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Entry version 128 (16 Oct 2019)
Sequence version 1 (01 Jun 2001)
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Protein

Uncharacterized protein C7orf50

Gene

C7orf50

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Uncharacterized protein C7orf50
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:C7orf50
ORF Names:FP15621
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:22421 C7orf50

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9BRJ6

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
84310

Open Targets

More...
OpenTargetsi
ENSG00000146540

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162380546

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9BRJ6

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
C7orf50

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74732893

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003095101 – 194Uncharacterized protein C7orf50Add BLAST194

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei23PhosphoserineCombined sources1
Modified residuei59PhosphoserineCombined sources1
Modified residuei97PhosphoserineCombined sources1
Modified residuei175PhosphoserineCombined sources1

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9BRJ6

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9BRJ6

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9BRJ6

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9BRJ6

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9BRJ6

PeptideAtlas

More...
PeptideAtlasi
Q9BRJ6

PRoteomics IDEntifications database

More...
PRIDEi
Q9BRJ6

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
78770

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9BRJ6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9BRJ6

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q9BRJ6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000146540 Expressed in 189 organ(s), highest expression level in pituitary gland

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9BRJ6 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9BRJ6 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA052281

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
THAP1Q9NVV95EBI-751612,EBI-741515

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
124036, 53 interactors

Protein interaction database and analysis system

More...
IntActi
Q9BRJ6, 26 interactors

Molecular INTeraction database

More...
MINTi
Q9BRJ6

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000380286

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9BRJ6

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4829 Eukaryota
ENOG411268U LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000017838

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000111595

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9BRJ6

Identification of Orthologs from Complete Genome Data

More...
OMAi
HQSWRFQ

Database of Orthologous Groups

More...
OrthoDBi
1360485at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9BRJ6

TreeFam database of animal gene trees

More...
TreeFami
TF326634

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR019327 DUF2373

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF10180 DUF2373, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q9BRJ6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAKQKRKVPE VTEKKNKKLK KASAEGPLLG PEAAPSGEGA GSKGEAVLRP
60 70 80 90 100
GLDAEPELSP EEQRVLERKL KKERKKEERQ RLREAGLVAQ HPPARRSGAE
110 120 130 140 150
LALDYLCRWA QKHKNWRFQK TRQTWLLLHM YDSDKVPDEH FSTLLAYLEG
160 170 180 190
LQGRARELTV QKAEALMREL DEEGSDPPLP GRAQRIRQVL QLLS
Length:194
Mass (Da):22,083
Last modified:June 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iEDFF8B6A335416F3
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JQV0C9JQV0_HUMAN
Uncharacterized protein C7orf50
C7orf50
192Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C0T1H7C0T1_HUMAN
Uncharacterized protein C7orf50
C7orf50
162Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C2R9H7C2R9_HUMAN
Uncharacterized protein C7orf50
C7orf50
179Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF495721 mRNA Translation: AAQ06675.1
BC006224 mRNA Translation: AAH06224.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS5320.1

NCBI Reference Sequences

More...
RefSeqi
NP_001127867.1, NM_001134395.1
NP_001127868.1, NM_001134396.1
NP_001305181.1, NM_001318252.1
NP_115726.1, NM_032350.5

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000357429; ENSP00000350011; ENSG00000146540
ENST00000397098; ENSP00000380286; ENSG00000146540
ENST00000397100; ENSP00000380288; ENSG00000146540

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
84310

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:84310

UCSC genome browser

More...
UCSCi
uc003sju.3 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF495721 mRNA Translation: AAQ06675.1
BC006224 mRNA Translation: AAH06224.1
CCDSiCCDS5320.1
RefSeqiNP_001127867.1, NM_001134395.1
NP_001127868.1, NM_001134396.1
NP_001305181.1, NM_001318252.1
NP_115726.1, NM_032350.5

3D structure databases

SMRiQ9BRJ6
ModBaseiSearch...

Protein-protein interaction databases

BioGridi124036, 53 interactors
IntActiQ9BRJ6, 26 interactors
MINTiQ9BRJ6
STRINGi9606.ENSP00000380286

PTM databases

iPTMnetiQ9BRJ6
PhosphoSitePlusiQ9BRJ6
SwissPalmiQ9BRJ6

Polymorphism and mutation databases

BioMutaiC7orf50
DMDMi74732893

Proteomic databases

EPDiQ9BRJ6
jPOSTiQ9BRJ6
MassIVEiQ9BRJ6
MaxQBiQ9BRJ6
PaxDbiQ9BRJ6
PeptideAtlasiQ9BRJ6
PRIDEiQ9BRJ6
ProteomicsDBi78770

Genome annotation databases

EnsembliENST00000357429; ENSP00000350011; ENSG00000146540
ENST00000397098; ENSP00000380286; ENSG00000146540
ENST00000397100; ENSP00000380288; ENSG00000146540
GeneIDi84310
KEGGihsa:84310
UCSCiuc003sju.3 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
84310
DisGeNETi84310

GeneCards: human genes, protein and diseases

More...
GeneCardsi
C7orf50
HGNCiHGNC:22421 C7orf50
HPAiHPA052281
neXtProtiNX_Q9BRJ6
OpenTargetsiENSG00000146540
PharmGKBiPA162380546

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG4829 Eukaryota
ENOG411268U LUCA
GeneTreeiENSGT00390000017838
HOGENOMiHOG000111595
InParanoidiQ9BRJ6
OMAiHQSWRFQ
OrthoDBi1360485at2759
PhylomeDBiQ9BRJ6
TreeFamiTF326634

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
C7orf50 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
84310
PharosiQ9BRJ6

Protein Ontology

More...
PROi
PR:Q9BRJ6

Gene expression databases

BgeeiENSG00000146540 Expressed in 189 organ(s), highest expression level in pituitary gland
ExpressionAtlasiQ9BRJ6 baseline and differential
GenevisibleiQ9BRJ6 HS

Family and domain databases

InterProiView protein in InterPro
IPR019327 DUF2373
PfamiView protein in Pfam
PF10180 DUF2373, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCG050_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9BRJ6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: June 1, 2001
Last modified: October 16, 2019
This is version 128 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
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