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UniProtKB - Q9BR61 (ACBD6_HUMAN)
Protein
Acyl-CoA-binding domain-containing protein 6
Gene
ACBD6
Organism
Homo sapiens (Human)
Status
Functioni
Binds long-chain acyl-coenzyme A molecules with a strong preference for unsaturated C18:1-CoA, lower affinity for unsaturated C20:4-CoA, and very weak affinity for saturated C16:0-CoA. Does not bind fatty acids.
1 PublicationSites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 95 | Acyl-CoABy similarity | 1 | |
Binding sitei | 114 | Acyl-CoABy similarity | 1 |
GO - Molecular functioni
- fatty-acyl-CoA binding Source: InterPro
- lipid binding Source: UniProtKB-KW
Keywordsi
Ligand | Lipid-binding |
Enzyme and pathway databases
PathwayCommonsi | Q9BR61 |
Reactomei | R-HSA-77289, Mitochondrial Fatty Acid Beta-Oxidation |
SignaLinki | Q9BR61 |
Names & Taxonomyi
Protein namesi | Recommended name: Acyl-CoA-binding domain-containing protein 6 |
Gene namesi | Name:ACBD6 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:23339, ACBD6 |
MIMi | 616352, gene |
neXtProti | NX_Q9BR61 |
VEuPathDBi | HostDB:ENSG00000230124 |
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm 1 Publication
Cytosol
- cytosol Source: Reactome
Keywords - Cellular componenti
CytoplasmPathology & Biotechi
Organism-specific databases
DisGeNETi | 84320 |
MalaCardsi | ACBD6 |
OpenTargetsi | ENSG00000230124 |
PharmGKBi | PA134925459 |
Miscellaneous databases
Pharosi | Q9BR61, Tbio |
Genetic variation databases
BioMutai | ACBD6 |
DMDMi | 74762703 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000232879 | 1 – 282 | Acyl-CoA-binding domain-containing protein 6Add BLAST | 282 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 106 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q9BR61 |
jPOSTi | Q9BR61 |
MassIVEi | Q9BR61 |
MaxQBi | Q9BR61 |
PaxDbi | Q9BR61 |
PeptideAtlasi | Q9BR61 |
PRIDEi | Q9BR61 |
ProteomicsDBi | 78745 |
PTM databases
iPTMneti | Q9BR61 |
MetOSitei | Q9BR61 |
PhosphoSitePlusi | Q9BR61 |
Expressioni
Tissue specificityi
Detected in placenta and spleen (at protein level). Detected in placenta, umbilical cord blood, CD34-positive hematopoietic progenitor cells and bone marrow.1 Publication
Gene expression databases
Bgeei | ENSG00000230124, Expressed in cortical plate and 203 other tissues |
ExpressionAtlasi | Q9BR61, baseline and differential |
Genevisiblei | Q9BR61, HS |
Organism-specific databases
HPAi | ENSG00000230124, Low tissue specificity |
Interactioni
Subunit structurei
Monomer.
1 PublicationBinary interactionsi
Protein-protein interaction databases
BioGRIDi | 124046, 16 interactors |
IntActi | Q9BR61, 8 interactors |
STRINGi | 9606.ENSP00000356567 |
Miscellaneous databases
RNActi | Q9BR61, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
AlphaFoldDBi | Q9BR61 |
SMRi | Q9BR61 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q9BR61 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 42 – 127 | ACBPROSITE-ProRule annotationAdd BLAST | 86 | |
Repeati | 191 – 220 | ANK 1Add BLAST | 30 | |
Repeati | 224 – 253 | ANK 2Add BLAST | 30 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 31 | DisorderedSequence analysisAdd BLAST | 31 | |
Regioni | 69 – 73 | Acyl-CoA bindingBy similarity | 5 |
Keywords - Domaini
ANK repeat, RepeatPhylogenomic databases
eggNOGi | KOG0817, Eukaryota |
GeneTreei | ENSGT00940000157458 |
HOGENOMi | CLU_050309_1_0_1 |
InParanoidi | Q9BR61 |
OMAi | MKARSKW |
OrthoDBi | 1575996at2759 |
PhylomeDBi | Q9BR61 |
TreeFami | TF329102 |
Family and domain databases
Gene3Di | 1.20.80.10, 1 hit 1.25.40.20, 2 hits |
InterProi | View protein in InterPro IPR000582, Acyl-CoA-binding_protein IPR035984, Acyl-CoA-binding_sf IPR002110, Ankyrin_rpt IPR036770, Ankyrin_rpt-contain_sf IPR014352, FERM/acyl-CoA-bd_prot_sf |
Pfami | View protein in Pfam PF00887, ACBP, 1 hit PF12796, Ank_2, 1 hit |
PRINTSi | PR00689, ACOABINDINGP PR01415, ANKYRIN |
SMARTi | View protein in SMART SM00248, ANK, 2 hits |
SUPFAMi | SSF47027, SSF47027, 1 hit SSF48403, SSF48403, 1 hit |
PROSITEi | View protein in PROSITE PS51228, ACB_2, 1 hit PS50297, ANK_REP_REGION, 1 hit PS50088, ANK_REPEAT, 2 hits |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q9BR61-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MASSFLPAGA ITGDSGGELS SGDDSGEVEF PHSPEIEETS CLAELFEKAA
60 70 80 90 100
AHLQGLIQVA SREQLLYLYA RYKQVKVGNC NTPKPSFFDF EGKQKWEAWK
110 120 130 140 150
ALGDSSPSQA MQEYIAVVKK LDPGWNPQIP EKKGKEANTG FGGPVISSLY
160 170 180 190 200
HEETIREEDK NIFDYCRENN IDHITKAIKS KNVDVNVKDE EGRALLHWAC
210 220 230 240 250
DRGHKELVTV LLQHRADINC QDNEGQTALH YASACEFLDI VELLLQSGAD
260 270 280
PTLRDQDGCL PEEVTGCKTV SLVLQRHTTG KA
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A2R8Y544 | A0A2R8Y544_HUMAN | Acyl-CoA-binding domain-containing ... | ACBD6 | 255 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL445469 Genomic DNA No translation available. AL139141 Genomic DNA No translation available. AL358354 Genomic DNA No translation available. BC006505 mRNA Translation: AAH06505.1 |
CCDSi | CCDS1339.1 |
RefSeqi | NP_115736.1, NM_032360.3 |
Genome annotation databases
Ensembli | ENST00000367595.4; ENSP00000356567.3; ENSG00000230124.8 ENST00000642319.1; ENSP00000495710.1; ENSG00000230124.8 |
GeneIDi | 84320 |
KEGGi | hsa:84320 |
MANE-Selecti | ENST00000367595.4; ENSP00000356567.3; NM_032360.4; NP_115736.1 |
UCSCi | uc001gog.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL445469 Genomic DNA No translation available. AL139141 Genomic DNA No translation available. AL358354 Genomic DNA No translation available. BC006505 mRNA Translation: AAH06505.1 |
CCDSi | CCDS1339.1 |
RefSeqi | NP_115736.1, NM_032360.3 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2COP | NMR | - | A | 42-137 | [»] | |
AlphaFoldDBi | Q9BR61 | |||||
SMRi | Q9BR61 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 124046, 16 interactors |
IntActi | Q9BR61, 8 interactors |
STRINGi | 9606.ENSP00000356567 |
PTM databases
iPTMneti | Q9BR61 |
MetOSitei | Q9BR61 |
PhosphoSitePlusi | Q9BR61 |
Genetic variation databases
BioMutai | ACBD6 |
DMDMi | 74762703 |
Proteomic databases
EPDi | Q9BR61 |
jPOSTi | Q9BR61 |
MassIVEi | Q9BR61 |
MaxQBi | Q9BR61 |
PaxDbi | Q9BR61 |
PeptideAtlasi | Q9BR61 |
PRIDEi | Q9BR61 |
ProteomicsDBi | 78745 |
Protocols and materials databases
Antibodypediai | 72484, 206 antibodies from 28 providers |
DNASUi | 84320 |
Genome annotation databases
Ensembli | ENST00000367595.4; ENSP00000356567.3; ENSG00000230124.8 ENST00000642319.1; ENSP00000495710.1; ENSG00000230124.8 |
GeneIDi | 84320 |
KEGGi | hsa:84320 |
MANE-Selecti | ENST00000367595.4; ENSP00000356567.3; NM_032360.4; NP_115736.1 |
UCSCi | uc001gog.4, human |
Organism-specific databases
CTDi | 84320 |
DisGeNETi | 84320 |
GeneCardsi | ACBD6 |
HGNCi | HGNC:23339, ACBD6 |
HPAi | ENSG00000230124, Low tissue specificity |
MalaCardsi | ACBD6 |
MIMi | 616352, gene |
neXtProti | NX_Q9BR61 |
OpenTargetsi | ENSG00000230124 |
PharmGKBi | PA134925459 |
VEuPathDBi | HostDB:ENSG00000230124 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0817, Eukaryota |
GeneTreei | ENSGT00940000157458 |
HOGENOMi | CLU_050309_1_0_1 |
InParanoidi | Q9BR61 |
OMAi | MKARSKW |
OrthoDBi | 1575996at2759 |
PhylomeDBi | Q9BR61 |
TreeFami | TF329102 |
Enzyme and pathway databases
PathwayCommonsi | Q9BR61 |
Reactomei | R-HSA-77289, Mitochondrial Fatty Acid Beta-Oxidation |
SignaLinki | Q9BR61 |
Miscellaneous databases
BioGRID-ORCSi | 84320, 13 hits in 1078 CRISPR screens |
ChiTaRSi | ACBD6, human |
EvolutionaryTracei | Q9BR61 |
GenomeRNAii | 84320 |
Pharosi | Q9BR61, Tbio |
PROi | PR:Q9BR61 |
RNActi | Q9BR61, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000230124, Expressed in cortical plate and 203 other tissues |
ExpressionAtlasi | Q9BR61, baseline and differential |
Genevisiblei | Q9BR61, HS |
Family and domain databases
Gene3Di | 1.20.80.10, 1 hit 1.25.40.20, 2 hits |
InterProi | View protein in InterPro IPR000582, Acyl-CoA-binding_protein IPR035984, Acyl-CoA-binding_sf IPR002110, Ankyrin_rpt IPR036770, Ankyrin_rpt-contain_sf IPR014352, FERM/acyl-CoA-bd_prot_sf |
Pfami | View protein in Pfam PF00887, ACBP, 1 hit PF12796, Ank_2, 1 hit |
PRINTSi | PR00689, ACOABINDINGP PR01415, ANKYRIN |
SMARTi | View protein in SMART SM00248, ANK, 2 hits |
SUPFAMi | SSF47027, SSF47027, 1 hit SSF48403, SSF48403, 1 hit |
PROSITEi | View protein in PROSITE PS51228, ACB_2, 1 hit PS50297, ANK_REP_REGION, 1 hit PS50088, ANK_REPEAT, 2 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | ACBD6_HUMAN | |
Accessioni | Q9BR61Primary (citable) accession number: Q9BR61 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 18, 2006 |
Last sequence update: | June 1, 2001 | |
Last modified: | May 25, 2022 | |
This is version 165 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references