UniProtKB - Q9BRH9 (ZN251_HUMAN)
Protein
Zinc finger protein 251
Gene
ZNF251
Organism
Homo sapiens (Human)
Status
Functioni
May be involved in transcriptional regulation.
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 209 – 231 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 237 – 259 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 265 – 287 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 293 – 315 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 321 – 343 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 349 – 371 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 377 – 399 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 405 – 427 | C2H2-type 8PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 433 – 455 | C2H2-type 9PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 461 – 483 | C2H2-type 10PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 489 – 511 | C2H2-type 11PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 566 – 588 | C2H2-type 12; degeneratePROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 594 – 616 | C2H2-type 13PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 622 – 644 | C2H2-type 14; degeneratePROSITE-ProRule annotationAdd BLAST | 23 |
GO - Molecular functioni
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- metal ion binding Source: UniProtKB-KW
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
GO - Biological processi
- hematopoietic stem cell homeostasis Source: Ensembl
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | DNA-binding |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | Q9BRH9 |
Names & Taxonomyi
Protein namesi | Recommended name: Zinc finger protein 251 |
Gene namesi | Name:ZNF251 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:13045, ZNF251 |
neXtProti | NX_Q9BRH9 |
VEuPathDBi | HostDB:ENSG00000198169.8 |
Subcellular locationi
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
OpenTargetsi | ENSG00000198169 |
PharmGKBi | PA37623 |
Miscellaneous databases
Pharosi | Q9BRH9, Tdark |
Genetic variation databases
BioMutai | ZNF251 |
DMDMi | 317373550 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000047485 | 1 – 671 | Zinc finger protein 251Add BLAST | 671 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Cross-linki | 114 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 157 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 162 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 403 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources |
Keywords - PTMi
Isopeptide bond, Ubl conjugationProteomic databases
EPDi | Q9BRH9 |
jPOSTi | Q9BRH9 |
MassIVEi | Q9BRH9 |
MaxQBi | Q9BRH9 |
PaxDbi | Q9BRH9 |
PeptideAtlasi | Q9BRH9 |
PRIDEi | Q9BRH9 |
ProteomicsDBi | 78765 |
PTM databases
iPTMneti | Q9BRH9 |
PhosphoSitePlusi | Q9BRH9 |
Expressioni
Gene expression databases
Bgeei | ENSG00000198169, Expressed in right lobe of thyroid gland and 181 other tissues |
ExpressionAtlasi | Q9BRH9, baseline and differential |
Genevisiblei | Q9BRH9, HS |
Organism-specific databases
HPAi | ENSG00000198169, Low tissue specificity |
Interactioni
Binary interactionsi
Hide detailsQ9BRH9
With | #Exp. | IntAct |
---|---|---|
FHL5 [Q5TD97] | 3 | EBI-7254491,EBI-750641 |
KRTAP10-9 [P60411] | 3 | EBI-7254491,EBI-10172052 |
TRIM41 [Q8WV44] | 3 | EBI-7254491,EBI-725997 |
Protein-protein interaction databases
BioGRIDi | 124784, 11 interactors |
IntActi | Q9BRH9, 13 interactors |
MINTi | Q9BRH9 |
STRINGi | 9606.ENSP00000292562 |
Miscellaneous databases
RNActi | Q9BRH9, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 15 – 86 | KRABPROSITE-ProRule annotationAdd BLAST | 72 |
Sequence similaritiesi
Belongs to the krueppel C2H2-type zinc-finger protein family.Curated
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 209 – 231 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 237 – 259 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 265 – 287 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 293 – 315 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 321 – 343 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 349 – 371 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 377 – 399 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 405 – 427 | C2H2-type 8PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 433 – 455 | C2H2-type 9PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 461 – 483 | C2H2-type 10PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 489 – 511 | C2H2-type 11PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 566 – 588 | C2H2-type 12; degeneratePROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 594 – 616 | C2H2-type 13PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 622 – 644 | C2H2-type 14; degeneratePROSITE-ProRule annotationAdd BLAST | 23 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000163332 |
HOGENOMi | CLU_002678_44_5_1 |
InParanoidi | Q9BRH9 |
OMAi | IHIKKIF |
OrthoDBi | 1318335at2759 |
PhylomeDBi | Q9BRH9 |
TreeFami | TF350822 |
Family and domain databases
CDDi | cd07765, KRAB_A-box, 1 hit |
InterProi | View protein in InterPro IPR001909, KRAB IPR036051, KRAB_dom_sf IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF01352, KRAB, 1 hit PF00096, zf-C2H2, 12 hits |
SMARTi | View protein in SMART SM00349, KRAB, 1 hit SM00355, ZnF_C2H2, 12 hits |
SUPFAMi | SSF109640, SSF109640, 1 hit SSF57667, SSF57667, 8 hits |
PROSITEi | View protein in PROSITE PS50805, KRAB, 1 hit PS00028, ZINC_FINGER_C2H2_1, 12 hits PS50157, ZINC_FINGER_C2H2_2, 13 hits |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q9BRH9-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAATFQLPGH QEMPLTFQDV AVYFSQAEGR QLGPQQRALY RDVMLENYGN
60 70 80 90 100
VASLGFPVPK PELISQLEQG KELWVLNLLG AEEPDILKSC QKDSEVGTKK
110 120 130 140 150
ELSILNQKFS EEVKTPEFVS RRLLRDNAQA AEFREAWGRE GKLKERVGNS
160 170 180 190 200
AGQSLNKPNI HKRVLTEATV GRERSLGERT QECSAFDRNL NLDQNVVRLQ
210 220 230 240 250
RNKTGERVFK CDICSKTFKY NSDLSRHQRS HTGEKPYECG RCGRAFTHSS
260 270 280 290 300
NLVLHHHIHT GNKPFKCDEC GKTFGLNSHL RLHRRIHTGE KPFGCGECGK
310 320 330 340 350
AFSRSSTLIQ HRIIHTGEKP YKCNECGRGF SQSPQLTQHQ RIHTGEKPHE
360 370 380 390 400
CSHCGKAFSR SSSLIQHERI HTGEKPHKCN QCGKAFSQSS SLFLHHRVHT
410 420 430 440 450
GEKPYVCNEC GRAFGFNSHL TEHVRIHTGE KPYVCNECGK AFRRSSTLVQ
460 470 480 490 500
HRRVHTGEKP YQCVECGKAF SQSSQLTLHQ RVHTGEKPYD CGDCGKAFSR
510 520 530 540 550
RSTLIQHQKV HSGETRKCRK HGPAFVHGSS LTADGQIPTG EKHGRAFNHG
560 570 580 590 600
ANLILRWTVH TGEKSFGCNE YGKAFSPTSR PTEDQIMHAG EKPYKCQECG
610 620 630 640 650
NAFSGKSTLI QHQVTHTGQK PCHCSVYGKA FSQSSQLTPP QQTRVGEKPA
660 670
LNDGSKRYFI HIKKIFQERH F
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketH0YCK5 | H0YCK5_HUMAN | Zinc finger protein 251 | ZNF251 | 147 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 204 | T → A in AK000435 (PubMed:14702039).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK000435 mRNA No translation available. AF186192 Genomic DNA No translation available. BC006258 mRNA Translation: AAH06258.2 BC112137 mRNA Translation: AAI12138.1 |
CCDSi | CCDS47944.1 |
RefSeqi | NP_612376.1, NM_138367.1 |
Genome annotation databases
Ensembli | ENST00000292562; ENSP00000292562; ENSG00000198169 ENST00000612318; ENSP00000477765; ENSG00000278062 |
GeneIDi | 90987 |
KEGGi | hsa:90987 |
UCSCi | uc003zdv.5, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK000435 mRNA No translation available. AF186192 Genomic DNA No translation available. BC006258 mRNA Translation: AAH06258.2 BC112137 mRNA Translation: AAI12138.1 |
CCDSi | CCDS47944.1 |
RefSeqi | NP_612376.1, NM_138367.1 |
3D structure databases
SMRi | Q9BRH9 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 124784, 11 interactors |
IntActi | Q9BRH9, 13 interactors |
MINTi | Q9BRH9 |
STRINGi | 9606.ENSP00000292562 |
PTM databases
iPTMneti | Q9BRH9 |
PhosphoSitePlusi | Q9BRH9 |
Genetic variation databases
BioMutai | ZNF251 |
DMDMi | 317373550 |
Proteomic databases
EPDi | Q9BRH9 |
jPOSTi | Q9BRH9 |
MassIVEi | Q9BRH9 |
MaxQBi | Q9BRH9 |
PaxDbi | Q9BRH9 |
PeptideAtlasi | Q9BRH9 |
PRIDEi | Q9BRH9 |
ProteomicsDBi | 78765 |
Protocols and materials databases
Antibodypediai | 7908, 107 antibodies |
Genome annotation databases
Ensembli | ENST00000292562; ENSP00000292562; ENSG00000198169 ENST00000612318; ENSP00000477765; ENSG00000278062 |
GeneIDi | 90987 |
KEGGi | hsa:90987 |
UCSCi | uc003zdv.5, human |
Organism-specific databases
CTDi | 90987 |
GeneCardsi | ZNF251 |
HGNCi | HGNC:13045, ZNF251 |
HPAi | ENSG00000198169, Low tissue specificity |
neXtProti | NX_Q9BRH9 |
OpenTargetsi | ENSG00000198169 |
PharmGKBi | PA37623 |
VEuPathDBi | HostDB:ENSG00000198169.8 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000163332 |
HOGENOMi | CLU_002678_44_5_1 |
InParanoidi | Q9BRH9 |
OMAi | IHIKKIF |
OrthoDBi | 1318335at2759 |
PhylomeDBi | Q9BRH9 |
TreeFami | TF350822 |
Enzyme and pathway databases
PathwayCommonsi | Q9BRH9 |
Miscellaneous databases
BioGRID-ORCSi | 90987, 9 hits in 896 CRISPR screens |
ChiTaRSi | ZNF251, human |
GenomeRNAii | 90987 |
Pharosi | Q9BRH9, Tdark |
PROi | PR:Q9BRH9 |
RNActi | Q9BRH9, protein |
Gene expression databases
Bgeei | ENSG00000198169, Expressed in right lobe of thyroid gland and 181 other tissues |
ExpressionAtlasi | Q9BRH9, baseline and differential |
Genevisiblei | Q9BRH9, HS |
Family and domain databases
CDDi | cd07765, KRAB_A-box, 1 hit |
InterProi | View protein in InterPro IPR001909, KRAB IPR036051, KRAB_dom_sf IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF01352, KRAB, 1 hit PF00096, zf-C2H2, 12 hits |
SMARTi | View protein in SMART SM00349, KRAB, 1 hit SM00355, ZnF_C2H2, 12 hits |
SUPFAMi | SSF109640, SSF109640, 1 hit SSF57667, SSF57667, 8 hits |
PROSITEi | View protein in PROSITE PS50805, KRAB, 1 hit PS00028, ZINC_FINGER_C2H2_1, 12 hits PS50157, ZINC_FINGER_C2H2_2, 13 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ZN251_HUMAN | |
Accessioni | Q9BRH9Primary (citable) accession number: Q9BRH9 Secondary accession number(s): Q2M219 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 24, 2004 |
Last sequence update: | January 11, 2011 | |
Last modified: | February 10, 2021 | |
This is version 160 of the entry and version 4 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 8
Human chromosome 8: entries, gene names and cross-references to MIM - SIMILARITY comments
Index of protein domains and families