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Entry version 152 (18 Sep 2019)
Sequence version 1 (01 Jun 2001)
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Protein

Zinc finger protein 559

Gene

ZNF559

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri91 – 113C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri119 – 141C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri147 – 179C2H2-type 3; degeneratePROSITE-ProRule annotationAdd BLAST33
Zinc fingeri185 – 207C2H2-type 4; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri241 – 263C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri297 – 319C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri325 – 347C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri353 – 375C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri381 – 403C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri409 – 431C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri437 – 459C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri465 – 487C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri493 – 515C2H2-type 13PROSITE-ProRule annotationAdd BLAST23

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-212436 Generic Transcription Pathway

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger protein 559
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZNF559
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Human Gene Nomenclature Database

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HGNCi
HGNC:28197 ZNF559

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9BR84

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
84527

Open Targets

More...
OpenTargetsi
ENSG00000188321

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134891126

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ZNF559

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74762704

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000476491 – 538Zinc finger protein 559Add BLAST538

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9BR84

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9BR84

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q9BR84

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9BR84

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9BR84

PeptideAtlas

More...
PeptideAtlasi
Q9BR84

PRoteomics IDEntifications database

More...
PRIDEi
Q9BR84

ProteomicsDB human proteome resource

More...
ProteomicsDBi
78749 [Q9BR84-1]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9BR84

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9BR84

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000188321 Expressed in 190 organ(s), highest expression level in secondary oocyte

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9BR84 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9BR84 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA059632
HPA065485

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
124118, 5 interactors

Protein interaction database and analysis system

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IntActi
Q9BR84, 6 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000468153

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q9BR84

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini14 – 89KRABPROSITE-ProRule annotationAdd BLAST76

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri91 – 113C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri119 – 141C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri147 – 179C2H2-type 3; degeneratePROSITE-ProRule annotationAdd BLAST33
Zinc fingeri185 – 207C2H2-type 4; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri241 – 263C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri297 – 319C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri325 – 347C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri353 – 375C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri381 – 403C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri409 – 431C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri437 – 459C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri465 – 487C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri493 – 515C2H2-type 13PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG1721 Eukaryota
COG5048 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000164004

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000234617

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9BR84

KEGG Orthology (KO)

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KOi
K09228

Database of Orthologous Groups

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OrthoDBi
1318335at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9BR84

Family and domain databases

Conserved Domains Database

More...
CDDi
cd07765 KRAB_A-box, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01352 KRAB, 1 hit
PF00096 zf-C2H2, 9 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 10 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 8 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 9 hits
PS50157 ZINC_FINGER_C2H2_2, 11 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 10 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9BR84-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MVAGWLTNYS QDSVTFEDVA VDFTQEEWTL LDQTQRNLYR DVMLENYKNL
60 70 80 90 100
VAVDWESHIN TKWSAPQQNF LQGKTSSVVE MERNHFGEEL FDFNQCEKAL
110 120 130 140 150
SEHSCLKTHR RTYFRKKTCE CNQCEKAFRK PSIFTLHKKT DIGEELPNCN
160 170 180 190 200
QCETAFSQHL HLVCKKTSQN LHLVCKKTHT QEKPYKCSDC EKGLPSSSHL
210 220 230 240 250
RECVRIYGGE RPYTHKEYVE TFSHSTALFV HMQTQDGEKF YECKACGKPF
260 270 280 290 300
TESSYLTQHL RTHSRVLPIE HKKFGKAFAF SPDLAKHIRL RTRGKHYVCN
310 320 330 340 350
ECGKEFTCFS KLNIHIRVHT GEKPYECNKC GKAFTDSSGL IKHRRTHTGE
360 370 380 390 400
KPYECKECGK AFANSSHLTV HMRTHTGEKP YQCKECGKAF INSSSFKSHM
410 420 430 440 450
QTHPGVKPYD CQQCGKAFIR SSFLIRHLRS HSAERPFECE ECGKAFRYSS
460 470 480 490 500
HLSQHKRIHT GERPYKCQKC GQAFSISSGL TVHMRTHTGE RPFECQECGK
510 520 530
AFTRSTYLIR HLRSHSVEKP YKECGQTFSN SSCLTECV
Length:538
Mass (Da):62,318
Last modified:June 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC8BB5EB44B92034A
GO
Isoform 2 (identifier: Q9BR84-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     82-84: ERN → NSE
     85-538: Missing.

Note: No experimental confirmation available.
Show »
Length:84
Mass (Da):9,822
Checksum:i93DEFF7161C2685D
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 10 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0A0MTT2A0A0A0MTT2_HUMAN
Zinc finger protein 559
ZNF559
602Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0A0MTS4A0A0A0MTS4_HUMAN
Zinc finger protein 559
ZNF559
112Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7ERK9K7ERK9_HUMAN
Zinc finger protein 559
ZNF559
68Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EKU6K7EKU6_HUMAN
Zinc finger protein 559
ZNF559
149Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EM21K7EM21_HUMAN
Zinc finger protein 559
ZNF559
81Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EQI4K7EQI4_HUMAN
Zinc finger protein 559
ZNF559
175Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EN17K7EN17_HUMAN
Zinc finger protein 559
ZNF559
52Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
S4R3U0S4R3U0_HUMAN
Zinc finger protein 559
ZNF559
524Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
S4R3F2S4R3F2_HUMAN
Zinc finger protein 559
ZNF559
147Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EK98K7EK98_HUMAN
Zinc finger protein 559
ZNF559
39Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_033576251T → N. Corresponds to variant dbSNP:rs16979670Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_04703982 – 84ERN → NSE in isoform 2. 1 Publication3
Alternative sequenceiVSP_04704085 – 538Missing in isoform 2. 1 PublicationAdd BLAST454

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AK027700 mRNA No translation available.
AC011451 Genomic DNA No translation available.
BC006436 mRNA Translation: AAH06436.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS12211.1 [Q9BR84-1]
CCDS59349.1 [Q9BR84-2]

NCBI Reference Sequences

More...
RefSeqi
NP_001189339.1, NM_001202410.1 [Q9BR84-2]
NP_001189341.1, NM_001202412.1 [Q9BR84-2]
NP_115886.1, NM_032497.2 [Q9BR84-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000317221; ENSP00000325393; ENSG00000188321 [Q9BR84-2]
ENST00000393883; ENSP00000377461; ENSG00000188321 [Q9BR84-1]
ENST00000585352; ENSP00000467048; ENSG00000188321 [Q9BR84-2]
ENST00000603380; ENSP00000474760; ENSG00000188321 [Q9BR84-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
84527

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:84527

UCSC genome browser

More...
UCSCi
uc002mlf.4 human [Q9BR84-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK027700 mRNA No translation available.
AC011451 Genomic DNA No translation available.
BC006436 mRNA Translation: AAH06436.1
CCDSiCCDS12211.1 [Q9BR84-1]
CCDS59349.1 [Q9BR84-2]
RefSeqiNP_001189339.1, NM_001202410.1 [Q9BR84-2]
NP_001189341.1, NM_001202412.1 [Q9BR84-2]
NP_115886.1, NM_032497.2 [Q9BR84-1]

3D structure databases

SMRiQ9BR84
ModBaseiSearch...

Protein-protein interaction databases

BioGridi124118, 5 interactors
IntActiQ9BR84, 6 interactors
STRINGi9606.ENSP00000468153

PTM databases

iPTMnetiQ9BR84
PhosphoSitePlusiQ9BR84

Polymorphism and mutation databases

BioMutaiZNF559
DMDMi74762704

Proteomic databases

EPDiQ9BR84
jPOSTiQ9BR84
MassIVEiQ9BR84
MaxQBiQ9BR84
PaxDbiQ9BR84
PeptideAtlasiQ9BR84
PRIDEiQ9BR84
ProteomicsDBi78749 [Q9BR84-1]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
84527
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000317221; ENSP00000325393; ENSG00000188321 [Q9BR84-2]
ENST00000393883; ENSP00000377461; ENSG00000188321 [Q9BR84-1]
ENST00000585352; ENSP00000467048; ENSG00000188321 [Q9BR84-2]
ENST00000603380; ENSP00000474760; ENSG00000188321 [Q9BR84-1]
GeneIDi84527
KEGGihsa:84527
UCSCiuc002mlf.4 human [Q9BR84-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
84527
DisGeNETi84527

GeneCards: human genes, protein and diseases

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GeneCardsi
ZNF559
HGNCiHGNC:28197 ZNF559
HPAiHPA059632
HPA065485
neXtProtiNX_Q9BR84
OpenTargetsiENSG00000188321
PharmGKBiPA134891126

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00940000164004
HOGENOMiHOG000234617
InParanoidiQ9BR84
KOiK09228
OrthoDBi1318335at2759
PhylomeDBiQ9BR84

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
ZNF559 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
84527

Pharos

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Pharosi
Q9BR84

Protein Ontology

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PROi
PR:Q9BR84

Gene expression databases

BgeeiENSG00000188321 Expressed in 190 organ(s), highest expression level in secondary oocyte
ExpressionAtlasiQ9BR84 baseline and differential
GenevisibleiQ9BR84 HS

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
PF00096 zf-C2H2, 9 hits
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 10 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 8 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 9 hits
PS50157 ZINC_FINGER_C2H2_2, 11 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZN559_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9BR84
Secondary accession number(s): K7EMG6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: June 1, 2001
Last modified: September 18, 2019
This is version 152 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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