UniProtKB - Q9BRF8 (CPPED_HUMAN)
Protein
Serine/threonine-protein phosphatase CPPED1
Gene
CPPED1
Organism
Homo sapiens (Human)
Status
Functioni
Protein phosphatase that dephosphorylates AKT family kinase specifically at 'Ser-473', blocking cell cycle progression and promoting cell apoptosis. May play an inhibitory role in glucose uptake by adipocytes.2 Publications
Catalytic activityi
Cofactori
a divalent metal cationBy similarityNote: Binds 2 divalent metal cations.By similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 53 | Divalent metal cation 1By similarity | 1 | |
Metal bindingi | 90 | Divalent metal cation 1By similarity | 1 | |
Metal bindingi | 90 | Divalent metal cation 2By similarity | 1 | |
Metal bindingi | 127 | Divalent metal cation 2By similarity | 1 | |
Metal bindingi | 247 | Divalent metal cation 2By similarity | 1 |
GO - Molecular functioni
- metal ion binding Source: UniProtKB-KW
- protein serine phosphatase activity Source: UniProtKB-EC
- protein threonine phosphatase activity Source: UniProtKB-EC
GO - Biological processi
- neutrophil degranulation Source: Reactome
Keywordsi
Molecular function | Hydrolase |
Ligand | Metal-binding |
Enzyme and pathway databases
PathwayCommonsi | Q9BRF8 |
Reactomei | R-HSA-6798695, Neutrophil degranulation |
Names & Taxonomyi
Protein namesi | Recommended name: Serine/threonine-protein phosphatase CPPED1 (EC:3.1.3.16)Alternative name(s): Calcineurin-like phosphoesterase domain-containing protein 1 Complete S-transactivated protein 1 |
Gene namesi | Name:CPPED1 Synonyms:CSTP1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:25632, CPPED1 |
MIMi | 615603, gene |
neXtProti | NX_Q9BRF8 |
VEuPathDBi | HostDB:ENSG00000103381.11 |
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm 1 Publication
Cytosol
- cytosol Source: HPA
Extracellular region or secreted
- extracellular region Source: Reactome
Lysosome
- azurophil granule lumen Source: Reactome
Plasma Membrane
- plasma membrane Source: HPA
Keywords - Cellular componenti
CytoplasmPathology & Biotechi
Organism-specific databases
DisGeNETi | 55313 |
OpenTargetsi | ENSG00000103381 |
PharmGKBi | PA164718110 |
Miscellaneous databases
Pharosi | Q9BRF8, Tbio |
Genetic variation databases
BioMutai | CPPED1 |
DMDMi | 317373448 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000320556 | 1 – 314 | Serine/threonine-protein phosphatase CPPED1Add BLAST | 314 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | PhosphoserineCombined sources | 1 | |
Modified residuei | 294 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q9BRF8 |
jPOSTi | Q9BRF8 |
MassIVEi | Q9BRF8 |
MaxQBi | Q9BRF8 |
PaxDbi | Q9BRF8 |
PeptideAtlasi | Q9BRF8 |
PRIDEi | Q9BRF8 |
ProteomicsDBi | 78760 [Q9BRF8-1] 78761 [Q9BRF8-2] |
PTM databases
DEPODi | CPPED1 |
iPTMneti | Q9BRF8 |
MetOSitei | Q9BRF8 |
PhosphoSitePlusi | Q9BRF8 |
Expressioni
Tissue specificityi
Expressed in subcutaneous adipose tissue.1 Publication
Developmental stagei
Expression levels are slightly decreased in subcutaneous adipose tissue following weight loss. Expression levels may be not affected by preadipocyte differentiation.1 Publication
Inductioni
Transactivated by the large envelope protein of the hepatitis B virus (HBV).1 Publication
Gene expression databases
Bgeei | ENSG00000103381, Expressed in blood and 217 other tissues |
Genevisiblei | Q9BRF8, HS |
Organism-specific databases
HPAi | ENSG00000103381, Tissue enhanced (blood) |
Interactioni
Protein-protein interaction databases
BioGRIDi | 120595, 9 interactors |
IntActi | Q9BRF8, 4 interactors |
MINTi | Q9BRF8 |
STRINGi | 9606.ENSP00000371193 |
Miscellaneous databases
RNActi | Q9BRF8, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 47 – 250 | CatalyticAdd BLAST | 204 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG1378, Eukaryota |
GeneTreei | ENSGT00390000008676 |
HOGENOMi | CLU_077151_0_0_1 |
InParanoidi | Q9BRF8 |
OMAi | YENPSKC |
OrthoDBi | 908967at2759 |
PhylomeDBi | Q9BRF8 |
TreeFami | TF329406 |
Family and domain databases
CDDi | cd07395, MPP_CSTP1, 1 hit |
Gene3Di | 3.60.21.10, 1 hit |
InterProi | View protein in InterPro IPR004843, Calcineurin-like_PHP_ApaH IPR029052, Metallo-depent_PP-like IPR041867, MPP_CSTP1 |
Pfami | View protein in Pfam PF00149, Metallophos, 1 hit |
s (3)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketIsoform 1 (identifier: Q9BRF8-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSAAEAGGVF HRARGRTLAA FPAEKESEWK GPFYFILGAD PQFGLIKAWS
60 70 80 90 100
TGDCDNGGDE WEQEIRLTEQ AVQAINKLNP KPKFFVLCGD LIHAMPGKPW
110 120 130 140 150
RTEQTEDLKR VLRAVDRAIP LVLVSGNHDI GNTPTAETVE EFCRTWGDDY
160 170 180 190 200
FSFWVGGVLF LVLNSQFYEN PSKCPSLKQA QDQWLDEQLS IARQRHCQHA
210 220 230 240 250
IVFQHIPLFL ESIDEDDDYY FNLSKSTRKK LADKFIHAGV KVVFSGHYHR
260 270 280 290 300
NAGGTYQNLD MVVSSAIGCQ LGRDPHGLRV VVVTAEKIVH RYYSLDELSE
310
KGIEDDLMDL IKKK
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 47 | K → R in CAE45887 (PubMed:17974005).Curated | 1 | |
Sequence conflicti | 77 | K → E in BAA92034 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 148 | D → Y in BAB14194 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 230 | K → E in BAA92034 (PubMed:14702039).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_039204 | 19 | A → D3 PublicationsCorresponds to variant dbSNP:rs3748976Ensembl. | 1 | |
Natural variantiVAR_039205 | 86 | V → I. Corresponds to variant dbSNP:rs3748980Ensembl. | 1 | |
Natural variantiVAR_039206 | 241 | K → RCombined sources4 PublicationsCorresponds to variant dbSNP:rs1713480Ensembl. | 1 | |
Natural variantiVAR_039207 | 290 | H → P. Corresponds to variant dbSNP:rs11645068Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_031658 | 97 – 238 | Missing in isoform 2. 1 PublicationAdd BLAST | 142 | |
Alternative sequenceiVSP_055218 | 97 – 122 | GKPWR…AIPLV → AGQRPPRAPSRGGHRRENCS PILQSR in isoform 3. 1 PublicationAdd BLAST | 26 | |
Alternative sequenceiVSP_055219 | 123 – 314 | Missing in isoform 3. 1 PublicationAdd BLAST | 192 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY553877 mRNA Translation: AAS64575.1 AK002013 mRNA Translation: BAA92034.1 AK022710 mRNA Translation: BAB14194.1 AK298662 mRNA Translation: BAG60830.1 BX640805 mRNA Translation: CAE45887.1 AC010333 Genomic DNA No translation available. AC092324 Genomic DNA No translation available. AC109597 Genomic DNA No translation available. BC006289 mRNA Translation: AAH06289.1 |
CCDSi | CCDS42119.1 [Q9BRF8-2] CCDS42120.1 [Q9BRF8-1] |
RefSeqi | NP_001092925.1, NM_001099455.1 [Q9BRF8-2] NP_060810.2, NM_018340.2 [Q9BRF8-1] |
Genome annotation databases
Ensembli | ENST00000261660; ENSP00000261660; ENSG00000103381 [Q9BRF8-3] ENST00000381774; ENSP00000371193; ENSG00000103381 [Q9BRF8-1] ENST00000433677; ENSP00000411127; ENSG00000103381 [Q9BRF8-2] |
GeneIDi | 55313 |
KEGGi | hsa:55313 |
UCSCi | uc002dca.5, human [Q9BRF8-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY553877 mRNA Translation: AAS64575.1 AK002013 mRNA Translation: BAA92034.1 AK022710 mRNA Translation: BAB14194.1 AK298662 mRNA Translation: BAG60830.1 BX640805 mRNA Translation: CAE45887.1 AC010333 Genomic DNA No translation available. AC092324 Genomic DNA No translation available. AC109597 Genomic DNA No translation available. BC006289 mRNA Translation: AAH06289.1 |
CCDSi | CCDS42119.1 [Q9BRF8-2] CCDS42120.1 [Q9BRF8-1] |
RefSeqi | NP_001092925.1, NM_001099455.1 [Q9BRF8-2] NP_060810.2, NM_018340.2 [Q9BRF8-1] |
3D structure databases
SMRi | Q9BRF8 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 120595, 9 interactors |
IntActi | Q9BRF8, 4 interactors |
MINTi | Q9BRF8 |
STRINGi | 9606.ENSP00000371193 |
PTM databases
DEPODi | CPPED1 |
iPTMneti | Q9BRF8 |
MetOSitei | Q9BRF8 |
PhosphoSitePlusi | Q9BRF8 |
Genetic variation databases
BioMutai | CPPED1 |
DMDMi | 317373448 |
Proteomic databases
EPDi | Q9BRF8 |
jPOSTi | Q9BRF8 |
MassIVEi | Q9BRF8 |
MaxQBi | Q9BRF8 |
PaxDbi | Q9BRF8 |
PeptideAtlasi | Q9BRF8 |
PRIDEi | Q9BRF8 |
ProteomicsDBi | 78760 [Q9BRF8-1] 78761 [Q9BRF8-2] |
Protocols and materials databases
Antibodypediai | 24789, 137 antibodies |
DNASUi | 55313 |
Genome annotation databases
Ensembli | ENST00000261660; ENSP00000261660; ENSG00000103381 [Q9BRF8-3] ENST00000381774; ENSP00000371193; ENSG00000103381 [Q9BRF8-1] ENST00000433677; ENSP00000411127; ENSG00000103381 [Q9BRF8-2] |
GeneIDi | 55313 |
KEGGi | hsa:55313 |
UCSCi | uc002dca.5, human [Q9BRF8-1] |
Organism-specific databases
CTDi | 55313 |
DisGeNETi | 55313 |
GeneCardsi | CPPED1 |
HGNCi | HGNC:25632, CPPED1 |
HPAi | ENSG00000103381, Tissue enhanced (blood) |
MIMi | 615603, gene |
neXtProti | NX_Q9BRF8 |
OpenTargetsi | ENSG00000103381 |
PharmGKBi | PA164718110 |
VEuPathDBi | HostDB:ENSG00000103381.11 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1378, Eukaryota |
GeneTreei | ENSGT00390000008676 |
HOGENOMi | CLU_077151_0_0_1 |
InParanoidi | Q9BRF8 |
OMAi | YENPSKC |
OrthoDBi | 908967at2759 |
PhylomeDBi | Q9BRF8 |
TreeFami | TF329406 |
Enzyme and pathway databases
PathwayCommonsi | Q9BRF8 |
Reactomei | R-HSA-6798695, Neutrophil degranulation |
Miscellaneous databases
BioGRID-ORCSi | 55313, 3 hits in 993 CRISPR screens |
ChiTaRSi | CPPED1, human |
GenomeRNAii | 55313 |
Pharosi | Q9BRF8, Tbio |
PROi | PR:Q9BRF8 |
RNActi | Q9BRF8, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000103381, Expressed in blood and 217 other tissues |
Genevisiblei | Q9BRF8, HS |
Family and domain databases
CDDi | cd07395, MPP_CSTP1, 1 hit |
Gene3Di | 3.60.21.10, 1 hit |
InterProi | View protein in InterPro IPR004843, Calcineurin-like_PHP_ApaH IPR029052, Metallo-depent_PP-like IPR041867, MPP_CSTP1 |
Pfami | View protein in Pfam PF00149, Metallophos, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CPPED_HUMAN | |
Accessioni | Q9BRF8Primary (citable) accession number: Q9BRF8 Secondary accession number(s): B4DQ68 Q9NUT6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 26, 2008 |
Last sequence update: | January 11, 2011 | |
Last modified: | April 7, 2021 | |
This is version 141 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 16
Human chromosome 16: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families