UniProtKB - Q9BR77 (CCD77_HUMAN)
Protein
Coiled-coil domain-containing protein 77
Gene
CCDC77
Organism
Homo sapiens (Human)
Status
Names & Taxonomyi
Protein namesi | Recommended name: Coiled-coil domain-containing protein 77 |
Gene namesi | Name:CCDC77 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000120647.9 |
HGNCi | HGNC:28203, CCDC77 |
neXtProti | NX_Q9BR77 |
Subcellular locationi
Cytoskeleton
- centrosome Source: UniProtKB
Other locations
- membrane Source: UniProtKB
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 84318 |
OpenTargetsi | ENSG00000120647 |
PharmGKBi | PA143485429 |
Miscellaneous databases
Pharosi | Q9BR77, Tdark |
Polymorphism and mutation databases
BioMutai | CCDC77 |
DMDMi | 74732846 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000271003 | 1 – 488 | Coiled-coil domain-containing protein 77Add BLAST | 488 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 36 | PhosphoserineBy similarity | 1 | |
Cross-linki | 51 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources |
Keywords - PTMi
Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | Q9BR77 |
jPOSTi | Q9BR77 |
MassIVEi | Q9BR77 |
MaxQBi | Q9BR77 |
PaxDbi | Q9BR77 |
PeptideAtlasi | Q9BR77 |
PRIDEi | Q9BR77 |
ProteomicsDBi | 78747 [Q9BR77-1] 78748 [Q9BR77-2] |
PTM databases
iPTMneti | Q9BR77 |
PhosphoSitePlusi | Q9BR77 |
Expressioni
Gene expression databases
Bgeei | ENSG00000120647, Expressed in oocyte and 162 other tissues |
ExpressionAtlasi | Q9BR77, baseline and differential |
Genevisiblei | Q9BR77, HS |
Organism-specific databases
HPAi | ENSG00000120647, Low tissue specificity |
Interactioni
Protein-protein interaction databases
BioGRIDi | 124044, 53 interactors |
IntActi | Q9BR77, 49 interactors |
MINTi | Q9BR77 |
STRINGi | 9606.ENSP00000239830 |
Miscellaneous databases
RNActi | Q9BR77, protein |
Family & Domainsi
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 55 – 118 | Sequence analysisAdd BLAST | 64 | |
Coiled coili | 208 – 488 | Sequence analysisAdd BLAST | 281 |
Keywords - Domaini
Coiled coilPhylogenomic databases
eggNOGi | ENOG502QT8A, Eukaryota |
GeneTreei | ENSGT00390000010251 |
HOGENOMi | CLU_035281_0_0_1 |
InParanoidi | Q9BR77 |
OMAi | QYRVQCK |
OrthoDBi | 1565693at2759 |
PhylomeDBi | Q9BR77 |
TreeFami | TF329022 |
Family and domain databases
InterProi | View protein in InterPro IPR037696, CCDC77 |
PANTHERi | PTHR22091, PTHR22091, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q9BR77-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MNFTPTHTPV CRKRTVVSKR GVAVSGPTKR RGMADSLEST PLPSPEDRLA
60 70 80 90 100
KLHPSKELLE YYQKKMAECE AENEDLLKKL ELYKEACEGQ HKLECDLQQR
110 120 130 140 150
EEEIAELQKA LSDMQVCLFQ EREHVLRLYS ENDRLRIREL EDKKKIQNLL
160 170 180 190 200
ALVGTDAGEV TYFCKEPPHK VTILQKTIQA VGECEQSESS AFKADPKISK
210 220 230 240 250
RRPSRERKES SEHYQRDIQT LILQVEALQA QLGEQTKLSR EQIEGLIEDR
260 270 280 290 300
RIHLEEIQVQ HQRNQNKIKE LTKNLHHTQE LLYESTKDFL QLRSENQNKE
310 320 330 340 350
KSWMLEKDNL MSKIKQYRVQ CKKKEDKIGK VLPVMHESHH AQSEYIKSLK
360 370 380 390 400
DKLVQEKKLS NMYQEQCISL EEELARIREE EGMRREIFKD RTNKMGKRLQ
410 420 430 440 450
IMTKRYEALE RRRILEVEGF KTDIKVLRQK LKDLEQMLYK ATVNARANQD
460 470 480
LALLCEVRDS NRRAHKIQGE LKNLKSKVFG LENELRLC
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketF5H0W5 | F5H0W5_HUMAN | Coiled-coil domain-containing prote... | CCDC77 | 386 | Annotation score: | ||
F5H5Q8 | F5H5Q8_HUMAN | Coiled-coil domain-containing prote... | CCDC77 | 92 | Annotation score: |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_029838 | 25 | S → R. Corresponds to variant dbSNP:rs4980895Ensembl. | 1 | |
Natural variantiVAR_029839 | 335 | M → T. Corresponds to variant dbSNP:rs735295Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_043135 | 1 – 32 | Missing in isoform 2. 1 PublicationAdd BLAST | 32 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK027638 mRNA Translation: BAB55255.1 AK293165 mRNA Translation: BAG56709.1 AK316029 mRNA Translation: BAH14400.1 AC005844 Genomic DNA No translation available. CH471116 Genomic DNA Translation: EAW88967.1 BC006444 mRNA Translation: AAH06444.1 |
CCDSi | CCDS44781.1 [Q9BR77-2] CCDS8503.1 [Q9BR77-1] |
RefSeqi | NP_001123618.1, NM_001130146.1 [Q9BR77-2] NP_001123619.1, NM_001130147.1 [Q9BR77-2] NP_001123620.1, NM_001130148.1 [Q9BR77-2] NP_115734.1, NM_032358.3 [Q9BR77-1] |
Genome annotation databases
Ensembli | ENST00000239830; ENSP00000239830; ENSG00000120647 [Q9BR77-1] ENST00000412006; ENSP00000412925; ENSG00000120647 [Q9BR77-2] ENST00000422000; ENSP00000391870; ENSG00000120647 [Q9BR77-2] ENST00000540180; ENSP00000440554; ENSG00000120647 [Q9BR77-2] |
GeneIDi | 84318 |
KEGGi | hsa:84318 |
UCSCi | uc001qig.4, human [Q9BR77-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK027638 mRNA Translation: BAB55255.1 AK293165 mRNA Translation: BAG56709.1 AK316029 mRNA Translation: BAH14400.1 AC005844 Genomic DNA No translation available. CH471116 Genomic DNA Translation: EAW88967.1 BC006444 mRNA Translation: AAH06444.1 |
CCDSi | CCDS44781.1 [Q9BR77-2] CCDS8503.1 [Q9BR77-1] |
RefSeqi | NP_001123618.1, NM_001130146.1 [Q9BR77-2] NP_001123619.1, NM_001130147.1 [Q9BR77-2] NP_001123620.1, NM_001130148.1 [Q9BR77-2] NP_115734.1, NM_032358.3 [Q9BR77-1] |
3D structure databases
SMRi | Q9BR77 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 124044, 53 interactors |
IntActi | Q9BR77, 49 interactors |
MINTi | Q9BR77 |
STRINGi | 9606.ENSP00000239830 |
PTM databases
iPTMneti | Q9BR77 |
PhosphoSitePlusi | Q9BR77 |
Polymorphism and mutation databases
BioMutai | CCDC77 |
DMDMi | 74732846 |
Proteomic databases
EPDi | Q9BR77 |
jPOSTi | Q9BR77 |
MassIVEi | Q9BR77 |
MaxQBi | Q9BR77 |
PaxDbi | Q9BR77 |
PeptideAtlasi | Q9BR77 |
PRIDEi | Q9BR77 |
ProteomicsDBi | 78747 [Q9BR77-1] 78748 [Q9BR77-2] |
Protocols and materials databases
Antibodypediai | 50661, 10 antibodies |
Genome annotation databases
Ensembli | ENST00000239830; ENSP00000239830; ENSG00000120647 [Q9BR77-1] ENST00000412006; ENSP00000412925; ENSG00000120647 [Q9BR77-2] ENST00000422000; ENSP00000391870; ENSG00000120647 [Q9BR77-2] ENST00000540180; ENSP00000440554; ENSG00000120647 [Q9BR77-2] |
GeneIDi | 84318 |
KEGGi | hsa:84318 |
UCSCi | uc001qig.4, human [Q9BR77-1] |
Organism-specific databases
CTDi | 84318 |
DisGeNETi | 84318 |
EuPathDBi | HostDB:ENSG00000120647.9 |
GeneCardsi | CCDC77 |
HGNCi | HGNC:28203, CCDC77 |
HPAi | ENSG00000120647, Low tissue specificity |
neXtProti | NX_Q9BR77 |
OpenTargetsi | ENSG00000120647 |
PharmGKBi | PA143485429 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QT8A, Eukaryota |
GeneTreei | ENSGT00390000010251 |
HOGENOMi | CLU_035281_0_0_1 |
InParanoidi | Q9BR77 |
OMAi | QYRVQCK |
OrthoDBi | 1565693at2759 |
PhylomeDBi | Q9BR77 |
TreeFami | TF329022 |
Enzyme and pathway databases
PathwayCommonsi | Q9BR77 |
Miscellaneous databases
BioGRID-ORCSi | 84318, 19 hits in 845 CRISPR screens |
ChiTaRSi | CCDC77, human |
GenomeRNAii | 84318 |
Pharosi | Q9BR77, Tdark |
PROi | PR:Q9BR77 |
RNActi | Q9BR77, protein |
Gene expression databases
Bgeei | ENSG00000120647, Expressed in oocyte and 162 other tissues |
ExpressionAtlasi | Q9BR77, baseline and differential |
Genevisiblei | Q9BR77, HS |
Family and domain databases
InterProi | View protein in InterPro IPR037696, CCDC77 |
PANTHERi | PTHR22091, PTHR22091, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CCD77_HUMAN | |
Accessioni | Q9BR77Primary (citable) accession number: Q9BR77 Secondary accession number(s): B4DDE8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 9, 2007 |
Last sequence update: | June 1, 2001 | |
Last modified: | December 2, 2020 | |
This is version 124 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - Human chromosome 12
Human chromosome 12: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations