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Entry version 113 (11 Dec 2019)
Sequence version 2 (05 Oct 2010)
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Protein

TM2 domain-containing protein 3

Gene

TM2D3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
TM2 domain-containing protein 3
Alternative name(s):
Beta-amyloid-binding protein-like protein 2
Short name:
BBP-like protein 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TM2D3
Synonyms:BLP2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 15

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000184277.12

Human Gene Nomenclature Database

More...
HGNCi
HGNC:24128 TM2D3

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
610014 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9BRN9

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei180 – 200HelicalSequence analysisAdd BLAST21
Transmembranei216 – 236HelicalSequence analysisAdd BLAST21

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
80213

Open Targets

More...
OpenTargetsi
ENSG00000184277

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA142670800

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9BRN9 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
TM2D3

Domain mapping of disease mutations (DMDM)

More...
DMDMi
308153510

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 29Sequence analysisAdd BLAST29
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000029898930 – 247TM2 domain-containing protein 3Add BLAST218

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi140N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9BRN9

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9BRN9

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9BRN9

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9BRN9

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9BRN9

PeptideAtlas

More...
PeptideAtlasi
Q9BRN9

PRoteomics IDEntifications database

More...
PRIDEi
Q9BRN9

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
78790 [Q9BRN9-1]
78791 [Q9BRN9-2]

PTM databases

GlyConnect protein glycosylation platform

More...
GlyConnecti
1814

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9BRN9

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9BRN9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000184277 Expressed in 231 organ(s), highest expression level in secondary oocyte

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9BRN9 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9BRN9 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA054064

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
123181, 32 interactors

Protein interaction database and analysis system

More...
IntActi
Q9BRN9, 26 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000330433

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9BRN9 protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TM2 family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IU6Z Eukaryota
ENOG4111HJK LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000158389

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000017272

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9BRN9

Identification of Orthologs from Complete Genome Data

More...
OMAi
WKSAIGK

Database of Orthologous Groups

More...
OrthoDBi
1385397at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9BRN9

TreeFam database of animal gene trees

More...
TreeFami
TF314896

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR007829 TM2

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF05154 TM2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9BRN9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAGGVLPLRG LRALCRVLLF LSQFCILSGG EQSQALAQSI KDPGPTRTFT
60 70 80 90 100
VVPRAAESTE IPPYVMKCPS NGLCSRLPAD CIDCTTNFSC TYGKPVTFDC
110 120 130 140 150
AVKPSVTCVD QDFKSQKNFI INMTCRFCWQ LPETDYECTN STSCMTVSCP
160 170 180 190 200
RQRYPANCTV RDHVHCLGNR TFPKMLYCNW TGGYKWSTAL ALSITLGGFG
210 220 230 240
ADRFYLGQWR EGLGKLFSFG GLGIWTLIDV LLIGVGYVGP ADGSLYI
Length:247
Mass (Da):27,118
Last modified:October 5, 2010 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9E18F6F1E50E41E7
GO
Isoform 2 (identifier: Q9BRN9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     31-56: Missing.

Show »
Length:221
Mass (Da):24,367
Checksum:i6E0623AF1A28FC9D
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B3KT51B3KT51_HUMAN
TM2 domain containing 3, isoform CR...
TM2D3 hCG_26600
182Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YNS4H0YNS4_HUMAN
TM2 domain-containing protein 3
TM2D3
209Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E7EPS7E7EPS7_HUMAN
TM2 domain-containing protein 3
TM2D3
183Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YNF6H0YNF6_HUMAN
TM2 domain-containing protein 3
TM2D3
161Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YM84H0YM84_HUMAN
TM2 domain-containing protein 3
TM2D3
42Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BSX6H3BSX6_HUMAN
TM2 domain-containing protein 3
TM2D3
21Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti6L → R in AAK35066 (PubMed:11278849).Curated1
Sequence conflicti6L → R in BAB15415 (PubMed:14702039).Curated1
Sequence conflicti6L → R in BAG37956 (PubMed:14702039).Curated1
Sequence conflicti6L → R in EAX02315 (Ref. 4) Curated1
Sequence conflicti6L → R in AAH06150 (PubMed:15489334).Curated1
Sequence conflicti6L → R in AAH08873 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_02749631 – 56Missing in isoform 2. 3 PublicationsAdd BLAST26

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF353992 mRNA Translation: AAK35066.1
AK026257 mRNA Translation: BAB15415.1
AK315584 mRNA Translation: BAG37956.1
AC090164 Genomic DNA No translation available.
CH471101 Genomic DNA Translation: EAX02315.1
BC006150 mRNA Translation: AAH06150.1
BC008873 mRNA Translation: AAH08873.1
AL512689 mRNA Translation: CAC21647.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS10392.1 [Q9BRN9-2]
CCDS10393.1 [Q9BRN9-1]

NCBI Reference Sequences

More...
RefSeqi
NP_079417.2, NM_025141.3 [Q9BRN9-2]
NP_510883.2, NM_078474.2 [Q9BRN9-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000333202; ENSP00000330433; ENSG00000184277 [Q9BRN9-1]
ENST00000347970; ENSP00000327584; ENSG00000184277 [Q9BRN9-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
80213

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:80213

UCSC genome browser

More...
UCSCi
uc002bxi.4 human [Q9BRN9-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF353992 mRNA Translation: AAK35066.1
AK026257 mRNA Translation: BAB15415.1
AK315584 mRNA Translation: BAG37956.1
AC090164 Genomic DNA No translation available.
CH471101 Genomic DNA Translation: EAX02315.1
BC006150 mRNA Translation: AAH06150.1
BC008873 mRNA Translation: AAH08873.1
AL512689 mRNA Translation: CAC21647.1
CCDSiCCDS10392.1 [Q9BRN9-2]
CCDS10393.1 [Q9BRN9-1]
RefSeqiNP_079417.2, NM_025141.3 [Q9BRN9-2]
NP_510883.2, NM_078474.2 [Q9BRN9-1]

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi123181, 32 interactors
IntActiQ9BRN9, 26 interactors
STRINGi9606.ENSP00000330433

PTM databases

GlyConnecti1814
iPTMnetiQ9BRN9
PhosphoSitePlusiQ9BRN9

Polymorphism and mutation databases

BioMutaiTM2D3
DMDMi308153510

Proteomic databases

EPDiQ9BRN9
jPOSTiQ9BRN9
MassIVEiQ9BRN9
MaxQBiQ9BRN9
PaxDbiQ9BRN9
PeptideAtlasiQ9BRN9
PRIDEiQ9BRN9
ProteomicsDBi78790 [Q9BRN9-1]
78791 [Q9BRN9-2]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
80213

Genome annotation databases

EnsembliENST00000333202; ENSP00000330433; ENSG00000184277 [Q9BRN9-1]
ENST00000347970; ENSP00000327584; ENSG00000184277 [Q9BRN9-2]
GeneIDi80213
KEGGihsa:80213
UCSCiuc002bxi.4 human [Q9BRN9-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
80213
DisGeNETi80213
EuPathDBiHostDB:ENSG00000184277.12

GeneCards: human genes, protein and diseases

More...
GeneCardsi
TM2D3
HGNCiHGNC:24128 TM2D3
HPAiHPA054064
MIMi610014 gene
neXtProtiNX_Q9BRN9
OpenTargetsiENSG00000184277
PharmGKBiPA142670800

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IU6Z Eukaryota
ENOG4111HJK LUCA
GeneTreeiENSGT00940000158389
HOGENOMiHOG000017272
InParanoidiQ9BRN9
OMAiWKSAIGK
OrthoDBi1385397at2759
PhylomeDBiQ9BRN9
TreeFamiTF314896

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
80213
PharosiQ9BRN9 Tbio

Protein Ontology

More...
PROi
PR:Q9BRN9
RNActiQ9BRN9 protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000184277 Expressed in 231 organ(s), highest expression level in secondary oocyte
ExpressionAtlasiQ9BRN9 baseline and differential
GenevisibleiQ9BRN9 HS

Family and domain databases

InterProiView protein in InterPro
IPR007829 TM2
PfamiView protein in Pfam
PF05154 TM2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTM2D3_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9BRN9
Secondary accession number(s): B2RDK9, Q9H046, Q9H651
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 21, 2007
Last sequence update: October 5, 2010
Last modified: December 11, 2019
This is version 113 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
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