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Protein

Programmed cell death protein 2-like

Gene

PDCD2L

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Over-expression suppresses AP1, CREB, NFAT, and NF-kB transcriptional activation, and delays cell cycle progression at S phase.1 Publication

GO - Biological processi

Keywordsi

Biological processCell cycle

Names & Taxonomyi

Protein namesi
Recommended name:
Programmed cell death protein 2-like
Gene namesi
Name:PDCD2L
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000126249.7
HGNCiHGNC:28194 PDCD2L
MIMi615661 gene
neXtProtiNX_Q9BRP1

Subcellular locationi

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000126249
PharmGKBiPA144596395

Polymorphism and mutation databases

BioMutaiPDCD2L
DMDMi74732907

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00002726452 – 358Programmed cell death protein 2-likeAdd BLAST357

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei20PhosphoserineCombined sources1
Modified residuei22PhosphothreonineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9BRP1
MaxQBiQ9BRP1
PaxDbiQ9BRP1
PeptideAtlasiQ9BRP1
PRIDEiQ9BRP1
ProteomicsDBi78794

PTM databases

iPTMnetiQ9BRP1
PhosphoSitePlusiQ9BRP1

Expressioni

Tissue specificityi

Higher expression in lung, colon, mammary gland, cervix, stomach and small intestine.1 Publication

Gene expression databases

BgeeiENSG00000126249 Expressed in 185 organ(s), highest expression level in quadriceps femoris
CleanExiHS_PDCD2L
ExpressionAtlasiQ9BRP1 baseline and differential
GenevisibleiQ9BRP1 HS

Organism-specific databases

HPAiHPA052181

Interactioni

Protein-protein interaction databases

BioGridi124032, 28 interactors
IntActiQ9BRP1, 5 interactors
STRINGi9606.ENSP00000246535

Structurei

3D structure databases

ProteinModelPortaliQ9BRP1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiKOG2061 Eukaryota
ENOG410XRI4 LUCA
GeneTreeiENSGT00530000063570
HOGENOMiHOG000232160
HOVERGENiHBG060880
InParanoidiQ9BRP1
KOiK14801
OMAiDLMRYEH
OrthoDBiEOG091G0F9T
PhylomeDBiQ9BRP1
TreeFamiTF354282

Family and domain databases

InterProiView protein in InterPro
IPR007320 PDCD2_C
PfamiView protein in Pfam
PF04194 PDCD2_C, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9BRP1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAVLKPVLL GLRDAPVHGS PTGPGAWTAS KLGGIPDALP TVAAPRPVCQ
60 70 80 90 100
RCGQPLALVV QVYCPLEGSP FHRLLHVFAC ACPGCSTGGA RSWKVFRSQC
110 120 130 140 150
LQVPEREAQD AQKQGNSLAA EDWCEGADDW GSDTEEGPSP QFTLDFGNDA
160 170 180 190 200
SSAKDVDWTA RLQDLRLQDA VLGAAHPVPP GLPLFLPYYI CVADEDDYRD
210 220 230 240 250
FVNLDHAHSL LRDYQQREGI AMDQLLSQSL PNDGDEKYEK TIIKSGDQTF
260 270 280 290 300
YKFMKRIAAC QEQILRYSWS GEPLFLTCPT SEVTELPACS QCGGQRIFEF
310 320 330 340 350
QLMPALVSML KSANLGLSVE FGTILVYTCE KSCWPPNHQT PMEEFCIIQE

DPDELLFK
Length:358
Mass (Da):39,417
Last modified:June 1, 2001 - v1
Checksum:i3946A6E4AD760155
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
U3KQL1U3KQL1_HUMAN
Programmed cell death protein 2-lik...
PDCD2L
56Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC008747 Genomic DNA No translation available.
AC092073 Genomic DNA No translation available.
BC006146 mRNA Translation: AAH06146.1
CCDSiCCDS12438.1
RefSeqiNP_115722.1, NM_032346.1
UniGeneiHs.515344

Genome annotation databases

EnsembliENST00000246535; ENSP00000246535; ENSG00000126249
GeneIDi84306
KEGGihsa:84306
UCSCiuc002nvj.4 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC008747 Genomic DNA No translation available.
AC092073 Genomic DNA No translation available.
BC006146 mRNA Translation: AAH06146.1
CCDSiCCDS12438.1
RefSeqiNP_115722.1, NM_032346.1
UniGeneiHs.515344

3D structure databases

ProteinModelPortaliQ9BRP1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124032, 28 interactors
IntActiQ9BRP1, 5 interactors
STRINGi9606.ENSP00000246535

PTM databases

iPTMnetiQ9BRP1
PhosphoSitePlusiQ9BRP1

Polymorphism and mutation databases

BioMutaiPDCD2L
DMDMi74732907

Proteomic databases

EPDiQ9BRP1
MaxQBiQ9BRP1
PaxDbiQ9BRP1
PeptideAtlasiQ9BRP1
PRIDEiQ9BRP1
ProteomicsDBi78794

Protocols and materials databases

DNASUi84306
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000246535; ENSP00000246535; ENSG00000126249
GeneIDi84306
KEGGihsa:84306
UCSCiuc002nvj.4 human

Organism-specific databases

CTDi84306
EuPathDBiHostDB:ENSG00000126249.7
GeneCardsiPDCD2L
HGNCiHGNC:28194 PDCD2L
HPAiHPA052181
MIMi615661 gene
neXtProtiNX_Q9BRP1
OpenTargetsiENSG00000126249
PharmGKBiPA144596395
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2061 Eukaryota
ENOG410XRI4 LUCA
GeneTreeiENSGT00530000063570
HOGENOMiHOG000232160
HOVERGENiHBG060880
InParanoidiQ9BRP1
KOiK14801
OMAiDLMRYEH
OrthoDBiEOG091G0F9T
PhylomeDBiQ9BRP1
TreeFamiTF354282

Miscellaneous databases

ChiTaRSiPDCD2L human
GenomeRNAii84306
PROiPR:Q9BRP1
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000126249 Expressed in 185 organ(s), highest expression level in quadriceps femoris
CleanExiHS_PDCD2L
ExpressionAtlasiQ9BRP1 baseline and differential
GenevisibleiQ9BRP1 HS

Family and domain databases

InterProiView protein in InterPro
IPR007320 PDCD2_C
PfamiView protein in Pfam
PF04194 PDCD2_C, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPDD2L_HUMAN
AccessioniPrimary (citable) accession number: Q9BRP1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: June 1, 2001
Last modified: September 12, 2018
This is version 111 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  2. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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