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Protein

39S ribosomal protein L45, mitochondrial

Gene

MRPL45

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-HSA-5368286 Mitochondrial translation initiation
R-HSA-5389840 Mitochondrial translation elongation
R-HSA-5419276 Mitochondrial translation termination

Names & Taxonomyi

Protein namesi
Recommended name:
39S ribosomal protein L45, mitochondrial
Short name:
L45mt
Short name:
MRP-L45
Alternative name(s):
Mitochondrial large ribosomal subunit protein mL451 Publication
Gene namesi
Name:MRPL45
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:16651 MRPL45
MIMi611850 gene
neXtProtiNX_Q9BRJ2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Polymorphism and mutation databases

BioMutaiMRPL45
DMDMi29611869

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000030563? – 30639S ribosomal protein L45, mitochondrial
Transit peptidei1 – ?MitochondrionSequence analysis

Proteomic databases

EPDiQ9BRJ2
MaxQBiQ9BRJ2
PaxDbiQ9BRJ2
PeptideAtlasiQ9BRJ2
PRIDEiQ9BRJ2
ProteomicsDBi78769

PTM databases

iPTMnetiQ9BRJ2
PhosphoSitePlusiQ9BRJ2
SwissPalmiQ9BRJ2

Expressioni

Gene expression databases

CleanExiHS_MRPL45

Organism-specific databases

HPAiHPA023373
HPA023385

Interactioni

Subunit structurei

Component of the mitochondrial large ribosomal subunit (mt-LSU). Mature mammalian 55S mitochondrial ribosomes consist of a small (28S) and a large (39S) subunit. The 28S small subunit contains a 12S ribosomal RNA (12S mt-rRNA) and 30 different proteins. The 39S large subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial valine transfer RNA (mt-tRNA(Val)), which plays an integral structural role, and 52 different proteins.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
TRIM23P364063EBI-2514313,EBI-740098

Protein-protein interaction databases

CORUMiQ9BRJ2
DIPiDIP-53786N
IntActiQ9BRJ2, 32 interactors
MINTiQ9BRJ2
STRINGi9606.ENSP00000308901

Structurei

Secondary structure

1306
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi53 – 63Combined sources11
Helixi119 – 129Combined sources11
Helixi134 – 136Combined sources3
Helixi137 – 154Combined sources18
Helixi157 – 163Combined sources7
Turni166 – 168Combined sources3
Helixi169 – 173Combined sources5
Turni175 – 178Combined sources4
Beta strandi184 – 186Combined sources3
Beta strandi193 – 198Combined sources6
Beta strandi209 – 221Combined sources13
Beta strandi227 – 229Combined sources3
Beta strandi240 – 251Combined sources12
Beta strandi260 – 265Combined sources6
Beta strandi280 – 282Combined sources3

3D structure databases

ProteinModelPortaliQ9BRJ2
SMRiQ9BRJ2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG4599 Eukaryota
ENOG411019B LUCA
HOVERGENiHBG044506
InParanoidiQ9BRJ2
OrthoDBiEOG091G0LCT
PhylomeDBiQ9BRJ2
TreeFamiTF105825

Family and domain databases

InterProiView protein in InterPro
IPR032710 NTF2-like_dom_sf
IPR007379 Tim44-like_dom
PfamiView protein in Pfam
PF04280 Tim44, 1 hit
SMARTiView protein in SMART
SM00978 Tim44, 1 hit
SUPFAMiSSF54427 SSF54427, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9BRJ2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAPIPQGFS CLSRFLGWWF RQPVLVTQSA AIVPVRTKKR FTPPIYQPKF
60 70 80 90 100
KTEKEFMQHA RKAGLVIPPE KSDRSIHLAC TAGIFDAYVP PEGDARISSL
110 120 130 140 150
SKEGLIERTE RMKKTMASQV SIRRIKDYDA NFKIKDFPEK AKDIFIEAHL
160 170 180 190 200
CLNNSDHDRL HTLVTEHCFP DMTWDIKYKT VRWSFVESLE PSHVVQVRCS
210 220 230 240 250
SMMNQGNVYG QITVRMHTRQ TLAIYDRFGR LMYGQEDVPK DVLEYVVFEK
260 270 280 290 300
QLTNPYGSWR MHTKIVPPWA PPKQPILKTV MIPGPQLKPE EEYEEAQGEA

QKPQLA
Length:306
Mass (Da):35,351
Last modified:April 4, 2003 - v2
Checksum:iC00CC379D337910A
GO

Sequence cautioni

The sequence BC006235 differs from that shown. Reason: Frameshift at position 40.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti139E → G in BAD18730 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_061810298G → V. Corresponds to variant dbSNP:rs34749623Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK172741 mRNA Translation: BAD18730.1
BC006235 mRNA No translation available.
BC130382 mRNA Translation: AAI30383.1
BC130384 mRNA Translation: AAI30385.1
CCDSiCCDS11326.1
UniGeneiHs.537279
Hs.744110

Genome annotation databases

EnsembliENST00000621878; ENSP00000483030; ENSG00000277936
UCSCiuc032gks.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiRM45_HUMAN
AccessioniPrimary (citable) accession number: Q9BRJ2
Secondary accession number(s): A1L436, Q6ZMJ5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 4, 2003
Last sequence update: April 4, 2003
Last modified: July 18, 2018
This is version 148 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Ribosomal proteins
    Ribosomal proteins families and list of entries
  7. SIMILARITY comments
    Index of protein domains and families

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