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UniProtKB - Q9BR11 (ZSWM1_HUMAN)

Protein

Zinc finger SWIM domain-containing protein 1

Gene

ZSWIM1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri363 – 405SWIM-typePROSITE-ProRule annotationAdd BLAST43

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

View the complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandMetal-binding, Zinc

Enzyme and pathway databases

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q9BR11

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger SWIM domain-containing protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZSWIM1
Synonyms:C20orf162
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 20

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000168612.4

Human Gene Nomenclature Database

More...HGNCi		HGNC:16155 ZSWIM1

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9BR11

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...OpenTargetsi		ENSG00000168612

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA25704

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		ZSWIM1

Domain mapping of disease mutations (DMDM)

More...DMDMi		73920980

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002230951 – 485Zinc finger SWIM domain-containing protein 1Add BLAST485

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q9BR11

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q9BR11

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9BR11

PeptideAtlas

More...PeptideAtlasi		Q9BR11

PRoteomics IDEntifications database

More...PRIDEi		Q9BR11

ProteomicsDB human proteome resource

More...ProteomicsDBi		78737

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9BR11

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9BR11

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000168612 Expressed in 129 organ(s), highest expression level in cerebellum

CleanEx database of gene expression profiles

More...CleanExi		HS_ZSWIM1

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9BR11 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		HPA041147
HPA046751

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		124678, 2 interactors

Protein interaction database and analysis system

More...IntActi		Q9BR11, 4 interactors

Molecular INTeraction database

More...MINTi		Q9BR11

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...ProteinModelPortali		Q9BR11

Database of comparative protein structure models

More...ModBasei		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri363 – 405SWIM-typePROSITE-ProRule annotationAdd BLAST43

Keywords - Domaini

Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG410IK5N Eukaryota
ENOG4111FY6 LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00390000017273

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		HOG000231003

The HOVERGEN Database of Homologous Vertebrate Genes

More...HOVERGENi		HBG099855

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9BR11

Identification of Orthologs from Complete Genome Data

More...OMAi		CKFLQGK

Database of Orthologous Groups

More...OrthoDBi		EOG091G01A2

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9BR11

TreeFam database of animal gene trees

More...TreeFami		TF335703

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR007527 Znf_SWIM
IPR040303 ZSWIM1

The PANTHER Classification System

More...PANTHERi		PTHR31569:SF0 PTHR31569:SF0, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF04434 SWIM, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50966 ZF_SWIM, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9BR11-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLERLKAPWS AALQRKYFDL GIWTAPISPM ALTMLNGLLI KDSSPPMLLH 
        60         70         80         90        100
QVNKTAQLDT FNYQSCFMQS VFDHFPEILF IHRTYNPRGK VLYTFLVDGP 
       110        120        130        140        150
RVQLEGHLAR AVYFAIPAKE DTEGLAQMFQ VFKKFNPAWE RVCTILVDPH 
       160        170        180        190        200
FLPLPILAME FPTAEVLLSA FHICKFLQAK FYQLSLERPV ERLLLTSLQS 
       210        220        230        240        250
TMCSATAGNL RKLYTLLSNC IPPAKLPELH SHWLLNDRIW LAHRWRSRAE 
       260        270        280        290        300
SSHYFQSLEV TTHILSQFFG TTPSEKQGMA SLFRYMQQNS ADKANFNQGL 
       310        320        330        340        350
CAQNNHAPSD TIPESPKLEQ LVESHIQHSL NAICTGPAAQ LCLGELAVVQ 
       360        370        380        390        400
KSTHLIGSGS EKMNIQILED THKVQPQPPA SCSCYFNQAF HLPCRHILAM 
       410        420        430        440        450
LSARRQVLQP DMLPAQWTAG CATSLDSILG SKWSETLDKH LAVTHLTEEV 
       460        470        480 
GQLLQHCTKE EFERRYSTLR ELADSWIGPY EQVQL
Length:485
Mass (Da):55,071
Last modified:August 30, 2005 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF7447E98EFC6FD6E
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_020445101R → Q. Corresponds to variant dbSNP:rs3746500Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AL008726 Genomic DNA No translation available.
BC001672 mRNA Translation: AAH01672.3
BC080525 mRNA Translation: AAH80525.2

The Consensus CDS (CCDS) project

More...CCDSi		CCDS13382.2

NCBI Reference Sequences

More...RefSeqi		NP_542170.3, NM_080603.4
XP_005260667.1, XM_005260610.4
XP_005260668.1, XM_005260611.4
XP_011527402.1, XM_011529100.2

UniGene gene-oriented nucleotide sequence clusters

More...UniGenei		Hs.517075

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000372520; ENSP00000361598; ENSG00000168612
ENST00000372523; ENSP00000361601; ENSG00000168612

Database of genes from NCBI RefSeq genomes

More...GeneIDi		90204

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:90204

UCSC genome browser

More...UCSCi		uc010ghi.4 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL008726 Genomic DNA No translation available.
BC001672 mRNA Translation: AAH01672.3
BC080525 mRNA Translation: AAH80525.2
CCDSiCCDS13382.2
RefSeqiNP_542170.3, NM_080603.4
XP_005260667.1, XM_005260610.4
XP_005260668.1, XM_005260611.4
XP_011527402.1, XM_011529100.2
UniGeneiHs.517075

3D structure databases

ProteinModelPortaliQ9BR11
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124678, 2 interactors
IntActiQ9BR11, 4 interactors
MINTiQ9BR11

PTM databases

iPTMnetiQ9BR11
PhosphoSitePlusiQ9BR11

Polymorphism and mutation databases

BioMutaiZSWIM1
DMDMi73920980

Proteomic databases

EPDiQ9BR11
MaxQBiQ9BR11
PaxDbiQ9BR11
PeptideAtlasiQ9BR11
PRIDEiQ9BR11
ProteomicsDBi78737

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000372520; ENSP00000361598; ENSG00000168612
ENST00000372523; ENSP00000361601; ENSG00000168612
GeneIDi90204
KEGGihsa:90204
UCSCiuc010ghi.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		90204
EuPathDBiHostDB:ENSG00000168612.4

GeneCards: human genes, protein and diseases

More...GeneCardsi		ZSWIM1
HGNCiHGNC:16155 ZSWIM1
HPAiHPA041147
HPA046751
neXtProtiNX_Q9BR11
OpenTargetsiENSG00000168612
PharmGKBiPA25704

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG410IK5N Eukaryota
ENOG4111FY6 LUCA
GeneTreeiENSGT00390000017273
HOGENOMiHOG000231003
HOVERGENiHBG099855
InParanoidiQ9BR11
OMAiCKFLQGK
OrthoDBiEOG091G01A2
PhylomeDBiQ9BR11
TreeFamiTF335703

Enzyme and pathway databases

SignaLinkiQ9BR11

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		ZSWIM1 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		90204

Protein Ontology

More...PROi		PR:Q9BR11

Gene expression databases

BgeeiENSG00000168612 Expressed in 129 organ(s), highest expression level in cerebellum
CleanExiHS_ZSWIM1
GenevisibleiQ9BR11 HS

Family and domain databases

InterProiView protein in InterPro
IPR007527 Znf_SWIM
IPR040303 ZSWIM1
PANTHERiPTHR31569:SF0 PTHR31569:SF0, 1 hit
PfamiView protein in Pfam
PF04434 SWIM, 1 hit
PROSITEiView protein in PROSITE
PS50966 ZF_SWIM, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZSWM1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9BR11
Secondary accession number(s): Q5JZH2, Q9BR12, Q9BV30
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 25, 2003
Last sequence update: August 30, 2005
Last modified: December 5, 2018
This is version 118 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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