, 1 hit
PROSITEiView protein in PROSITE
PS01359 ZF_PHD_1, 1 hit
PS50016 ZF_PHD_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPYGO2_HUMAN
AccessioniPrimary (citable) accession number: Q9BRQ0
Secondary accession number(s): Q8WYZ4, Q96CY2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: September 19, 2002
Last modified: November 7, 2018
This is version 152 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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Main funding by: National Institutes of Health

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