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Protein

Matrix remodeling-associated protein 8

Gene

MXRA8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play a role in the maturation and maintenance of blood-brain barrier.By similarity
(Microbial infection) Contributes to arthritogenic alphavirus pathogenesis and acts as a receptor for these viruses.1 Publication

GO - Biological processi

Keywordsi

Biological processHost-virus interaction

Enzyme and pathway databases

ReactomeiR-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-HSA-8957275 Post-translational protein phosphorylation

Names & Taxonomyi

Protein namesi
Recommended name:
Matrix remodeling-associated protein 8
Alternative name(s):
Limitrin
Gene namesi
Name:MXRA8
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000162576.16
HGNCiHGNC:7542 MXRA8
MIMi617293 gene
neXtProtiNX_Q9BRK3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini20 – 341ExtracellularSequence analysisAdd BLAST322
Transmembranei342 – 362HelicalSequence analysisAdd BLAST21
Topological domaini363 – 442CytoplasmicSequence analysisAdd BLAST80

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000162576
PharmGKBiPA31343

Polymorphism and mutation databases

DMDMi74761214

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000029866520 – 442Matrix remodeling-associated protein 8Add BLAST423

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi54 ↔ 137PROSITE-ProRule annotation
Glycosylationi119N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi186 ↔ 272PROSITE-ProRule annotation
Modified residuei228Phosphoserine; by FAM20C1 Publication1
Glycosylationi306N-linked (GlcNAc...) asparagineSequence analysis1

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei325 – 326CleavageBy similarity2

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

EPDiQ9BRK3
MaxQBiQ9BRK3
PaxDbiQ9BRK3
PeptideAtlasiQ9BRK3
PRIDEiQ9BRK3
ProteomicsDBi78776
78777 [Q9BRK3-2]

PTM databases

iPTMnetiQ9BRK3
PhosphoSitePlusiQ9BRK3

Expressioni

Gene expression databases

BgeeiENSG00000162576 Expressed in 217 organ(s), highest expression level in right ovary
CleanExiHS_MXRA8
GenevisibleiQ9BRK3 HS

Organism-specific databases

HPAiHPA053958
HPA055780

Interactioni

Subunit structurei

(Microbial infection) Interacts with chikungunya virus spike glycoprotein E2.1 Publication

Protein-protein interaction databases

IntActiQ9BRK3, 9 interactors
MINTiQ9BRK3
STRINGi9606.ENSP00000307887

Structurei

3D structure databases

ProteinModelPortaliQ9BRK3
SMRiQ9BRK3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini29 – 157Ig-like V-type 1Add BLAST129
Domaini160 – 288Ig-like V-type 2Add BLAST129

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi364 – 367Poly-Arg4

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IJVY Eukaryota
ENOG41113W9 LUCA
GeneTreeiENSGT00390000001509
HOGENOMiHOG000065729
HOVERGENiHBG058527
InParanoidiQ9BRK3
OMAiNDRQRVV
OrthoDBiEOG091G09TD
PhylomeDBiQ9BRK3
TreeFamiTF332884

Family and domain databases

Gene3Di2.60.40.10, 2 hits
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR013106 Ig_V-set
PfamiView protein in Pfam
PF07686 V-set, 2 hits
SMARTiView protein in SMART
SM00409 IG, 2 hits
SM00406 IGv, 2 hits
SUPFAMiSSF48726 SSF48726, 2 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 2 hits

Sequences (4)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q9BRK3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MALPSRILLW KLVLLQSSAV LLHSGSSVPA AAGSSVVSES AVSWEAGARA
60 70 80 90 100
VLRCQSPRMV WTQDRLHDRQ RVLHWDLRGP GGGPARRLLD LYSAGEQRVY
110 120 130 140 150
EARDRGRLEL SASAFDDGNF SLLIRAVEET DAGLYTCNLH HHYCHLYESL
160 170 180 190 200
AVRLEVTDGP PATPAYWDGE KEVLAVARGA PALLTCVNRG HVWTDRHVEE
210 220 230 240 250
AQQVVHWDRQ PPGVPHDRAD RLLDLYASGE RRAYGPLFLR DRVAVGADAF
260 270 280 290 300
ERGDFSLRIE PLEVADEGTY SCHLHHHYCG LHERRVFHLT VAEPHAEPPP
310 320 330 340 350
RGSPGNGSSH SGAPGPDPTL ARGHNVINVI VPESRAHFFQ QLGYVLATLL
360 370 380 390 400
LFILLLVTVL LAARRRRGGY EYSDQKSGKS KGKDVNLAEF AVAAGDQMLY
410 420 430 440
RSEDIQLDYK NNILKERAEL AHSPLPAKYI DLDKGFRKEN CK
Length:442
Mass (Da):49,132
Last modified:June 1, 2001 - v1
Checksum:iB08F89D726222CA1
GO
Isoform 2 (identifier: Q9BRK3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     407-407: L → LASSPPT
     435-442: GFRKENCK → DPSGLCPLGA

Show »
Length:450
Mass (Da):49,620
Checksum:i93865CBB68AC1C04
GO
Isoform 3 (identifier: Q9BRK3-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-17: MALPSRILLWKLVLLQS → MIRCAATG

Note: No experimental confirmation available.
Show »
Length:433
Mass (Da):47,972
Checksum:iAFECF654C299D6D6
GO
Isoform 4 (identifier: Q9BRK3-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     25-125: Missing.

Note: No experimental confirmation available.
Show »
Length:341
Mass (Da):38,070
Checksum:i788EDD861A10CCF5
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti405I → V in BAB55010 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_070893396D → N1 PublicationCorresponds to variant dbSNP:rs150058708Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0545281 – 17MALPS…VLLQS → MIRCAATG in isoform 3. 1 PublicationAdd BLAST17
Alternative sequenceiVSP_05452925 – 125Missing in isoform 4. 1 PublicationAdd BLAST101
Alternative sequenceiVSP_027448407L → LASSPPT in isoform 2. 1 Publication1
Alternative sequenceiVSP_027449435 – 442GFRKENCK → DPSGLCPLGA in isoform 2. 1 Publication8

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB052096 mRNA Translation: BAD05132.1
AK027269 mRNA Translation: BAB55010.1
AK095966 mRNA Translation: BAG53178.1
AK293442 mRNA Translation: BAG56945.1
AL139287 Genomic DNA No translation available.
BC006213 mRNA Translation: AAH06213.1
BC017312 mRNA Translation: AAH17312.1
CCDSiCCDS24.1 [Q9BRK3-1]
CCDS59950.1 [Q9BRK3-4]
CCDS59951.1 [Q9BRK3-2]
CCDS59952.1 [Q9BRK3-3]
RefSeqiNP_001269511.1, NM_001282582.1 [Q9BRK3-1]
NP_001269512.1, NM_001282583.1 [Q9BRK3-3]
NP_001269513.1, NM_001282584.1 [Q9BRK3-4]
NP_001269514.1, NM_001282585.1 [Q9BRK3-2]
NP_115724.1, NM_032348.3 [Q9BRK3-1]
UniGeneiHs.515687

Genome annotation databases

EnsembliENST00000309212; ENSP00000307887; ENSG00000162576 [Q9BRK3-1]
ENST00000342753; ENSP00000344998; ENSG00000162576 [Q9BRK3-4]
ENST00000445648; ENSP00000399229; ENSG00000162576 [Q9BRK3-2]
ENST00000477278; ENSP00000436135; ENSG00000162576 [Q9BRK3-3]
GeneIDi54587
KEGGihsa:54587
UCSCiuc001aew.5 human [Q9BRK3-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB052096 mRNA Translation: BAD05132.1
AK027269 mRNA Translation: BAB55010.1
AK095966 mRNA Translation: BAG53178.1
AK293442 mRNA Translation: BAG56945.1
AL139287 Genomic DNA No translation available.
BC006213 mRNA Translation: AAH06213.1
BC017312 mRNA Translation: AAH17312.1
CCDSiCCDS24.1 [Q9BRK3-1]
CCDS59950.1 [Q9BRK3-4]
CCDS59951.1 [Q9BRK3-2]
CCDS59952.1 [Q9BRK3-3]
RefSeqiNP_001269511.1, NM_001282582.1 [Q9BRK3-1]
NP_001269512.1, NM_001282583.1 [Q9BRK3-3]
NP_001269513.1, NM_001282584.1 [Q9BRK3-4]
NP_001269514.1, NM_001282585.1 [Q9BRK3-2]
NP_115724.1, NM_032348.3 [Q9BRK3-1]
UniGeneiHs.515687

3D structure databases

ProteinModelPortaliQ9BRK3
SMRiQ9BRK3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9BRK3, 9 interactors
MINTiQ9BRK3
STRINGi9606.ENSP00000307887

PTM databases

iPTMnetiQ9BRK3
PhosphoSitePlusiQ9BRK3

Polymorphism and mutation databases

DMDMi74761214

Proteomic databases

EPDiQ9BRK3
MaxQBiQ9BRK3
PaxDbiQ9BRK3
PeptideAtlasiQ9BRK3
PRIDEiQ9BRK3
ProteomicsDBi78776
78777 [Q9BRK3-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000309212; ENSP00000307887; ENSG00000162576 [Q9BRK3-1]
ENST00000342753; ENSP00000344998; ENSG00000162576 [Q9BRK3-4]
ENST00000445648; ENSP00000399229; ENSG00000162576 [Q9BRK3-2]
ENST00000477278; ENSP00000436135; ENSG00000162576 [Q9BRK3-3]
GeneIDi54587
KEGGihsa:54587
UCSCiuc001aew.5 human [Q9BRK3-1]

Organism-specific databases

CTDi54587
EuPathDBiHostDB:ENSG00000162576.16
GeneCardsiMXRA8
HGNCiHGNC:7542 MXRA8
HPAiHPA053958
HPA055780
MIMi617293 gene
neXtProtiNX_Q9BRK3
OpenTargetsiENSG00000162576
PharmGKBiPA31343
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IJVY Eukaryota
ENOG41113W9 LUCA
GeneTreeiENSGT00390000001509
HOGENOMiHOG000065729
HOVERGENiHBG058527
InParanoidiQ9BRK3
OMAiNDRQRVV
OrthoDBiEOG091G09TD
PhylomeDBiQ9BRK3
TreeFamiTF332884

Enzyme and pathway databases

ReactomeiR-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-HSA-8957275 Post-translational protein phosphorylation

Miscellaneous databases

ChiTaRSiMXRA8 human
GenomeRNAii54587
PROiPR:Q9BRK3
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000162576 Expressed in 217 organ(s), highest expression level in right ovary
CleanExiHS_MXRA8
GenevisibleiQ9BRK3 HS

Family and domain databases

Gene3Di2.60.40.10, 2 hits
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR013106 Ig_V-set
PfamiView protein in Pfam
PF07686 V-set, 2 hits
SMARTiView protein in SMART
SM00409 IG, 2 hits
SM00406 IGv, 2 hits
SUPFAMiSSF48726 SSF48726, 2 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiMXRA8_HUMAN
AccessioniPrimary (citable) accession number: Q9BRK3
Secondary accession number(s): B3KTR6
, B4DE34, Q5TA39, Q96KC3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 21, 2007
Last sequence update: June 1, 2001
Last modified: November 7, 2018
This is version 146 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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