UniProtKB - Q9BR26 (OCSTP_HUMAN)
Protein
Osteoclast stimulatory transmembrane protein
Gene
OCSTAMP
Organism
Homo sapiens (Human)
Status
Functioni
Probable cell surface receptor that plays a role in cellular fusion and cell differentiation. Cooperates with DCSTAMP in modulating cell-cell fusion in both osteoclasts and foreign body giant cells (FBGCs). Involved in osteoclast bone resorption. Promotes osteoclast differentiation and may play a role in the multinucleated osteoclast maturation (By similarity).By similarity
GO - Biological processi
- cellular response to estrogen stimulus Source: UniProtKB
- cellular response to tumor necrosis factor Source: UniProtKB
- multinuclear osteoclast differentiation Source: UniProtKB
- positive regulation of macrophage fusion Source: Ensembl
- positive regulation of osteoclast differentiation Source: UniProtKB
- positive regulation of osteoclast proliferation Source: UniProtKB
Keywordsi
Biological process | Differentiation |
Enzyme and pathway databases
PathwayCommonsi | Q9BR26 |
Protein family/group databases
TCDBi | 1.N.1.1.1, the osteoclast fusion complex (ofc) family |
Names & Taxonomyi
Protein namesi | Recommended name: Osteoclast stimulatory transmembrane proteinShort name: OC-STAMP |
Gene namesi | Name:OCSTAMP Synonyms:C20orf123 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:16116, OCSTAMP |
neXtProti | NX_Q9BR26 |
VEuPathDBi | HostDB:ENSG00000149635.2 |
Subcellular locationi
Other locations
- Membrane Curated; Multi-pass membrane protein Curated
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 51 | CytoplasmicSequence analysisAdd BLAST | 51 | |
Transmembranei | 52 – 72 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 73 – 81 | ExtracellularSequence analysis | 9 | |
Transmembranei | 82 – 102 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 103 – 128 | CytoplasmicSequence analysisAdd BLAST | 26 | |
Transmembranei | 129 – 149 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 150 – 227 | ExtracellularSequence analysisAdd BLAST | 78 | |
Transmembranei | 228 – 248 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 249 – 304 | CytoplasmicSequence analysisAdd BLAST | 56 | |
Transmembranei | 305 – 325 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 326 – 398 | ExtracellularSequence analysisAdd BLAST | 73 | |
Transmembranei | 399 – 419 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 420 – 566 | CytoplasmicSequence analysisAdd BLAST | 147 |
Keywords - Cellular componenti
MembranePathology & Biotechi
Organism-specific databases
OpenTargetsi | ENSG00000149635 |
PharmGKBi | PA25664 |
Miscellaneous databases
Pharosi | Q9BR26, Tdark |
Genetic variation databases
BioMutai | OCSTAMP |
DMDMi | 193806176 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000342121 | 1 – 566 | Osteoclast stimulatory transmembrane proteinAdd BLAST | 566 |
Proteomic databases
PaxDbi | Q9BR26 |
PRIDEi | Q9BR26 |
ProteomicsDBi | 78739 |
PTM databases
PhosphoSitePlusi | Q9BR26 |
Expressioni
Gene expression databases
Bgeei | ENSG00000149635, Expressed in material anatomical entity and 9 other tissues |
Organism-specific databases
HPAi | ENSG00000149635, Tissue enhanced (adipose tissue, blood) |
Interactioni
Protein-protein interaction databases
STRINGi | 9606.ENSP00000279028 |
Miscellaneous databases
RNActi | Q9BR26, protein |
Family & Domainsi
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 59 – 63 | Poly-Ala | 5 |
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502QWNK, Eukaryota |
GeneTreei | ENSGT00940000153269 |
HOGENOMi | CLU_045128_0_0_1 |
InParanoidi | Q9BR26 |
OMAi | LRCVLTM |
OrthoDBi | 1224213at2759 |
PhylomeDBi | Q9BR26 |
TreeFami | TF332562 |
Family and domain databases
InterProi | View protein in InterPro IPR012858, DC_STAMP-like |
Pfami | View protein in Pfam PF07782, DC_STAMP, 1 hit |
i Sequence
Sequence statusi: Complete.
Q9BR26-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MPGHPGAAEQ LVKTGWRSWH LGFWKALAPL QAAWDAFSQP VPASCGQLLT
60 70 80 90 100
QLLLCASLAA AAAGLVYHWL ASLLLYPPGP SAMVATVCGL LVFLSLGLVP
110 120 130 140 150
PVRCLFALSV PTLGMEQGRR LLLSYSTATL AIAVVPNVLA NVGAAGQVLR
160 170 180 190 200
CVTEGSLESL LNTTHQLHAA SRALGPTGQA GSRGLTFEAQ DNGSAFYLHM
210 220 230 240 250
LRVTQQVLED FSGLESLARA AALGTQRVVT GLFMLGLLVE SAWYLHCYLT
260 270 280 290 300
DLRFDNIYAT QQLTQRLAQA QATHLLAPPP TWLLQAAQLR LSQEELLSCL
310 320 330 340 350
LRLGLLALLL VATAVAVATD HVAFLLAQAT VDWAQKLPTV PITLTVKYDV
360 370 380 390 400
AYTVLGFIPF LFNQLAPESP FLSVHSSYQW ELRLTSARCP LLPARRPRAA
410 420 430 440 450
APLAAGALQL LAGSTVLLEA YARRLRHAIA ASFFTAQEAR RVRHLHARLQ
460 470 480 490 500
RRHDRHQGQQ LPLGDPSCVP TPRPACKPPA WIDYRLDALR TESSEGEGKE
510 520 530 540 550
LWSCRDLSCN LGPVPPPCVT LGKSLHLSEP RFLHLHNDSI FTIDVTYFPR
560
RDVVRMEGNT GHDRPG
Sequence cautioni
The sequence AL935075 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_050919 | 565 | P → S. Corresponds to variant dbSNP:rs847079Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL034424 Genomic DNA No translation available. AL935075 mRNA No translation available. AL935089 mRNA No translation available. BX281477 mRNA No translation available. |
CCDSi | CCDS54468.1 |
RefSeqi | NP_542452.1, NM_080721.2 |
Genome annotation databases
Ensembli | ENST00000279028; ENSP00000279028; ENSG00000149635 |
GeneIDi | 128506 |
KEGGi | hsa:128506 |
UCSCi | uc010zxu.3, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL034424 Genomic DNA No translation available. AL935075 mRNA No translation available. AL935089 mRNA No translation available. BX281477 mRNA No translation available. |
CCDSi | CCDS54468.1 |
RefSeqi | NP_542452.1, NM_080721.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 9606.ENSP00000279028 |
Protein family/group databases
TCDBi | 1.N.1.1.1, the osteoclast fusion complex (ofc) family |
PTM databases
PhosphoSitePlusi | Q9BR26 |
Genetic variation databases
BioMutai | OCSTAMP |
DMDMi | 193806176 |
Proteomic databases
PaxDbi | Q9BR26 |
PRIDEi | Q9BR26 |
ProteomicsDBi | 78739 |
Protocols and materials databases
Antibodypediai | 28113, 14 antibodies |
Genome annotation databases
Ensembli | ENST00000279028; ENSP00000279028; ENSG00000149635 |
GeneIDi | 128506 |
KEGGi | hsa:128506 |
UCSCi | uc010zxu.3, human |
Organism-specific databases
CTDi | 128506 |
GeneCardsi | OCSTAMP |
HGNCi | HGNC:16116, OCSTAMP |
HPAi | ENSG00000149635, Tissue enhanced (adipose tissue, blood) |
neXtProti | NX_Q9BR26 |
OpenTargetsi | ENSG00000149635 |
PharmGKBi | PA25664 |
VEuPathDBi | HostDB:ENSG00000149635.2 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QWNK, Eukaryota |
GeneTreei | ENSGT00940000153269 |
HOGENOMi | CLU_045128_0_0_1 |
InParanoidi | Q9BR26 |
OMAi | LRCVLTM |
OrthoDBi | 1224213at2759 |
PhylomeDBi | Q9BR26 |
TreeFami | TF332562 |
Enzyme and pathway databases
PathwayCommonsi | Q9BR26 |
Miscellaneous databases
BioGRID-ORCSi | 128506, 9 hits in 978 CRISPR screens |
GenomeRNAii | 128506 |
Pharosi | Q9BR26, Tdark |
PROi | PR:Q9BR26 |
RNActi | Q9BR26, protein |
Gene expression databases
Bgeei | ENSG00000149635, Expressed in material anatomical entity and 9 other tissues |
Family and domain databases
InterProi | View protein in InterPro IPR012858, DC_STAMP-like |
Pfami | View protein in Pfam PF07782, DC_STAMP, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | OCSTP_HUMAN | |
Accessioni | Q9BR26Primary (citable) accession number: Q9BR26 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 1, 2008 |
Last sequence update: | July 1, 2008 | |
Last modified: | April 7, 2021 | |
This is version 110 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 20
Human chromosome 20: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports