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Entry version 183 (12 Aug 2020)
Sequence version 1 (01 Jun 2001)
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Protein

45 kDa calcium-binding protein

Gene

SDF4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May regulate calcium-dependent activities in the endoplasmic reticulum lumen or post-ER compartment.By similarity
Isoform 5 may be involved in the exocytosis of zymogens by pancreatic acini.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) of the calcium-binding region(s) within the protein. One common calcium-binding motif is the EF-hand, but other calcium-binding motifs also exist.<p><a href='/help/ca_bind' target='_top'>More...</a></p>Calcium bindingi111 – 1221PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi150 – 1612PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi209 – 2203PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi246 – 2574PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi291 – 3025PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi327 – 3386PROSITE-ProRule annotationAdd BLAST12

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processExocytosis
LigandCalcium, Metal-binding

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q9BRK5

Protein family/group databases

Transport Classification Database

More...
TCDBi
8.A.82.3.1, the calmodulin calcium binding protein (calmodulin) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
45 kDa calcium-binding protein
Short name:
Cab45
Alternative name(s):
Stromal cell-derived factor 4
Short name:
SDF-4
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SDF4
Synonyms:CAB45
ORF Names:PSEC0034
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000078808.16

Human Gene Nomenclature Database

More...
HGNCi
HGNC:24188, SDF4

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
614282, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9BRK5

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cell projection, Cytoplasm, Golgi apparatus, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi257E → Q: Does not affect calcium-binding. 1 Publication1
Mutagenesisi302E → Q: Inhibits calcium-binding. 1 Publication1
Mutagenesisi338E → Q: Does not affect calcium-binding. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
51150

Open Targets

More...
OpenTargetsi
ENSG00000078808

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA142670940

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9BRK5, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SDF4

Domain mapping of disease mutations (DMDM)

More...
DMDMi
21263447

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 36Sequence analysisAdd BLAST36
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000000415637 – 36245 kDa calcium-binding proteinAdd BLAST326

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi40N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei99PhosphoserineCombined sources1
Modified residuei193PhosphothreonineCombined sources1
Modified residuei217PhosphothreonineCombined sources1
Modified residuei265PhosphothreonineCombined sources1
Modified residuei299PhosphothreonineCombined sources1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9BRK5

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9BRK5

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9BRK5

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9BRK5

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9BRK5

PeptideAtlas

More...
PeptideAtlasi
Q9BRK5

PRoteomics IDEntifications database

More...
PRIDEi
Q9BRK5

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
78779 [Q9BRK5-1]
78780 [Q9BRK5-2]
78781 [Q9BRK5-3]
78782 [Q9BRK5-4]
78783 [Q9BRK5-5]
78784 [Q9BRK5-6]

Consortium for Top Down Proteomics

More...
TopDownProteomicsi
Q9BRK5-4 [Q9BRK5-4]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...
GlyGeni
Q9BRK5, 3 sites, 1 O-linked glycan (1 site)

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9BRK5

MetOSite database of methionine sulfoxide sites

More...
MetOSitei
Q9BRK5

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9BRK5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitous. Isoform 5 is expressed in pancreas.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000078808, Expressed in stromal cell of endometrium and 228 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9BRK5, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9BRK5, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000078808, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Isoform 5 interacts with STXBP1; the interaction is enhanced in presence of calcium.

Isoform 5 interacts with STX3.

1 Publication

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
119334, 109 interactors

Protein interaction database and analysis system

More...
IntActi
Q9BRK5, 82 interactors

Molecular INTeraction database

More...
MINTi
Q9BRK5

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000353094

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9BRK5, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9BRK5

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini98 – 133EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini137 – 172EF-hand 2PROSITE-ProRule annotationAdd BLAST36
Domaini197 – 232EF-hand 3PROSITE-ProRule annotationAdd BLAST36
Domaini233 – 268EF-hand 4PROSITE-ProRule annotationAdd BLAST36
Domaini278 – 313EF-hand 5PROSITE-ProRule annotationAdd BLAST36
Domaini314 – 349EF-hand 6PROSITE-ProRule annotationAdd BLAST36

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni309 – 362Necessary for intracellular retention in Golgi apparatus lumenBy similarityAdd BLAST54

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Binds calcium via its EF-hands (By similarity). Isoform 5 binds calcium.By similarity

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the CREC family.Curated

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4251, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000182801

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_044718_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9BRK5

KEGG Orthology (KO)

More...
KOi
K19934

Identification of Orthologs from Complete Genome Data

More...
OMAi
IMNNARE

Database of Orthologous Groups

More...
OrthoDBi
1156280at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9BRK5

TreeFam database of animal gene trees

More...
TreeFami
TF314849

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011992, EF-hand-dom_pair
IPR018247, EF_Hand_1_Ca_BS
IPR002048, EF_hand_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13202, EF-hand_5, 1 hit
PF13499, EF-hand_7, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00054, EFh, 5 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47473, SSF47473, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00018, EF_HAND_1, 5 hits
PS50222, EF_HAND_2, 5 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (6+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 6 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 6 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9BRK5-1) [UniParc]FASTAAdd to basket
Also known as: Cab45a, Cab45-G

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MVWPWVAMAS RWGPLIGLAP CCLWLLGAVL LMDASARPAN HSSTRERVAN
60 70 80 90 100
REENEILPPD HLNGVKLEMD GHLNRGFHQE VFLGKDLGGF DEDAEPRRSR
110 120 130 140 150
RKLMVIFSKV DVNTDRKISA KEMQRWIMEK TAEHFQEAME ESKTHFRAVD
160 170 180 190 200
PDGDGHVSWD EYKVKFLASK GHSEKEVADA IRLNEELKVD EETQEVLENL
210 220 230 240 250
KDRWYQADSP PADLLLTEEE FLSFLHPEHS RGMLRFMVKE IVRDLDQDGD
260 270 280 290 300
KQLSVPEFIS LPVGTVENQQ GQDIDDNWVK DRKKEFEELI DSNHDGIVTA
310 320 330 340 350
EELESYMDPM NEYNALNEAK QMIAVADENQ NHHLEPEEVL KYSEFFTGSK
360
LVDYARSVHE EF
Length:362
Mass (Da):41,807
Last modified:June 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i440C6990149AAE2C
GO
Isoform 2 (identifier: Q9BRK5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-103: Missing.

Show »
Length:259
Mass (Da):30,197
Checksum:i3745A23BB8FF6D40
GO
Isoform 3 (identifier: Q9BRK5-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     193-254: TQEVLENLKD...LDQDGDKQLS → SCAPLSTGSP...GDRPGPGPGR
     255-362: Missing.

Show »
Length:254
Mass (Da):27,826
Checksum:i77FACCE59B472125
GO
Isoform 4 (identifier: Q9BRK5-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     193-202: TQEVLENLKD → RHGPPGPRAL
     203-362: Missing.

Show »
Length:202
Mass (Da):23,031
Checksum:i5F208F14504756F7
GO
Isoform 5 (identifier: Q9BRK5-5) [UniParc]FASTAAdd to basket
Also known as: Cab45b, Cab45-C

The sequence of this isoform differs from the canonical sequence as follows:
     1-232: Missing.

Show »
Length:130
Mass (Da):15,139
Checksum:i22545D121BB56827
GO
Isoform 6 (identifier: Q9BRK5-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     305-362: SYMDPMNEYN...DYARSVHEEF → NVPTLPLQPI...PLARRATWTP

Show »
Length:348
Mass (Da):39,608
Checksum:i1832BC4741A9506A
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3V1E2G3V1E2_HUMAN
45 kDa calcium-binding protein
SDF4 hCG_19193
254Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A5F9UJX7A0A5F9UJX7_HUMAN
45 kDa calcium-binding protein
SDF4
341Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A5F9UP49A0A5F9UP49_HUMAN
45 kDa calcium-binding protein
SDF4
355Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y3T6H0Y3T6_HUMAN
45 kDa calcium-binding protein
SDF4
243Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAL75950 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti78H → Q in AAL75950 (Ref. 2) Curated1
Sequence conflicti86D → N in AAL75950 (Ref. 2) Curated1
Sequence conflicti89G → C in AAL75950 (Ref. 2) Curated1
Sequence conflicti92E → R in AAL75950 (Ref. 2) Curated1
Sequence conflicti94A → T in AAL75950 (Ref. 2) Curated1
Sequence conflicti97R → P in AAL75950 (Ref. 2) Curated1
Sequence conflicti117K → R in BAC11563 (PubMed:16303743).Curated1
Sequence conflicti133E → G in BAC11563 (PubMed:16303743).Curated1
Sequence conflicti150D → G in AAL75950 (Ref. 2) Curated1
Sequence conflicti188K → R in BAG37898 (PubMed:14702039).Curated1
Sequence conflicti193T → A in BAD96241 (Ref. 7) Curated1
Sequence conflicti234L → P in BAD96799 (Ref. 7) Curated1
Sequence conflicti281 – 282DR → KK in AAL75950 (Ref. 2) Curated2
Sequence conflicti286F → L in AAL75950 (Ref. 2) Curated1
Sequence conflicti321Q → R in BAD96799 (Ref. 7) Curated1
Sequence conflicti356R → S in AAL75950 (Ref. 2) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_04865950N → D. Corresponds to variant dbSNP:rs12745364Ensembl.1
Natural variantiVAR_035461148A → T in a colorectal cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs766752243Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0374841 – 232Missing in isoform 5. CuratedAdd BLAST232
Alternative sequenceiVSP_0374851 – 103Missing in isoform 2. 1 PublicationAdd BLAST103
Alternative sequenceiVSP_037486193 – 254TQEVL…DKQLS → SCAPLSTGSPGEPEGPLVPG GQPPCRPAADGGGVPVGPPP RAQPGNAQVHGEGDRPGPGP GR in isoform 3. 1 PublicationAdd BLAST62
Alternative sequenceiVSP_037487193 – 202TQEVLENLKD → RHGPPGPRAL in isoform 4. 1 Publication10
Alternative sequenceiVSP_037488203 – 362Missing in isoform 4. 1 PublicationAdd BLAST160
Alternative sequenceiVSP_037489255 – 362Missing in isoform 3. 1 PublicationAdd BLAST108
Alternative sequenceiVSP_040559305 – 362SYMDP…VHEEF → NVPTLPLQPIGTLNSHFVRL AAELGGGKATLTCAPLARRA TWTP in isoform 6. 1 PublicationAdd BLAST58

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
L79912 mRNA Translation: AAL40084.1
AF132749 mRNA Translation: AAL75950.1 Frameshift.
AF153686 mRNA Translation: AAD51612.1
AF178986 mRNA Translation: AAF44350.1
AK027277 mRNA Translation: BAB55012.1
AK299810 mRNA Translation: BAG61683.1
AK315517 mRNA Translation: BAG37898.1
AK075352 mRNA Translation: BAC11563.1
AK222521 mRNA Translation: BAD96241.1
AK223079 mRNA Translation: BAD96799.1
AL162741 Genomic DNA No translation available.
CH471183 Genomic DNA Translation: EAW56272.1
CH471183 Genomic DNA Translation: EAW56273.1
BC006211 mRNA Translation: AAH06211.1
BC007625 mRNA Translation: AAH07625.1
BC008917 mRNA Translation: AAH08917.1
BC011244 mRNA Translation: AAH11244.1
BC022375 mRNA Translation: AAH22375.1

NCBI Reference Sequences

More...
RefSeqi
NP_057260.2, NM_016176.3 [Q9BRK5-1]
NP_057631.1, NM_016547.2
XP_011539858.1, XM_011541556.1 [Q9BRK5-4]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000660930; ENSP00000499296; ENSG00000078808 [Q9BRK5-6]

Database of genes from NCBI RefSeq genomes

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GeneIDi
51150

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:51150

UCSC genome browser

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UCSCi
uc001adh.5, human [Q9BRK5-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L79912 mRNA Translation: AAL40084.1
AF132749 mRNA Translation: AAL75950.1 Frameshift.
AF153686 mRNA Translation: AAD51612.1
AF178986 mRNA Translation: AAF44350.1
AK027277 mRNA Translation: BAB55012.1
AK299810 mRNA Translation: BAG61683.1
AK315517 mRNA Translation: BAG37898.1
AK075352 mRNA Translation: BAC11563.1
AK222521 mRNA Translation: BAD96241.1
AK223079 mRNA Translation: BAD96799.1
AL162741 Genomic DNA No translation available.
CH471183 Genomic DNA Translation: EAW56272.1
CH471183 Genomic DNA Translation: EAW56273.1
BC006211 mRNA Translation: AAH06211.1
BC007625 mRNA Translation: AAH07625.1
BC008917 mRNA Translation: AAH08917.1
BC011244 mRNA Translation: AAH11244.1
BC022375 mRNA Translation: AAH22375.1
RefSeqiNP_057260.2, NM_016176.3 [Q9BRK5-1]
NP_057631.1, NM_016547.2
XP_011539858.1, XM_011541556.1 [Q9BRK5-4]

3D structure databases

SMRiQ9BRK5
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi119334, 109 interactors
IntActiQ9BRK5, 82 interactors
MINTiQ9BRK5
STRINGi9606.ENSP00000353094

Protein family/group databases

TCDBi8.A.82.3.1, the calmodulin calcium binding protein (calmodulin) family

PTM databases

GlyGeniQ9BRK5, 3 sites, 1 O-linked glycan (1 site)
iPTMnetiQ9BRK5
MetOSiteiQ9BRK5
PhosphoSitePlusiQ9BRK5

Polymorphism and mutation databases

BioMutaiSDF4
DMDMi21263447

Proteomic databases

EPDiQ9BRK5
jPOSTiQ9BRK5
MassIVEiQ9BRK5
MaxQBiQ9BRK5
PaxDbiQ9BRK5
PeptideAtlasiQ9BRK5
PRIDEiQ9BRK5
ProteomicsDBi78779 [Q9BRK5-1]
78780 [Q9BRK5-2]
78781 [Q9BRK5-3]
78782 [Q9BRK5-4]
78783 [Q9BRK5-5]
78784 [Q9BRK5-6]
TopDownProteomicsiQ9BRK5-4 [Q9BRK5-4]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
26159, 275 antibodies

The DNASU plasmid repository

More...
DNASUi
51150

Genome annotation databases

EnsembliENST00000660930; ENSP00000499296; ENSG00000078808 [Q9BRK5-6]
GeneIDi51150
KEGGihsa:51150
UCSCiuc001adh.5, human [Q9BRK5-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
51150
DisGeNETi51150
EuPathDBiHostDB:ENSG00000078808.16

GeneCards: human genes, protein and diseases

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GeneCardsi
SDF4
HGNCiHGNC:24188, SDF4
HPAiENSG00000078808, Low tissue specificity
MIMi614282, gene
neXtProtiNX_Q9BRK5
OpenTargetsiENSG00000078808
PharmGKBiPA142670940

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG4251, Eukaryota
GeneTreeiENSGT00950000182801
HOGENOMiCLU_044718_1_0_1
InParanoidiQ9BRK5
KOiK19934
OMAiIMNNARE
OrthoDBi1156280at2759
PhylomeDBiQ9BRK5
TreeFamiTF314849

Enzyme and pathway databases

PathwayCommonsiQ9BRK5

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
51150, 2 hits in 871 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
SDF4, human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
SDF4

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
51150
PharosiQ9BRK5, Tbio

Protein Ontology

More...
PROi
PR:Q9BRK5
RNActiQ9BRK5, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000078808, Expressed in stromal cell of endometrium and 228 other tissues
ExpressionAtlasiQ9BRK5, baseline and differential
GenevisibleiQ9BRK5, HS

Family and domain databases

InterProiView protein in InterPro
IPR011992, EF-hand-dom_pair
IPR018247, EF_Hand_1_Ca_BS
IPR002048, EF_hand_dom
PfamiView protein in Pfam
PF13202, EF-hand_5, 1 hit
PF13499, EF-hand_7, 1 hit
SMARTiView protein in SMART
SM00054, EFh, 5 hits
SUPFAMiSSF47473, SSF47473, 2 hits
PROSITEiView protein in PROSITE
PS00018, EF_HAND_1, 5 hits
PS50222, EF_HAND_2, 5 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCAB45_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9BRK5
Secondary accession number(s): B1AME5
, B1AME6, B2RDF1, B4DSM1, Q53G52, Q53HQ9, Q8NBQ3, Q96AA1, Q9NZP7, Q9UN53
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 27, 2002
Last sequence update: June 1, 2001
Last modified: August 12, 2020
This is version 183 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families
  5. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
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