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Entry version 131 (08 May 2019)
Sequence version 1 (01 Jun 2001)
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Protein

Vesicle-trafficking protein SEC22c

Gene

SEC22C

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be involved in vesicle transport between the ER and the Golgi complex.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processER-Golgi transport, Protein transport, Transport

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-204005 COPII-mediated vesicle transport

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Vesicle-trafficking protein SEC22c
Alternative name(s):
SEC22 vesicle-trafficking protein homolog C
SEC22 vesicle-trafficking protein-like 3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SEC22C
Synonyms:SEC22L3
ORF Names:UNQ459/PRO784
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:16828 SEC22C

Online Mendelian Inheritance in Man (OMIM)

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MIMi
604028 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9BRL7

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 183CytoplasmicSequence analysisAdd BLAST183
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei184 – 204HelicalSequence analysisAdd BLAST21
Topological domaini205 – 223LumenalSequence analysisAdd BLAST19
Transmembranei224 – 244HelicalSequence analysisAdd BLAST21
Topological domaini245 – 248CytoplasmicSequence analysis4
Transmembranei249 – 269HelicalSequence analysisAdd BLAST21
Topological domaini270LumenalSequence analysis1
Transmembranei271 – 291HelicalSequence analysisAdd BLAST21
Topological domaini292 – 303CytoplasmicSequence analysisAdd BLAST12

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000093183

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134952972

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SEC22C

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74732899

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003241611 – 303Vesicle-trafficking protein SEC22cAdd BLAST303

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q9BRL7

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9BRL7

PeptideAtlas

More...
PeptideAtlasi
Q9BRL7

PRoteomics IDEntifications database

More...
PRIDEi
Q9BRL7

ProteomicsDB human proteome resource

More...
ProteomicsDBi
78787
78788 [Q9BRL7-2]
78789 [Q9BRL7-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9BRL7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9BRL7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitously expressed.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000093183 Expressed in 202 organ(s), highest expression level in epithelium of mammary gland

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q9BRL7 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q9BRL7 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA055594

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
FATE1Q969F06EBI-10297029,EBI-743099

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
114565, 7 interactors

Protein interaction database and analysis system

More...
IntActi
Q9BRL7, 4 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000264454

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9BRL7

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini8 – 119LonginPROSITE-ProRule annotationAdd BLAST112

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the synaptobrevin family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0862 Eukaryota
COG5143 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000159338

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000007733

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q9BRL7

KEGG Orthology (KO)

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KOi
K08520

Identification of Orthologs from Complete Genome Data

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OMAi
RDVACMA

Database of Orthologous Groups

More...
OrthoDBi
903466at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9BRL7

TreeFam database of animal gene trees

More...
TreeFami
TF105933

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR011012 Longin-like_dom_sf
IPR010908 Longin_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13774 Longin, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01270 Longin, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF64356 SSF64356, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50859 LONGIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 8 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9BRL7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSVIFFACVV RVRDGLPLSA STDFYHTQDF LEWRRRLKSL ALRLAQYPGR
60 70 80 90 100
GSAEGCDFSI HFSSFGDVAC MAICSCQCPA AMAFCFLETL WWEFTASYDT
110 120 130 140 150
TCIGLASRPY AFLEFDSIIQ KVKWHFNYVS SSQMECSLEK IQEELKLQPP
160 170 180 190 200
AVLTLEDTDV ANGVMNGHTP MHLEPAPNFR MEPVTALGIL SLILNIMCAA
210 220 230 240 250
LNLIRGVHLA EHSLQVAHEE IGNILAFLVP FVACIFQCYL YLFYSPARTM
260 270 280 290 300
KVVLMLLFIC LGNMYLHGLR NLWQILFHIG VAFLSSYQIL TRQLQEKQSD

CGV
Length:303
Mass (Da):34,269
Last modified:June 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i24F908848A8A9625
GO
Isoform 2 (identifier: Q9BRL7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     238-250: CYLYLFYSPARTM → DPRSWFCWLDQTS
     251-303: Missing.

Show »
Length:250
Mass (Da):28,148
Checksum:i278379E87068F5DF
GO
Isoform 3 (identifier: Q9BRL7-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     216-228: VAHEEIGNILAFL → DPRSWFCWLDQTS
     229-303: Missing.

Show »
Length:228
Mass (Da):25,735
Checksum:i4CAC49089C1AEF48
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H7C479H7C479_HUMAN
Vesicle-trafficking protein SEC22c
SEC22C
225Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J448C9J448_HUMAN
Vesicle-trafficking protein SEC22c
SEC22C
236Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J9A4C9J9A4_HUMAN
Vesicle-trafficking protein SEC22c
SEC22C
107Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J2R1C9J2R1_HUMAN
Vesicle-trafficking protein SEC22c
SEC22C
142Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8VQT7F8VQT7_HUMAN
Vesicle-trafficking protein SEC22c
SEC22C
72Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JNW1C9JNW1_HUMAN
Vesicle-trafficking protein SEC22c
SEC22C
75Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WDR5F8WDR5_HUMAN
Vesicle-trafficking protein SEC22c
SEC22C
143Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WBN1F8WBN1_HUMAN
Vesicle-trafficking protein SEC22c
SEC22C
61Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_032161216 – 228VAHEE…ILAFL → DPRSWFCWLDQTS in isoform 3. 1 PublicationAdd BLAST13
Alternative sequenceiVSP_032162229 – 303Missing in isoform 3. 1 PublicationAdd BLAST75
Alternative sequenceiVSP_032163238 – 250CYLYL…PARTM → DPRSWFCWLDQTS in isoform 2. 3 PublicationsAdd BLAST13
Alternative sequenceiVSP_032164251 – 303Missing in isoform 2. 3 PublicationsAdd BLAST53

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF039568 mRNA Translation: AAD02171.1
AK292856 mRNA Translation: BAF85545.1
AY359041 mRNA Translation: AAQ89400.1
CH471055 Genomic DNA Translation: EAW64653.1
CH471055 Genomic DNA Translation: EAW64654.1
BC006178 mRNA Translation: AAH06178.1
BC018437 mRNA Translation: AAH18437.1
CR749670 mRNA Translation: CAH18461.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS2699.1 [Q9BRL7-2]
CCDS2700.1 [Q9BRL7-1]
CCDS56246.1 [Q9BRL7-3]

Protein sequence database of the Protein Information Resource

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PIRi
JE0157

NCBI Reference Sequences

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RefSeqi
NP_001188501.1, NM_001201572.1 [Q9BRL7-2]
NP_001188513.1, NM_001201584.1 [Q9BRL7-3]
NP_004197.1, NM_004206.3 [Q9BRL7-2]
NP_116752.1, NM_032970.3 [Q9BRL7-1]
XP_011532514.1, XM_011534212.1 [Q9BRL7-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000264454; ENSP00000264454; ENSG00000093183 [Q9BRL7-1]
ENST00000273156; ENSP00000273156; ENSG00000093183 [Q9BRL7-2]
ENST00000417572; ENSP00000407564; ENSG00000093183 [Q9BRL7-2]
ENST00000423701; ENSP00000414576; ENSG00000093183 [Q9BRL7-3]

Database of genes from NCBI RefSeq genomes

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GeneIDi
9117

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:9117

UCSC genome browser

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UCSCi
uc003clh.4 human [Q9BRL7-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF039568 mRNA Translation: AAD02171.1
AK292856 mRNA Translation: BAF85545.1
AY359041 mRNA Translation: AAQ89400.1
CH471055 Genomic DNA Translation: EAW64653.1
CH471055 Genomic DNA Translation: EAW64654.1
BC006178 mRNA Translation: AAH06178.1
BC018437 mRNA Translation: AAH18437.1
CR749670 mRNA Translation: CAH18461.1
CCDSiCCDS2699.1 [Q9BRL7-2]
CCDS2700.1 [Q9BRL7-1]
CCDS56246.1 [Q9BRL7-3]
PIRiJE0157
RefSeqiNP_001188501.1, NM_001201572.1 [Q9BRL7-2]
NP_001188513.1, NM_001201584.1 [Q9BRL7-3]
NP_004197.1, NM_004206.3 [Q9BRL7-2]
NP_116752.1, NM_032970.3 [Q9BRL7-1]
XP_011532514.1, XM_011534212.1 [Q9BRL7-1]

3D structure databases

SMRiQ9BRL7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114565, 7 interactors
IntActiQ9BRL7, 4 interactors
STRINGi9606.ENSP00000264454

PTM databases

iPTMnetiQ9BRL7
PhosphoSitePlusiQ9BRL7

Polymorphism and mutation databases

BioMutaiSEC22C
DMDMi74732899

Proteomic databases

jPOSTiQ9BRL7
PaxDbiQ9BRL7
PeptideAtlasiQ9BRL7
PRIDEiQ9BRL7
ProteomicsDBi78787
78788 [Q9BRL7-2]
78789 [Q9BRL7-3]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
9117
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000264454; ENSP00000264454; ENSG00000093183 [Q9BRL7-1]
ENST00000273156; ENSP00000273156; ENSG00000093183 [Q9BRL7-2]
ENST00000417572; ENSP00000407564; ENSG00000093183 [Q9BRL7-2]
ENST00000423701; ENSP00000414576; ENSG00000093183 [Q9BRL7-3]
GeneIDi9117
KEGGihsa:9117
UCSCiuc003clh.4 human [Q9BRL7-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
9117

GeneCards: human genes, protein and diseases

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GeneCardsi
SEC22C
HGNCiHGNC:16828 SEC22C
HPAiHPA055594
MIMi604028 gene
neXtProtiNX_Q9BRL7
OpenTargetsiENSG00000093183
PharmGKBiPA134952972

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG0862 Eukaryota
COG5143 LUCA
GeneTreeiENSGT00940000159338
HOGENOMiHOG000007733
InParanoidiQ9BRL7
KOiK08520
OMAiRDVACMA
OrthoDBi903466at2759
PhylomeDBiQ9BRL7
TreeFamiTF105933

Enzyme and pathway databases

ReactomeiR-HSA-204005 COPII-mediated vesicle transport

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
SEC22C human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
9117

Protein Ontology

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PROi
PR:Q9BRL7

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000093183 Expressed in 202 organ(s), highest expression level in epithelium of mammary gland
ExpressionAtlasiQ9BRL7 baseline and differential
GenevisibleiQ9BRL7 HS

Family and domain databases

InterProiView protein in InterPro
IPR011012 Longin-like_dom_sf
IPR010908 Longin_dom
PfamiView protein in Pfam
PF13774 Longin, 1 hit
SMARTiView protein in SMART
SM01270 Longin, 1 hit
SUPFAMiSSF64356 SSF64356, 1 hit
PROSITEiView protein in PROSITE
PS50859 LONGIN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSC22C_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9BRL7
Secondary accession number(s): O95152, Q68CX3, Q6UW18
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: June 1, 2001
Last modified: May 8, 2019
This is version 131 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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