Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 155 (17 Jun 2020)
Sequence version 2 (01 Mar 2004)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

Leucine zipper putative tumor suppressor 2

Gene

LZTS2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Negative regulator of katanin-mediated microtubule severing and release from the centrosome. Required for central spindle formation and the completion of cytokinesis. May negatively regulate axonal outgrowth by preventing the formation of microtubule bundles that are necessary for transport within the elongating axon. Negative regulator of the Wnt signaling pathway. Represses beta-catenin-mediated transcriptional activation by promoting the nuclear exclusion of beta-catenin.UniRule annotation4 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell cycle, Cell division, Mitosis, Wnt signaling pathway

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Leucine zipper putative tumor suppressor 2UniRule annotation
Short name:
hLZTS2
Alternative name(s):
Protein LAPSER1UniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:LZTS2UniRule annotation
Synonyms:KIAA1813, LAPSER1UniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000107816.17

Human Gene Nomenclature Database

More...
HGNCi
HGNC:29381 LZTS2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
610454 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9BRK4

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi638L → A: Induces nuclear accumulation. Impairs nuclear exclusion of beta-catenin; when associated with A-640. 1 Publication1
Mutagenesisi640L → A: Induces nuclear accumulation. Impairs nuclear exclusion of beta-catenin; when associated with A-38. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
84445

Open Targets

More...
OpenTargetsi
ENSG00000107816

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134944540

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9BRK4 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
LZTS2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
46396501

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001829741 – 669Leucine zipper putative tumor suppressor 2Add BLAST669

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei249PhosphoserineBy similarity1
Modified residuei296PhosphoserineBy similarity1
Modified residuei570PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9BRK4

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9BRK4

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9BRK4

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9BRK4

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9BRK4

PeptideAtlas

More...
PeptideAtlasi
Q9BRK4

PRoteomics IDEntifications database

More...
PRIDEi
Q9BRK4

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
78778

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9BRK4

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9BRK4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in prostate and testis, and at slightly lower levels in spleen, thymus, uterus, small intestine and colon.1 Publication

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

By inhibition of NF-kappa-B signaling.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000107816 Expressed in esophagogastric junction muscularis propria and 188 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9BRK4 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9BRK4 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000107816 Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with KATNB1.

Also interacts with CTNNB1, gamma-tubulin and KIF23.

UniRule annotation2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Q9BRK4
With#Exp.IntAct
ABI2 - isoform 2 [Q9NYB9-2]3EBI-741037,EBI-11096309
ABT1 [Q9ULW3]3EBI-741037,EBI-2602396
AEN [Q8WTP8]3EBI-741037,EBI-8637627
AEN - isoform 2 [Q8WTP8-2]3EBI-741037,EBI-12119298
ANKRD36BP1 [Q96IX9]3EBI-741037,EBI-744859
AP1M1 [Q9BXS5]3EBI-741037,EBI-541426
ARHGAP32 [A7KAX9]3EBI-741037,EBI-308663
ARMC7 [Q9H6L4]3EBI-741037,EBI-742909
ATPAF2 [Q8N5M1]6EBI-741037,EBI-1166928
BAHD1 [Q8TBE0]7EBI-741037,EBI-742750
BEX2 [Q9BXY8]3EBI-741037,EBI-745073
BYSL [Q13895]6EBI-741037,EBI-358049
C1orf109 [Q9NX04]6EBI-741037,EBI-8643161
C2CD6 [Q53TS8]3EBI-741037,EBI-739879
C8orf33 [Q9H7E9]3EBI-741037,EBI-715389
CABP5 [Q9NP86]3EBI-741037,EBI-10311131
CARD9 [Q9H257]3EBI-741037,EBI-751319
CATSPER1 [Q8NEC5]3EBI-741037,EBI-744545
CBX8 [Q9HC52]6EBI-741037,EBI-712912
CCDC198 [Q9NVL8]3EBI-741037,EBI-10238351
CCNC [P24863]3EBI-741037,EBI-395261
CCNG1 [P51959]3EBI-741037,EBI-3905829
CCNK [O75909]3EBI-741037,EBI-739806
CDC23 [Q9UJX2]3EBI-741037,EBI-396137
CDK18 [Q07002]3EBI-741037,EBI-746238
CDKL3 [Q8IVW4]3EBI-741037,EBI-3919850
CDKN1A [P38936]3EBI-741037,EBI-375077
CEP57L1 [Q8IYX8]3EBI-741037,EBI-1104570
CEP57L1 - isoform 2 [Q8IYX8-2]3EBI-741037,EBI-10181988
CFAP206 [Q8IYR0]3EBI-741037,EBI-749051
CHCHD3 [Q9NX63]3EBI-741037,EBI-743375
CHIC2 [Q9UKJ5]3EBI-741037,EBI-741528
CLIP4 [Q8N3C7]3EBI-741037,EBI-5655540
CNNM3 [Q8NE01]3EBI-741037,EBI-741032
CNNM3 - isoform 3 [Q8NE01-3]3EBI-741037,EBI-10269984
CSNK1D [P48730]3EBI-741037,EBI-751621
CWF19L2 [Q2TBE0]3EBI-741037,EBI-5453285
DCUN1D1 [Q96GG9]6EBI-741037,EBI-740086
DGCR6L [Q9BY27]3EBI-741037,EBI-742953
DUSP4 [Q13115]3EBI-741037,EBI-6591081
DYRK1A [Q13627]3EBI-741037,EBI-1053596
DYRK1B [Q9Y463]3EBI-741037,EBI-634187
DYRK2 [Q92630]3EBI-741037,EBI-749432
EHHADH [Q08426]3EBI-741037,EBI-2339219
EIF3D [O15371]3EBI-741037,EBI-353818
EIF4E2 [O60573]3EBI-741037,EBI-398610
EXOSC5 [Q9NQT4]3EBI-741037,EBI-371876
FAM107A - isoform 3 [O95990-3]3EBI-741037,EBI-10192902
FAM124B [Q9H5Z6]3EBI-741037,EBI-741626
FAM161A [Q3B820]6EBI-741037,EBI-719941
FAM214B [Q7L5A3]3EBI-741037,EBI-745689
FAM221B [A6H8Z2]3EBI-741037,EBI-12006844
FAM50B [Q9Y247]3EBI-741037,EBI-742802
FAM74A6 [Q5TZK3]3EBI-741037,EBI-10247271
FAM90A1 [Q86YD7]3EBI-741037,EBI-6658203
FANCL [Q9NW38]3EBI-741037,EBI-2339898
FBF1 - isoform 6 [Q8TES7-6]3EBI-741037,EBI-10244131
FEM1C [Q96JP0]3EBI-741037,EBI-2515330
FGF12 [P61328]3EBI-741037,EBI-6657662
FKBP6 [O75344]7EBI-741037,EBI-744771
FNDC11 [Q9BVV2]3EBI-741037,EBI-744935
FRG1 [Q14331]3EBI-741037,EBI-2515248
FRMD6 [Q96NE9]3EBI-741037,EBI-741729
GADD45GIP1 [Q8TAE8]3EBI-741037,EBI-372506
GATA1 - isoform 2 [P15976-2]3EBI-741037,EBI-9090198
GCC1 [Q96CN9]3EBI-741037,EBI-746252
GEM [P55040]6EBI-741037,EBI-744104
GIPC2 [Q8TF65]3EBI-741037,EBI-712067
GLYCTK [Q8IVS8]3EBI-741037,EBI-748515
GMCL2 [Q8NEA9]3EBI-741037,EBI-745707
GNL3L [Q9NVN8]3EBI-741037,EBI-746682
GPANK1 [O95872]4EBI-741037,EBI-751540
GPATCH2L [Q9NWQ4]3EBI-741037,EBI-5666657
GRB2 [P62993]3EBI-741037,EBI-401755
HM13 [Q8TCT9]3EBI-741037,EBI-347472
HOMER2 [Q9NSB8]3EBI-741037,EBI-2126733
HOXB9 [P17482]4EBI-741037,EBI-745290
HSPD1 [P10809]7EBI-741037,EBI-352528
IGFN1 - isoform 5 [Q86VF2-5]3EBI-741037,EBI-11955401
INO80B [Q9C086]3EBI-741037,EBI-715611
IQCN [Q9H0B3]3EBI-741037,EBI-745878
KAT5 [Q92993]6EBI-741037,EBI-399080
KAZN [Q674X7]3EBI-741037,EBI-949239
KIFC3 [Q9BVG8]3EBI-741037,EBI-2125614
KIFC3 - isoform 4 [Q9BVG8-5]3EBI-741037,EBI-14069005
KPNA2 [P52292]3EBI-741037,EBI-349938
LASP1 [Q14847]3EBI-741037,EBI-742828
LCK [P06239]3EBI-741037,EBI-1348
LIN37 [Q96GY3]3EBI-741037,EBI-748884
LMO1 [P25800]3EBI-741037,EBI-8639312
LMO2 [P25791]3EBI-741037,EBI-739696
LMO3 - isoform 4 [Q8TAP4-4]3EBI-741037,EBI-11742507
MAB21L3 [Q8N8X9]6EBI-741037,EBI-10268010
MAGEB4 [O15481]3EBI-741037,EBI-751857
MAPK1 [P28482]4EBI-741037,EBI-959949
MEMO1 [Q9Y316]3EBI-741037,EBI-1104564
MGC50722 [Q8IVT4]3EBI-741037,EBI-14086479
MID2 - isoform 2 [Q9UJV3-2]3EBI-741037,EBI-10172526
MORF4L1 [Q9UBU8]3EBI-741037,EBI-399246
MORF4L1 - isoform 2 [Q9UBU8-2]3EBI-741037,EBI-10288852
MORF4L2 [Q15014]3EBI-741037,EBI-399257
MORN3 [Q6PF18]3EBI-741037,EBI-9675802
MOS [P00540]3EBI-741037,EBI-1757866
MTA1 [Q13330]3EBI-741037,EBI-714236
MYOZ1 [Q9NP98]3EBI-741037,EBI-744402
NCBP2 [P52298]3EBI-741037,EBI-464729
NCK2 [O43639]6EBI-741037,EBI-713635
NEBL [O76041]3EBI-741037,EBI-2880203
NEK6 [Q9HC98]3EBI-741037,EBI-740364
NEK6 - isoform 4 [Q9HC98-4]3EBI-741037,EBI-11750983
NIP7 [Q9Y221]3EBI-741037,EBI-749003
OTUB2 [Q96DC9]3EBI-741037,EBI-746259
PATZ1 - isoform 4 [Q9HBE1-4]3EBI-741037,EBI-11022007
PHF1 [O43189]3EBI-741037,EBI-530034
PHF19 [Q5T6S3]3EBI-741037,EBI-2339674
PKP4 [Q99569]3EBI-741037,EBI-726447
PLEKHN1 [Q494U1]3EBI-741037,EBI-10241513
POLDIP3 [Q8WUT1]6EBI-741037,EBI-10276663
POLR1C [O15160]3EBI-741037,EBI-1055079
PPP1R18 [Q6NYC8]3EBI-741037,EBI-2557469
PQBP1 [O60828]6EBI-741037,EBI-713867
PRKAA2 [P54646]3EBI-741037,EBI-1383852
PRKAB2 [O43741]4EBI-741037,EBI-1053424
PRPF18 [Q99633]3EBI-741037,EBI-2798416
PRPF31 [Q8WWY3]3EBI-741037,EBI-1567797
PRR35 [P0CG20]3EBI-741037,EBI-11986293
PSMA1 [P25786]3EBI-741037,EBI-359352
QARS1 [P47897]6EBI-741037,EBI-347462
QARS1 - isoform 2 [P47897-2]3EBI-741037,EBI-10209725
RAC1 [P63000]3EBI-741037,EBI-413628
RAD51D [O75771]9EBI-741037,EBI-1055693
RAMAC [Q9BTL3]3EBI-741037,EBI-744023
RBM15 [Q96T37]3EBI-741037,EBI-2514922
RBM41 [Q96IZ5]3EBI-741037,EBI-740773
RCOR3 [Q9P2K3]3EBI-741037,EBI-743428
RHNO1 [Q9BSD3]3EBI-741037,EBI-9658624
RIN1 [Q13671]9EBI-741037,EBI-366017
RNF41 [Q9H4P4]3EBI-741037,EBI-2130266
RTP5 [Q14D33]3EBI-741037,EBI-10217913
RUNX1T1 - isoform 4 [Q06455-4]3EBI-741037,EBI-10224192
SCNM1 [Q9BWG6]3EBI-741037,EBI-748391
SFRS2 [Q6NXQ0]3EBI-741037,EBI-10251550
SH2D4A [Q9H788]3EBI-741037,EBI-747035
SH3KBP1 [Q96B97]3EBI-741037,EBI-346595
SH3RF2 [Q08AM8]3EBI-741037,EBI-10225873
SHFL [Q9NUL5]3EBI-741037,EBI-10313866
SLC15A3 [Q05CH4]3EBI-741037,EBI-10223741
SLC25A6 [P12236]3EBI-741037,EBI-356254
SLC39A14 - isoform 3 [Q15043-2]3EBI-741037,EBI-12176399
SLU7 [O95391]3EBI-741037,EBI-750559
SMARCD1 [Q96GM5]3EBI-741037,EBI-358489
SMIM3 [Q9BZL3]3EBI-741037,EBI-741850
SNW1 [Q13573]3EBI-741037,EBI-632715
SNX31 [Q8N9S9]3EBI-741037,EBI-9380649
SPATA2 [Q9UM82]3EBI-741037,EBI-744066
SPATA24 [Q86W54]3EBI-741037,EBI-3916986
SPATC1L [Q9H0A9]3EBI-741037,EBI-372911
SPG7 [Q9UQ90]3EBI-741037,EBI-717201
STAC [Q8WUK8]3EBI-741037,EBI-10276615
STAC [Q99469]3EBI-741037,EBI-2652799
SUPV3L1 [Q8IYB8]3EBI-741037,EBI-2876787
SUV39H1 [O43463]6EBI-741037,EBI-349968
SYT17 [Q9BSW7]3EBI-741037,EBI-745392
TBC1D7 [Q9P0N9]3EBI-741037,EBI-3258000
TCEA2 [Q15560]3EBI-741037,EBI-710310
TCHP [Q9BT92]3EBI-741037,EBI-740781
TEAD4 [D3DUQ6]3EBI-741037,EBI-10176734
TEAD4 [Q15561]3EBI-741037,EBI-747736
THAP10 [Q9P2Z0]3EBI-741037,EBI-745404
THAP7 [Q9BT49]6EBI-741037,EBI-741350
TLE5 - isoform 2 [Q08117-2]3EBI-741037,EBI-11741437
TNIP3 [Q96KP6]6EBI-741037,EBI-2509913
TRIM29 [Q14134]4EBI-741037,EBI-702370
TRIM42 [Q8IWZ5]3EBI-741037,EBI-5235829
TSSK2 [Q96PF2]3EBI-741037,EBI-852089
TSSK3 [Q96PN8]3EBI-741037,EBI-3918381
TTC23 [Q5W5X9]3EBI-741037,EBI-6447954
TTC23 - isoform 3 [Q5W5X9-3]3EBI-741037,EBI-9090990
TTLL10 - isoform 3 [Q6ZVT0-3]3EBI-741037,EBI-11979997
TXNL4A [P83876]3EBI-741037,EBI-746539
UBASH3A - isoform 2 [P57075-2]3EBI-741037,EBI-7353612
UBASH3B [Q8TF42]3EBI-741037,EBI-1380492
USF2 [Q15853]3EBI-741037,EBI-1055994
USP2 [O75604]6EBI-741037,EBI-743272
UTP14C [Q08E77]4EBI-741037,EBI-10225961
VEZF1 [Q14119]3EBI-741037,EBI-11980193
WDYHV1 [Q96HA8]3EBI-741037,EBI-741158
WT1-AS [Q06250]3EBI-741037,EBI-10223946
ZBTB25 [P24278]3EBI-741037,EBI-739899
ZC2HC1C - isoform 2 [Q53FD0-2]3EBI-741037,EBI-14104088
ZGPAT [A0A0S2Z6H0]4EBI-741037,EBI-16428984
ZGPAT [Q8N5A5]3EBI-741037,EBI-3439227
ZGPAT - isoform 2 [Q8N5A5-2]9EBI-741037,EBI-10183064
ZKSCAN3 [Q9BRR0]3EBI-741037,EBI-1965777
ZMAT2 [Q96NC0]3EBI-741037,EBI-2682299
ZMYND19 [Q96E35]4EBI-741037,EBI-746595
ZNF124 [Q15973]3EBI-741037,EBI-2555767
ZNF20 [P17024]3EBI-741037,EBI-717634
ZNF250 - isoform 3 [P15622-3]3EBI-741037,EBI-10177272
ZNF408 [Q9H9D4]4EBI-741037,EBI-347633
ZNF417 [Q8TAU3]6EBI-741037,EBI-740727
ZNF426 [Q9BUY5]3EBI-741037,EBI-743265
ZNF446 - isoform 2 [Q9NWS9-2]3EBI-741037,EBI-740232
ZNF490 [Q9ULM2]3EBI-741037,EBI-1105370
ZNF572 [Q7Z3I7]6EBI-741037,EBI-10172590
ZNF581 [Q9P0T4]4EBI-741037,EBI-745520
ZNF648 [Q5T619]3EBI-741037,EBI-11985915
A8K9323EBI-741037,EBI-10174671
Q95HA43EBI-741037,EBI-10236795
Q9H6F03EBI-741037,EBI-10307481
tax [P03410] from Human T-cell leukemia virus 2.5EBI-741037,EBI-9676218
P0C206 from Human T-cell leukemia virus 1 (isolate Caribbea HS-35 subtype A).4EBI-741037,EBI-9675596

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
124083, 290 interactors

Protein interaction database and analysis system

More...
IntActi
Q9BRK4, 310 interactors

Molecular INTeraction database

More...
MINTi
Q9BRK4

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000359240

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9BRK4 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9BRK4

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 332Required for centrosomal localizationBy similarityAdd BLAST332
Regioni447 – 669Sufficient for interaction with CTNNB11 PublicationAdd BLAST223
Regioni450 – 669Sufficient for interaction with KATNB1 and for inhibition of katanin-mediated microtubule severingBy similarityAdd BLAST220

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili328 – 649UniRule annotationAdd BLAST322

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi631 – 640Nuclear export signal10

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi188 – 306Ser-richAdd BLAST119

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the LZTS2 family.UniRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IGJE Eukaryota
ENOG4111JZA LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154078

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_026379_2_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9BRK4

Identification of Orthologs from Complete Genome Data

More...
OMAi
MAIVHTV

Database of Orthologous Groups

More...
OrthoDBi
1014871at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9BRK4

TreeFam database of animal gene trees

More...
TreeFami
TF331420

Family and domain databases

HAMAP database of protein families

More...
HAMAPi
MF_03026 LZTS2, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR028597 LZTS2

The PANTHER Classification System

More...
PANTHERi
PTHR19354:SF4 PTHR19354:SF4, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

Q9BRK4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAIVQTLPVP LEPAPEAATA PQAPVMGSVS SLISGRPCPG GPAPPRHHGP
60 70 80 90 100
PGPTFFRQQD GLLRGGYEAQ EPLCPAVPPR KAVPVTSFTY INEDFRTESP
110 120 130 140 150
PSPSSDVEDA REQRAHNAHL RGPPPKLIPV SGKLEKNMEK ILIRPTAFKP
160 170 180 190 200
VLPKPRGAPS LPSFMGPRAT GLSGSQGSLT QLFGGPASSS SSSSSSSAAD
210 220 230 240 250
KPLAFSGWAS GCPSGTLSDS GRNSLSSLPT YSTGGAEPTT SSPGGHLPSH
260 270 280 290 300
GSGRGALPGP ARGVPTGPSH SDSGRSSSSK STGSLGGRVA GGLLGSGTRA
310 320 330 340 350
SPDSSSCGER SPPPPPPPPS DEALLHCVLE GKLRDREAEL QQLRDSLDEN
360 370 380 390 400
EATMCQAYEE RQRHWQRERE ALREDCAAQA QRAQRAQQLL QLQVFQLQQE
410 420 430 440 450
KRQLQDDFAQ LLQEREQLER RCATLEREQR ELGPRLEETK WEVCQKSGEI
460 470 480 490 500
SLLKQQLKES QAELVQKGSE LVALRVALRE ARATLRVSEG RARGLQEAAR
510 520 530 540 550
ARELELEACS QELQRHRQEA EQLREKAGQL DAEAAGLREP PVPPATADPF
560 570 580 590 600
LLAESDEAKV QRAAAGVGGS LRAQVERLRV ELQRERRRGE EQRDSFEGER
610 620 630 640 650
LAWQAEKEQV IRYQKQLQHN YIQMYRRNRQ LEQELQQLSL ELEARELADL
660
GLAEQAPCIC LEEITATEI
Length:669
Mass (Da):72,759
Last modified:March 1, 2004 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1274FD9A36A217E6
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B1AL13B1AL13_HUMAN
Leucine zipper putative tumor suppr...
LZTS2
240Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B1AL11B1AL11_HUMAN
Leucine zipper putative tumor suppr...
LZTS2
198Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B1AL12B1AL12_HUMAN
Leucine zipper putative tumor suppr...
LZTS2
220Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
S4R3W7S4R3W7_HUMAN
Leucine zipper putative tumor suppr...
LZTS2
136Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAB47442 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti289V → L in AAH58938 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_036364121R → H in a colorectal cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs367898512Ensembl.1
Natural variantiVAR_036365291G → R in a breast cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs1235690743Ensembl.1
Natural variantiVAR_018277299R → W. Corresponds to variant dbSNP:rs2275381Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB058716 mRNA Translation: BAB47442.1 Different initiation.
AL133215 Genomic DNA No translation available.
CH471066 Genomic DNA Translation: EAW49790.1
CH471066 Genomic DNA Translation: EAW49791.1
CH471066 Genomic DNA Translation: EAW49792.1
BC006212 mRNA Translation: AAH06212.2
BC058938 mRNA Translation: AAH58938.1
AY029201 mRNA Translation: AAK31577.1
AL834338 mRNA Translation: CAD39005.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS7507.1

NCBI Reference Sequences

More...
RefSeqi
NP_001305028.1, NM_001318099.1
NP_001305029.1, NM_001318100.1
NP_001305030.1, NM_001318101.1
NP_115805.1, NM_032429.3
XP_005270279.1, XM_005270222.4
XP_016872269.1, XM_017016780.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000370220; ENSP00000359240; ENSG00000107816
ENST00000370223; ENSP00000359243; ENSG00000107816

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
84445

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:84445

UCSC genome browser

More...
UCSCi
uc001ksj.4 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB058716 mRNA Translation: BAB47442.1 Different initiation.
AL133215 Genomic DNA No translation available.
CH471066 Genomic DNA Translation: EAW49790.1
CH471066 Genomic DNA Translation: EAW49791.1
CH471066 Genomic DNA Translation: EAW49792.1
BC006212 mRNA Translation: AAH06212.2
BC058938 mRNA Translation: AAH58938.1
AY029201 mRNA Translation: AAK31577.1
AL834338 mRNA Translation: CAD39005.1
CCDSiCCDS7507.1
RefSeqiNP_001305028.1, NM_001318099.1
NP_001305029.1, NM_001318100.1
NP_001305030.1, NM_001318101.1
NP_115805.1, NM_032429.3
XP_005270279.1, XM_005270222.4
XP_016872269.1, XM_017016780.1

3D structure databases

SMRiQ9BRK4
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi124083, 290 interactors
IntActiQ9BRK4, 310 interactors
MINTiQ9BRK4
STRINGi9606.ENSP00000359240

PTM databases

iPTMnetiQ9BRK4
PhosphoSitePlusiQ9BRK4

Polymorphism and mutation databases

BioMutaiLZTS2
DMDMi46396501

Proteomic databases

EPDiQ9BRK4
jPOSTiQ9BRK4
MassIVEiQ9BRK4
MaxQBiQ9BRK4
PaxDbiQ9BRK4
PeptideAtlasiQ9BRK4
PRIDEiQ9BRK4
ProteomicsDBi78778

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
31240 148 antibodies

The DNASU plasmid repository

More...
DNASUi
84445

Genome annotation databases

EnsembliENST00000370220; ENSP00000359240; ENSG00000107816
ENST00000370223; ENSP00000359243; ENSG00000107816
GeneIDi84445
KEGGihsa:84445
UCSCiuc001ksj.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
84445
DisGeNETi84445
EuPathDBiHostDB:ENSG00000107816.17

GeneCards: human genes, protein and diseases

More...
GeneCardsi
LZTS2
HGNCiHGNC:29381 LZTS2
HPAiENSG00000107816 Low tissue specificity
MIMi610454 gene
neXtProtiNX_Q9BRK4
OpenTargetsiENSG00000107816
PharmGKBiPA134944540

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IGJE Eukaryota
ENOG4111JZA LUCA
GeneTreeiENSGT00940000154078
HOGENOMiCLU_026379_2_0_1
InParanoidiQ9BRK4
OMAiMAIVHTV
OrthoDBi1014871at2759
PhylomeDBiQ9BRK4
TreeFamiTF331420

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
84445 0 hits in 790 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
LZTS2 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
84445
PharosiQ9BRK4 Tbio

Protein Ontology

More...
PROi
PR:Q9BRK4
RNActiQ9BRK4 protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000107816 Expressed in esophagogastric junction muscularis propria and 188 other tissues
ExpressionAtlasiQ9BRK4 baseline and differential
GenevisibleiQ9BRK4 HS

Family and domain databases

HAMAPiMF_03026 LZTS2, 1 hit
InterProiView protein in InterPro
IPR028597 LZTS2
PANTHERiPTHR19354:SF4 PTHR19354:SF4, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLZTS2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9BRK4
Secondary accession number(s): B1AL14
, D3DR72, Q8N3I0, Q96J79, Q96JL2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: March 1, 2004
Last modified: June 17, 2020
This is version 155 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again