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UniProtKB - Q9BRH9 (ZN251_HUMAN)

Entry version 160 (10 Feb 2021)
Sequence version 4 (11 Jan 2011)
Previous versions | rss
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Protein

Zinc finger protein 251

Gene

ZNF251

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri209 – 231C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri237 – 259C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri265 – 287C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri293 – 315C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri321 – 343C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri349 – 371C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri377 – 399C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri405 – 427C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri433 – 455C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri461 – 483C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri489 – 511C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri566 – 588C2H2-type 12; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri594 – 616C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri622 – 644C2H2-type 14; degeneratePROSITE-ProRule annotationAdd BLAST23

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q9BRH9

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger protein 251
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZNF251
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:13045, ZNF251

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9BRH9

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000198169.8

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...OpenTargetsi		ENSG00000198169

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA37623

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9BRH9, Tdark

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		ZNF251

Domain mapping of disease mutations (DMDM)

More...DMDMi		317373550

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000474851 – 671Zinc finger protein 251Add BLAST671

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki114Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki157Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki162Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki403Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q9BRH9

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q9BRH9

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9BRH9

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q9BRH9

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9BRH9

PeptideAtlas

More...PeptideAtlasi		Q9BRH9

PRoteomics IDEntifications database

More...PRIDEi		Q9BRH9

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		78765

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9BRH9

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9BRH9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000198169, Expressed in right lobe of thyroid gland and 181 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9BRH9, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9BRH9, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000198169, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		124784, 11 interactors

Protein interaction database and analysis system

More...IntActi		Q9BRH9, 13 interactors

Molecular INTeraction database

More...MINTi		Q9BRH9

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000292562

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9BRH9, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9BRH9

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini15 – 86KRABPROSITE-ProRule annotationAdd BLAST72

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the krueppel C2H2-type zinc-finger protein family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri209 – 231C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri237 – 259C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri265 – 287C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri293 – 315C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri321 – 343C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri349 – 371C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri377 – 399C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri405 – 427C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri433 – 455C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri461 – 483C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri489 – 511C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri566 – 588C2H2-type 12; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri594 – 616C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri622 – 644C2H2-type 14; degeneratePROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1721, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000163332

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_002678_44_5_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9BRH9

Identification of Orthologs from Complete Genome Data

More...OMAi		IHIKKIF

Database of Orthologous Groups

More...OrthoDBi		1318335at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9BRH9

TreeFam database of animal gene trees

More...TreeFami		TF350822

Family and domain databases

Conserved Domains Database

More...CDDi		cd07765, KRAB_A-box, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR001909, KRAB
IPR036051, KRAB_dom_sf
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type

Pfam protein domain database

More...Pfami		View protein in Pfam
PF01352, KRAB, 1 hit
PF00096, zf-C2H2, 12 hits

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00349, KRAB, 1 hit
SM00355, ZnF_C2H2, 12 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF109640, SSF109640, 1 hit
SSF57667, SSF57667, 8 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50805, KRAB, 1 hit
PS00028, ZINC_FINGER_C2H2_1, 12 hits
PS50157, ZINC_FINGER_C2H2_2, 13 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9BRH9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAATFQLPGH QEMPLTFQDV AVYFSQAEGR QLGPQQRALY RDVMLENYGN 
        60         70         80         90        100
VASLGFPVPK PELISQLEQG KELWVLNLLG AEEPDILKSC QKDSEVGTKK 
       110        120        130        140        150
ELSILNQKFS EEVKTPEFVS RRLLRDNAQA AEFREAWGRE GKLKERVGNS 
       160        170        180        190        200
AGQSLNKPNI HKRVLTEATV GRERSLGERT QECSAFDRNL NLDQNVVRLQ 
       210        220        230        240        250
RNKTGERVFK CDICSKTFKY NSDLSRHQRS HTGEKPYECG RCGRAFTHSS 
       260        270        280        290        300
NLVLHHHIHT GNKPFKCDEC GKTFGLNSHL RLHRRIHTGE KPFGCGECGK 
       310        320        330        340        350
AFSRSSTLIQ HRIIHTGEKP YKCNECGRGF SQSPQLTQHQ RIHTGEKPHE 
       360        370        380        390        400
CSHCGKAFSR SSSLIQHERI HTGEKPHKCN QCGKAFSQSS SLFLHHRVHT 
       410        420        430        440        450
GEKPYVCNEC GRAFGFNSHL TEHVRIHTGE KPYVCNECGK AFRRSSTLVQ 
       460        470        480        490        500
HRRVHTGEKP YQCVECGKAF SQSSQLTLHQ RVHTGEKPYD CGDCGKAFSR 
       510        520        530        540        550
RSTLIQHQKV HSGETRKCRK HGPAFVHGSS LTADGQIPTG EKHGRAFNHG 
       560        570        580        590        600
ANLILRWTVH TGEKSFGCNE YGKAFSPTSR PTEDQIMHAG EKPYKCQECG 
       610        620        630        640        650
NAFSGKSTLI QHQVTHTGQK PCHCSVYGKA FSQSSQLTPP QQTRVGEKPA 
       660        670 
LNDGSKRYFI HIKKIFQERH F
Length:671
Mass (Da):75,763
Last modified:January 11, 2011 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iBDD04357D9D7825F
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YCK5H0YCK5_HUMAN
Zinc finger protein 251
ZNF251
147Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti204T → A in AK000435 (PubMed:14702039).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AK000435 mRNA No translation available.
AF186192 Genomic DNA No translation available.
BC006258 mRNA Translation: AAH06258.2
BC112137 mRNA Translation: AAI12138.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS47944.1

NCBI Reference Sequences

More...RefSeqi		NP_612376.1, NM_138367.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000292562; ENSP00000292562; ENSG00000198169
ENST00000612318; ENSP00000477765; ENSG00000278062

Database of genes from NCBI RefSeq genomes

More...GeneIDi		90987

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:90987

UCSC genome browser

More...UCSCi		uc003zdv.5, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK000435 mRNA No translation available.
AF186192 Genomic DNA No translation available.
BC006258 mRNA Translation: AAH06258.2
BC112137 mRNA Translation: AAI12138.1
CCDSiCCDS47944.1
RefSeqiNP_612376.1, NM_138367.1

3D structure databases

SMRiQ9BRH9
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi124784, 11 interactors
IntActiQ9BRH9, 13 interactors
MINTiQ9BRH9
STRINGi9606.ENSP00000292562

PTM databases

iPTMnetiQ9BRH9
PhosphoSitePlusiQ9BRH9

Genetic variation databases

BioMutaiZNF251
DMDMi317373550

Proteomic databases

EPDiQ9BRH9
jPOSTiQ9BRH9
MassIVEiQ9BRH9
MaxQBiQ9BRH9
PaxDbiQ9BRH9
PeptideAtlasiQ9BRH9
PRIDEiQ9BRH9
ProteomicsDBi78765

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		7908, 107 antibodies

Genome annotation databases

EnsembliENST00000292562; ENSP00000292562; ENSG00000198169
ENST00000612318; ENSP00000477765; ENSG00000278062
GeneIDi90987
KEGGihsa:90987
UCSCiuc003zdv.5, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		90987

GeneCards: human genes, protein and diseases

More...GeneCardsi		ZNF251
HGNCiHGNC:13045, ZNF251
HPAiENSG00000198169, Low tissue specificity
neXtProtiNX_Q9BRH9
OpenTargetsiENSG00000198169
PharmGKBiPA37623
VEuPathDBiHostDB:ENSG00000198169.8

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1721, Eukaryota
GeneTreeiENSGT00940000163332
HOGENOMiCLU_002678_44_5_1
InParanoidiQ9BRH9
OMAiIHIKKIF
OrthoDBi1318335at2759
PhylomeDBiQ9BRH9
TreeFamiTF350822

Enzyme and pathway databases

PathwayCommonsiQ9BRH9

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		90987, 9 hits in 896 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		ZNF251, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		90987
PharosiQ9BRH9, Tdark

Protein Ontology

More...PROi		PR:Q9BRH9
RNActiQ9BRH9, protein

Gene expression databases

BgeeiENSG00000198169, Expressed in right lobe of thyroid gland and 181 other tissues
ExpressionAtlasiQ9BRH9, baseline and differential
GenevisibleiQ9BRH9, HS

Family and domain databases

CDDicd07765, KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909, KRAB
IPR036051, KRAB_dom_sf
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type
PfamiView protein in Pfam
PF01352, KRAB, 1 hit
PF00096, zf-C2H2, 12 hits
SMARTiView protein in SMART
SM00349, KRAB, 1 hit
SM00355, ZnF_C2H2, 12 hits
SUPFAMiSSF109640, SSF109640, 1 hit
SSF57667, SSF57667, 8 hits
PROSITEiView protein in PROSITE
PS50805, KRAB, 1 hit
PS00028, ZINC_FINGER_C2H2_1, 12 hits
PS50157, ZINC_FINGER_C2H2_2, 13 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZN251_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9BRH9
Secondary accession number(s): Q2M219
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: January 11, 2011
Last modified: February 10, 2021
This is version 160 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
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