UniProtKB - Q9BR76 (COR1B_HUMAN)
Protein
Coronin-1B
Gene
CORO1B
Organism
Homo sapiens (Human)
Status
Functioni
Regulates leading edge dynamics and cell motility in fibroblasts. May be involved in cytokinesis and signal transduction (By similarity).By similarity1 Publication
GO - Molecular functioni
- actin filament binding Source: UniProtKB
- Arp2/3 complex binding Source: UniProtKB
- cadherin binding Source: BHF-UCL
- identical protein binding Source: UniProtKB
GO - Biological processi
- actin cytoskeleton organization Source: CACAO
- actin filament branching Source: UniProtKB
- actin filament bundle assembly Source: UniProtKB
- actin filament organization Source: GO_Central
- cell migration Source: UniProtKB
- cellular response to platelet-derived growth factor stimulus Source: UniProtKB
- endothelial cell chemotaxis Source: UniProtKB
- negative regulation of Arp2/3 complex-mediated actin nucleation Source: UniProtKB
- negative regulation of smooth muscle cell chemotaxis Source: UniProtKB
- positive regulation of lamellipodium morphogenesis Source: UniProtKB
- protein localization to cell leading edge Source: UniProtKB
- regulation of Arp2/3 complex-mediated actin nucleation Source: UniProtKB
- ruffle organization Source: UniProtKB
- wound healing Source: UniProtKB
Keywordsi
Molecular function | Actin-binding |
Enzyme and pathway databases
PathwayCommonsi | Q9BR76 |
SignaLinki | Q9BR76 |
SIGNORi | Q9BR76 |
Names & Taxonomyi
Protein namesi | Recommended name: Coronin-1BAlternative name(s): Coronin-2 |
Gene namesi | Name:CORO1B |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:2253, CORO1B |
MIMi | 609849, gene |
neXtProti | NX_Q9BR76 |
VEuPathDBi | HostDB:ENSG00000172725.13 |
Subcellular locationi
Cytoskeleton
- cytoskeleton 1 Publication
- stress fiber 1 Publication
Note: Localized to the leading edge in fibroblasts, as well as weakly along actin stress fibers.1 Publication
Cytoskeleton
- actin filament Source: UniProtKB
- stress fiber Source: UniProtKB
Cytosol
- cytosol Source: UniProtKB
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
Plasma Membrane
- plasma membrane Source: CACAO
Other locations
- cell leading edge Source: UniProtKB
- cell periphery Source: UniProtKB
- cytoplasm Source: UniProtKB
- focal adhesion Source: UniProtKB
- lamellipodium Source: UniProtKB
- perinuclear region of cytoplasm Source: UniProtKB
Keywords - Cellular componenti
Cytoplasm, CytoskeletonPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 2 | S → A: Stronger interaction with the Arp2/3 complex. Does not affect homo-oligomerization. Enhanced ruffling in response to phorbol 12-myristate 13-acetate (PMA) and increased speed in fibroblasts. 1 Publication | 1 | |
Mutagenesisi | 2 | S → D: Weaker interaction with the Arp2/3 complex. Does not affect homo-oligomerization. Attenuated PMA-induced ruffling and slower speed in fibroblasts. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 57175 |
OpenTargetsi | ENSG00000172725 |
PharmGKBi | PA26769 |
Miscellaneous databases
Pharosi | Q9BR76, Tbio |
Genetic variation databases
BioMutai | CORO1B |
DMDMi | 21263481 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000050922 | 1 – 489 | Coronin-1BAdd BLAST | 489 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | Phosphoserine; by PKC1 Publication | 1 |
Post-translational modificationi
Phosphorylation by PKC on Ser-2 regulates the interaction with the Arp2/3 complex and cell motility in fibroblasts. Phosphorylation does not seem to affect subcellular location.1 Publication
Keywords - PTMi
PhosphoproteinProteomic databases
CPTACi | CPTAC-339 CPTAC-340 |
EPDi | Q9BR76 |
jPOSTi | Q9BR76 |
MassIVEi | Q9BR76 |
MaxQBi | Q9BR76 |
PaxDbi | Q9BR76 |
PeptideAtlasi | Q9BR76 |
PRIDEi | Q9BR76 |
ProteomicsDBi | 78746 |
PTM databases
iPTMneti | Q9BR76 |
MetOSitei | Q9BR76 |
PhosphoSitePlusi | Q9BR76 |
SwissPalmi | Q9BR76 |
Expressioni
Gene expression databases
Bgeei | ENSG00000172725, Expressed in mucosa of transverse colon and 116 other tissues |
ExpressionAtlasi | Q9BR76, baseline and differential |
Genevisiblei | Q9BR76, HS |
Organism-specific databases
HPAi | ENSG00000172725, Low tissue specificity |
Interactioni
Subunit structurei
Forms homooligomers, but does not form complexes with the other coronins.
Interacts with Arp2/3 complex components, including ACTR2, ARPC1B and ARPC2. Binds actin (By similarity).
By similarityBinary interactionsi
Hide detailsQ9BR76
With | #Exp. | IntAct |
---|---|---|
ARPC2 [O15144] | 2 | EBI-351152,EBI-352356 |
CORO1C [Q9ULV4] | 3 | EBI-351152,EBI-351384 |
LHX4 [Q969G2] | 3 | EBI-351152,EBI-2865388 |
SSH1 [Q8WYL5] | 3 | EBI-351152,EBI-1222387 |
TERF1 [P54274] | 2 | EBI-351152,EBI-710997 |
GO - Molecular functioni
- actin filament binding Source: UniProtKB
- cadherin binding Source: BHF-UCL
- identical protein binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 121425, 132 interactors |
DIPi | DIP-33176N |
IntActi | Q9BR76, 51 interactors |
MINTi | Q9BR76 |
STRINGi | 9606.ENSP00000377471 |
Miscellaneous databases
RNActi | Q9BR76, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 18 – 72 | WD 1Add BLAST | 55 | |
Repeati | 73 – 122 | WD 2Add BLAST | 50 | |
Repeati | 123 – 166 | WD 3Add BLAST | 44 | |
Repeati | 167 – 210 | WD 4Add BLAST | 44 | |
Repeati | 211 – 256 | WD 5Add BLAST | 46 | |
Repeati | 257 – 296 | WD 6Add BLAST | 40 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 449 – 474 | Sequence analysisAdd BLAST | 26 |
Sequence similaritiesi
Belongs to the WD repeat coronin family.Curated
Keywords - Domaini
Coiled coil, Repeat, WD repeatPhylogenomic databases
eggNOGi | KOG0303, Eukaryota |
GeneTreei | ENSGT00940000159031 |
HOGENOMi | CLU_026859_0_1_1 |
InParanoidi | Q9BR76 |
OMAi | GDRICRL |
OrthoDBi | 552726at2759 |
PhylomeDBi | Q9BR76 |
TreeFami | TF314280 |
Family and domain databases
Gene3Di | 2.130.10.10, 1 hit |
InterProi | View protein in InterPro IPR027340, Coro1b IPR015505, Coronin IPR015048, DUF1899 IPR015943, WD40/YVTN_repeat-like_dom_sf IPR001680, WD40_repeat IPR019775, WD40_repeat_CS IPR017986, WD40_repeat_dom IPR036322, WD40_repeat_dom_sf |
PANTHERi | PTHR10856, PTHR10856, 1 hit PTHR10856:SF24, PTHR10856:SF24, 1 hit |
Pfami | View protein in Pfam PF08953, DUF1899, 1 hit PF00400, WD40, 3 hits |
SMARTi | View protein in SMART SM01166, DUF1899, 1 hit SM00320, WD40, 3 hits |
SUPFAMi | SSF50978, SSF50978, 1 hit |
PROSITEi | View protein in PROSITE PS00678, WD_REPEATS_1, 1 hit PS50082, WD_REPEATS_2, 2 hits PS50294, WD_REPEATS_REGION, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All
Q9BR76-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSFRKVVRQS KFRHVFGQPV KNDQCYEDIR VSRVTWDSTF CAVNPKFLAV
60 70 80 90 100
IVEASGGGAF LVLPLSKTGR IDKAYPTVCG HTGPVLDIDW CPHNDEVIAS
110 120 130 140 150
GSEDCTVMVW QIPENGLTSP LTEPVVVLEG HTKRVGIIAW HPTARNVLLS
160 170 180 190 200
AGCDNVVLIW NVGTAEELYR LDSLHPDLIY NVSWNHNGSL FCSACKDKSV
210 220 230 240 250
RIIDPRRGTL VAEREKAHEG ARPMRAIFLA DGKVFTTGFS RMSERQLALW
260 270 280 290 300
DPENLEEPMA LQELDSSNGA LLPFYDPDTS VVYVCGKGDS SIRYFEITEE
310 320 330 340 350
PPYIHFLNTF TSKEPQRGMG SMPKRGLEVS KCEIARFYKL HERKCEPIVM
360 370 380 390 400
TVPRKSDLFQ DDLYPDTAGP EAALEAEEWV SGRDADPILI SLREAYVPSK
410 420 430 440 450
QRDLKISRRN VLSDSRPAMA PGSSHLGAPA STTTAADATP SGSLARAGEA
460 470 480
GKLEEVMQEL RALRALVKEQ GDRICRLEEQ LGRMENGDA
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketF5H0D2 | F5H0D2_HUMAN | Coronin | CORO1B | 139 | Annotation score: | ||
F5H390 | F5H390_HUMAN | Coronin | CORO1B | 282 | Annotation score: | ||
A0A087WW53 | A0A087WW53_HUMAN | Coronin | CORO1B | 260 | Annotation score: |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_035877 | 411 | V → M in a colorectal cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs756117196Ensembl. | 1 | |
Natural variantiVAR_053389 | 476 | R → L. Corresponds to variant dbSNP:rs2286624Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK315399 mRNA Translation: BAG37792.1 CH471076 Genomic DNA Translation: EAW74623.1 BC006449 mRNA Translation: AAH06449.1 |
CCDSi | CCDS8164.1 |
RefSeqi | NP_001018080.1, NM_001018070.2 NP_065174.1, NM_020441.2 |
Genome annotation databases
Ensembli | ENST00000341356; ENSP00000340211; ENSG00000172725 ENST00000393893; ENSP00000377471; ENSG00000172725 |
GeneIDi | 57175 |
KEGGi | hsa:57175 |
UCSCi | uc001olk.2, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK315399 mRNA Translation: BAG37792.1 CH471076 Genomic DNA Translation: EAW74623.1 BC006449 mRNA Translation: AAH06449.1 |
CCDSi | CCDS8164.1 |
RefSeqi | NP_001018080.1, NM_001018070.2 NP_065174.1, NM_020441.2 |
3D structure databases
SMRi | Q9BR76 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 121425, 132 interactors |
DIPi | DIP-33176N |
IntActi | Q9BR76, 51 interactors |
MINTi | Q9BR76 |
STRINGi | 9606.ENSP00000377471 |
PTM databases
iPTMneti | Q9BR76 |
MetOSitei | Q9BR76 |
PhosphoSitePlusi | Q9BR76 |
SwissPalmi | Q9BR76 |
Genetic variation databases
BioMutai | CORO1B |
DMDMi | 21263481 |
Proteomic databases
CPTACi | CPTAC-339 CPTAC-340 |
EPDi | Q9BR76 |
jPOSTi | Q9BR76 |
MassIVEi | Q9BR76 |
MaxQBi | Q9BR76 |
PaxDbi | Q9BR76 |
PeptideAtlasi | Q9BR76 |
PRIDEi | Q9BR76 |
ProteomicsDBi | 78746 |
Protocols and materials databases
Antibodypediai | 4316, 225 antibodies |
DNASUi | 57175 |
Genome annotation databases
Ensembli | ENST00000341356; ENSP00000340211; ENSG00000172725 ENST00000393893; ENSP00000377471; ENSG00000172725 |
GeneIDi | 57175 |
KEGGi | hsa:57175 |
UCSCi | uc001olk.2, human |
Organism-specific databases
CTDi | 57175 |
DisGeNETi | 57175 |
GeneCardsi | CORO1B |
HGNCi | HGNC:2253, CORO1B |
HPAi | ENSG00000172725, Low tissue specificity |
MIMi | 609849, gene |
neXtProti | NX_Q9BR76 |
OpenTargetsi | ENSG00000172725 |
PharmGKBi | PA26769 |
VEuPathDBi | HostDB:ENSG00000172725.13 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0303, Eukaryota |
GeneTreei | ENSGT00940000159031 |
HOGENOMi | CLU_026859_0_1_1 |
InParanoidi | Q9BR76 |
OMAi | GDRICRL |
OrthoDBi | 552726at2759 |
PhylomeDBi | Q9BR76 |
TreeFami | TF314280 |
Enzyme and pathway databases
PathwayCommonsi | Q9BR76 |
SignaLinki | Q9BR76 |
SIGNORi | Q9BR76 |
Miscellaneous databases
BioGRID-ORCSi | 57175, 6 hits in 874 CRISPR screens |
GenomeRNAii | 57175 |
Pharosi | Q9BR76, Tbio |
PROi | PR:Q9BR76 |
RNActi | Q9BR76, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000172725, Expressed in mucosa of transverse colon and 116 other tissues |
ExpressionAtlasi | Q9BR76, baseline and differential |
Genevisiblei | Q9BR76, HS |
Family and domain databases
Gene3Di | 2.130.10.10, 1 hit |
InterProi | View protein in InterPro IPR027340, Coro1b IPR015505, Coronin IPR015048, DUF1899 IPR015943, WD40/YVTN_repeat-like_dom_sf IPR001680, WD40_repeat IPR019775, WD40_repeat_CS IPR017986, WD40_repeat_dom IPR036322, WD40_repeat_dom_sf |
PANTHERi | PTHR10856, PTHR10856, 1 hit PTHR10856:SF24, PTHR10856:SF24, 1 hit |
Pfami | View protein in Pfam PF08953, DUF1899, 1 hit PF00400, WD40, 3 hits |
SMARTi | View protein in SMART SM01166, DUF1899, 1 hit SM00320, WD40, 3 hits |
SUPFAMi | SSF50978, SSF50978, 1 hit |
PROSITEi | View protein in PROSITE PS00678, WD_REPEATS_1, 1 hit PS50082, WD_REPEATS_2, 2 hits PS50294, WD_REPEATS_REGION, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | COR1B_HUMAN | |
Accessioni | Q9BR76Primary (citable) accession number: Q9BR76 Secondary accession number(s): B2RD45 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 27, 2002 |
Last sequence update: | June 1, 2001 | |
Last modified: | February 10, 2021 | |
This is version 178 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants