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Protein

Ferredoxin-fold anticodon-binding domain-containing protein 1

Gene

FDXACB1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Ferredoxin-fold anticodon-binding domain-containing protein 1
Short name:
FDX-ACDB domain-containing protein 1
Gene namesi
Name:FDXACB1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000255561.6
HGNCiHGNC:25110 FDXACB1
neXtProtiNX_Q9BRP7

Subcellular locationi

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000255561
PharmGKBiPA164720055

Polymorphism and mutation databases

BioMutaiFDXACB1
DMDMi296439342

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003259561 – 624Ferredoxin-fold anticodon-binding domain-containing protein 1Add BLAST624

Proteomic databases

MaxQBiQ9BRP7
PaxDbiQ9BRP7
PeptideAtlasiQ9BRP7
PRIDEiQ9BRP7
ProteomicsDBi78797

PTM databases

iPTMnetiQ9BRP7
PhosphoSitePlusiQ9BRP7

Expressioni

Gene expression databases

BgeeiENSG00000255561
CleanExiHS_FDXACB1
ExpressionAtlasiQ9BRP7 baseline and differential
GenevisibleiQ9BRP7 HS

Organism-specific databases

HPAiHPA039012
HPA061375

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
TRAF2Q129335EBI-10297077,EBI-355744

Protein-protein interaction databases

BioGridi124890, 5 interactors
IntActiQ9BRP7, 6 interactors
STRINGi9606.ENSP00000260257

Structurei

3D structure databases

ProteinModelPortaliQ9BRP7
SMRiQ9BRP7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini531 – 624FDX-ACBPROSITE-ProRule annotationAdd BLAST94

Phylogenomic databases

eggNOGiKOG2783 Eukaryota
KOG4174 Eukaryota
ENOG41108X7 LUCA
GeneTreeiENSGT00530000063467
HOGENOMiHOG000112565
HOVERGENiHBG069342
InParanoidiQ9BRP7
OMAiRFQHPKT
OrthoDBiEOG091G01ZZ
PhylomeDBiQ9BRP7
TreeFamiTF329685

Family and domain databases

Gene3Di3.30.70.380, 1 hit
InterProiView protein in InterPro
IPR019446 DUF2431
IPR005121 Fdx_antiC-bd
IPR036690 Fdx_antiC-bd_sf
PfamiView protein in Pfam
PF10354 DUF2431, 1 hit
PF03147 FDX-ACB, 1 hit
SMARTiView protein in SMART
SM00896 FDX-ACB, 1 hit
SUPFAMiSSF54991 SSF54991, 1 hit
PROSITEiView protein in PROSITE
PS51447 FDX_ACB, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9BRP7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAPRRLLLVG EGNFSFAAAL SETLDQSTQL TATCLQRPAE LARDPLAWEN
60 70 80 90 100
LQCLRERGID VRFGVDCTQL ADVFELHERE FDQIYFIFPH CGRKAGVAKN
110 120 130 140 150
RELLAKFFQS CADVLAEEGE VHVALCRGQG GTPADKPQRE WHNSWQVVAM
160 170 180 190 200
AALGGLILSD VYPFSCKAVA GYKCTGYRSQ DKSFHVEGAL NHIFTRSLPF
210 220 230 240 250
EGSQPRIFRI KLGNQWFSFP EPEALVGKLN RGFLEAPSCH PIKTINEKLI
260 270 280 290 300
AELGKVFPLK RLKCSYPLLP QEGTSVLPFW NCDFLSAAFW ISLHEDNSNS
310 320 330 340 350
ESLTGGTSQD VEDFLVSFSE LSLLKNPGRD GKEEACEGTC GQAKICLRPS
360 370 380 390 400
LLVHVQDVIE VPDFLSGSLH ILSGPVFQKC HILPFTMPAF HETLFILGVN
410 420 430 440 450
QNLKDGCLQS LLDHLKGILD SLLTQTLPES SKLSSLVKFV LQSNGKDYMI
460 470 480 490 500
RVKTHNFSPD CTEDLIIGSV ITSATSVIHK DQCFVFVSMN LDLLAMLVWC
510 520 530 540 550
ISDWRMLWTF DNRFLKNFVP GKIEPFKSHS LYPPCYVHDV SFWIDQKKGF
560 570 580 590 600
DELEFHTVAR AVSQDTIISI QFLSRFQHPK TQQVSLCYRL TYQTCDKALT
610 620
QQQVASMQSQ FRKEIQQHLY VIPR
Length:624
Mass (Da):70,416
Last modified:May 18, 2010 - v3
Checksum:i13E0C603F94B3E06
GO
Isoform 2 (identifier: Q9BRP7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-149: Missing.

Note: No experimental confirmation available.
Show »
Length:475
Mass (Da):53,689
Checksum:i98DAF2D22D7265DD
GO

Sequence cautioni

The sequence AAH06136 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06216528T → A. Corresponds to variant dbSNP:rs59164893Ensembl.1
Natural variantiVAR_06032187I → N2 PublicationsCorresponds to variant dbSNP:rs611010Ensembl.1
Natural variantiVAR_060322475T → P. Corresponds to variant dbSNP:rs3168263Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0569971 – 149Missing in isoform 2. 1 PublicationAdd BLAST149

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK300795 mRNA Translation: BAG62454.1
AP001781 Genomic DNA No translation available.
CH471065 Genomic DNA Translation: EAW67156.1
BC006136 mRNA Translation: AAH06136.1 Different initiation.
BC127680 mRNA Translation: AAI27681.1
CCDSiCCDS44729.1 [Q9BRP7-1]
RefSeqiNP_612387.1, NM_138378.2 [Q9BRP7-1]
UniGeneiHs.697132

Genome annotation databases

EnsembliENST00000260257; ENSP00000260257; ENSG00000255561 [Q9BRP7-1]
GeneIDi91893
KEGGihsa:91893
UCSCiuc001pmc.5 human [Q9BRP7-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiFDXA1_HUMAN
AccessioniPrimary (citable) accession number: Q9BRP7
Secondary accession number(s): A0PJW7, B4DUU2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: May 18, 2010
Last modified: June 20, 2018
This is version 111 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations

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